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An invention of the probes "antibody bound magnetism nanoparticles" for the macromolecule measurement in the brain, and the practical use to the brain function researches

Research Project

Project/Area Number 17390013
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Physical pharmacy
Research InstitutionFukuoka University

Principal Investigator

YAMAGUCHI Masatoshi  Fukuoka University, Faculty of Pharmaceutical Sciences, Professor (50117280)

Co-Investigator(Kenkyū-buntansha) INOUE Osamu  Osaka University, Graduate School of Medicine, Professor (50159969)
NOHTA Hitoshi  Fukuoka University, Faculty of Pharmaceutical Sciences, Professor (20164668)
YOSHIDA Hideyuki  Fukuoka University, Faculty of Pharmaceutical Sciences, Assistant Professor (20301690)
TODOROKI Kenichiro  Fukuoka University, Faculty of Pharmaceutical Sciences, Assistant Professor (70341451)
YOSHITAKE Takashi  International University of Health and Welfare, School of Pharmaceutical Sciences, Associate Professor (90406249)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,740,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
KeywordsAnalytical Chemistry / Brain and Neuron / Bioactivity / Imaging / Liauid chromatography / Microdialysis / Magnetic resonance imaging / Nano-device / 分析科学
Research Abstract

We studied the development of antibody bound magnetism nanoparticles from the standpoint of the metrology and were aimed for various assay methods construction for the evaluation of function. In the research process, composition and evaluation of function of magnetism nanoparticles with/without antibody, high resolution tracking of the nanopartides by nudear magnetic resonance imaging, establishment of the high precision microdialysis method for the magnetism nanopartides or the substances within brain, construction of the highly sensitive and selective measurement methods for biogunic compounds and neuropeptides etc. and so on was carried out. The concrete result is as follows.
1. Some acquisition or a part was newly synthesized for different magnetism nanoparticles, such as a process (composition and coating method) and size, and various creations of the antibody bound nanopartides were carried out.
2. We established a condition to track the various magnetism nanopartides with high res … More olution by MRI method and performed fundamental examination of the basics to relate to diffusion, disappearance and recovery of the nanopartides that we administered to a rat. We confirmed that gold-coated nanopartides showed a superior characteristic.
3. As a result of considering the recovery yield and the temporal change of state of the gold-coated magnetism nanopartides that collected by microdialysis, the good condusion was obtained about the possibility of this study. We enabled highly precise in vivo monitoring of the biological compounds in the brain using HPLC-fluorescence and electrochemical methods.
4. By using the interaction between fluorescence molecules like excimer fluorescence and FRET, we newly established the measuring methods for bioactive peptides and proteins with high sensitivity and selectivity. We introduced fluorescence derivatization methods to the examination for microdialysate and got an extremely good result.
Above-mentioned results of this study advance a brain-neurosciences research greatly from the analytical chemistry side. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (124 results)

All 2008 2007 2006 2005

All Journal Article (51 results) (of which Peer Reviewed: 22 results) Presentation (73 results)

  • [Journal Article] Simplified method for determination of polycarbamate fungicide in water samples by liquid chromatography with tandem mass spectrometry following derivatization with dimethyl sulfate2007

    • Author(s)
      T.Hayama, K.Yada, S.Onimaru, H.Yoshida, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Journal of Chromatography A 1141

      Pages: 251-258

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection2007

    • Author(s)
      J.Kehr, X.J.Hu, T.Yoshitake, D.Scheller
    • Journal Title

      Journal of Chromatography B 845

      Pages: 109-113

    • NAID

      10019944257

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Liquid chromatography method for detecting native fluorescent bioamines in urine using post-column derivatization and intramolecular FRET detection2007

    • Author(s)
      M.Yoshitake, H.Nohta, S.Ogata, K.Todoroki, H.Yoshida, T.Yoshitake, M.Yamaguchi
    • Journal Title

      Journal of Chromatography B 858

      Pages: 307-312

    • NAID

      10025810690

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Determination of catecholamines and indoleamines in human urine based on intramolecular excimer-forming derivatization and fluorescence detection2007

    • Author(s)
      H.Yoshida, F.Kido, M.Yoshitake, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytical Sciences 23

      Pages: 485-488

    • NAID

      10018914496

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Selective determination of tryptophan-containing peptides through precolumn derivatization and liquid chromatography using intramolecular fluorescence resonance energy transfer detection2007

    • Author(s)
      M.Yoshitake, N.Sejima, H.Yoshida, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytical Sciences 23

      Pages: 949-953

    • NAID

      10019747525

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] [^<14>C]Benzyl acetate is a potential radiotracer for the measurement of glial metabolism in the rat brain2007

    • Author(s)
      S.Momosaki, R.Hosoi, T.Sanuki, K.Todoroki, M.Yamaguchi, A.Gee, O.Inoue
    • Journal Title

