Spatial Control of Bio-Materials by Suspended Carbon Nanotubes
| Project/Area Number |
17360019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thin film/Surface and interfacial physical properties
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| Research Institution | Yokohama National University |
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Principal Investigator |
OGINO Toshio Yokohama National University, Dept. of Electrical and Computer Engineering, Professor (70361871)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,810,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥810,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥8,500,000 (Direct Cost: ¥8,500,000)
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| Keywords | Bio-materials / Advanced Functional Devices / Nanotubes / Nanao-Biotechnology / Surfaces and Interfaces / カーボンナノチューブ / ナノテクノロジー / バイオテクノロジー / 化学気相成長 / フェリチン / DNA / 生体分子 |
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| Research Abstract |
The purpose of this project is classified into two themes:
(1) Control of carbon nanotube networks toward nano-integrated devices including semiconductors, carbon nanotube interconnections and bio-functional components.
(2) Investigation of adsorption mechanism of bio-molecules onto carbon nanotubes toward bio- and medical-application of carbon nanotubes.
For these goals, we have studied fabrication techniques of carbon nanotube three-dimensional networks and characterization of bio-molecules, such as proteins and DNAs, adsorbed on carbon nanotube surfaces.
In carbon nanotube networks, we have developed a grafting technique using a chemical vapor deposition assisted with metal catalysts. In this technique, carbon nanotubes are grown from catalyst particle deposited on the pie-grown suspended carbon nanotubes. Using this technique, a three-dimensional carbon nanotube networks can be fabricated. It was found that the carbon nanotube grafting is powerful to observe the growth mechanism using
… More
a transmission electron microscopy because the catalyst particles and grown carbon nanotubes are fixed in a free space.
Carbon nanotube sheets were fabricated by the chemical vapor deposition using a porous silica film as a supporting material for catalyst particles. DNAs were immobilized on the grown carbon nanotube sheets through chemical bonds. DNAs were labeled with fluorescent molecules and observed using fluorescence microscopy. We succeeded to observe adsorption of DNAs onto the carbon nanotube sheets and hybridization of DNAs.
Adsorption properties of protein molecules are important in application of carbon nanotubes to bio-technology and medicine. We applied carbon nanotubes to adsorption materials in plasma exchange to remove bilirubin which causes liver disease. The adsorption behavior was analyzed by infrared vibration spectroscopy. We found that protein molecules, such as albumin and avidin, are adsorbed on carbon nanotube surfaces at a high efficiency.
In conclusion, we have fabricated three-dimensional carbon nanotube networks and applied them to immobilization of protein and DNA molecules. Less
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Report
(4 results)
Research Products
(249 results)
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[Presentation] Formation of Lipid Bilayers on Solid Surfaces2007
Author(s)
H. Tanaka, T. Isono, T. Oya, and T. Ogino
Organizer
1st Int'1 Symp. on Nanomedicine-from Basic to Applications-(ISNM2007)and 2nd Molecule-Based Information Transmission and Reception(MB-ITR2007)
Place of Presentation
Okazaki, Japan
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Bilirubin/Albumin Adsorption on Carbon Nanotubes2007
Author(s)
K. Ando, A. Ueda, T. Oya, T. Koyama, T. Takai, and T. Ogino
Organizer
1st Int'1 Symp. on Nanomedicine-from Basic to Applications-(ISNM2007)and 2nd Molecule-Based Information Transmission and Reception(MB-ITR2007)
Place of Presentation
Okazaki, Japan
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 固体表面への分子吸着2007
Author(s)
青木隆仁, 葉玉康仁, 荻野俊郎
Organizer
文部科学省平成18年度ナノテク支援実績報告会
Place of Presentation
岡崎
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] 固体表面上への脂質二重膜の形成2007
Author(s)
磯野俊成, 田中華子, 塚本貴広, 大矢剛嗣, 荻野俊郎
Organizer
文部科学省平成18年度ナノテク支援実績報告会
Place of Presentation
岡崎
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Bilirubin/Albumin Adsorption on Carbon Nanotube Surfaces for Medical Treatment2007
Author(s)
K, Ando, A. Ueda, S, Yamada, T, Oya, T, Koyama*, T, Takai*, T, Ogino
Organizer
ACSIN-9 PS1-76 308
Place of Presentation
Tokyo
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Formation of Lipid Bilayers on Solid Surfaces2007
Author(s)
H, Tanaka, T, Isono, T, Oya, T, Ogino
Organizer
1st Int'l Symp. on Nanomedicine - from Basic to Applications-(ISNM2007) and 2nd Molecule-Based Information Transmission and Reception(MB-ITR2007)
Place of Presentation
Okazaki, Japan
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] Bilirubin/ Albumin Adsorption on Carbon Nanotubes2007
Author(s)
K, Ando, A. Ueda, T, Oya, T, Koyama*, T, T, akai*, T, Ogino
Organizer
1st Int'l Symp. on Nanomedicine -from Basic to Applications-(ISNM2007) and 2nd Molecule-Based Information Transmission and Reception(MB-ITR2007)
Place of Presentation
Okazaki, Japan
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Presentation] サファイア基板上への生体分子固定2005
Author(s)
青木隆仁, 葉玉康仁, 河中崇博, 三澤宣雄, Md. Mashir Rahman, 手老龍吾, 宇理須恒雄, 竹内敦子, 荻野俊郎
Organizer
第66回応用物理学会秋季学術講演会
Place of Presentation
徳島
Description
「研究成果報告書概要(和文)」より
Related Report
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[Presentation] Immobilization of bio-materials on step-controlled sapphire substrates2005
Author(s)
R, Aoki, Y, Hadama, T, Kawanaka, N, Misawa, M, Rahman, R, Tero, T, Urisu, A. Takeuchi, T, Arakawa, T, Ogino
Organizer
ISSS-4
Place of Presentation
Omiya, Japan
Description
「研究成果報告書概要(欧文)」より
Related Report
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