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Identification of cell-type specific active sites from laminins and characterization of the functional mechanisms

Research Project

Project/Area Number 17390024
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

NOMIZU Motoyoshi  Tokyo University of Pharmacy and Life Science, 薬学部, 教授 (00311522)

Co-Investigator(Kenkyū-buntansha) 山田 純司  東京薬科大学, 薬学部, 准教授 (60200721)
宇谷 厚志  京都大学, 大学院・医学研究科, 准教授 (10292707)
門谷 裕一  北里大学, 医学部, 講師 (10185887)
高木 充弘  東京薬科大学, 薬学部, 助手 (90267493)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥16,800,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2006: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2005: ¥3,900,000 (Direct Cost: ¥3,900,000)
Keywords細胞・組織 / 生体分子 / 蛋白質 / 再生医学 / 薬学 / ラミニン / 基底膜 / ペプチド / インテグリン / シンデカン / 細胞接着 / α-ジストログリカン / キトサン / CD44
Research Abstract

細胞外マトリックスは細胞接着をはじめ器官形成、神経網再生、血管新生やがんの増殖転移などの様々な生命現象や病態に深く関わっている。細胞外マトリックスの主役的な巨大分子であるラミニンの細胞接着活性部位を組換えタンパクと1000種類以上の合成ペプチドを用いて同定し、それぞれの活性部位の細胞膜上のレセプターや様々な生物活性を解析し、さらにはそれらのペプチドを用いた創薬や再生医療への応用研究を行った。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (100 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (38 results) (of which Peer Reviewed: 25 results) Presentation (61 results) Remarks (1 results)

  • [Journal Article] Chain-specific heparin-binding sequences in the laminin・chain LG4-5 modules2009

    • Author(s)
      Hozumi K, Suzuki N, Uchiyama Y, Katagiri F, Kikkawa Y, Nomizu M
    • Journal Title

      Biochemistry (印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clustering of syndecan-4 and integrin・1 by laminin・3 chain-derived peptide promotes keratinocyte migration2009

    • Author(s)
      Araki E, Momota Y, Togo T, Tanioka M, Hozumi K, Nomizu M, Miyachi Y, Utani A
    • Journal Title

      Mol. Biol. Cell (印刷中)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide-chitosan matrix : a new multifunctional biomaterial2009

    • Author(s)
      Nomizu M, Yamagata N, Mochizuki M, Kikkawa Y, Kadoya Y
    • Journal Title

      Adv. Exp. Med. Biol 611

      Pages: 253-255

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mixed peptide-chitosan membranes can mimic biological activities of a multifunctional laminin ・1 chain LG4 module2009

    • Author(s)
      Hozumi K, Yamagata N, Otagiri D, Fujimori C, Kikkawa Y, Kadoya Y, Nomizu M
    • Journal Title

      Biomaterials 30

      Pages: 1596-1603

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell adhesive scaffold material for delivering keratinocytes reduces granulation tissue in dermal wounds2009

    • Author(s)
      Masuda R, Mochizuki M, Hozumi K, Takeda A, Uchinuma E, Yamashina S, Nomizu M, Kadoya Y
    • Journal Title

      Wound Repair Regen 17

      Pages: 127-135

    • NAID

      10031181541

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mixed peptide-chitosan membranes can mimic biological activities of a multifunctional laminin alphal chain LG4 module2009

    • Author(s)
      Kentaro Hozumiら
    • Journal Title

      Biomaterials 30

      Pages: 1596-1603

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell adhesive scaffold material for delivering keratinocytes reduces granulation tissue in dermal wounds.2009

    • Author(s)
      Ryuji Masudaら
    • Journal Title

      Wound Repair Regeneration 17

      Pages: 127-135

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequence specificity of the PHSRN peptide from fibronectin on corneal epithelial migration.2009

    • Author(s)
      Atsushi Hattoriら
    • Journal Title

      Biochem, Biophys. Res. Commun. 79

      Pages: 346-350

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational requirement on peptides to exert laminin's activities and search for protein segments with the laminin's activities.2009