      Nuclear Medicine and Biology 34

      Pages: 939-944

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate2007

    • Author(s)
      S.Hirose, Y.Umetani, M.Amitani, R.Hosoi, S.Momosaki, J.Hatazawa, A.Gee, O.Inoue
    • Journal Title

      Neuroscience Letters 415

      Pages: 259-263

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Sensitive reduction in ^<14>C-acetate uptake in a short-term ischemic rat brain2007

    • Author(s)
      R.Hosoi, Y.Kashiwagi, M.Tokumura, K.Abe, J.Hatazawa, O.Inoue
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases 16

      Pages: 77-81

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Simplified method for determination of polycarbamate fungicide in water samples by liquid chromatography with tandem mass spectrometry following derivatization with dimethyl sulfate2007

    • Author(s)
      T. Hayama, K. Yada, S. Onimaru, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Journal Title

      Journal of Chromatography A 1141

      Pages: 251-258

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Determination of the dopamine agonist rotigotine in microdialy sates from the rat brain by microbore column liquid chromatography with electrochemical detection2007

    • Author(s)
      J. Kehr, X. J. Hu, T. Yoshitake, D. Scheller
    • Journal Title

      Journal of Chromatography B 845

      Pages: 109-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Liquid chromatography method for detecting native fluorescent bioamines in urine using post-column derivatization and intramolecular FRET detection2007

    • Author(s)
      M. Yoshitake, H. Nohta, S. Ogata, K. Todoroki, H. Yoshida, T. Yoshitake, M. Yamaguchi
    • Journal Title

      Journal of Chromatography B 858

      Pages: 307-312

    • NAID

      10025810690

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Determination of catecholamines and indoleamines in human urine based on intramolecular exci mer-forming derivati zation and fluorescence detection2007

    • Author(s)
      H. Yoshida, F. Kido, M. Yoshitake, K. Todoroki, H. Nohta, M. Yamaguchi
    • Journal Title

      Analytical Sciences 23

      Pages: 485-488

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Selective determination of tryptophan-containing peptides through precolumn derivatization and liquid chromatography using intramolecular fluorescence resonance energy transfer detection2007

    • Author(s)
      M. Yoshitake, N. Sejima, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Journal Title

      Analytical Sciences 23

      Pages: 949-953

    • NAID

      10019747525

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] [^<14>C]jBenzyl acetate is a potential radiotracer for the measurement of glial metabolism in the rat brain2007

    • Author(s)
      S. Momosaki, R. Hosoi, T. Sanuki, K. Todoroki, M. Yamaguchi, A. Gee, O. Inoue
    • Journal Title

      Nuclear Medicine and Biology 34

      Pages: 939-944

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate2007

    • Author(s)
      S. Hirose, Y. Umetani, M. Amitani, R. Hosoi, S. Momosaki, J. Hatazawa, A. Gee, O. Inoue
    • Journal Title

      Neuroscience Letters 415

      Pages: 259-263

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sensitive reduction in ^<14>C-acetate uptake in a short-term ischemic rat brain2007

    • Author(s)
      R. Hosoi, Y. Kashiwagi, M. Tokumura, K. Abe, J. Hatazawa, O. Inoue
    • Journal Title

      Journal of Stroke and Cerebro vascular Diseases 16

      Pages: 77-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development and validation of a liquid chromatographic method for the analysis of positron emission tomography radiophamiaceuticals with Ru(bpy)_3^<2+>-KMnO_4 chemiluminescence2007

    • Author(s)
      R.Nakao, K.Furutsuka, M.Yamaguchi, K.Suniki
    • Journal Title

      Analytical Sciences 23

      Pages: 151-155

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective determination of tryptophan-containing peptides through precolumn derivatization and Iiquid chromatography using intramolecular fluorescence resonance energy transfer detection2007

    • Author(s)
      M.Yoshitake, N.Sejima, H.Yoshida, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytical Sciences 23

      Pages: 949-953

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liquid chromatography method for detecting native fluorescent bioamines inurine using post-column derivatization and intramolecular FRET detection2007

    • Author(s)
      M.Yoshitake, H.Nohta, S.Ogata, K.Todoroki, H.Yoshida, T.Yoshitake, M.Yamaguchi
    • Journal Title

      Journal of Chromiatography B 858

      Pages: 307-312

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate2007

    • Author(s)
      S.Hirose, Y.Umetani, M.Amitani, R.Hosoi, S.Momosaki, J, Hatazawa, A.Gee, O.Inoue
    • Journal Title

      Neuroscience Letters 415

      Pages: 259-263

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive Reduction in ^<14>C-acetate Uptake in a Short-term Ischemic Rat Brain2007

    • Author(s)
      R.Hosoi, Y.Kashiwagi, M.Tokumura, K.Abe, J.Hatazawa, O.Inoue
    • Journal Title

