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Molecular mechanisms of recovery of stalled DNA replication fork

Research Project

Project/Area Number 17370063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

HISAJI Maki  Nara Institute of Science and Technology, Graduate school of Biological Sciences, Deapartment of Molecular Biology, Professor (20199649)

Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,660,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 2005: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywordsgenetics / gene / genome / DNA replication / mutation
Research Abstract

An assay measuring synchronized, processive DNA replication by Escherichia coli DNA polymerase III holoenzyme (Pol III HE) was used to reveal replacement of Pol III by the specialized lesion bypass Pol IV when the replicative polymerase is stalled. When idled replication is restarted, a rapid burst of Pol III-catalyzed synthesis accompanied by 〜7-kb full-length products is strongly inhibited by the presence of Pol IV. The production of slower-forming shorter-length DNA reflects a rapid takeover of DNA synthesis by Pol IV. We demonstrated that Pol IV rapidly (<15 sec) obstructs the stable interaction between Pol III^* and the beta damp (the lifetime of the complex >5 min), causing the removal of Pol III^* from template DNA. We propose that the rapid replacement of Pol III^* on the beta damp with Pol IV is mediated by two processes, an interaction between Pol IV and the beta clamp and a separate interaction between Pol IV and Pol III^*. This newly discovered property of Pol IV facilitates a dynamic exchange between the two free polymerases at the primer terminus. Our study suggests a model in which the interaction between Pol III^* and the beta clamp is mediated by Pol IV to ensure that DNA replication proceeds with minimal interruption.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (87 results)

All 2008 2007 2006 2005

All Journal Article (27 results) (of which Peer Reviewed: 13 results) Presentation (58 results) Book (2 results)

  • [Journal Article] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp.2008

    • Author(s)
      A. Furukohri
    • Journal Title

      J. Biol. Chem. 283

      Pages: 11260-11269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Spontaneous mutagenesis associated with nucleotide excision repair in Escherichia coli.2008

    • Author(s)
      K. Hasegawa
    • Journal Title

      Genes to Cells 13

      Pages: 459-469

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp2008

    • Author(s)
      A. Furukohri
    • Journal Title

      J. Biol. Chem 283

      Pages: 11260-11269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli2008

    • Author(s)
      K. Hasegawa
    • Journal Title

      Genes to Cells 13

      Pages: 459-469

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A dynamic polymerase exchange with Escherichia coli pol IV replacing pol III on the sliding clamp2008

    • Author(s)
      A. Furukohri
    • Journal Title

      J Biol Chem(電子出版)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli2008

    • Author(s)
      K. Hasegawa
    • Journal Title

      Genes Cells (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis.2007

    • Author(s)
      K. Sakamoto
    • Journal Title

      Cancer Research 67

      Pages: 6599-6604

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The dnaE173 mutator mutation confers on the a subunit of Escherichia coli DNA polymerase III a capacity for highly processive DNA synthesis and stable binding to primer-template DNA.2007

    • Author(s)
      F. Yanagihara
    • Journal Title

      Genes Genet. Systems 82

      Pages: 273-280

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Roles of RecA protein in spontaneous mutagenesis in Escherichia coli.2007

    • Author(s)
      S. Kanie
    • Journal Title

      Genes Genet. Systems 82

      Pages: 99-108

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Abnormality in initiation program of DNA replication is monitored by the highly repetitive rDNA array on chromosome XII in budding yeast.2007

    • Author(s)
      S. Ide
    • Journal Title

      Mol. Cell Biol. 27

      Pages: 568-578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The dnaE173 mutator mutation confers on the a subunit of Escherichia coli DNA polymerase III a capacity for highly processive DNA synthesis and stable binding toprimer-template DNA2007

    • Author(s)
      F. Yanagihara
    • Journal Title

      Genes Genet Systems 82(4)

      Pages: 273-280

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis2007

    • Author(s)
      K. Sakamoto
    • Journal Title

      Cancer Research 67(14)

      Pages: 6599-6604

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Roles of RecA protein in spontaneous mutagenesis in Escherichia coli2007

    • Author(s)
      S. Kanie
    • Journal Title

      Genes Genet Systems 82(2)

