Identification of cell-type specific active sites from laminins and characterization of the functional mechanisms

• Project/Area Number: 17390024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: NOMIZU Motoyoshi Tokyo University of Pharmacy and Life Science, 薬学部, 教授 (00311522)
• Co-Investigator(Kenkyū-buntansha): 山田 純司 東京薬科大学, 薬学部, 准教授 (60200721) ; 宇谷 厚志 京都大学, 大学院・医学研究科, 准教授 (10292707) ; 門谷 裕一 北里大学, 医学部, 講師 (10185887) ; 高木 充弘 東京薬科大学, 薬学部, 助手 (90267493)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,800,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥2,100,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000); Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
• Keywords: 細胞・組織 / 生体分子 / 蛋白質 / 再生医学 / 薬学 / ラミニン / 基底膜 / ペプチド / インテグリン / シンデカン / 細胞接着 / α-ジストログリカン / キトサン / CD44

Research Abstract

細胞外マトリックスは細胞接着をはじめ器官形成、神経網再生、血管新生やがんの増殖転移などの様々な生命現象や病態に深く関わっている。細胞外マトリックスの主役的な巨大分子であるラミニンの細胞接着活性部位を組換えタンパクと1000種類以上の合成ペプチドを用いて同定し、それぞれの活性部位の細胞膜上のレセプターや様々な生物活性を解析し、さらにはそれらのペプチドを用いた創薬や再生医療への応用研究を行った。

Research Products

• [Journal Article] Chain-specific heparin-binding sequences in the laminin・chain LG4-5 modules (2009)
  • Author(s): Hozumi K, Suzuki N, Uchiyama Y, Katagiri F, Kikkawa Y, Nomizu M
  • Journal Title: Biochemistry (印刷中)
  • Peer Reviewed
• [Journal Article] Clustering of syndecan-4 and integrin・1 by laminin・3 chain-derived peptide promotes keratinocyte migration (2009)
  • Author(s): Araki E, Momota Y, Togo T, Tanioka M, Hozumi K, Nomizu M, Miyachi Y, Utani A
  • Journal Title: Mol. Biol. Cell (印刷中)
  • Peer Reviewed
• [Journal Article] Peptide-chitosan matrix : a new multifunctional biomaterial (2009)
  • Author(s): Nomizu M, Yamagata N, Mochizuki M, Kikkawa Y, Kadoya Y
  • Journal Title: Adv. Exp. Med. Biol 611 Pages: 253-255
  • Peer Reviewed
• [Journal Article] Mixed peptide-chitosan membranes can mimic biological activities of a multifunctional laminin ・1 chain LG4 module (2009)
  • Author(s): Hozumi K, Yamagata N, Otagiri D, Fujimori C, Kikkawa Y, Kadoya Y, Nomizu M
  • Journal Title: Biomaterials 30 Pages: 1596-1603
  • Peer Reviewed
• [Journal Article] A novel cell adhesive scaffold material for delivering keratinocytes reduces granulation tissue in dermal wounds (2009)
  • Author(s): Masuda R, Mochizuki M, Hozumi K, Takeda A, Uchinuma E, Yamashina S, Nomizu M, Kadoya Y
  • Journal Title: Wound Repair Regen 17 Pages: 127-135
  • NAID: 10031181541
  • Peer Reviewed
• [Journal Article] Mixed peptide-chitosan membranes can mimic biological activities of a multifunctional laminin alphal chain LG4 module (2009)
  • Author(s): Kentaro Hozumiら
  • Journal Title: Biomaterials 30 Pages: 1596-1603
  • Peer Reviewed
• [Journal Article] A novel cell adhesive scaffold material for delivering keratinocytes reduces granulation tissue in dermal wounds. (2009)
  • Author(s): Ryuji Masudaら
  • Journal Title: Wound Repair Regeneration 17 Pages: 127-135
  • Peer Reviewed
• [Journal Article] Sequence specificity of the PHSRN peptide from fibronectin on corneal epithelial migration. (2009)
  • Author(s): Atsushi Hattoriら
  • Journal Title: Biochem, Biophys. Res. Commun. 79 Pages: 346-350
  • Peer Reviewed
• [Journal Article] Conformational requirement on peptides to exert laminin's activities and search for protein segments with the laminin's activities. (2009)
  • Author(s): Koji Umezawaら
  • Journal Title: Biopolymers 29 Pages: 124-131
  • Peer Reviewed
