Development and Application of"Cancer Cell lnformatics" for identifying novel drug seeds

• Project/Area Number: 17390032
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: YAMORI Takao Japanese Foundation For Cancer Research, 分子薬理部, 部長 (60200854)
• Co-Investigator(Kenkyū-buntansha): DAN Shingo 財団法人癌研究会・癌化学療法センター, 分子薬理部, 研究員 (70332202)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,900,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥1,800,000); Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2005: ¥5,100,000 (Direct Cost: ¥5,100,000)
• Keywords: Cancer Ce11 Informatics / 分子標的予測 / がん / がん細胞パネル / PI3K / 薬剤感受性 / 抗がん剤探索 / データベース / Cancer Cell Informatics

Research Abstract

抗がん剤として分子標的薬の創薬が注目されている。われわれは、生物学的実験とコンピュータを組み合わせることによって化合物の分子標的を予測するユニークなシステムを開発し、これを実際に創薬に応用した。多くの新規化合物を試験した結果、PI3キナーゼ(がんの悪性増殖の原因、がん治療の有力な分子標的の一つ)を標的として攻撃する新規化合物ZSTK474をはじめとする種々の分子標的薬候補を見出すことができた。よって、本システムは分子標的薬の開発を支援、加速するものと考えられ、今後の活用が期待できる。

Research Products

• [Journal Article] SKl and MELl cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells (2009)
  • Author(s): Takahata M, lnoue Y, Tsuda H, lmoto l, Koinuma D, Hayashi M, lchikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, lnazawa J, Miyazono K, Tmamura T
  • Journal Title: The Journal of biological chemistry 284(5) Pages: 3334-44
• [Journal Article] Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase lnhibitor, on DNA-Dependent Protein Kinase (2009)
  • Author(s): Kong D, Yaguchi S, Yamori T
  • Journal Title: Biological&pharmaceutical bulletin 32(2) Pages: 297-300
• [Journal Article] Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor (2009)
  • Author(s): Kong D, 0kamura M, Yoshimi H, Yamori T
  • Journal Title: Eur J Cancer 45(5) Pages: 857-65
• [Journal Article] Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but GO/Gl arrest (2009)
  • Author(s): Dan S, Yoshimi H, 0kamura M, Mukai Y, Yamori T
  • Journal Title: Biochemical and biophysical research communications 379(1) Pages: 104-9
• [Journal Article] Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS (2009)
  • Author(s): Akashi T, Yamori T
  • Journal Title: Proteome science 7 Pages: 14-14
• [Journal Article] Proteomic Analysis of Phosphoproteins Sensitive to a Phosphati dylinositol 3-Kinase Inhibitor, ZSTK474, by using SELDI-TOF MS (2009)
  • Author(s): Akashi T, Yamori T.
  • Journal Title: Proteome Science (in press)
  • Peer Reviewed
• [Journal Article] SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells (2009)
  • Author(s): Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T.
  • Journal Title: The Journal of biological chemistry 284 Pages: 3334-44
  • Peer Reviewed
• [Journal Article] Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor, on DNA-Dependent Protein Kinase (2009)
  • Author(s): Kong D, Yaguchi S, Yamori T.
  • Journal Title: Biological & pharmaceutical bulletin 32 Pages: 297-300
  • NAID: 110007042148
  • Peer Reviewed
• [Journal Article] Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor (2009)
  • Author(s): Kong D, Okamura M, Yoshimi H, Yamori T.
  • Journal Title: Eur J Cancer 45 Pages: 857-65
  • Peer Reviewed
• [Journal Article] Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest (2009)
  • Author(s): Dan S, Yoshimi H, Okamura M, Mukai Y, Yamori T.