      Joumal of Stroke and Cerebrovascular Diseases 16

      Pages: 77-81

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detemination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection2007

    • Author(s)
      J.Kehr, X.J.Hu, T.Yoshitake, D.Scheller
    • Journal Title

      Journal of Chromatography B 845(1)

      Pages: 109-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Simplified method for detemination of polycardamate fungicide in water samples by liquid chromatography with tandem mass spectrometry following derivatization with dimethyl sulfate2007

    • Author(s)
      T.Hayama, K.Yada, S.Onimaru, H.Yoshida, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Journal of Chromatography A 1141(2)

      Pages: 251-258

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selective determination of native fluorescent bioamines through precolumn derivatization and liquid chromatography using intramolecular fluorescence resonance energy transfer detection2006

    • Author(s)
      M.Yoshitake, H.Nohta, H.Yoshida, T.Yoshitake, K.Todoroki, M.Yamaguchi
    • Journal Title

      Analytical Chemistry 78

      Pages: 920-927

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] On-line photocatalytic device for highly selective pre-column fluorescence derivatization of 5-hydroxyindoles with benzylamine2006

    • Author(s)
      K.Todoroki, Y.Nakashima, H.Yoshida, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytica Chimica Acta 555

      Pages: 14-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Simultaneous liquid chromatographic measurement of melatonin and related indoles through post-column electrochemical demethylation and fluorescence derivatization2006

    • Author(s)
      K.Todoroki, K.Ishimaru, H.Yoshida, T.Yoshitake, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytical Sciences 22

      Pages: 281-286

    • NAID

      10017246617

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 分子内エキシマー蛍光の発現に基づく誘導体化分析法の開発2006

    • Author(s)
      吉田 秀幸, 能田 均, 山口 政俊
    • Journal Title

      分折化学 55

      Pages: 213-221

    • NAID

      110004729111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Derivatization chemistries for determination of serotonin,norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection2006

    • Author(s)
      T.Yoshitake, J.Kehr, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Biomedical Chromatography 20

      Pages: 267-281

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evaluation of [^<14>C]phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain2006

    • Author(s)
      O.Inoue, R.Hosoi, S.Momosaki, K.Yamamoto, M.Amitani, M.Yamaguchi, A.Gee
    • Journal Title

      Nuclear Medicine and Biology 33

      Pages: 985-989

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Glial metabolic dysfunction caused neural damage by short-term ischemia in brain2006

    • Author(s)
      R.Hosoi, Y.Kashiwagi, J.Hatazawa, A.Gee, O.Inoue
    • Journal Title

      Annals of Nuclear Medicine 20

      Pages: 377-380

    • NAID

      10018775728

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Selective determination of native fluorescent bioamines through precolumn derivatization and liquid chromatography using intramolecular fluorescence resonance energy transfer detection2006

    • Author(s)
      M. Yoshitake, H. Nohta, H. Yoshida, T. Yoshitake, K. Todoroki, M. Yamaguchi
    • Journal Title

      Analytical Chemistry 78

      Pages: 920-927

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] On-line photocatalytic device for highly selective pre-column fluorescence derivatization of 5-hydroxyindoles with benzylamine2006

    • Author(s)
      K. Todoroki, Y. Nakashima, H. Yoshida, H. Nohta, M. Yamaguchi
    • Journal Title

      Analytica Chimica Acta 555

      Pages: 14-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Simultaneous liquid chromatographic measurement of melatonin and related indoles through post-column electrochemical demethylation and fluorescence derivatization2006

    • Author(s)
      K. Todoroki, K. Ishimaru, H. Yoshida, T. Yoshitake, H. Nohta, M. Yamaguchi
    • Journal Title

      Analytical Sciences 22

      Pages: 281-286

    • NAID

      10017246617

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Highly selective determination method based on intramolecular excimer-forming fluorescence derivatization2006

    • Author(s)
      H. Yoshida, H. Nohta, M. Yamaguchi
    • Journal Title

      Bunseki Kagaku 55

      Pages: 213-221

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Derivatization chemistries for determination of serotonin, norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection2006

    • Author(s)
      T. Yoshitake, J. Kehr, K. Todoroki, H. Nohta, M. Yamaguchi
    • Journal Title

      Biomedical Chromatography 20

      Pages: 267-281

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of[^<14>C]phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain2006

    • Author(s)
      0. Inoue, R. Hosoi, S. Momosaki, K. Yamamoto, M. Amitani, M. Yamaguchi, A. Gee
    • Journal Title

      Nuclear Medicine and Biology 33

      Pages: 985-989

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glial metabolic dysfunction caused neural damage by short-term ischemia in brain2006

    • Author(s)
      R. Hosoi, Y. Kashiwagi, J. Hatazawa, A. Gee, O. Inoue
    • Journal Title