      Pages: 99-108

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Abnormality in initiation program of DNA replication is monitored by the highly repetitive rDNA array on chromosome XII in budding yeast2007

    • Author(s)
      S. Ide
    • Journal Title

      Mol. Cell Biol 27

      Pages: 568-578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] MUTYH-null mice are susceptible to spontaneous and oxidative-stress-induced intestinal tumorigenesis.2007

    • Author(s)
      K. Sakamoto
    • Journal Title

      Cancer Research 67(14)

      Pages: 6599-6604

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dnaE173 mutator mutation confers on the a subunit of Escherichia coli DNA polymerase III a capacity for highly processive DNA synthesis and stable binding to primer-template DNA2007

    • Author(s)
      F. Yanagihara
    • Journal Title

      Genes Genet Systems 82(4)

      Pages: 273-280

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormality in initiation program of DNA replication is monitored by the highly repetitive rDNA array on chromosome XII in budding yeast.2007

    • Author(s)
      S.Ide
    • Journal Title

      Mol Cell Bio 27

      Pages: 568-578

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli.2006

    • Author(s)
      A. Sakai
    • Journal Title

      Genes to Cells 11

      Pages: 767-778

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae.2006

    • Author(s)
      T. Tsubota
    • Journal Title

      J. Biol. Chem. 281

      Pages: 32898-32908

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli2006

    • Author(s)
      A. Sakai
    • Journal Title

      Genes Cells 11

      Pages: 767-778

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharornyces cerevisiae2006

    • Author(s)
      T. Tsubota
    • Journal Title

      J. Biol. Chem, ASBMB Today 281, 5

      Pages: 32898-32908

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae.2006

    • Author(s)
      T.Tsubota
    • Journal Title

      J Biol Chem 281

      Pages: 32898-32908

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli.2006

    • Author(s)
      A.Sakai
    • Journal Title

      Genes Cells 11

      Pages: 767-778

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DNA polymerases η and κ are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimmer in Xenopus laevis oocyte extracts.2005

    • Author(s)
      Y. Yagi
    • Journal Title

      DNA Repair 4

      Pages: 1252-1269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DNA polymerases η and κ are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimer in Xenopus laevis oocyte extracts2005

    • Author(s)
      Y. Yagi
    • Journal Title

      DNA Repair (Amst) 4

      Pages: 1252-1269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] RNAi-mediated silencing of OsGEN-L (OsGEN-like), a new member of the RAD2/XPG nuclease family, causes male sterility by defect of microspore development in rice.2005

    • Author(s)
      S.Moritoh
    • Journal Title

      Plant Cell Physiol. 46

      Pages: 699-715

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA polymerases η and κ are responsible for error-free translesion DNA synthesis activity over a cis-syn thymine dimmer in Xenopus laevis oocyte extracts.2005

    • Author(s)
      Y.Yagi
    • Journal Title

      DNA Repair 4

      Pages: 1252-1269

    • Related Report
      2005 Annual Research Report
  • [Presentation] 大腸菌in vitro DNA複製系におけるDNA polymerase switchの解析:PolIVによるPOL III制御機構2008

    • Author(s)
      古郡麻子
    • Organizer
      組換え・染色体再編ワークショップ、第19回DNA複製・分配ワークショップ(合同開催)
    • Place of Presentation
      ラフォーレ修繕寺(伊豆市)
    • Year and Date
      2008-03-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌in vitro DNA複製系におけるDNA polymerase switchの解析:Pol IVによるPOL III制御機構2008

    • Author(s)
      古郡麻子
    • Organizer
      組換え・染色体再編ワークショップ、第19回DNA複製・分配ワークショップ(合同開催)
    • Place of Presentation
      フォーレ修繕寺(伊豆市)
    • Year and Date
      2008-03-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 大腸菌in vitro DNA複製系を用いたDNAポリメラーゼスイッチの解析:Pol IVによるPol III制御機構2007

    • Author(s)
      古郡麻子
    • Organizer
      日本遺伝学会第79回大会
    • Place of Presentation
      岡山大学理学部
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vitro analysis of polymerase switch using E. coli DNA polymerases : A novel effect of translesion polymerase Pol IV on replicative Pol III HE2007