  • Journal Title: Biochemical and biophysical research communications 379 Pages: 104-9
  • Peer Reviewed
• [Journal Article] A new evaluation method for quantifying PI3K activity by HTRF assay (2008)
  • Author(s): Sugita H, Dan S, Kong D, Tomida A, Yamori T
  • Journal Title: Biochemical and biophysical research communications 377(3) Pages: 941-5
• [Journal Article] Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents (2008)
  • Author(s): Shiina I, Sano Y, Nakata K, Kikuchi T, Sasaki A, Ikekita M, Nagahara Y,Hasome Y, Yamori T, Yamazaki K
  • Journal Title: Biochem Pharmacol 75(5) Pages: 1014-26
• [Journal Article] Phosphatidylinositol 3-kinase inhibitors : promising drug candidates for cancer therapy (2008)
  • Author(s): Kong D, Yamori T
  • Journal Title: Cancer science 99(9) Pages: 1734-40
  • NAID: 10024010628
• [Journal Article] Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines (2008)
  • Author(s): Kojima N, Hayashi H, Suzuki S, Tominaga H, Maezaki N, Tanaka T, Yamori T
  • Journal Title: Bioorganic & medicinal chemistry letters 18(24) Pages: 6451-3
• [Journal Article] Synthesis of hybrid acetogenins, alpha, beta-unsaturated-gamm a-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines (2008)
  • Author(s): Kojima N, Fushimi T, Maezaki N, Tanaka T, Yamori T
  • Journal Title: Bioorganic & medicinal chemistry letters 18(5) Pages: 1637-41
• [Journal Article] Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226 (2008)
  • Author(s): Chen CJ, Hsu MH, Huang LJ, Yamori T, Chung JG, Lee FY, Teng CM, Kuo SC
  • Journal Title: Biochem Pharmacol 75(2) Pages: 360-8
• [Journal Article] The polar neutral and basic taxoids isolated from needles and twigs of Taxus cuspidata and their biological activity (2008)
  • Author(s): Wang L, Bai L, Tokunaga D, Watanabe Y, Hasegawa T, Sakai J, Tang W, Bai Y, Hirose K, Yamori T, Tomida A, Tsuruo T, Ando M.
  • Journal Title: Journal of Wood Science 54 Pages: 390-401
  • NAID: 10025388074
  • Peer Reviewed
• [Journal Article] A new evaluation method for quantifying PI3K activity by HTRF assay (2008)
  • Author(s): Sugita H, Dan S, Kong D, Tomida A, Yamori T.
  • Journal Title: Biochemical and biophysical research communications 377 Pages: 941-5
  • Peer Reviewed
• [Journal Article] Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents (2008)
  • Author(s): Shiina I, Sano Y, Nakata K, Kikuchi T, Sasaki A, Ikekita M, Nagahara Y, Hasome Y, Yamori T, Yamazaki K.
  • Journal Title: Biochem Pharmacol 75 Pages: 1014-26
  • Peer Reviewed
• [Journal Article] Motif-programmed artificial protein induces apoptosis in several cancer cells by disrupting mitochondria (2008)
  • Author(s): Saito H, Minamisawa T, Yamori T, Shiba K.
  • Journal Title: Cancer science 99 Pages: 398-406
  • NAID: 10024002827
  • Peer Reviewed
• [Journal Article] Phosphatidylinositol 3-kinase inhibitors : promising drug candidates for cancer therapy (2008)
  • Author(s): Kong D, Yamori T.
  • Journal Title: Cancer science 99 Pages: 1734-40
  • NAID: 10024010628
  • Peer Reviewed
• [Journal Article] Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines (2008)
  • Author(s): Kojima N, Hayashi H, Suzuki S, Tominaga H, Maezaki N, Tanaka T, Yamori T.
  • Journal Title: Bioorganic & medicinal chemistry letters 18 Pages: 6451-3
  • Peer Reviewed
• [Journal Article] Synthesis of hybrid acetogenins, alpha,beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines (2008)
  • Author(s): Kojima N, Fushimi T, Maezaki N, Tanaka T, Yamori T.
  • Journal Title: Bioorganic & medicinal chemistry letters 18 Pages: 1637-41
  • Peer Reviewed
• [Journal Article] Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226 (2008)
  • Author(s): Chen CJ, Hsu MH, Huang LJ, Yamori T, Chung JG, Lee FY, Teng CM, Kuo SC.