      Annals of Nuclear Medicine 20

      Pages: 377-380

    • NAID

      10018775728

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of [^<14>C] phenylacetate as a prototype tracer for the measurement of glial metabolism in the rat brain2006

    • Author(s)
      O.Inoue, R.Hosoi, S.Momosaki, K.Yamamoto, M.Amitani, M.Yamaguchi, A.Gee
    • Journal Title

      Nuclear Medicine and Biology 33(8)

      Pages: 985-989

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Glialmetabolicdysfunction caused neural damage by short-temischemia in brain2006

    • Author(s)
      R.Hosoi, Y.Kashiwagi, J.Hatazawa, A.Gee, O.Inoue
    • Journal Title

      Annals of Nuclear Medicine 20(5)

      Pages: 377-380

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Derivatization chemistries for detemination of serotonin,norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection2006

    • Author(s)
      T.Yoshitaka, J.Kehr, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Biomedical Chromatography 20(3)

      Pages: 267-281

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 分子内エキシマー蛍光の発現に基づく誘導体化分析法の開発2006

    • Author(s)
      吉田秀幸, 能田均, 山口政俊
    • Journal Title

      分析化学 55(4)

      Pages: 213-221

    • NAID

      110004729111

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Derivatization chemistries for determination of serotonin, norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection2006

    • Author(s)
      T.Yoshitake, J.Kehr, K.Todoroki, H.Nohta, M.Yamaguchi
    • Journal Title

      Biomedical Chromatography In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Simultaneous liquid chromatographic measurement of melatonin and related indoles through post-column electrochemical demethylation and fluorescence derivatization2006

    • Author(s)
      K.Todoroki, K.Ishimaru, H.Yoshida, T.Yoshitake, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytical Sciences 22(2)

      Pages: 281-286

    • NAID

      10017246617

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Selective determination of native fluorescent bioamines through precolumn derivatization and liquid chromatography using intramolecular fluorescence resonance energy transfer detection2006

    • Author(s)
      M.Yoshitake, H.Nohta, H.Yoshida, T.Yoshitake, K.Todoroki, M.Yamaguchi
    • Journal Title

      Analytical Chemistry 78(3)

      Pages: 920-927

    • Related Report
      2005 Annual Research Report
  • [Journal Article] On-line photocatalytic device for highly selective pre-column fluorescence derivatization of 5-hydbroxymdoles with benzylamine2006

    • Author(s)
      K.Todoroki, Y.Nakashima, H.Yoshida, H.Nohta, M.Yamaguchi
    • Journal Title

      Analytica Chimica Acta 555(1)

      Pages: 14-19

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A simple liquid chromatographic method based on intramolecular excimer-forming derivatization and fluorescence detection for the determination of tyrosine and tyramine in urine2005

    • Author(s)
      H.Yoshida, H.Nohta, Y.Harada, M.Yoshitake, K.Todoroki, K.Yamagata, M.Yamaguchi
    • Journal Title

      Journal of Chromatography B 821

      Pages: 88-93

    • NAID

      10017125009

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 光触媒酸化反応を利用する5-ヒドロキシインドール類のプレカラム蛍光誘導体化液体クロマトグラフィー2005

    • Author(s)
      轟木 堅一郎, 有坂 雅恵, 中島 佳彦, 吉田 秀幸, 能田 均, 山口 政俊
    • Journal Title

      分折化学 54

      Pages: 1211-1214

    • NAID

      110002973732

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A simple liquid chromatographic method based on intramolecular excimer-forming derivatization and fluorescence detection for the determination of tyrosine and tyramine in urine2005

    • Author(s)
      H. Yoshida, H. Nohta, Y. Harada, M. Yoshitake, K. Todoroki, K. Yamagata, M. Yamaguchi
    • Journal Title

      Journal of Chromatography B 821

      Pages: 88-93

    • NAID

      10017125009

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Liquid chromatography of 5-hydroxyindoles based on pre-column fluorescence derivatization by photocatalytic oxidation2005

    • Author(s)
      K. Todoroki, M. Arisaka, Y. Nakashima, H. Yoshida, H. Nohta, M. Yamaguchi
    • Journal Title

      Bunseki Kagaku 54

      Pages: 1211-1214

    • NAID

      110002973732

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 光触媒酸化反応を利用する5-ヒドロキシインドール類のプレカラム蛍光誘導体化液体クロマトグラフィー2005

    • Author(s)
      轟木堅一郎, 有坂雅恵, 中島佳彦, 吉田秀幸, 能田均, 山口政俊
    • Journal Title

      分析化学 54(12)

      Pages: 1211-1214

    • NAID

      110002973732

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A simple liquid chromatographic method based on intramolecular excimer-forming derivatization and fluorescence detection for the determination of tyrosine and tyramine in urine2005

    • Author(s)
      H.Yoshida, H.Nohta, Y.Harada, M.Yoshitake, K.Todoroki, K.Yamagata, M.Yamaguchi
    • Journal Title