    • Author(s)
      A. Furukohri
    • Organizer
      The 79th Annual Meeting of the Genetics Society of Japan
    • Place of Presentation
      Okayama University, Japan
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌in vitro DNA複製系を用いたDNAポリメラーゼスイッチの解析:Pol IVによるPol III制御機構2007

    • Author(s)
      古郡麻子
    • Organizer
      日本遺伝学会第79回大会
    • Place of Presentation
      岡山大学理学部・創立50周年記念館
    • Year and Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 複製開始制御異常に起因する染色体異常と細胞死の誘発;rDNA領域の役割2007

    • Author(s)
      真木寿治
    • Organizer
      日本遺伝学会第79回大会
    • Place of Presentation
      岡山大学理学部
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAポリメラーゼDinBによるDNA複製の阻害2007

    • Author(s)
      秋山昌広
    • Organizer
      日本遺伝学会第79回大会
    • Place of Presentation
      岡山大学理学部
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of rDNA locus in monitoring abnormal initiation program of chromosomal replication by DNA damage check-point control2007

    • Author(s)
      M. Hisaji
    • Organizer
      The 79th Annual Meeting of the Genetics Society of Japan
    • Place of Presentation
      Okayama University, Japan
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibition of DNA replication by DNA polymerase DinB2007

    • Author(s)
      M. Akiyama
    • Organizer
      The 79th Annual Meeting of the Genetics Society of Japan
    • Place of Presentation
      Okayama University, Japan
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 複製開始制御異常に起因する染色体異常と細胞死の誘発;rDNA領域の役割2007

    • Author(s)
      真木寿治
    • Organizer
      日本遺伝学会第79回大会
    • Place of Presentation
      岡山大学理学部・創立50周年記念館
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] DNAポリメラーゼDinBによるDNA複製の阻害2007

    • Author(s)
      秋山昌広
    • Organizer
      日本遺伝学会第79回大会
    • Place of Presentation
      岡山大学理学部・創立50周年記念館
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] A new pathway of spontaneous mutagenesis: repair DNA synthesis error during unnecessary action of nucleotide excision repair.2007

    • Author(s)
      真木寿治
    • Organizer
      第3回 日米DNA修復会議
    • Place of Presentation
      クレセントホテル(仙台市)
    • Year and Date
      2007-05-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel activity of DNA polymerase IV(DinB)to promote the dissociation of a replicative enzyme complex, Pol III, from beta clamp subunit on primer-template DNA.2007

    • Author(s)
      古郡麻子
    • Organizer
      第3回 日米DNA修復会議
    • Place of Presentation
      クレセントホテル(仙台市)
    • Year and Date
      2007-05-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A new pathway of spontaneous mutagenesis: repair DNA synthesis error during unnecessary action of nucleotide excision repair2007

    • Author(s)
      M. Hisaji
    • Organizer
      3rd Japan-US DNA Repair Meeting
    • Place of Presentation
      Akiu, Sendai, Japan
    • Year and Date
      2007-05-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel activity of DNA polymerase IV (DinB) to promote the dissociation of a replicative enzyme complex, Pol III, from beta clamp subunit on primer-template DNA2007

    • Author(s)
      A. Furukohri
    • Organizer
      3rd Japan-US DNA Repair Meeting
    • Place of Presentation
      Akiu, Sendai, Japan
    • Year and Date
      2007-05-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 染色体複製開始異常のモニター機構2006

    • Author(s)
      井手 聖
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-12-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAポリメラーゼスイッチングに関する生化学的解析:大腸菌DNA Pol VI(DinB)による複製酵素DNA Pol IIIの制御2006

    • Author(s)
      古郡麻子
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌DNAポリメラーゼIIIにより誘発される配列置換変異に関する研究2006

    • Author(s)
      柳原 芳光
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAポリメラーゼDinBの過剰発現による大腸菌のDNA複製の阻害2006

    • Author(s)
      秋山 昌広
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] sgs1欠損のサプレッサー遺伝子であるSHU1、SHU2の新規機能の探索2006

    • Author(s)
      中磯 和敏
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] リボソームRNA遺伝子のExtra-coding機構2006

