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A novel therapeutic strategy for zoonotic emerging and reemerging infections

Research Project

Project/Area Number 17380179
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionThe University of Tokyo

Principal Investigator

HORIMOTO Taisuke  The University of Tokyo, 医科学研究所, 准教授 (00222282)

Co-Investigator(Kenkyū-buntansha) GOTOH Hideo  東京大学, 医科学研究所, 助教 (50323639)
TAKADA Ayato  北海道大学, 人畜共通感染症リサーチセンター, 教授 (10292062)
YASUDA Jiro  科学警察研究所, 法科学第一部, 室長 (10282518)
SHIMOJIMA Masayuki  東京大学, 医科学研究所, 助教 (10422411)
Co-Investigator(Renkei-kenkyūsha) TAKADA Ayato  北海道大学, 人畜共通感染症リサーチセンター, 教授 (10292062)
YASUDA Jiro  科学警察研究所, 法科学第一部, 室長 (10282518)
SHIMOJIMA Masayuki  東京大学, 医科学研究所, 助教 (10422411)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,780,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥4,100,000 (Direct Cost: ¥4,100,000)
Keywordsインフルエンザ / ワクチン / ベクター / 高病原性鳥インフルエンザ / H5N1
Research Abstract

人畜共通新興再興感染症は人類の脅威である。特に、H5N1 高病原性鳥インフルエンザの世界的な蔓延とヒトへの感染は、インフルエンザの新たな世界的大流行(パンデミック) を危惧させている。本研究では、こういった世界情勢を鑑み、H5N1 ワクチン開発のための基礎研究を実施した。その結果、不活化ワクチン製造のためのシードウイルスの発育鶏卵ならびにMDCK 細胞における増殖基盤を明らかにし、その知見をもとに高増殖性シードウイルスの作出に成功した。本成果は、今後のインフルエンザワクチン開発におおいに貢献することが期待される。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (45 results)

All 2008 2007 2006 2005 2004

All Journal Article (35 results) (of which Peer Reviewed: 22 results) Presentation (7 results) Book (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Ko S-Y, Park S-H, Kweon M-N : Sublingual vaccination with influenza virus protects mice against lethal viral infection2008

    • Author(s)
      Song J-H, Lee A-Y, Nguyen HH, Czerkinsky C, Cubura N, Horimoto T
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 1644-1649

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of canine RNA polymerase I-driven reverse genetics for influenza A virus : its application for H5N1 vaccine production2008

    • Author(s)
      Murakami S, Horimoto T, Yamada S, Kakugawa S, Goto H, Kawaoka Y
    • Journal Title

      J Virol 82

      Pages: 1605-1609

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells2008

    • Author(s)
      Murakami S, Horimoto T, Le QM, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y
    • Journal Title

      J Virol 82

      Pages: 10502-10509

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model2008

    • Author(s)
      Murakami S, Iwasa A, Iwatsuki-HK, Ito M, Kiso M, Kida H, Takada A, Nidom CA, Le QM, Yamada S, Imai H, Sakai-T Y, Kawaoka Y, Horimoto T
    • Journal Title

      Vaccine 26

      Pages: 6398-6404

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-clade protective immunity of H5N1 influenza vaccines in a mouse model.2008

    • Author(s)
      Murakami S
    • Journal Title

      Vaccine 26

      Pages: 6398-6404

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells.2008

    • Author(s)
      Murakami S
    • Journal Title

      J Virol 82

      Pages: 10502-10509

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sublingual vaccination with influenza virus protects mice against lethal viral infection.2008

    • Author(s)
      Song J-H
    • Journal Title

      Proc Natl Acad Sci USA 105

      Pages: 1644-1649

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced growth of seed viruses for H5N1 influenza vaccines2007

    • Author(s)
      Horimoto T, Murakami S, Muramoto Y, Yamada S, Fujii K , Kiso M, Iwatsuki-H K, Kino Y, Kawaoka Y
    • Journal Title

      Virology 366

      Pages: 23-27

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A single intranasal immunization with inactivated influenza virus and alphagalactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system2007

    • Author(s)
      Youn H-J, Ko S-Y, Lee K-A, Ko H-J, Lee Y-S, Fujihashi K, Boyaka PN, Kim S-H, Horimoto T, Kweon M-N, Kang C-Y
    • Journal Title

      Vaccine 25

      Pages: 5189-5198

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An adenoviral vector-mediated reverse genetics system for influenza A virus generation2007

    • Author(s)
      Ozawa M, et. al.
    • Journal Title

      J Virol 81

      Pages: 9556-9559

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced growth of seed viruses for H5N1 influenza vaccines2007