    • Author(s)
      Koji Umezawaら
    • Journal Title

      Biopolymers 29

      Pages: 124-131

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of ZO-1 in cultured human corneal epithelial cells by a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin.2009

    • Author(s)
      Ryoji Yanaiら
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule2008

    • Author(s)
      Kikkawa Y, Sudo R, Kon J, Mizuguchi T, Nomizu M, Hirata K, Mitaka T
    • Journal Title

      Exp. Cell Res 314

      Pages: 2579-2590

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule2008

    • Author(s)
      Kikkawa Yamatoら
    • Journal Title

      Exp Cell Res. 314

      Pages: 2579-2590

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peptide-chitosan matrix: a new multifunctional biomaterial2008

    • Author(s)
      Nomizu Motoyoshi, ら
    • Journal Title

      Peptides (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The LG1-3 tandem of laminin ・5 harbors the binding sites of Lutheran/basal cell adhesion molecule and ・3・1/・6・1 integrins2007

    • Author(s)
      Kikkawa Y, Sasaki T, Nguyen MT, Nomizu M, Mitaka T, Miner JH
    • Journal Title

      J. Biol. Chem 282

      Pages: 14853-14860

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of multiple amyloidogenic sequences in laminin-12007

    • Author(s)
      Kasai S, Urushibata S, Hozumi K, Yokoyama F, Ichikawa N, Kadoya Y, Nishi N, Watanabe N, Yamada Y, Nomizu M
    • Journal Title

      Biochemistry 46

      Pages: 3966-3974

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Integrin- dependent cell behavior on ECM peptide- conjugated chitosan membranes2007

    • Author(s)
      Mochizuki M, Yamagata N, Philp D, Hozumi K, Watanabe T, Kikkawa Y, Kadoya Y, Kleinman HK, Nomizu M
    • Journal Title

      Biopolymers 88

      Pages: 122-130

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclic peptide analysis of the biologically active loop region in the laminin alpha 3 chain LG4 module2007

    • Author(s)
      Kato-Takagaki K, Suzuki N, Yokoyama F, Takaki S, Mochizuki M, Kikkawa Y, Oishi S, Utani A, Nomizu M
    • Journal Title

      Biochemistry 46

      Pages: 1952-1960

    • Related Report
      2008 Final Research Report
  • [Journal Article] Angiogenic activitiy of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT)2007

    • Author(s)
      Mochizuki M, Philp D, Kleinman HK, Nomizu M
    • Journal Title

      Arch. Biochem. Biophys 459

      Pages: 249-255

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of multiple amyloidogenic sequences in laminin-12007

    • Author(s)
      Kasai Shingo, ら
    • Journal Title

      Biochemistry 46

      Pages: 3966-3974

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The LG1-3 Tandem of Laminin a5 Harbors the Binding Sites of Lutheran/Basal Cell Adhesion Molecule and a3 b1/a6 b1 Integrins2007

    • Author(s)
      Kikkawa Yamato, ら
    • Journal Title

      J. Biol. Chem. 282

      Pages: 14853-14860

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes.2007

    • Author(s)
      Mochizuki Mayumiら
    • Journal Title

      Biopolymers (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin alpha3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity.2007

    • Author(s)
      Kato-Takagaki Kら
    • Journal Title

      Biochemistry (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Angiogenic activitiy of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT).2007

    • Author(s)
      Mochizuki Mayumiら
    • Journal Title

      Arch Biochem Biophys (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of Multiple Amyloidogenic Sequences in Laminin-1.2007

    • Author(s)
      Kasai Shingoら
    • Journal Title

      Biochemistry (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Laminin ・1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin・2・12006

    • Author(s)
      Hozumi K, Suzuki N, Nielsen PK, Nomizu M, Yamada Y
    • Journal Title

      J. Biol. Chem 281

      Pages: 32929-32940

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin peptide-conjugated chitosan membrane : a new system for cell delivery in wounded skin2006

    • Author(s)
      Ikemoto S, Mochizuki M, Yamada M, Takeda A, Uchinuma E, Yamashina S, Nomizu M, Kadoya Y
    • Journal Title