  • Journal Title: Biochem Pharmacol 75 Pages: 360-8
  • Peer Reviewed
• [Journal Article] Cancer Cell Informatics の活用と分子標的薬の探索評価 (2008)
  • Author(s): 矢守隆夫
  • Journal Title: Mebio Oncology 5号 Pages: 18-28
• [Journal Article] がん分子標的研究の基盤となる Cancer Cell Informatics (2008)
  • Author(s): 矢守隆夫
  • Journal Title: MEDCHEM NEWS 18号 Pages: 23-7
  • NAID: 130007958898
• [Journal Article] プロテオミクスによる薬剤感受性の検討 (2008)
  • Author(s): 明石哲行, 矢守隆夫
  • Journal Title: 腫瘍内科 2号 Pages: 130-5
• [Journal Article] PI3Kの新しい阻害剤 (2008)
  • Author(s): 孔徳新, 矢守隆夫
  • Journal Title: 生体の科学 59号 Pages: 541-7
• [Journal Article] Synthesis of hybrid acetogenins,alpha,beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogues,and their cytotoxicity against human cancer cell lines (2008)
  • Author(s): Kojima N, Fushimi T, Maezaki N, Tanaka T, Yamori T.
  • Journal Title: Bioorg Med Chem Lett. (in press)
  • Peer Reviewed
• [Journal Article] Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents (2008)
  • Author(s): Shiina I, Sano Y, Nakata K, Kikuchi T, Sasaki A, Ikekita M, Nagahara Y, Hasome Y, Yamori T, Yamazaki K.
  • Journal Title: Biochem Pharmacol 75(5) Pages: 1014-1026
  • Peer Reviewed
• [Journal Article] Motif-programmed artificial protein induces apoptosis in several cancer cells by disrupting mitochondria (2008)
  • Author(s): Saito H, Minamisawa T, Yamori T, Shiba K.
  • Journal Title: Cancer Sci. 99(2) Pages: 398-406
  • NAID: 10024002827
  • Peer Reviewed
• [Journal Article] Anticancer mechanisms of YC-1 in human lung cancer cell line,NCI-H226 (2008)
  • Author(s): Chen CJ, Hsu MH, Huang LJ, Yamori T, Chung JG, Lee FY, Teng CM, Kuo SC.
  • Journal Title: Biochem Pharmacol 75(2) Pages: 360-368
  • Peer Reviewed
• [Journal Article] Glaziovianin A,a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells (2007)
  • Author(s): Yokosuka A, Haraguchi M, Usui T, Kazami S, 0sada H, Yamori T, Mimaki Y
  • Journal Title: Bioorganic & medicinal chemistry letters 17(11) Pages: 3091-4
• [Journal Article] Identification of JTP-70902, a p15(INK4♭)-inductive compound, as a novel MEK1/2 inhibitor (2007)
  • Author(s): Yamaguchi T, Yoshida T, Kurachi R, Kakegawa J, Hori Y, Nanayama T, Hayakawa K, Abe H, Takagi K, Matsuzaki Y, Koyama M, Yogosawa S, Sowa Y, Yamori T, Tajima N, Sakai T
  • Journal Title: Cancer science 98(11) Pages: 1809-16
• [Journal Article] Evaluation of Action Mechanisms of Toxic Chemicals using JFCR39, a Panel of Human Cancer Cell lines (2007)
  • Author(s): Nakatsu N, Nakamura T, Yamazaki K, Sadahiro S, Makuuchi H, Kanno J, Yamori T
  • Journal Title: Mol Pharmacol 72(5) Pages: 1171-80
• [Journal Article] Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR (2007)
  • Author(s): Nakamura H, Dan S, Akashi T,Unno M, Yamori T
  • Journal Title: Biological & pharmaceutical bulletin 30(6) Pages: 1181-4
  • NAID: 110006278417
• [Journal Article] Sesquiterpenoids and flavonoids from the aerial parts of Tithonia diversifolia and their cytotoxic activity (2007)
  • Author(s): Kuroda M, Yokosuka A, Kobayashi R, Jitsuno M, Kando H, Nosaka K, Ishii H, Yamori T, Mimaki Y
  • Journal Title: Chemical & pharmaceutical bulletin 55(8) Pages: 1240-4
  • NAID: 110006366547
• [Journal Article] ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3kinase isoforms (2007)