    • Author(s)
      Horimoto T, et. al.
    • Journal Title

      Virology 366

      Pages: 23-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新型インフルエンザワクチンの開発2007

    • Author(s)
      堀本 泰介
    • Journal Title

      治療学 41(10)

      Pages: 59-62

    • Related Report
      2007 Annual Research Report
  • [Journal Article] The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate2006

    • Author(s)
      Horimoto T, Takada A, Fujii K, Goto H, Hatta M, Watanabe S, Iwatsuki-H K, Ito M, Tagawa-S Y, Yamada S, Ito H, Ito T, Imai M, Itamura S, Odagiri T, Tashiro M, Lim W, Guan Y, Peiris M, Kawaoka Y
    • Journal Title

      Vaccine 24

      Pages: 3669-3676

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly2006

    • Author(s)
      Iwatsuki-H K, Horimoto T, Noda T, Kiso M, Maeda J, Watanabe S, Muramoto Y, Fujii K, Kawaoka Y
    • Journal Title

      J Virol 80

      Pages: 5233-5240

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors2006

    • Author(s)
      Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y
    • Journal Title

      Nature 444

      Pages: 378-382

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The development and characterizationof H5 influenza virus vaccines derived from a 2003 human isolate.2006

    • Author(s)
      Horimoto T, et al.
    • Journal Title

      Vaccine 24

      Pages: 3669-3676

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions.2006

    • Author(s)
      Muramoto Y, et al.
    • Journal Title

      J Virol 80

      Pages: 2318-2325

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly.2006

    • Author(s)
      Iwatsuki-Horimoto K, et al.
    • Journal Title

      J Virol 80

      Pages: 5233-5240

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptos.2006

    • Author(s)
      Yamada S, et al.
    • Journal Title

      Nature 444

      Pages: 378-382

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Strategies for developing vaccines for H5N1 influenza A viruses.2006

    • Author(s)
      Horimoto T, et al.
    • Journal Title

      Trends Mol Med 12

      Pages: 506-514

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新型インフルエンザに対するワクチン開発2006

    • Author(s)
      堀本泰介
    • Journal Title

      カレントテラピー 24

      Pages: 54-58

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization of H5N1 influenza A viruses isolated during the outbreaks(in Japan)2005

    • Author(s)
      Mase M, Tsukamoto K, Imada T, Imai K, Tanimura N, Nakamura K, Yamamoto Y, Hitomi T, Kira T, Nakai T, Kiso M, Horimoto T, Kawaoka Y, Yamaguchi S
    • Journal Title

      Virology 332

      Pages: 167-176

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The importance of both the coding and segment-specific noncoding regions of the influenza A virus NS segment for its efficient incorporation into virions2005

    • Author(s)
      Fujii K, Fujii Y, Noda T, Muramoto Y, Watanabe T, Takada A, Goto H, Horimoto T, Kawaoka Y
    • Journal Title

      Virol 79

      Pages: 3766-3774

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a human H5N1 influenza A virus isolated in 20032005

    • Author(s)
      Shinya K, Hatta M, Yamada S, Takada A, Watanabe S, Halfmann P, Horimoto T, Neumann G, Kim JH, Lim W, Guan Y, Peiris M, Kiso M, Suzuki T, Suzuki Y, Kawaoka Y
    • Journal Title

      J Virol 79

      Pages: 9926-9932

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of a genotypically unique H5N1 influenza virus from duck meat imported into Japan from China2005

    • Author(s)
      Mase M, Eto M, Tanimura N, Imai K, Tsukamoto K, Horimoto T, Kawaoka Y, Yamaguchi S
    • Journal Title

      Virology 339

      Pages: 101-109

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A drug-resistant H5N1 flu virus2005

    • Author(s)
      Le QM, Kiso M, Someya K, Sakai YT, Nguyen TH, Nguyen KH, Pham ND, Ngyen HH, Yamada S, Muramoto Y, Horimoto T, Takada A, Goto H, Suzuki T, Suzuki Y, Kawaoka Y
    • Journal Title

      Nature 437

      Pages: 1108-1108

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of H5N1 influenza A viruses isolated during the outbreaks in Japan.2005

    • Author(s)
      Mase, M
    • Journal Title

      Virology 332

      Pages: 167-176

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Influenza : lessons from past pandemics, warnings from current incidents2005

    • Author(s)
      Horimoto, T
    • Journal Title

      Nature Rev.Microbiol. 3

      Pages: 591-600

    • Related Report
      2005 Annual Research Report
  • [Journal Article] パンデミックは再来する 鳥トリインフルエンザに隠された殺人鬼の影2005