• [Journal Article] Up-regulation of ZO-1 in cultured human corneal epithelial cells by a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin. (2009)
  • Author(s): Ryoji Yanaiら
  • Journal Title: Invest. Ophthalmol. Vis. Sci. (印刷中)
  • Peer Reviewed
• [Journal Article] Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule (2008)
  • Author(s): Kikkawa Y, Sudo R, Kon J, Mizuguchi T, Nomizu M, Hirata K, Mitaka T
  • Journal Title: Exp. Cell Res 314 Pages: 2579-2590
  • Peer Reviewed
• [Journal Article] Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule (2008)
  • Author(s): Kikkawa Yamatoら
  • Journal Title: Exp Cell Res. 314 Pages: 2579-2590
  • Peer Reviewed
• [Journal Article] Peptide-chitosan matrix: a new multifunctional biomaterial (2008)
  • Author(s): Nomizu Motoyoshi, ら
  • Journal Title: Peptides (印刷中)
  • Peer Reviewed
• [Journal Article] The LG1-3 tandem of laminin ・5 harbors the binding sites of Lutheran/basal cell adhesion molecule and ・3・1/・6・1 integrins (2007)
  • Author(s): Kikkawa Y, Sasaki T, Nguyen MT, Nomizu M, Mitaka T, Miner JH
  • Journal Title: J. Biol. Chem 282 Pages: 14853-14860
  • Peer Reviewed
• [Journal Article] Identification of multiple amyloidogenic sequences in laminin-1 (2007)
  • Author(s): Kasai S, Urushibata S, Hozumi K, Yokoyama F, Ichikawa N, Kadoya Y, Nishi N, Watanabe N, Yamada Y, Nomizu M
  • Journal Title: Biochemistry 46 Pages: 3966-3974
  • Peer Reviewed
• [Journal Article] Integrin- dependent cell behavior on ECM peptide- conjugated chitosan membranes (2007)
  • Author(s): Mochizuki M, Yamagata N, Philp D, Hozumi K, Watanabe T, Kikkawa Y, Kadoya Y, Kleinman HK, Nomizu M
  • Journal Title: Biopolymers 88 Pages: 122-130
  • Peer Reviewed
• [Journal Article] Cyclic peptide analysis of the biologically active loop region in the laminin alpha 3 chain LG4 module (2007)
  • Author(s): Kato-Takagaki K, Suzuki N, Yokoyama F, Takaki S, Mochizuki M, Kikkawa Y, Oishi S, Utani A, Nomizu M
  • Journal Title: Biochemistry 46 Pages: 1952-1960
• [Journal Article] Angiogenic activitiy of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT) (2007)
  • Author(s): Mochizuki M, Philp D, Kleinman HK, Nomizu M
  • Journal Title: Arch. Biochem. Biophys 459 Pages: 249-255
  • Peer Reviewed
• [Journal Article] Identification of multiple amyloidogenic sequences in laminin-1 (2007)
  • Author(s): Kasai Shingo, ら
  • Journal Title: Biochemistry 46 Pages: 3966-3974
  • Peer Reviewed
• [Journal Article] The LG1-3 Tandem of Laminin a5 Harbors the Binding Sites of Lutheran/Basal Cell Adhesion Molecule and a3 b1/a6 b1 Integrins (2007)
  • Author(s): Kikkawa Yamato, ら
  • Journal Title: J. Biol. Chem. 282 Pages: 14853-14860
  • Peer Reviewed
• [Journal Article] Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes. (2007)
  • Author(s): Mochizuki Mayumiら
  • Journal Title: Biopolymers (印刷中)
• [Journal Article] Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin alpha3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity. (2007)
  • Author(s): Kato-Takagaki Kら
  • Journal Title: Biochemistry (印刷中)
• [Journal Article] Angiogenic activitiy of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT). (2007)
  • Author(s): Mochizuki Mayumiら
  • Journal Title: Arch Biochem Biophys (印刷中)
• [Journal Article] Identification of Multiple Amyloidogenic Sequences in Laminin-1. (2007)
  • Author(s): Kasai Shingoら
  • Journal Title: Biochemistry (印刷中)