      Journal of Chromatography B 821(1)

      Pages: 88-93

    • NAID

      10017125009

    • Related Report
      2005 Annual Research Report
  • [Presentation] エキシマー蛍光誘導体化-HPLC法によるリジン含有ペプチドの選択的分析2008

    • Author(s)
      室田 美沙紀, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 微小透析法を用いた肝臓中ヒスタミン定量法の開発と発ガン性マーカーへの応用2008

    • Author(s)
      井尻 聡一郎, 吉武 尚, 能田 均, 山口 政俊
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] イオン選択性電極を用いたアセチルコリンセンサーの開発2008

    • Author(s)
      吉里 香織, 轟木 堅一郎, 前田 博志, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Liquid Chromatographic Determination of Lysine-containing Peptides Based on Intramolecular Excimer-forming Fluorescence Derivatization2008

    • Author(s)
      M. Murota, H. Yoshida, K. Todoroki, H. Nohta, M, Yamaguchi
    • Organizer
      128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Microdialysis Determination of Histamine in Rat Liver and Application to Evaluation of Carcinogenic Marker2008

    • Author(s)
      S. Ijiri, T. Yoshitake, H. Nohta, M. Yamaguchi
    • Organizer
      128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of Acetylcholine Senser Using Ion-selective Electrode2008

    • Author(s)
      K. Yoshizato, K. Todoroki, H. Maeda, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      128th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] FRET誘導体化によるフェルビナクの新規定量法の開発2008

    • Author(s)
      吉武 誠, 緒方 進, 馬場 恵里香, 轟木 堅一郎, 吉田 秀幸, 能田 均, 後藤 一洋, 山口 政俊
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] エキシマー蛍光誘導体化法によるヒト血漿中ポリアミン類の分析2007

    • Author(s)
      糸山 美紀, 新海 彩子, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] システイン含有ペプチドのエキシマー蛍光誘導体化-HPLC分析2007

    • Author(s)
      首藤 麻希, 雪竹 英志, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Determination of Polyamines in Human Plasma using Intramolecular Excimer-forming Fluorescence Derivatization Method2007

    • Author(s)
      M. Itoyama, A. Shinkai, K. Todoroki, H. Yoshida, H. Nohta, M, Yamaguchi
    • Organizer
      24th Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Liquid Chromatographic Determination of Cysteine-containing Peptides Based on Intramolecular Excimer-forming Fluorescence Derivatization2007

    • Author(s)
      M. Sudo, E. Yukitaka, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      24th Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イオン選択性電極によるアセチルコリン関連化合物のセンシング〜HPLC分析への応用〜2007

    • Author(s)
      吉里 香織, 前田 博志, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sensing of Acetylcholine-related Componunds with Potentiometric Ion Sensor-Application to HPLC Analysis-2007

    • Author(s)
      K. Yoshizato, H. Maeda, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      24th Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2007-12-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イオン選択性電極によるアセチルコリン関連化合物のセンシング-HPLC分析への応用2007

    • Author(s)
      吉里 香織, 前田 博志, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第24回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 癌の治療効果判定法の開発を目的としたヒト血漿中アミン類のHPLC分析2007

    • Author(s)
      糸山 美紀, 越智 裕子, 冨田 陵子, 新海 彩子, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第18回クロマトグラフィー科学会議
    • Place of Presentation
      函館
    • Year and Date
      2007-11-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] チオール類のポストカラムーエキシマー蛍光誘導体化分析2007

    • Author(s)
      首藤 麻希, 雪竹 英志, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第18回クロマトグラフィー科学会議
    • Place of Presentation
      函館
    • Year and Date
      2007-11-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Fluorescence Monitoring of Protein Denaturation and Aggregation Processes Based on FRET Phenomenon2007

    • Author(s)
      M. Yoshitake, M. Takada, A. Kato, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      127th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Year and Date
      2007-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー蛍光誘導体化による甲状腺ホルモン分析2007

    • Author(s)
      吉田 秀幸, 秋吉 正貴, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      日本分析化学会第56年会
    • Place of Presentation
      徳島
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Selective Determination of Thyroid Hormones Based on Intramolecular Excimer-forming Fluorescence Derivatization2007

    • Author(s)
      H. Yoshida, M. Akiyoshi, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      56th Annual Meeting of the Japan Society for Analytical Chemistry
    • Place of Presentation
      Tokushima
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HPLC Analysis of Bioactive Amines in Human Plasma for an Assessment of Cancer Treatment2007

    • Author(s)
      M. Itoyama, Y. Ochi, R. Tomita, A. Shinkai, K. Todoroki, H. Yoshida, H. Nohta, M, Yamaguchi
    • Organizer
      18th Conference of the Society for Chromatographic Sciences
    • Place of Presentation
      Hakodate
    • Year and Date
      2007-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Liquid Chromatographic Determination of Thiol Compounds Using Intramolecular Excimer-fonning Fluorescence Methood with Post-column Derivatization2007