  • Author(s): Kong D ,Yamori T
  • Journal Title: Cancer science 98(10) Pages: 1638-42
  • NAID: 10019997789
• [Journal Article] Marine diterpenoids with a briarane skeleton from the okinawan soft cora1 Pachyclavularia violacea (2007)
  • Author(s): Ito H, lwasaki J, Sato Y, Aoyagi M, Iguchi K, Yamori T
  • Journal Title: Chemical & pharmaceutical bulletin 55(12) Pages: 1671-6
• [Journal Article] Development and characterization of a model of liver metastasis using human colon cancer HCT-II6 cells (2007)
  • Author(s): Ishizu K, Sunose N, Yamazaki K, Tsuruo T, Sadahiro S, Makuuchi H, Yamori T
  • Journal Title: Biological & pharmaceutical bulletin 30(9) Pages: 1779-83
• [Journal Article] Enantioselective Total Synthesis of (+)-Ottelione A, (-)-Ottelione B, (+)-3-epi-Ottelione A and Preliminary Evaluation of Their Antitumor Activity (2007)
  • Author(s): Araki H, Inoue M, Suzuki T, Yamori T,Kohno M, Watanabe K, Abe H, Katoh T
  • Journal Title: Chemistry 13(35) Pages: 9866-81
• [Journal Article] Variation in cytostatic constituents of asponge-derived Gymnascella dankaliensis by manipulating the carbon source (2007)
  • Author(s): Amagata T, Tanaka M, Yamada T, Doi M, Minoura K, 0hishi H, Yamori T, Numata A
  • Journal Title: Journal of natural products 70(11) Pages: 1731-40
• [Journal Article] A novel method for analyzing phosphoproteins using SELDI-TOF MS in combination with a series of recombinant proteins (2007)
  • Author(s): Akashi T, Yamori T
  • Journal Title: Proteomics 7(14) Pages: 2350-4
• [Journal Article] Proteomics-based identification of biomarkers for predicting sensitivity to a PI3-kinase inhibitor in cancer (2007)
  • Author(s): Akashi T, Nishimura Y, Wakatabe R, Shiwa M, Yamori T
  • Journal Title: Biochemicaland biophysical research communications 352(2) Pages: 514-21
• [Journal Article] Proteomics-based identification of biomarkers for predicting sensitivety to a PI3-kinase inhibitor in cancer (2007)
  • Author(s): Akashi T, Nishimura Y, Wakatabe R, Shiwa M, Yamori T.
  • Journal Title: Biochemical and biophysical research communications 352(2) Pages: 514-521
  • Peer Reviewed
• [Journal Article] A novel method for analyzing phosphoproteins using SELDI-TOF MS in combination with a series of recombinant proteins (2007)
  • Author(s): Akashi T, Yamori T.
  • Journal Title: Proteomics 7(14) Pages: 2350-2354
  • Peer Reviewed
• [Journal Article] Variation in cytostatic constituents of a sponge-derived Gymnascella dankaliensis by manipulating the carbon source (2007)
  • Author(s): Amagata T, Tanaka M, Yamada T, Doi M, Minoura K, Ohishi H, YamoriT, Numata A.
  • Journal Title: Journal of natural products 70(11) Pages: 1731-1740
  • Peer Reviewed
• [Journal Article] Enantioselective Total Synthesis of(+)-Ottelione A,(-)-Ottelione B,(+)-3-epi-Ottelione A and Preliminary Evaluation of Their Antitumor Activity (2007)
  • Author(s): Araki H, Inoue M, Suzuki T, Yamori T, Kohno M, Watanabe K, Abe H, Katoh T.
  • Journal Title: Chemistry 13(35) Pages: 9866-9881
  • Peer Reviewed
• [Journal Article] Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells (2007)
  • Author(s): Hasegawa T, Bai J, Dai J, Bai L, Sakai J, Nishizawa S, Bai Y, Kikuchi M, Abe M, Yamori T, TomidaA, Tsuruo T, Hirose K, Ando M.