• [Journal Article] Laminin ・1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin・2・1 (2006)
  • Author(s): Hozumi K, Suzuki N, Nielsen PK, Nomizu M, Yamada Y
  • Journal Title: J. Biol. Chem 281 Pages: 32929-32940
  • Peer Reviewed
• [Journal Article] Laminin peptide-conjugated chitosan membrane : a new system for cell delivery in wounded skin (2006)
  • Author(s): Ikemoto S, Mochizuki M, Yamada M, Takeda A, Uchinuma E, Yamashina S, Nomizu M, Kadoya Y
  • Journal Title: J. Biomed. Mater. Res. A 79 Pages: 716-722
  • Peer Reviewed
• [Journal Article] Laminin peptide-conjugated chitosan membrane : Application for keratinocyte delivery in wounded skin. (2006)
  • Author(s): Ikemoto Shigehiroら
  • Journal Title: J Biomed Mater Res A. 79 Pages: 716-722
• [Journal Article] Laminin alphal chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1. (2006)
  • Author(s): Hozumi Kentaroら
  • Journal Title: J Biol Chem 281 Pages: 32929-32940
• [Journal Article] Laminin ・3 LG4 module induces keratinocyte migration : involvement of matrix metalloproteinase-9 (2005)
  • Author(s): Momota Y, Suzuki N, Kasuya Y, Kobayashi T, Mizoguchi M, Yokoyama F, Nomizu M, Shinkai H, Iwasaki T, Utani A
  • Journal Title: J. Recept. Signal Transduct. Res 25 Pages: 1-17
  • Peer Reviewed
• [Journal Article] Laminin alpha 5 chain metastasisi- and angiogenesisi- inhibiting peptide blocks FGF2 activity by binding to the heparan sulfate chains of CD44 (2005)
  • Author(s): Hibino S, Shibuya M, Hoffman MP, Engbring JA, Hossain R, Mochizuki M, Kudoh S, Nomizu M, Kleinman HK
  • Journal Title: Cancer Res 65 Pages: 10494-10501
  • Peer Reviewed
• [Journal Article] Bifunctional peptides derived from homologuos Loop regions in the laminin・・chain LG4 modules interact with both・2・1 integrin and syndecan-2 (2005)
  • Author(s): Yokoyama F, Suzuki N, Kadoya Y, Utani A, Nakatsuka H, Nishi N, Haruki M, Kleinman HK, Nomizu M
  • Journal Title: Biochemistry 44 Pages: 9581-9589
  • Peer Reviewed
• [Journal Article] Functional sites in the laminin alpha chains (2005)
  • Author(s): Suzuki N, Yokoyama F, Nomizu M
  • Journal Title: Connect. Tissue Res 46 Pages: 142-152
  • NAID: 10018086866
  • Peer Reviewed
• [Journal Article] Laminin α3 LG4 module induces keratinocyte migration : involvement of matrix metalloproteinase-9. (2005)
  • Author(s): Yutaka Momota ら
  • Journal Title: J.Recept.Signal Transduct.Res. 25 Pages: 1-17
• [Journal Article] Identification of neurite outgrowth active sites on the laminin α4 chain G domain. (2005)
  • Author(s): Naoki Ichikawa ら
  • Journal Title: Biochemistry 44 Pages: 5755-5762
• [Journal Article] Bifunctional peptides derived from homologuos loop regions in the laminin α chain LG4 modules interact with both α2β1 integrin and syndecan-2. (2005)
  • Author(s): Fumiharu Yokoyama ら
  • Journal Title: Biochemistry 44 Pages: 9581-9589
• [Journal Article] Laminin alpha 5 chain metastasisi- and angiogenesisi-inhibiting peptide blocks FGF2 activity by binding to the heparan sulfate chains of CD44. (2005)
  • Author(s): Suguru Hibino ら
  • Journal Title: Cancer Res 65 Pages: 10494-10501
• [Journal Article] Functional sites in the laminin alpha chains. (2005)
  • Author(s): Nobuharu Suzuki ら
  • Journal Title: Connect.Tissue Res. 46 Pages: 142-152
• [Journal Article] 人工基底膜の創製 -ラミニン活性ペプチドの新たなチャレンジ- (2005)
  • Author(s): 望月麻友美ら
  • Journal Title: 蛋白質核酸酵素 45 Pages: 2475-2482
