| Project/Area Number |
17380181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Gifu University |
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Principal Investigator |
FUKUSHI Hideto Gifu University, Faculty of Applied Biological Sciences, Professor (10156763)
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| Co-Investigator(Kenkyū-buntansha) |
YANAI Tokuma Gifu University, Faculty of Applied Biological Sciences, Professor (10242744)
YAMAGUCHI Tsuyoshi Tottori University, Faculty of Agriculture, Professor (70210367)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥17,010,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥6,400,000 (Direct Cost: ¥6,400,000)
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| Keywords | herpesvirus / proteome / neurological science / regulation of gene expression / infectious disease / ヘルペスウイルス / 神経病原性 / 遺伝子発現制御 / ヘルペスウイルス(2)(3))(5)(6) |
|---|
| Research Abstract |
Herpesviruses have a strong host specificity. After their acute infection, they latently infect in the host. However, the herpesvirus accidentally jumps the species barrier to cause the lethal severe neurological disease in the alien host We have isolated a new herpesvirus, Gazelle Herpesvirus 1 (GHV-1), from Thomson's gazelles showing encephalitis. GHV-1 is now assigned as Equine herpesvirus 9 (EHV-9) because of the phylogenic relatedness to the equine herpesvirus 1 (EHV-1). EHV-9 is known to cause lethal infection in gazelles, goats, dogs, cats, mice and hamsters as welll as inapparent infection in horses, cattle and pigs. The differences of the degree of virulence is now clear. We planned to investigate genes and proteins involving the pathogenesis and virulence of EHV-9 by protemics approach. During the cause of experiments, we found that the proteomics had a limit to detect such differences of EHV-9 pathogenicity because of the low sensitivity of the proteomics assay. Therefore we have added another approach of comparative analyses by using EHV-1. Analyzing EHV-9 and EHV-1, we revealed the genes and proteins of EHV-9 and EHV-1 in their pathogenicity and virulence in this project.
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