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Mechanism of pathogenicity manifestation by fish parasites through host switching

Research Project

Project/Area Number 17380114
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General fisheries
Research InstitutionThe University of Tokyo

Principal Investigator

OGAWA Kazuo  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Professor (20092174)

Co-Investigator(Kenkyū-buntansha) URAWA Shigehiko  Nat. Salmon Resources Center, さけますセンター・さけます研究部, Chief Scientist (60425460)
YOSHINAGA Tomoyoshi  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Associate Professor (20345185)
YOKOYAMA Hiroshi  The University of Tokyo, Graduate School of Agricultural and Life Sciences, Assistant (70261956)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2007: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsFisheries Science / Fish Pathology / Fish parasite / Pathogenicity / Host switch / Neoheterobothrium hirame / Enteromyxum leei / Kabatana takedai / Pseudodactylogyrus bini
Research Abstract

In order to elucidate mechanisms of new disease outbreaks through host switch by fish parasites, infection experiments were conducted using natural and unnatural fish hosts and susceptibility among different host fish species was analysed and infection dynamics were compared.
1) Pseudodactylogyrus bini and P. anguillae (Monogenea) of eels: Infection experiments were carried out of Japanese and European eels with the two species of monogeneans and infection dynamics were compared by regular samplings. As a result, European eel, an unnatural host, was more heavily infected in terms of both prevalence and intensity than Japanese eel, and parasites grew faster on the former eel than on the latter.
2) Heterobothrium okamotoi (Monogenea) of tiger puffer: Settlement rates of hatched larvae (oncomiracidia) of the parasite on the host were compared among many marine fishes including tiger puffer, the natural host. It was revealed that the oncomiracidia selectively settled on the gills of fishes o … More f the genus Takifugu, suggesting its high host specificity upon settlement. It was also suggested that more than one factor was involved in inducing oncomiracidial settlement on the gills in the process of host selection by H. okamotoi.
3) Enteromyxum leei (Myxozoa) of tiger puffer: Infection experiments show that Japanese flounder, red sea bream and clownfish were as susceptible as tiger puffer, originally known host fish to the myxozoan, suggesting the possibility that the infection might spread to cultured fish other than tiger puffer and marine ornamental fish as well. Mortality and infection dynamics were affected by host size, salinity of rearing water and water temperature.
4) Kabatana takedai (Microsporea) of salmonid fishes: By exposing fish to water containing an unknown infectious stage of the microsporean, infection levels were compared among three strains of masu salmon, the natural host, and rainbow trout. Although no differences in the infection level were observed among the masu salmon strains, rainbow trout was more heavily infected in the heart muscle than masu salmon. It suggests the possibility that the parasite causes disease not only to masu salmon, but also to rainbow trout, an introduced fish from North America. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007 2005

All Journal Article (14 results) (of which Peer Reviewed: 8 results) Presentation (6 results)

  • [Journal Article] Myxosporean emaciation disease of cultured red sea bream Pagrus major and spotted knifejaw Oplegnathus punctatus2008

    • Author(s)
      Yanagida T., et al.
    • Journal Title

      Fish Pathol. 43

      Pages: 45-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of susceptibility between Japanese and European eels to infections with Pseudodactylogyrus spp. (Monogenea).2008

    • Author(s)
      Fang J., et al.
    • Journal Title

      Fish Pathol. 43

      Pages: 144-151

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Myxosporean emaciation disease of cultured red sea bream Pagrus major and spotted knifejaw Oplegnathus punctatus.2008

    • Author(s)
      Yanagida, T., O. Palenzuela, T. Hirae, S. Tanaka, H. Yokoyama, K. Ogawa
    • Journal Title

      Fish Pathology 43 (1)

      Pages: 45-48

    • NAID

      10021214830

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of susceptibility between Japanese and European eels to in fections with Pseudodactylogyrus spp. (Monogenea).2008

    • Author(s)
      Fang, J., S. Shirakashi, K. Ogawa
    • Journal Title

      Fish Pathology 43 (4)

      Pages: 144-151

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of susceptibility between Japanese and European eels to infections with Pseudodactylogyrus spp. (Monogenea)2008