• [Presentation] Cell adhesive peptides-conjugated chitosan membranes promote diverse biological activities (2008)
  • Author(s): Otagiri D, Fujimori C, Hozumi K, Kikkawa Y, Nomizu M
  • Organizer: The American Society for Cell Biology 48th Annual Meeting, San Francisco
  • Place of Presentation: CA, USA
  • Year and Date: 2008-12-13
• [Presentation] Heparin binding sequences in the laminin alpha5 chain LG4-5module (2008)
  • Author(s): Uchiyama Yoshihiko ら
  • Organizer: The American Society for Cell Biology : 48th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-13
• [Presentation] Cell adhesive peptides-conjugated chitosan membranes promote diverse biological activities (2008)
  • Author(s): Otagiri Dai ら
  • Organizer: The American Society for Cell Biology : 48th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-13
• [Presentation] Identification of biologically active peptides from the laminin gamma2 chain (2008)
  • Author(s): Koike Yasuhiro ら
  • Organizer: The American Society for Cell Biology : 48th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-12-13
• [Presentation] Identification of cell adhesive and neurite outgrowth promoting sequences in the laminin・2 chain G domain (2008)
  • Author(s): Urushibata S, Hayashi T, Kobayashi K, Hozumi K, Kikkawa Y, Nomizu M
  • Organizer: 4^<th> Korea-Japan Workshop on Combinatorial Bioengineering
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-22
• [Presentation] Identification of cell adhesive and neurite outgrowth promoting sequences in the laminin alpha2 chain G domain (2008)
  • Author(s): Urushibata Shunsukeら
  • Organizer: 4th Korea-Japan Workshop on Combinatorial Bioengineering
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-22
• [Presentation] Bioactivities of peptides derived from homologous loop regions in the laminin alpha chain G domains (2008)
  • Author(s): Yamada Yuji ら
  • Organizer: 4th Korea-Japan Workshop on Combinatorial Bioengineering
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-22
• [Presentation] Cell ahhesive laminin-derived peptide-polysaccharide complexes (2008)
  • Author(s): Yamada Y, Hozumi K, Nomizu M
  • Organizer: 12^<th> Korean Petide-Protein Society Symposium Seoul
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-21
• [Presentation] Bioactive sequences in the laminin alpha2 chain LG4-5 module reveal heparin and alpha-distroglycan binding activities (2008)
  • Author(s): Urushibata Shunsukeら
  • Organizer: 12th Korean Peptide-Protein Society Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-21
• [Presentation] Cell adhesive laminin-derived peptide-polysaccharide complexes (2008)
  • Author(s): Yamada Yujiら
  • Organizer: 12th Korean Peptide-Protein Society Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-11-21
• [Presentation] Biological activities of loop region in the laminin alphachain G domains (2008)
  • Author(s): Hara Toshihiroら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Screening of amyloid-like structure forming peptides from laminin (2008)
  • Author(s): Taguchi Yuzoら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Identification of laminin-111 peptides active for adhesion of hepatic sinusoidal endothelial cells (2008)
  • Author(s): Akizuki Taneyasuら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Effect of mixed peptide-chitosan membranes on cell adhesion (2008)