  • Journal Title: Bioorganic&medicinal chemistry letters 17(13) Pages: 3722-3728
  • Peer Reviewed
• [Journal Article] Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad (2007)
  • Author(s): Ichikawa K, Sakabe E, Kuninobu K, Yamori T, Tsuruo T, Yao T, Tsuneyoshi M, Utsumi H.
  • Journal Title: Antioxidants&redox signaling 9(10) Pages: 1699-1707
  • Peer Reviewed
• [Journal Article] Comparative profiling of the gene expression for estrogen responsiveness in cultured human cell lines (2007)
  • Author(s): Inoue A, Seino Y, Terasaka S, Hayashi S, Yamori T, Tanji M, Kiyama R.
  • Journal Title: Toxicol In Vitro 21(4) Pages: 741-752
  • Peer Reviewed
• [Journal Article] Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells (2007)
  • Author(s): Ishizu K, Sunose N, Yamazaki K, Tsuruo T, Sadahiro S, Makuuchi H, Yamori T.
  • Journal Title: Biological&pharmaceutical bulletin 30(9) Pages: 1779-1783
  • NAID: 110006380268
  • Peer Reviewed
• [Journal Article] Marine diterpenoids with a briarane skeleton from the Okinawan soft coral Pachyclavularia violacea (2007)
  • Author(s): Ito H, Iwasaki J, Sato Y, Aoyagi M, Iguchi K, Yamori T.
  • Journal Title: Chemical&pharmaceutical bulletin 55(12) Pages: 1671-1676
  • NAID: 110006532106
  • Peer Reviewed
• [Journal Article] ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinosito 13 kinase isoforms (2007)
  • Author(s): Kong D, Yamori T.
  • Journal Title: Cancer science 98(10) Pages: 1638-1642
  • Peer Reviewed
• [Journal Article] Sesquiterpenoids and flavonoids from the aerial parts of Tithonia diversifolia and their cytotoxic activity (2007)
  • Author(s): Kuroda M, Yokosuka A, Kobayashi R, Jitsuno M, Kando H, Nosaka K, Ishii H, Yamori T, Mimaki Y.
  • Journal Title: Chemical&pharmaceutical bulletin 55(8) Pages: 1240-1244
  • NAID: 110006366547
  • Peer Reviewed
• [Journal Article] Urukthapelstatin A, a novel cytotoxic substance from marine-derived Mechercharimyces asporophorigenens YM11-542.I.Fermentation,isolation and biological activities (2007)
  • Author(s): Matsuo Y, Kanoh K, Yamori T, Kasai H, Katsuta A, Adachi K, Shin-Ya K, Shizuri Y.
  • Journal Title: The Journal of antibiotics 60(4) Pages: 251-255
  • Peer Reviewed
• [Journal Article] A novel candidate compound with urethane structure for anticancer drug development (2007)
  • Author(s): Matsuoka A, Isama K, Tanimura S, Kohno M, Yamori T.
  • Journal Title: Current drug discovery technologies 4(2) Pages: 69-76
  • Peer Reviewed
• [Journal Article] Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR (2007)
  • Author(s): Nakamura H, Dan S, Akashi T, Unno M, Yamori T.
  • Journal Title: Biological&pharmaceutical bulletin 30(6) Pages: 1181-1184
  • NAID: 110006278417
  • Peer Reviewed
• [Journal Article] Evaluation of Action Mechanisms of Toxic Chemicals Using JFCR39,a Panel of Human Cancer Cell Lines (2007)
  • Author(s): Nakatsu N, Nakamura T, Yamazaki K, Sadahiro S, Makuuchi H, Kanno J, Yamori T.
  • Journal Title: Mol Pharmacol 72(5) Pages: 1171-1180
  • Peer Reviewed
• [Journal Article] Identification of JTP-70902,a p15(INK4b)-inductive compound,as a novel MEK1/2 inhibitor (2007)
  • Author(s): Yamaguchi T, Yoshida T, Kurachi R, Kakegawa J, Hori Y, Nanayama T, Hayakawa K, Abe H, Takagi K, Matsuzaki Y, Koyama M, Yogosawa S, Sowa Y, Yamori T, Tajima N, Sakai T.