      J. Biomed. Mater. Res. A 79

      Pages: 716-722

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin peptide-conjugated chitosan membrane : Application for keratinocyte delivery in wounded skin.2006

    • Author(s)
      Ikemoto Shigehiroら
    • Journal Title

      J Biomed Mater Res A. 79

      Pages: 716-722

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Laminin alphal chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1.2006

    • Author(s)
      Hozumi Kentaroら
    • Journal Title

      J Biol Chem 281

      Pages: 32929-32940

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Laminin ・3 LG4 module induces keratinocyte migration : involvement of matrix metalloproteinase-92005

    • Author(s)
      Momota Y, Suzuki N, Kasuya Y, Kobayashi T, Mizoguchi M, Yokoyama F, Nomizu M, Shinkai H, Iwasaki T, Utani A
    • Journal Title

      J. Recept. Signal Transduct. Res 25

      Pages: 1-17

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin alpha 5 chain metastasisi- and angiogenesisi- inhibiting peptide blocks FGF2 activity by binding to the heparan sulfate chains of CD442005

    • Author(s)
      Hibino S, Shibuya M, Hoffman MP, Engbring JA, Hossain R, Mochizuki M, Kudoh S, Nomizu M, Kleinman HK
    • Journal Title

      Cancer Res 65

      Pages: 10494-10501

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bifunctional peptides derived from homologuos Loop regions in the laminin・・chain LG4 modules interact with both・2・1 integrin and syndecan-22005

    • Author(s)
      Yokoyama F, Suzuki N, Kadoya Y, Utani A, Nakatsuka H, Nishi N, Haruki M, Kleinman HK, Nomizu M
    • Journal Title

      Biochemistry 44

      Pages: 9581-9589

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional sites in the laminin alpha chains2005

    • Author(s)
      Suzuki N, Yokoyama F, Nomizu M
    • Journal Title

      Connect. Tissue Res 46

      Pages: 142-152

    • NAID

      10018086866

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Laminin α3 LG4 module induces keratinocyte migration : involvement of matrix metalloproteinase-9.2005

    • Author(s)
      Yutaka Momota ら
    • Journal Title

      J.Recept.Signal Transduct.Res. 25

      Pages: 1-17

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of neurite outgrowth active sites on the laminin α4 chain G domain.2005

    • Author(s)
      Naoki Ichikawa ら
    • Journal Title

      Biochemistry 44

      Pages: 5755-5762

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Bifunctional peptides derived from homologuos loop regions in the laminin α chain LG4 modules interact with both α2β1 integrin and syndecan-2.2005

    • Author(s)
      Fumiharu Yokoyama ら
    • Journal Title

      Biochemistry 44

      Pages: 9581-9589

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Laminin alpha 5 chain metastasisi- and angiogenesisi-inhibiting peptide blocks FGF2 activity by binding to the heparan sulfate chains of CD44.2005

    • Author(s)
      Suguru Hibino ら
    • Journal Title

      Cancer Res 65

      Pages: 10494-10501

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Functional sites in the laminin alpha chains.2005

    • Author(s)
      Nobuharu Suzuki ら
    • Journal Title

      Connect.Tissue Res. 46

      Pages: 142-152

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 人工基底膜の創製 -ラミニン活性ペプチドの新たなチャレンジ-2005

    • Author(s)
      望月麻友美ら
    • Journal Title

      蛋白質核酸酵素 45

      Pages: 2475-2482

    • Related Report
      2005 Annual Research Report
  • [Presentation] Cell adhesive peptides-conjugated chitosan membranes promote diverse biological activities2008

    • Author(s)
      Otagiri D, Fujimori C, Hozumi K, Kikkawa Y, Nomizu M
    • Organizer
      The American Society for Cell Biology 48th Annual Meeting, San Francisco
    • Place of Presentation
      CA, USA
    • Year and Date
      2008-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Heparin binding sequences in the laminin alpha5 chain LG4-5module2008