    • Author(s)
      M. Sudo, E. Yukitaka, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      18th Conference of the Society for Chromatographic Sciences
    • Place of Presentation
      Hakodate
    • Year and Date
      2007-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー蛍光誘導体化-HPLC法によるチオール類の高選択的定量2007

    • Author(s)
      首藤 麻希, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第44回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] イオン選択性マイクロ電極を用いたアセチルコリン関連化合物のセンシング2007

    • Author(s)
      吉里 香織, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第44回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Selective Determination of Thiols with HPLC Based on Excimer-forming Fluorescence Derivatization2007

    • Author(s)
      M. Sudo, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      44th Kyushu Branch Annual Meeting of the Japan Union of Chemical Science and Technology
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sensing of Acetylcholine-related Componunds with Potentiometric Micro Ion Sensor2007

    • Author(s)
      K. Yoshizato, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      44th Kyushu Branch Annual Meeting of the Japan Union of Chemical Science and Technology
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2007-07-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 陽イオン選択性電極を用いたアセチルコリン関連化合物のセンシング2007

    • Author(s)
      吉里 香織, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第68回分析化学討論会
    • Place of Presentation
      宇都宮
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Sensing of Acetylcholine-related Componunds with Potentiometric Cation Sensor2007

    • Author(s)
      K. Yoshizato, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      68th Symposium on the Japan Society for Analytical Chemistry
    • Place of Presentation
      Utsunomiya
    • Year and Date
      2007-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ルテニウム錯体化学発光法によるコリン類の分析2007

    • Author(s)
      吉田 秀幸, 小南 萌子, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第68回分析化学討論会
    • Place of Presentation
      宇都宮
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Determination of Cholines Using HPLC with Tris(2, 2'-bipyridyl) tuthenium(II) Electrogenerated Chemiluminescence Detection Method2007

    • Author(s)
      H. Yoshida, M. Kominami, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      68th Symposium on the Japan Society for Analytical Chemistry
    • Place of Presentation
      Utsunomiya
    • Year and Date
      2007-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] タンパク質変性・凝集過程のFRET蛍光モニタリング2007

    • Author(s)
      吉武 誠, 高田 誠, 加藤 綾, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー蛍光誘導体化による甲状腺ホルモンの高選択的分析2006

    • Author(s)
      秋吉 正貴, 小迫 仁美, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第23回日本薬学会九州支部大会
    • Place of Presentation
      熊本
    • Year and Date
      2006-12-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自然蛍光性カルボン酸のFRET誘導体化・HPLC分析2006

    • Author(s)
      緒方 進, 白川 哲, 吉武 誠, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第23回日本薬学会九州支部大会
    • Place of Presentation
      熊本
    • Year and Date
      2006-12-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Selective Determination of Thyroid Hormones Based on Intramolecular Excimer-forming Fluorescence Derivatization2006

    • Author(s)
      M. Akiyoshi, H. Kozako, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      23rd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kumamoto
    • Year and Date
      2006-12-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Liquid Chromatographic Determination of Native-fluorescent Carboxylic Acids Based on Fluorescence Resonance Energy Transfer2006

    • Author(s)
      S. Ogata, T. Shirakawa, M. Yoshitake, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      23rd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kumamoto
    • Year and Date
      2006-12-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アセチルコリン及びコリンのルテニウム錯体化学発光分析-アセチルコリン製剤への適用-2006

    • Author(s)
      小南 萌子, 江崎 有里子, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第23回日本薬学会九州支部大会
    • Place of Presentation
      熊本
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蛍光共鳴エネルギー移動現象を利用するタンパク質変性・凝集過程のモニタリング法の開発-各種タンパク質解析への応用-2006

    • Author(s)
      高田 誠, 加藤 綾, 吉武 誠, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第23回日本薬学会九州支部大会
    • Place of Presentation
      熊本
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Determination of Acetylcholine and Choline Using HPLC with Tris(2, 2'-bipyridyl) tuthenium(II) Electrogenerated Chemiluminescence Detection-Application to the Analysis of Pharmaceutical Preparations-2006

    • Author(s)
      M. Kominami, Y. Ezaki, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      23rd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kumamoto
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Monitoring of Protein Denaturation and Aggregation Process Based on FRET-Application to Protein Analysis-2006

    • Author(s)
      M. Takada, A. Kato, M. Yoshitake, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      23rd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Kumamoto
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 甲状腺ホルモンのエキシマー蛍光誘導体化-HPLC分析2006

    • Author(s)
      秋吉 正貴, 小迫 仁美, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第17回クロマトグラフィー科学会議
    • Place of Presentation
      仙台
    • Year and Date
      2006-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Liquid Chromatographic Determination of Thyroid Hormones Using Intramolecular Excimer-forming Fluorescence Derivatization Method2006