  • Journal Title: Cancer science 98(11) Pages: 1809-1816
  • Peer Reviewed
• [Journal Article] Iaziovianin A,a new isoflavone,from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells (2007)
  • Author(s): Yokosuka A, Haraguchi M, Usui T, Kazami S, Osada H, Yamori T, Mimaki Y.
  • Journal Title: Bioorganic&medicinal chemistry letters 17(11) Pages: 3091-3094
  • Peer Reviewed
• [Journal Article] Glaziovianin A, a new isoflavone, from the leaves of Atelier glazioviana and its cytotoxic activity against human cancer cells. (2007)
  • Author(s): Yokosuka, A., Haraguchi, M., Usui, T., Kazami, S., Osada, H., Yamori, T., Mimaki, Y.
  • Journal Title: Bioorg. Med. Chem. Lett. (in press)
• [Journal Article] Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR. (2007)
  • Author(s): Nakamura, H., Dan, S., Akashi, T., Unno, M., Yamori, T.
  • Journal Title: Biol. Pharm. Bull. (in press)
  • NAID: 110006278417
• [Journal Article] Comparative profiling of the gene expression for estrogen responsiveness in cultured human cell lines. (2007)
  • Author(s): Inoue, A., Seino, Y., Terasaka, S., Hayashi, SI., Yamori, T., Tanji, M., Kiyama, R.
  • Journal Title: Toxicol. In Vitro. 21・4 Pages: 741-52
• [Journal Article] Proteomics-based identification of biomarkers predicting sensitivity to a PI3-kinase inhibitor in cancer. (2007)
  • Author(s): Akashi, T., Nishimura, Y., Wakatabe, R., Shiwa, M., Yamori, T.
  • Journal Title: Biochem. Biophys. Res. Commun. 352・2 Pages: 514-21
• [Journal Article] Antitumor activity of ZSTK474,a new phosphatidylinositol 3-kinase inhibitor (2006)
  • Author(s): Yaguchi S, Fukui Y, Koshimizu I, Yoshimi H, Matsuno T, Gouda H, Hirono S, Yamazaki K, Yamori T
  • Journal Title: J Nat1 Cancer Inst 98(8) Pages: 545-56
• [Journal Article] Potent antitumor activity of 3,4-seco-8betaH-Ferna-4(23), 9(11)-die n-3-oic acid (EC-2) and 3,4-seco-01eana-4(23), 18-dien-3-oic acid(EC-4), evaluated by an in vitro human cancer cell line panel (2006)
  • Author(s): Tanaka R, Wada S, Yamada T, Yamori T
  • Journal Title: Planta Med 72(14) Pages: 1347-9
• [Journal Article] Synthesis and biological evaluation of boronic acid containing cis-stilbenes as apoptotic tubulin polymerization inhibitors (2006)
  • Author(s): Nakamura H, Kuroda H, Saito H, Suzuki R, Yamori T, Maruyama K, Haga T
  • Journal Title: ChemMedChem 1(7) Pages: 729-40
• [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid (2006)
  • Author(s): Kishi Y, 0kudaira S, Tanaka M, Hama K, Shida D, Kitayama J, Yamori T, Aoki J, Fujimaki T, Arai H
  • Journal Title: he Journal of biological chemistry 281(25) Pages: 17492-500
• [Journal Article] Modification of pyrimidine derivatives from antiviral agents to antitumor agents (2006)
  • Author(s): Kimura H, Katoh T, Kajimoto T, Node M, Hisaki M, Sugimoto Y, Majima T, Uehara Y, Yamori T
  • Journal Title: Anticancer Res 26(1A) Pages: 91-7
• [Journal Article] Modification of pyrimidine derivatives from antiviral agents to antitumor agents. (2006)
  • Author(s): Kimura, H., Katho, T., Kajimoto, T., Node, M., Hisaki, M., Sugimoto, Y., Majima, T., Uehara, Y., Yamori, T.
  • Journal Title: Anticancer Res. 26 Pages: 91-97
• [Journal Article] Antitumor Activity of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor. (2006)
  • Author(s): Yaguchi, S., Fukui, Y., Koshimizu, I., Yoshimi, H., Matsuno, T., Gouda, H., Hirono, S., Yamazaki, K., Yamori, T.