    • Author(s)
      小林 武彦
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2006-12-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] sgs1欠損のサプレッサー遺伝子であるSHU1、SHU2の新規機能の探索2006

    • Author(s)
      中磯 和敏
    • Organizer
      組換え・染色体再編ワークショップ
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAポリメラーゼスイッチングに関する生化学的解析:大腸菌DNAPolVI(DinB)による複製酵素DNAPolIIIの制御2006

    • Author(s)
      古郡 麻子
    • Organizer
      第18回DNA複製・分配ワークショップ
    • Place of Presentation
      KKRホテル熱海
    • Year and Date
      2006-10-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 染色体の複製開始制御異常をモニターする機構2006

    • Author(s)
      井手 聖
    • Organizer
      第18回DNA複製・分配ワークショップ
    • Place of Presentation
      KKRホテル熱海
    • Year and Date
      2006-10-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌DNAポリメラーゼIIIにより誘発される配列置換変異に関する研究2006

    • Author(s)
      柳原 芳光
    • Organizer
      第18回 DNA複製・分配ワークショップ
    • Place of Presentation
      KKRホテル熱海
    • Year and Date
      2006-10-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAポリメラーゼDinBの過剰発現による大腸菌のDNA複製の阻害2006

    • Author(s)
      秋山 昌広
    • Organizer
      第18回DNA複製・分配ワークショップ
    • Place of Presentation
      KKRホテル熱海
    • Year and Date
      2006-10-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路2006

    • Author(s)
      沙魚川 公子
    • Organizer
      第3回21世紀大腸菌研究会
    • Place of Presentation
      ウェルサシピア滋賀
    • Year and Date
      2006-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 染色体複製開始異常のモニター機構2006

    • Author(s)
      井手 聖
    • Organizer
      日本遺伝学会第78回大会
    • Place of Presentation
      つくば国際会議場エポカル
    • Year and Date
      2006-09-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌のY型DNAポリメラーゼDinBの渦剰発現によるDNA複製の阻害2006

    • Author(s)
      内田 香里
    • Organizer
      日本遺伝学会第78回大会
    • Place of Presentation
      つくば国際会議場エポカル
    • Year and Date
      2006-09-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌DNAポリメラーゼIのエキソヌクレアーゼ活性は配列置換変異の発生を抑制するか?2006

    • Author(s)
      大橋 慧也
    • Organizer
      日本遺伝学会第78回大会
    • Place of Presentation
      つくば国際会議場エポカル
    • Year and Date
      2006-09-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路2006

    • Author(s)
      沙魚川 公子
    • Organizer
      日本遺伝学会第78回大会
    • Place of Presentation
      つくば国際会議場エポカル
    • Year and Date
      2006-09-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 出芽酵母DNAポリメラーゼε(Polε)のアクセサリーサブユニットDpb3pとDpb4pの新規の生化学的機能:一本鎖DNAセンシングとPolε-DNA相互作用の制御における役割2005

    • Author(s)
      田島 理絵
    • Organizer
      第28画日本分子生物学会年会
    • Place of Presentation
      ヤフードーム
    • Year and Date
      2005-12-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌dam mutS二重変異株における超高頻度DNA組み換え2005

    • Author(s)
      澤井 和子
    • Organizer
      第34回日本環境変異原学会大会
    • Place of Presentation
      こまばエミナース
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel biochemical properties of the dnaE173 mutant a subunit of Escherichia coli DNA polymerase III.2005

    • Author(s)
      柳原 芳光
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA polymerase η and κ are responsible for error-free translesion DNA synthesis over a cis-syn thymine dimer in Xenopus laevis oocyte extracts.2005

    • Author(s)
      秋山 昌広
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escherichia coli.2005

    • Author(s)
      沙魚川 公子
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Impact of Reactive Oxygen Species on Spontaneous Mutagenesis in Escherichia coli.2005

    • Author(s)
      坂井 亜紀子
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of rDNA locus in monitoring abnormality in the initiation program of chromosomal DNA replication by DNA damage checkpoint control.2005

    • Author(s)
      井手 聖
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of SRS2 in genome maintenance in Saccharomyces cerevisiae.2005