    • Author(s)
      M. Akiyoshi, H. Kozako, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      17th Conference of the Society for Chromatographic Sciences
    • Place of Presentation
      Sendai
    • Year and Date
      2006-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 二重ラベル化-FRET検出法に基づくシステイン類の高選択的LC分析:ヒト血漿試料への適応2006

    • Author(s)
      吉武 誠, 首藤 麻希, 吉田 秀幸, 轟木 堅一郎, 吉武 尚, 能田 均, 山口 政俊
    • Organizer
      日本分析化学会第55年会
    • Place of Presentation
      大阪
    • Year and Date
      2006-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蛍光共鳴エネルギー移動現象の発現を利用する高選択的蛍光誘導体化分析-バニリルマンデル酸・ホモバニリン酸への応用-2006

    • Author(s)
      緒方 進, 白川 哲, 吉武 誠, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      日本分析化学会第55年会
    • Place of Presentation
      大阪
    • Year and Date
      2006-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Highly Selective Determination of Cysteines by LC Based on Double-labeling Intramolecular Fret-forming Derivatization : Application to Human Plasma Analysis2006

    • Author(s)
      M. Yoshitake, M. Sudo, H. Yoshida, K. Todoroki, T. Yoshitake, H. Nohta, M. Yamaguchi
    • Organizer
      55th Annual Meeting of the Japan Society for Analytical Chemistry
    • Place of Presentation
      Osaka
    • Year and Date
      2006-09-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Selective Determination of Carboxylic Acids Based on Intramolecular FRET-forming Derivatization-Application to VMA and HVA Analysis-2006

    • Author(s)
      S. Ogata, T. Shirakawa, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      55th Annual Meeting of the Japan Society for Analytical Chemistry
    • Place of Presentation
      Osaka
    • Year and Date
      2006-09-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー蛍光誘導体化法による生体試料中ポリアミン類の分析2006

    • Author(s)
      糸山 美紀, 轟木 堅一郎, 吉田 秀幸, 曽根崎 新次, 能田 均, 山口 政俊
    • Organizer
      第19回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] タンパク質変性・凝集過程のFRET蛍光モニタリング2006

    • Author(s)
      高田 誠, 加藤 綾, 吉武 誠, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第19回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of Polyamines in Biological Samples by LC Based on Intramolecular Excimer-forming Fluorescence Derivatization2006

    • Author(s)
      M. Itoyama, K. Todoroki, H. Yoshida, S. Sonezaki, H. Nohta, M. Yamaguchi
    • Organizer
      19th Symposium on Biomedical-analytical Sciences
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Monitoring of Protein Denaturation and Aggregation Process Based on FRET2006

    • Author(s)
      M. Takada, A. Kato, M. Yoshitake, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      19th Symposium on Biomedical-analytical Sciences
    • Place of Presentation
      Fukuoka
    • Year and Date
      2006-08-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蛍光共鳴エネルギー移動現象を利用するタンパク質凝集・変性過程のモニタリング法の開発(2)〜蛍光プローブのスクリーニング〜2006

    • Author(s)
      高田 誠, 吉武 誠, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第43回化学関連支部合同九州大会
    • Place of Presentation
      北九州
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アセチルコリン及びコリンのルテニウム錯体化学発光分析2006

    • Author(s)
      小南 萌子, 江崎 有里子, 吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      生物発光化学発光研究会第24回学術講演会
    • Place of Presentation
      武蔵野
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Monitoring of Protein-aggregation and-unfolding Based on FRET Phenomenon-Screening of Fluorescent Reagents-2006

    • Author(s)
      M. Takada, M. Yoshitake, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      43rd Kyushu Branch Annual Meeting of the Japan Union of Chemical Science and Technology
    • Place of Presentation
      Kitakyushu
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Determination of Acetylcholine and Choline Using HPLC with Tris(2, 2'-bipyridyl) tuthenium(II) Electrogenerated Chemiluminescence Detection2006

    • Author(s)
      M. Kominami, Y. Ezaki, H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      24th Symposium on the Japan Association for BL and CL
    • Place of Presentation
      Musashino
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー蛍光誘導体化-HPLC法によるヒト尿中生理活性アミン類の分析2006

    • Author(s)
      吉田 秀幸, 木戸 史人, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      第67回分析化学討論会
    • Place of Presentation
      秋田
    • Year and Date
      2006-05-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蛍光共鳴エネルギー移動現象を利用するタンパク質凝集・変性過程のモニタリング法の開発2006

    • Author(s)
      高田 誠, 吉武 誠, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第67回分析化学討論会
    • Place of Presentation
      秋田
    • Year and Date
      2006-05-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Monitoring of Protein-aggregation and-unfolding Based on Fluorescence Resonance Energy Transfer(FRET) Phenomenon2006