  • Journal Title: J. Natl. Cancer Inst. 98・8 Pages: 545-56
  • NAID: 40015603056
• [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. (2006)
  • Author(s): Kishi, Y., Okudaira, S., Tanaka, M., Hama, K., Shida, D., Kitayama, J., Yamori, T., Aoki, J., Fujimaki, T., Arai, H.
  • Journal Title: J. Biol. Chem. 281・25 Pages: 17492-500
• [Journal Article] Synthesis and biological evaluation of boronic acid containing cis-stilbenes as apoptotic tubulin polymerization inhibitors. (2006)
  • Author(s): Nakamura, H., Kuroda, H., Saito, H., Suzuki, R., Yamori, T., Maruyama, K., Haga, T.
  • Journal Title: Chem. Med. Chem. 1・7 Pages: 279-40
• [Journal Article] Potent antitumor activity of 3,4-seco-8betaH-Fema-4(23), 9(11)-dien-3-oic acid (EC-") and 3,4-seco-Oleana-4(23), 18-dien-3-oic acid (EC-4), evaluated by an in vitro human cancer cell line panel. (2006)
  • Author(s): Tanaka, R., Wada, S., Yamada, T., Yamori, T.
  • Journal Title: Planta Med. 72・14 Pages: 1347-9
• [Journal Article] Antitumor Activity of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor. (2006)
  • Author(s): Yaguchi, S., Fukui, Y., Koshimizu, I., Yoshimi, H., Matsuno, T., Gouda, H., Hirano, S., Yamazaki, K., Yamori, T
  • Journal Title: J.Natl.Cancer Inst (印刷中)
  • NAID: 40015603056
• [Journal Article] Modification of pyrimidine derivatives from antiviral agents to antitumor agents. (2006)
  • Author(s): Kimura, H., Katoh, T., Kajimoto, T., Node, M., Hisaki, M., Sugimoto, Y., Majima, T., Uehara, Y., Yamori, T.
  • Journal Title: Anticancer Res,26:91-97 26 Pages: 91-97
• [Journal Article] Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B (2005)
  • Author(s): Yanagihara M, Sasaki-Takahashi N, Sugahara T, Yamamoto S, Shinomi M, Yamashita I, Hayashida M, Yamanoha B, Numata A,Yamori T, Andoh T
  • Journal Title: Cancer science 96(11) Pages: 816-24
  • NAID: 10017091804
• [Journal Article] YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I.fermentation, isolation and biological activities (2005)
  • Author(s): Sohda KY, Nagai K, Yamori T, Suzuki K, Tanaka A
  • Journal Title: The Journal of antibiotics 58(I) Pages: 27-31
• [Journal Article] Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexy lisothiocyanate of human breast cancer and melanoma cell lines studied in vitro (2005)
  • Author(s): Nomura T, Shinoda S, Yamori T, Sawaki S, Nagata I, Ryoyama K, Fuke Y
  • Journal Title: Cancer Detect Prev 29(2) Pages: 155-60
• [Journal Article] Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays (2005)
  • Author(s): Nakatsu N, Yoshida Y, Yamazaki K, Nakamura T, Dan S, Fukui Y, Yamori T
  • Journal Title: Mol Cancer Ther 4(3) Pages: 399-412
• [Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway : a new therapeutic target (2005)
  • Author(s): Mashima T, 0h-hara T, Sato S,Mochizuki M, Sugimoto Y, Yamazaki K, Hamada J, Tada M, Moriuchi T, Ishikawa Y, Kato Y, Tomoda H, Yamori T, Tsuruo T
  • Journal Title: J Nat1 Cancer Inst 97(10) Pages: 765-77
• [Journal Article] Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity (2005)
  • Author(s): Maezaki N, Tominaga H, Kojima N, Yanai M, Urabe D, Ueki R, Tanaka T, Yamori T
  • Journal Title: Chemistry 11(21) Pages: 6237-45
• [Journal Article] Synthesis and biological elationships of 3', 6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents (2005)
  • Author(s): Lai YY,Huang LJ,Lee KH,xiao Z, Bastow KF, Yamori T.,Kuo SC
  • Journal Title: Bioorg Med Chem 13(1) Pages: 265-75
• [Journal Article] New bisindole alkaloids isolated from Myxomycetes Arcyria cinerea and Lycogala epidendrum (2005)
  • Author(s): Kamata K, Kiyota M, Naoe A, Nakatani S, Yamamoto Y, Hayashi M, Komiyama K, Yamori T, Ishibashi M
  • Journal Title: Chemical & pharmaceutical bulletin 53(5) Pages: 594-7
  • NAID: 10016653963
• [Journal Article] Antitumor effect of cotylenin A plus interferon-alpha : Possible therapeutic agents against ovary carcinoma (2005)
  • Author(s): Honma Y, Kasukabe T, Yamori T, Kato N, Sassa T
  • Journal Title: Gynecol 0ncol 99(3) Pages: 680-8
• [Journal Article] Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an interated bioinformatical approach using cDNA arrays. (2005)
  • Author(s): Nakatsu, N., Yoshida, Y., Yamazaki, K., Nakamura, T., Dan, S., Fukui, Y., Yamori, T.