  • Author(s): Fujimori Chikaraら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Analysis of syndecan-mediated cell attachment and integrin-mediated cell attachment using two different peptides from laminin (2008)
  • Author(s): Kobayashi Kazukiら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Peptide-chitosan matrices using laminin-111 peptides (2008)
  • Author(s): Dai Otagiri ら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Cell adherent material using synthetic peptides (2008)
  • Author(s): Yamada Yuji ら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] Identification of the biological active peptides from laminin α2 chain LG4-5 modules (2008)
  • Author(s): Urushibata Shunsuke ら
  • Organizer: 第45回ペプチド討論会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-29
• [Presentation] 複数のペプチドを固定化した機能性キトサン膜 (2008)
  • Author(s): 藤森能、小田切大、保住建太郎、吉川大和、野水基義
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-24
• [Presentation] ラミニン由来活性ペプチドを付加した機能性キトサン膜の作製 (2008)
  • Author(s): 佐々木彩乃 ら
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪
  • Year and Date: 2008-09-24
• [Presentation] Cell adhesive laminin peptides for tissue engineering (2008)
  • Author(s): 野水基義、他5名
  • Organizer: 30^<th> European Peptide Symposium
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2008-08-31
• [Presentation] Cell adhesive laminin peptides for tissue engineering (2008)
  • Author(s): Nomizu Motoyoshi ら
  • Organizer: 30th European Peptide Symposium
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2008-08-31
• [Presentation] Identification of biologically active peptides from the N-terminal domain of laminin alpha2 chain (2008)
  • Author(s): Takemitsu Hayashi ら
  • Organizer: 30th European Peptide Symposium
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2008-08-31
• [Presentation] Peptide-chitosan membranes promote diverse biological functions (2008)
  • Author(s): 野水基義、他3名
  • Organizer: Gordon Research Conferences, Biddeford
  • Place of Presentation: ME, USA
  • Year and Date: 2008-07-22
• [Presentation] Peptide-chitosan membranes promote diverse biological functions (2008)
  • Author(s): Nomizu Motoyoshi
  • Organizer: Gordon Research Conerences
  • Place of Presentation: Biddeford, ME, USA
  • Year and Date: 2008-07-22
• [Presentation] ラミニンα2鎖LG4-5モジュールの生物活性部位の解明 (2008)
  • Author(s): 漆畑俊哉ら
  • Organizer: 第40回日本結合組織学会学術大会/第55回マトリックス研究会大会合同学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-29
• [Presentation] ラミニンα1鎖由来の合成ペプチドを用いたラット肝細胞の培養 (2008)
  • Author(s): 三輪隆博 ら
  • Organizer: 第40回日本結合組織学会学術大会/第55回マトリックス研究会大会合同学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-29
• [Presentation] シンデカンを介した細胞接着とインテグリンを介した細胞接着 (2008)
  • Author(s): 小林一樹 ら
  • Organizer: 第40回日本結合組織学会学術大会/第55回マトリックス研究会大会合同学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-29
• [Presentation] Cell adhesive peptide as a powerful tool for cell- and tissue-engineering (2008)
  • Author(s): 野水基義
  • Organizer: The 12^<th> Akabori Conference
  • Place of Presentation: 京都
  • Year and Date: 2008-05-15
• [Presentation] Cell adhesive peptide as a powerful tool for cell- and tissue-engineering (2008)
  • Author(s): Motoyoshi Nomizu
  • Organizer: The 12th Akabori Conference 2008
  • Place of Presentation: 京都
  • Year and Date: 2008-05-15
• [Presentation] マトリックスタンパクの分子解剖と医薬応用 (2008)
  • Author(s): 野水基義
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] Hepatocyto binding sequences in laminin alphal chain (2008)
  • Author(s): Matsuda Yuji ら