    • Author(s)
      Uchiyama Yoshihiko ら
    • Organizer
      The American Society for Cell Biology : 48th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell adhesive peptides-conjugated chitosan membranes promote diverse biological activities2008

    • Author(s)
      Otagiri Dai ら
    • Organizer
      The American Society for Cell Biology : 48th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of biologically active peptides from the laminin gamma2 chain2008

    • Author(s)
      Koike Yasuhiro ら
    • Organizer
      The American Society for Cell Biology : 48th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of cell adhesive and neurite outgrowth promoting sequences in the laminin・2 chain G domain2008

    • Author(s)
      Urushibata S, Hayashi T, Kobayashi K, Hozumi K, Kikkawa Y, Nomizu M
    • Organizer
      4^<th> Korea-Japan Workshop on Combinatorial Bioengineering
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of cell adhesive and neurite outgrowth promoting sequences in the laminin alpha2 chain G domain2008

    • Author(s)
      Urushibata Shunsukeら
    • Organizer
      4th Korea-Japan Workshop on Combinatorial Bioengineering
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bioactivities of peptides derived from homologous loop regions in the laminin alpha chain G domains2008

    • Author(s)
      Yamada Yuji ら
    • Organizer
      4th Korea-Japan Workshop on Combinatorial Bioengineering
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell ahhesive laminin-derived peptide-polysaccharide complexes2008

    • Author(s)
      Yamada Y, Hozumi K, Nomizu M
    • Organizer
      12^<th> Korean Petide-Protein Society Symposium Seoul
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Bioactive sequences in the laminin alpha2 chain LG4-5 module reveal heparin and alpha-distroglycan binding activities2008

    • Author(s)
      Urushibata Shunsukeら
    • Organizer
      12th Korean Peptide-Protein Society Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell adhesive laminin-derived peptide-polysaccharide complexes2008

    • Author(s)
      Yamada Yujiら
    • Organizer
      12th Korean Peptide-Protein Society Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biological activities of loop region in the laminin alphachain G domains2008

    • Author(s)
      Hara Toshihiroら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Screening of amyloid-like structure forming peptides from laminin2008

    • Author(s)
      Taguchi Yuzoら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of laminin-111 peptides active for adhesion of hepatic sinusoidal endothelial cells2008

    • Author(s)
      Akizuki Taneyasuら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of mixed peptide-chitosan membranes on cell adhesion2008

    • Author(s)
      Fujimori Chikaraら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of syndecan-mediated cell attachment and integrin-mediated cell attachment using two different peptides from laminin2008

    • Author(s)
      Kobayashi Kazukiら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Peptide-chitosan matrices using laminin-111 peptides2008

    • Author(s)
      Dai Otagiri ら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell adherent material using synthetic peptides2008

    • Author(s)
      Yamada Yuji ら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of the biological active peptides from laminin α2 chain LG4-5 modules2008

    • Author(s)
      Urushibata Shunsuke ら
    • Organizer
      第45回ペプチド討論会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 複数のペプチドを固定化した機能性キトサン膜2008

    • Author(s)
      藤森能、小田切大、保住建太郎、吉川大和、野水基義
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ラミニン由来活性ペプチドを付加した機能性キトサン膜の作製2008

    • Author(s)
      佐々木彩乃 ら
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell adhesive laminin peptides for tissue engineering2008

    • Author(s)
      野水基義、他5名
    • Organizer
      30^<th> European Peptide Symposium
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2008-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive laminin peptides for tissue engineering2008

    • Author(s)
      Nomizu Motoyoshi ら
    • Organizer
      30th European Peptide Symposium
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification of biologically active peptides from the N-terminal domain of laminin alpha2 chain2008

    • Author(s)
      Takemitsu Hayashi ら
    • Organizer
      30th European Peptide Symposium
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Peptide-chitosan membranes promote diverse biological functions2008

    • Author(s)
      野水基義、他3名
    • Organizer
      Gordon Research Conferences, Biddeford
    • Place of Presentation
      ME, USA
    • Year and Date
      2008-07-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Peptide-chitosan membranes promote diverse biological functions2008