    • Author(s)
      M. Takada, M. Yoshitake, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      67th Symposium on the Japan Society for Analytical Chemistry
    • Place of Presentation
      Akita
    • Year and Date
      2006-05-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高精密分子認識を志向したエキシマー蛍光誘導体化法2006

    • Author(s)
      吉田 秀幸, 轟木 堅一郎, 能田 均, 山口 政俊
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 5-Hydroxyindole類の光触媒酸化ポストカラム蛍光誘導体化HPLC分析2006

    • Author(s)
      轟木 堅一郎, 中島 佳彦, 下澤 美和子, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intramolecular Excimer Fluorescence Derivatization Method for Highly Selective Molecular Recognition2006

    • Author(s)
      H. Yoshida, K. Todoroki, H. Nohta, M. Yamaguchi
    • Organizer
      126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HPLC Analysis of 5-Hydroxyindoles Utilizing Photocatalytic Post-column Fluorescence Derivati zation2006

    • Author(s)
      K. Todoroki, Y. Nakashima, M. Shimosawa, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      126th Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 光触媒酸化反応を利用する5-Hydroxyindole類のポストカラム蛍光誘導体化HPLC分析2005

    • Author(s)
      中島 佳彦, 下澤 美和子, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第22回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2005-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蛍光共鳴エネルギー移動を利用する糖鎖の構造解析法の開発2005

    • Author(s)
      中島 智光, 白石 麻里子, 轟木 堅一郎, 井尻 聡一郎, 吉武 誠, 吉武 尚, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第22回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2005-12-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HPLC Analysis of 5-Hydroxyindoles Utilizing Post-column Photocatalytic Fluorescence Derivatization2005

    • Author(s)
      Y. Nakashima, M. Shimosawa, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      22nd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-12-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of Structure Analysis Method of Sugar Chains Using Fluorescence Resonance Energy Transfer2005

    • Author(s)
      T. Nakashima, M. Shiraishi, K. Todoroki, S. Ijiri, M. Yoshitake, T. Yoshitake, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      22nd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-12-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー誘導体化-HPLC法による生理活性アミン類の分析-実試料分析-2005

    • Author(s)
      木戸 史人, 松本 絵里, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第22回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2005-12-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Determination of Bioactive Amines by HPLC Based on Intramolecular Excimer-forming Fluorescence Derivatization-Analysis of Real Sample-2005

    • Author(s)
      F. Kido, E. Matsumoto, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      22nd Kyushu Branch Annual Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-12-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー誘導体化-HPLC法による生理活性アミン類の高選択的分析(2)2005

    • Author(s)
      木戸 史人, 松本 絵里, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      日本分析化学会第54年会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 蛍光共鳴エネルギー移動現象を利用する糖鎖のルミネッセンス構造解析法の開発2005

    • Author(s)
      中島 智光, 白石 麻里子, 轟木 堅一郎, 井尻 聡一郎, 吉武 誠, 吉田 秀幸, 吉武 尚, 能田 均, 山口 政俊
    • Organizer
      日本分析化学会第54年会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-09-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Determination of Bioactive Amines by High-performance Liquid Chromatography Based on Intramolecular Excimer-forming Fluorescence Derivatization2005

    • Author(s)
      F. Kido, E. Matsumoto, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      54th Annual Meeting of the Japan Society for Analytical Chemistry
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-09-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of Luminescent Structure Analysis Method of Sugar Chains in Protein Using FRET Phenomenon2005

    • Author(s)
      T. Nakashima, M. Shiraishi, K. Todoroki, S. Ijiri, M. Yoshitake, H. Yoshida, T. Yoshitake, H. Nohta, M. Yamaguchi
    • Organizer
      54th Annual Meeting of the Japan Society for Analytical Chemistry
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-09-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] エキシマー誘導体化-HPLC法による生理活性アミン類の高選択的分析2005

    • Author(s)
      木戸 史人, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第12回クロマトグララィーシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2005-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 光触媒酸化反応を利用する5-Hydroxyindole類のオンライン蛍光誘導体化HPLC分析2005

    • Author(s)
      中島 佳彦, 轟木 堅一郎, 吉田 秀幸, 能田 均, 山口 政俊
    • Organizer
      第12回クロマトグラフィーシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2005-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Determination of Bioactive Amines by High-performance Liquid Chromatography Based on Intramolecular Excimer-forming Fluorescence Derivatization2005

    • Author(s)
      F. Kido, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      12th Conference of The society for Chromatographic Sciences
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] HPLC Analysis of 5 -Hydroxyindoles Utilizing Online Photocatalytic Fluorescence Derivati zation2005

    • Author(s)
      Y. Nakashima, K. Todoroki, H. Yoshida, H. Nohta, M. Yamaguchi
    • Organizer
      12th Conference of The society for Chromatographic Sciences
    • Place of Presentation
      Fukuoka
    • Year and Date
      2005-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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