  • Organizer: The American Society for Cell Biology : 48th Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-02-13
• [Presentation] Cell adhesive peptide as a powerful tool for cell engineering (2007)
  • Author(s): 野水基義、他4名
  • Organizer: 4^<th> International Peptide Symposium/7^<th> Australian Peptide Conference
  • Place of Presentation: Cairns, Queensland, Australia
  • Year and Date: 2007-12-21
• [Presentation] Peptide-chitosan membranes promote diverse biological functions, The American Society for Cell Biology (2007)
  • Author(s): 野水基義、他2名
  • Organizer: 47th Annual Meeting, Washington
  • Place of Presentation: DC, USA
  • Year and Date: 2007-12-01
• [Presentation] Peptide-Chitosan Membranes Promote Diverse Biological Functions (2007)
  • Author(s): 野水基義, ら
  • Organizer: The American Society for Cell Biology47th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2007-12-01
• [Presentation] Identification of α-dystroglycan binding sequences in the laminin α2 chain G domain (2007)
  • Author(s): 漆畑俊哉, ら
  • Organizer: The American Society for Cell Biology47th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2007-12-01
• [Presentation] Cell adhesive peptide- chitosan membranes : a new multifunctional biomedical material (2007)
  • Author(s): 野水基義、他3名
  • Organizer: 11th Korean Peptide Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-11-30
• [Presentation] Cell adhesive peptide-chitosan membranes:a New multifunctional biomedical material (2007)
  • Author(s): 野水基義, ら
  • Organizer: 11th Korean Peptide Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-11-30
• [Presentation] Preparation of functional peptide-chitosan membranes using various biologically active peptides (2007)
  • Author(s): 小田切大, ら
  • Organizer: 11th Korean Peptide Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-11-30
• [Presentation] Amyloid-like fibril formation of laminin active peptides (2007)
  • Author(s): 田口雄三, ら
  • Organizer: 11th Korean Peptide Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2007-11-30
• [Presentation] Identification of biologically active sites on the N-terminal domain of laminin alpha2chain (2007)
  • Author(s): Hayashi T, Hozumi K, Kikkawa Y, Nomizu M
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 2007-11-10
• [Presentation] Peptide-chitosan membrane mimicking the dual-function of laminin α1 chain LG4 module (2007)
  • Author(s): 保住建太郎, ら
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 2007-11-10
• [Presentation] Biologically active sequences in tha globular domain of laminin gamma2 chain (2007)
  • Author(s): 小池康浩, ら
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 2007-11-10
• [Presentation] Cell adhesive peptide as a powerful tool for cell engineering (2007)
  • Author(s): 野水基義, ら
  • Organizer: 4th International Peptide Symposium/7th Australian Peptide Conferenc
  • Place of Presentation: Cairns, Queensland, Australia
  • Year and Date: 2007-10-21
• [Presentation] Peptide mosaic chitosan membranes promote diverse biological functions (2007)
  • Author(s): 山縣夏美, ら
  • Organizer: 4th International Peptide Symposium/7th Australian Peptide Conferenc
  • Place of Presentation: Cairns, Queensland, Australia
  • Year and Date: 2007-10-21
• [Presentation] 細胞接着ペプチドを付加した機能性キトサン膜の作成と生物活性 (2007)
  • Author(s): 小田切大, ら
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-19
• [Presentation] ラミニンLG4モジュールをミミックした多機能性ペプチド-キトサン膜の創製 (2007)
  • Author(s): 保住建太郎, ら