    • Author(s)
      Nomizu Motoyoshi
    • Organizer
      Gordon Research Conerences
    • Place of Presentation
      Biddeford, ME, USA
    • Year and Date
      2008-07-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラミニンα2鎖LG4-5モジュールの生物活性部位の解明2008

    • Author(s)
      漆畑俊哉ら
    • Organizer
      第40回日本結合組織学会学術大会/第55回マトリックス研究会大会合同学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラミニンα1鎖由来の合成ペプチドを用いたラット肝細胞の培養2008

    • Author(s)
      三輪隆博 ら
    • Organizer
      第40回日本結合組織学会学術大会/第55回マトリックス研究会大会合同学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] シンデカンを介した細胞接着とインテグリンを介した細胞接着2008

    • Author(s)
      小林一樹 ら
    • Organizer
      第40回日本結合組織学会学術大会/第55回マトリックス研究会大会合同学術大会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell adhesive peptide as a powerful tool for cell- and tissue-engineering2008

    • Author(s)
      野水基義
    • Organizer
      The 12^<th> Akabori Conference
    • Place of Presentation
      京都
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive peptide as a powerful tool for cell- and tissue-engineering2008

    • Author(s)
      Motoyoshi Nomizu
    • Organizer
      The 12th Akabori Conference 2008
    • Place of Presentation
      京都
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] マトリックスタンパクの分子解剖と医薬応用2008

    • Author(s)
      野水基義
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Hepatocyto binding sequences in laminin alphal chain2008

    • Author(s)
      Matsuda Yuji ら
    • Organizer
      The American Society for Cell Biology : 48th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-02-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cell adhesive peptide as a powerful tool for cell engineering2007

    • Author(s)
      野水基義、他4名
    • Organizer
      4^<th> International Peptide Symposium/7^<th> Australian Peptide Conference
    • Place of Presentation
      Cairns, Queensland, Australia
    • Year and Date
      2007-12-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Peptide-chitosan membranes promote diverse biological functions, The American Society for Cell Biology2007

    • Author(s)
      野水基義、他2名
    • Organizer
      47th Annual Meeting, Washington
    • Place of Presentation
      DC, USA
    • Year and Date
      2007-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Peptide-Chitosan Membranes Promote Diverse Biological Functions2007

    • Author(s)
      野水基義, ら
    • Organizer
      The American Society for Cell Biology47th Annual Meeting
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of α-dystroglycan binding sequences in the laminin α2 chain G domain2007

    • Author(s)
      漆畑俊哉, ら
    • Organizer
      The American Society for Cell Biology47th Annual Meeting
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell adhesive peptide- chitosan membranes : a new multifunctional biomedical material2007

    • Author(s)
      野水基義、他3名
    • Organizer
      11th Korean Peptide Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-11-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive peptide-chitosan membranes:a New multifunctional biomedical material2007

    • Author(s)
      野水基義, ら
    • Organizer
      11th Korean Peptide Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Preparation of functional peptide-chitosan membranes using various biologically active peptides2007

    • Author(s)
      小田切大, ら
    • Organizer
      11th Korean Peptide Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Amyloid-like fibril formation of laminin active peptides2007

    • Author(s)
      田口雄三, ら
    • Organizer
      11th Korean Peptide Symposium
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of biologically active sites on the N-terminal domain of laminin alpha2chain2007

    • Author(s)
      Hayashi T, Hozumi K, Kikkawa Y, Nomizu M
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-10
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Peptide-chitosan membrane mimicking the dual-function of laminin α1 chain LG4 module2007

    • Author(s)
      保住建太郎, ら
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biologically active sequences in tha globular domain of laminin gamma2 chain2007

    • Author(s)
      小池康浩, ら
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell adhesive peptide as a powerful tool for cell engineering2007

    • Author(s)
      野水基義, ら
    • Organizer
      4th International Peptide Symposium/7th Australian Peptide Conferenc
    • Place of Presentation
      Cairns, Queensland, Australia
    • Year and Date
      2007-10-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Peptide mosaic chitosan membranes promote diverse biological functions2007