    • Author(s)
      堀本泰介
    • Journal Title

      日経サイエンス 3月号

      Pages: 30-35

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A drug-resistant H5N1 flu virus.2005

    • Author(s)
      Le, Q.M
    • Journal Title

      Nature 437(7062)

      Pages: 1108-1108

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Characterization of a human H5N1 influenza A virus isolated in 2003.2005

    • Author(s)
      Shinya, K
    • Journal Title

      J.Virol. 79

      Pages: 9926-9932

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 鳥インフルエンザウイルス2005

    • Author(s)
      堀本泰介
    • Journal Title

      メディカルサイエンスダイジェスト 31(1)

      Pages: 9-12

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A protective immune response in mice to viral components other than hemagglutinin in a live influenza A virus vaccine model2004

    • Author(s)
      Horimoto T, Takada A, Iwatsuki-H K, Kawaoka Y
    • Journal Title

      Vaccine 22

      Pages: 2244-2247

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influenza A viruses possessing type B hemagglutinin and neuraminidase : potential as vaccine components2004

    • Author(s)
      Horimoto T, Iwatsuki-H K, Hatta M, Kawaoka Y
    • Journal Title

      Microb Infect 6

      Pages: 579-583

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Generation of influenza A virus NS2 (NEP) mutants with an altered nuclear export signal sequence2004

    • Author(s)
      Iwatsuki-H K, Horimoto T, Fujii Y, Kawaoka Y
    • Journal Title

      J Virol 78

      Pages: 10149-10155

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] H5N1不活化インフルエンザワクチンのクレード間交差防御免疫能の解析2008

    • Author(s)
      村上晋, 岩佐彩香, 岩附研子, 伊藤睦美, 木曽真紀, 喜田宏, 高田礼人, CA Nidom, Le Quynh Mai, 山田晋弥, 今井博貴, 坂井(田川)優子, 河岡義裕, 堀本泰介
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Related Report
      2008 Final Research Report
  • [Presentation] Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. XIV. International Congress of Virology2008

    • Author(s)
      Murakami S, Horimoto T, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-H K, Shimojima M, Kawaoka Y
    • Organizer
      国際ウイルス学会
    • Place of Presentation
      イスタンブール
    • Related Report
      2008 Final Research Report
  • [Presentation] Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells.2008

    • Author(s)
      Murakami S
    • Organizer
      XIV. International Congress of Virology
    • Place of Presentation
      Istanbul
    • Related Report
      2008 Annual Research Report
  • [Presentation] アデノウイルスベクターを用いたA型インフルエンザウイルスのリバースジェネティクス法2007

    • Author(s)
      小澤 真, ら
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] イヌRNAポリメラーゼIプロモーターを用いたインフルエンザウイルスリバースジェネティクス系の確立とH5N1ワクチンシードウイルスの作製2007

    • Author(s)
      村上晋, 堀本泰介, 河岡義裕
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] H5N1ワクチンシードウイルスのMDCK 細胞での増殖性を決める因子2007

    • Author(s)
      村上晋, 堀本泰介, 村本裕紀子, 岩佐彩香, 山田晋弥, 岩附研子, 岩田晃, 河岡義裕
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] インフルエンザ不活化ワクチンの製造基材である発育鶏卵でよく増殖するH5N1ワクチンシードウイルス候補株の作出2005

    • Author(s)
      堀本泰介, 本裕紀子, 藤井健, 山田晋弥, 岩附研子, 城野洋一郎, 河岡義裕
    • Organizer
      第53回日本ウイルス学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Book] ウイルスと感染のメカニズム : インフルエンザウイルス 微生物感染学(光山正雄)2005

    • Author(s)
      堀本泰介, 河岡義裕
    • Publisher
      南山堂
    • Related Report
      2008 Final Research Report
  • [Book] 微生物感染学2005

    • Author(s)
      堀本泰介
    • Total Pages
      312
    • Publisher
      南山堂
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] New composition comprising influenza virus vectors, useful in preparing high titer influenza viruses for use immunizing an individual against a pathogen2007

    • Inventor(s)
      KAWAOKA Y, HORIMOTO T, MURAKAMI S
    • Industrial Property Rights Holder
      KAWAOKA Y, HORIMOTO T, MURAKAMI S
    • Acquisition Date
      2007-10-04
    • Related Report
      2008 Final Research Report
    • Overseas

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Published: 2005-04-01   Modified: 2016-04-21  

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