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-19
• [Presentation] 2種類のレセプターに作用するペプチドーキトサン膜 (2007)
  • Author(s): 藤森能, ら
  • Organizer: 第56回高分子討論会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-09-19
• [Presentation] Cell adhesive peptide- chitosan matrix : a new multifunctional biomaterial (2007)
  • Author(s): 野水基義、他3名
  • Organizer: The 6^<th> Symposium on Frontiers in Protein Chemistry and Biotechnology
  • Place of Presentation: Changchun, China
  • Year and Date: 2007-08-22
• [Presentation] Cell adhesive peptide-chitosan matrix: a New multifunctional biomaterial (2007)
  • Author(s): 野水基義, ら
  • Organizer: The 6th Symposium on Frontiers in Protein Chemistry and Biotechnology(SFPCB'07)
  • Place of Presentation: Changchun, China
  • Year and Date: 2007-08-22
• [Presentation] Peptide-chitosan matrix : a new multifunctional biomaterial (2007)
  • Author(s): 野水基義、他4名
  • Organizer: 20^<th> American Peptide Society Symposium
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2007-06-26
• [Presentation] Peptide-chitosan matrix: a new multifunctional biomaterial (2007)
  • Author(s): 野水基義, ら
  • Organizer: 20th American Peptide Society Symposium
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2007-06-26
• [Presentation] Cyclic peptide analogs of laminin active sequences enhance the biological activity (2007)
  • Author(s): 高木崇, ら
  • Organizer: 20th American Peptide Society Symposium
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2007-06-26
• [Presentation] Identification of the sequence with a heparin and α-dystroglycan binding activity in the laminin α2 chain LG4-5 module (2007)
  • Author(s): 漆畑俊哉, ら
  • Organizer: 第39回日本結合組織学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-09
• [Presentation] Primary culture of hepatocytes on synthetic peptides derived from laminin-111 (2007)
  • Author(s): 吉川大和, ら
  • Organizer: 第39回日本結合組織学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-09
• [Presentation] An α-dystroglycan binding peptide derived from the laminin α2 chain (2006)
  • Author(s): 野水基義、他5名
  • Organizer: The American Society for Cell Biology 46^<th> Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2006-12-09
• [Presentation] Cell adhesive peptides as a powerful tool for biomedical materials (2006)
  • Author(s): 野水基義、他4名
  • Organizer: 11^<TH> Ababoori Conference
  • Place of Presentation: Kloster Banz, Germany
  • Year and Date: 2006-11-11
• [Presentation] Cell adhesive peptide- conjugated chitosan membrane : a new system for cell delivery (2006)
  • Author(s): 野水基義、他5名
  • Organizer: 第43回ペプチド討論会
  • Place of Presentation: 横浜
  • Year and Date: 2006-11-05
• [Presentation] Cell adhesive peptide- conjugated chitosan membrane : as a bio-medical basement membrane for tissue engineering (2006)
  • Author(s): 野水基義、他2名
  • Organizer: 29^<th> European Peptide Symposium
  • Place of Presentation: Gdansk, Poland
  • Year and Date: 2006-11-03
• [Presentation] 多機能性ペプチド-キトサン膜の創製 (2006)
  • Author(s): 山縣夏美、望月麻友美、吉川大和、山田真路、門谷裕一、野水基義
  • Organizer: 第55回高分子討論会
  • Place of Presentation: 富山
  • Year and Date: 2006-09-20
• [Presentation] Characterization of・-dystroglycan binding sequence in the laminin・2 chain LG45 module (2006)
  • Author(s): 野水基義、他5名
  • Organizer: Research Conferences
  • Place of Presentation: Barga, Italy
  • Year and Date: 2006-06-18
• [Remarks] 東京薬科大学薬学部病態生化学教室ホームページ
  • URL: http://www.ps.toyaku.ac.jp/~nomizu/