    • Author(s)
      中磯 和敏
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comprehensive analyses of genomic changes in mouse cells defective in DNA mismatch repair using Msh2-/-mice habouring the rpsL transgene.2005

    • Author(s)
      A. Egashira
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of DNA polymerase switching upon translesion DNA synthesis: A novel action of DinB protein on the DNA chain elongation by DNA polymerase III holoenzyme.2005

    • Author(s)
      真木 寿治
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2005-11-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of rDNA locus in monitoring abnormality in the initiation program of chromosomal DNA replication by DNA damage checkpoint control.2005

    • Author(s)
      真木 寿治
    • Organizer
      第51回基礎生物学研究所コンファレンス
    • Place of Presentation
      基礎生物学研究所
    • Year and Date
      2005-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 出芽酵母の染色体複製開始制御異常をモニターする機構2005

    • Author(s)
      井手 聖
    • Organizer
      日本遺伝学会第77回大会
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2005-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNAポリメラーゼIV(DinB)による複製フォーク進行阻害の回復機構2005

    • Author(s)
      真木 寿治
    • Organizer
      日本遺伝学会第77回大会
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然突然変異の発生における酸素ラジカルの役割2005

    • Author(s)
      坂井 亜紀子
    • Organizer
      日本遺伝学会第77回大会
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路2005

    • Author(s)
      沙魚川 公子
    • Organizer
      日本遺伝学会第77回大会
    • Place of Presentation
      国立オリンピック記念青少年総合センター
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 大腸菌のヌクレオチド除去修復による自然突然変異の誘発経路2005

    • Author(s)
      沙魚川 公子
    • Organizer
      第2回21世紀大腸菌研究会
    • Place of Presentation
      メルパール伊勢志摩
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然突然変異の発生と抑制の分子機構2005

    • Author(s)
      真木 寿治
    • Organizer
      日本環境変異原学会公開シンポジウム
    • Place of Presentation
      共立薬科大学記念講堂
    • Year and Date
      2005-05-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of DNA polymerase switching upon translesion DNA synthesis: A novel action of DinB protein on the DNA chainelongation by DNA polymerase III holoenzyme2005

    • Author(s)
      M. Hisaji
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel biochemical properties of the dnaE173 mutant a subunit of Escherichia coli DNA polymerase III2005

    • Author(s)
      F. Yanagihara
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA polymerase η and κ are responsible for error-free translesion DNA synthesis over a cis-syn thymine dimer in Xenopus laevis oocyte extracts2005

    • Author(s)
      M. Akiyama
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms of DNA polymerase switching upon translesion DNA synthesis: A novel action of DinB protein on the DNA chain elongation by DNA polymerase III holoenzyme2005

    • Author(s)
      A. Furukohri
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous Mutagenesis Associated with Nucleotide Excision Repair in Escharichth coil2005

    • Author(s)
      K. Hasegawa
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Impact of Reactive Oxygen Species on Spontaneous Mutagenesis in Escherichth coll2005

    • Author(s)
      A. Sakai
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of rDNA locus in monitoring abnormality in the initiation program of chromosomal DNA replication by DNA damage checkpoint control2005

    • Author(s)
      S. Ide
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of SRS2in genome maintenance in Saccharomyces cerevisiae2005

    • Author(s)
      K. Nakaiso
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Comprehensive analyses of genomic changes in mouse cells defective in DNA mismatch repair using Msh2-1-mice habouring the rpsL transgene2005

    • Author(s)
      A. Egashira
    • Organizer
      The 5th International 3R (DNA Replication, Recombination and Repair) Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of rDNA locus in monitoring abnormality in the initiation program of chromosomal DNA replication by DNA damage checkpoint control2005

    • Author(s)
      M. Hisaji
    • Organizer
      51st NIBB Conference
    • Place of Presentation
      Okazaki Conference Center, National Institute for Basic Biology, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] バイオインフォマティクス辞典2006

    • Author(s)
      真木 寿治
    • Publisher
      共立出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝子から生命をみる-分子生物学の誕生と発展-2006

    • Author(s)
      真木 寿治
    • Publisher
      共立出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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