    • Author(s)
      Fang, J., et al.
    • Journal Title

      Fish Pathol. 43

      Pages: 144-151

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of hyposalinity treatment on infection with Enteromyxum leei (Myxozoa) using anemonefish Amphiprion spp. as experimental host2007

    • Author(s)
      Yokoyama H., Shirakashi S.
    • Journal Title

      Bull. Eur. Ass. Fish Pathol. 27

      Pages: 74-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of host recognition by oncomiracidia and post-larval surviv ability in the host specificity of Heterobothrium okamotoi (Monogenea : Diclidophoridae).2007

    • Author(s)
      Ohhashi, Y., et al.
    • Journal Title

      Int. J. Parasitol 37

      Pages: 53-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of susceptibility to Kabatana takedai (Microspora) among salmonid fishes2007

    • Author(s)
      Miyajima S., et al.
    • Journal Title

      Fish Pathol. 43

      Pages: 149-157

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of host recognition and survivability in the host specificity of the monogenean parasite Heterobothrium okamotoi.2007

    • Author(s)
      Ohhashi, Y., T. Yoshinaga, K. Ogawa
    • Journal Title

      International Journal for Parasitology 37 (1)

      Pages: 53-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of susceptibility to Kabatana takedai(Microspora) among salmonid fish.2007

    • Author(s)
      Miyajima, S., S. Urawa, H. Yokoyama, K. Ogawa
    • Journal Title

      Fish Pathology 42 (3)

      Pages: 149-157

    • NAID

      10019858375

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of hyposalinity treatment on infection with Enteromyxum leei (Myxozoa) using anemonefish Amphiprion spp. as experimental host.2007

    • Author(s)
      Yokoyama, H., S. Shirakashi
    • Journal Title

      Bulletin of the European Association of Fish Pathologists 27 (2)

      Pages: 74-78

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of susceptibility to Kabatana takedai (Microspora) among salmonid fishes2007

    • Author(s)
      Miyajima S., et al.
    • Journal Title

      Fish Pathol. 42

      Pages: 149-157

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of host recognition by oncomiracidia and post-larval surviv ability in the host specificity of Heterobothrium okamotoi (Monogenea : Diclidophoridae)2007

    • Author(s)
      Ohhashi, Y., et al.
    • Journal Title

      Int. J. Parasitol 37

      Pages: 53-60

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of hyposalinity treatment on infection with Enteromyxumleei (Myxozoa) using anemonefish Amphiprion spp. as experimental host2007

    • Author(s)
      Yokoyama H. & Shirakashi S.
    • Journal Title

      Bull. Eur. Ass. Fish Pathol. 27・2

      Pages: 74-78

    • Related Report
      2006 Annual Research Report
  • [Presentation] In vitro and in vivo studies on viability of Enteromyxunm leei (Myxozoa), an enteric parasite of cultured puffer fish.2008

    • Author(s)
      Kageyama M., et al.
    • Organizer
      第5回日本魚病学会国際シンポジウム
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vitro and in vivo studies on viability of Enteromyxum leei (Myxozoa), an enteric parasite of cultured puffer fish.2008

    • Author(s)
      Kageyama, M, H. Yokoyama, T. Yanagida, K. Ogawa
    • Organizer
      5th International Symposium of the Japanese Society for Fish Pathology
    • Place of Presentation
      Tokyo, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vitro and in vivo studies on viability of Enteromyxum leei (Myxozoa), an enteric parasite of cultured puffer fish2008

    • Author(s)
      Kageyama M., et al.
    • Organizer
      第5回日本魚病学会国際シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel vital staining technique to determine the viability of Enteromyxum leei (Myxozoa)2007

    • Author(s)
      Yokoyama H., et al.
    • Organizer
      7th International Symposium on Fish Parasites
    • Place of Presentation
      イタリア、ヴィテルボ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] A novel vital staining technique to determine the viability of Enteromyxum leei (Myxozoa).2007

    • Author(s)
      Yokoyama, H., M. Kageyama, K. Ogawa
    • Organizer
      7th International Symposium on Fish Parasites
    • Place of Presentation
      Viterbo, Itraly
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Putative mechanisms of the host specificity of the monogenean parasite Heterobothrium okamotoi.2005

    • Author(s)
      Ohhashi Y., et al.
    • Organizer
      Fifth International Symposium on Monogeneans
    • Place of Presentation
      Guanzhou, China
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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