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Investigation of the Mechanism of the Production and the Evaluation as a Cell Culture Support of Polymer Porous Medium with Controlled 3-Dimensional Structure

Research Project

Project/Area Number 17360381
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Reaction engineering/Process system
Research InstitutionYokohama National University

Principal Investigator

NISHI Kazuhiko  Yokohama National University, Graduate School of Engineering, Associate Professor, 大学院工学研究院, 助教授 (20262412)

Co-Investigator(Kenkyū-buntansha) KAMINOYAMA Meguru  Yokohama National University, Graduate School of Engineering, Professor, 大学院工学研究院, 教授 (50233945)
MISUMI Ryuta  Yokohama National University, Graduate School of Engineering, Assistant, 大学院工学研究院, 助手 (40334635)
WATANABE Masatoshi  Yokohama National University, Graduate School of Engineering, Professor, 大学院工学研究院, 教授 (90273383)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥8,200,000 (Direct Cost: ¥8,200,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2005: ¥6,100,000 (Direct Cost: ¥6,100,000)
Keywordspolymerization / supercritical fluid / reaction, separation engineering / cell, cellular tissue / chemical engineering
Research Abstract

In this study, the production of the polymer porous medium by polymerization in supercritical carbon dioxide was investigated.
1.Control of 3-dimensional structure of the polymer porous medium
The cross linked polymerization of styrene and acrylics nitril was performed in supercritical carbon dioxide, and the control method of the 3-dimensional structure of the polymer porous medium was investigated. Polymerization was performed on various conditions of pressure, temperature and concentration. The relation between the polymerization conditions and the diameter of the porous medium, the diameter of a primary particle, specific surface area and the diameter distribution of fine pores was shown.
2.Mechanism of the polymer porous medium production
It is guessed that the solubility of the polymer in polymerizing field influences on the mechanism of polymer porous medium production. Based on time until polymer deposits out of polymerization solution, the solubility of polymer was shown quantitat … More ively, and the influence polymerization condition on structure was explained.
3.Production of the polymer porous medium using stirred type supercritical polymerization reactor
The industrial production of the polymer porous medium using stirred type supercritical polymerization reactor was considered. The procedure which produces a styrene porous medium was established. The influence of the impeller rotations number on the rate of polymerization and structure was shown.
4.Molding to polymer porous medium of the polymer particles and surface treatment, washing of the porous medium
The method of molding polymer particles on the porous medium by treating with supercritical carbon dioxide was discussed. Furthermore, the surface treatment and washing of the polymer porous medium using supercritical carbon dioxide were studied.
5.Cultivation of human prostatic cancer cell using polymer porous medium
The human prostatic cancer cell culture using the polystyrene and the poly acrylics nitrile porous medium as a culture support was performed. In all porous mediums, the cell was increasing to the inside of the porous medium, and it was confirmed that the polymer porous medium in this study can use it as a cell a culture support. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (3 results)

All 2006 2005

All Journal Article (3 results)

  • [Journal Article] On-line Measuring Method to Determine Crystal Size Distribution in Stirred-Type Crystallizers using a Real-Time, High-Speed Image Processing System2006

    • Author(s)
      Nishi, K., R.Misumi, M.Kaminoyama, M.Kamiwano
    • Journal Title

      Bulletin of the Society of Sea Water Science, Japan 60・5

      Pages: 365-378

    • NAID

      10017956192

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] On-line Measuring Method to Determine Crystal Size Distribution in Stirred-Type Crystallizers Using a Real-Time, High-speed Image Processing System2006

    • Author(s)
      Nishi, K., M.Kaminoyama, R.Misumi, M.Kamiwano
    • Journal Title

      Bull.Soc.Sea Water Sci. (Jpn.) 60

      Pages: 365-378

    • NAID

      10017956192

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Production of the Styrene Porous Medium by Cross-linked Polymerization in Supercritical Carbon Dioxide2005

    • Author(s)
      Nishi, K., Y.Morikawa, R.Misumi, M.Kaminoyama
    • Journal Title

      2005 International Symposium On Advanced Engineering

      Pages: 264-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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