    • Author(s)
      山縣夏美, ら
    • Organizer
      4th International Peptide Symposium/7th Australian Peptide Conferenc
    • Place of Presentation
      Cairns, Queensland, Australia
    • Year and Date
      2007-10-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 細胞接着ペプチドを付加した機能性キトサン膜の作成と生物活性2007

    • Author(s)
      小田切大, ら
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラミニンLG4モジュールをミミックした多機能性ペプチド-キトサン膜の創製2007

    • Author(s)
      保住建太郎, ら
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 2種類のレセプターに作用するペプチドーキトサン膜2007

    • Author(s)
      藤森能, ら
    • Organizer
      第56回高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cell adhesive peptide- chitosan matrix : a new multifunctional biomaterial2007

    • Author(s)
      野水基義、他3名
    • Organizer
      The 6^<th> Symposium on Frontiers in Protein Chemistry and Biotechnology
    • Place of Presentation
      Changchun, China
    • Year and Date
      2007-08-22
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive peptide-chitosan matrix: a New multifunctional biomaterial2007

    • Author(s)
      野水基義, ら
    • Organizer
      The 6th Symposium on Frontiers in Protein Chemistry and Biotechnology(SFPCB'07)
    • Place of Presentation
      Changchun, China
    • Year and Date
      2007-08-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Peptide-chitosan matrix : a new multifunctional biomaterial2007

    • Author(s)
      野水基義、他4名
    • Organizer
      20^<th> American Peptide Society Symposium
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2007-06-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Peptide-chitosan matrix: a new multifunctional biomaterial2007

    • Author(s)
      野水基義, ら
    • Organizer
      20th American Peptide Society Symposium
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2007-06-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cyclic peptide analogs of laminin active sequences enhance the biological activity2007

    • Author(s)
      高木崇, ら
    • Organizer
      20th American Peptide Society Symposium
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2007-06-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of the sequence with a heparin and α-dystroglycan binding activity in the laminin α2 chain LG4-5 module2007

    • Author(s)
      漆畑俊哉, ら
    • Organizer
      第39回日本結合組織学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Primary culture of hepatocytes on synthetic peptides derived from laminin-1112007

    • Author(s)
      吉川大和, ら
    • Organizer
      第39回日本結合組織学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] An α-dystroglycan binding peptide derived from the laminin α2 chain2006

    • Author(s)
      野水基義、他5名
    • Organizer
      The American Society for Cell Biology 46^<th> Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2006-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive peptides as a powerful tool for biomedical materials2006

    • Author(s)
      野水基義、他4名
    • Organizer
      11^<TH> Ababoori Conference
    • Place of Presentation
      Kloster Banz, Germany
    • Year and Date
      2006-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive peptide- conjugated chitosan membrane : a new system for cell delivery2006

    • Author(s)
      野水基義、他5名
    • Organizer
      第43回ペプチド討論会
    • Place of Presentation
      横浜
    • Year and Date
      2006-11-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Cell adhesive peptide- conjugated chitosan membrane : as a bio-medical basement membrane for tissue engineering2006

    • Author(s)
      野水基義、他2名
    • Organizer
      29^<th> European Peptide Symposium
    • Place of Presentation
      Gdansk, Poland
    • Year and Date
      2006-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 多機能性ペプチド-キトサン膜の創製2006

    • Author(s)
      山縣夏美、望月麻友美、吉川大和、山田真路、門谷裕一、野水基義
    • Organizer
      第55回高分子討論会
    • Place of Presentation
      富山
    • Year and Date
      2006-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Characterization of・-dystroglycan binding sequence in the laminin・2 chain LG45 module2006

    • Author(s)
      野水基義、他5名
    • Organizer
      Research Conferences
    • Place of Presentation
      Barga, Italy
    • Year and Date
      2006-06-18
    • Related Report
      2008 Final Research Report
  • [Remarks] 東京薬科大学薬学部病態生化学教室ホームページ

    • URL

      http://www.ps.toyaku.ac.jp/~nomizu/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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