  • Journal Title: Mol Cancer Ther. 4 Pages: 399-412
• [Journal Article] Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA toposiomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B. (2005)
  • Author(s): Yanagihara, M., Sasaki-Takahashi, N., Sugahara, T., Yamamoto, S., Shinomi, M., Yamashita, I., Hayashida, M., Yamanoha, B., Numata, A., Yamori, T., Andoh T.
  • Journal Title: Cancer Sci 96 Pages: 816-824
• [Journal Article] Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity (2005)
  • Author(s): Maezaki, N., Tominaga, H., Kojima, N., Yanai, M., Urabe, D., Ueki, R., Tanaka, T., Yamori, T.
  • Journal Title: Chemistry 11 Pages: 6237-6245
• [Journal Article] Antitumor effect of cotylenin A plus interferon-alpha : possible therapeutic agents against ovary carcinoma (2005)
  • Author(s): Honma, Y., Kasukabe, T., Yamori, T., Kato, N., Sassa, T.
  • Journal Title: Gynecol Onco 99 Pages: 680-688
• [Journal Article] Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vasucular endothelial growth factor-independent manner. (2005)
  • Author(s): Guleng, B., Tateishi, K., Ohta, M., Kanai, F., Jazag, A., Ijichi, H., Tanaka, Y., Washida, M., Morikane, K., Fukushima, Y., Yamori, T., Tsuruo, T., Kawabe, T., Miyagishi, M., Taira, K., Sata, M., Omata, M.
  • Journal Title: Cancer Res 65 Pages: 5864-5871
• [Journal Article] Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays. (2005)
  • Author(s): Nakatsu, N., Yoshida, Y., Yamazaki, K., Nakamura, T., Dan, S., Fukui, Y., Yamori, T.
  • Journal Title: Mol Cancer Ther. 4 Pages: 399-412
• [Journal Article] YM-216391, a novel cytotixic cyclic peptide from Streptomyces nobilis. I. fermentation, isolation and biological activities. (2005)
  • Author(s): Sohda, K.Y., Nagai, K., Yamori, T., Suzuki, K., Tanaka, A.
  • Journal Title: J Antibiot (Tokyo) 58 Pages: 27-31
• [Journal Article] Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro. (2005)
  • Author(s): Nomura, T., Shinoda, S., Yamori, T., Sawaki, S., Nagata, I., Ryoyama, K., Fuke
  • Journal Title: Cancer Detect Prev 29 Pages: 155-160
• [Journal Article] New bisindole alkaloids isolated from Myxomycetes Arcyria cinerea and Lycogala epidendrum (2005)
  • Author(s): Kamata, K., Kiyota, M., Naoe, A., Nakatani, S., Yamamoto, Y., Hayashi, M., Komiyama, K., Yamori, T., Ishibashi, M.
  • Journal Title: Chem Phram Bull (Tokyo) 53 Pages: 594-597
  • NAID: 10016653963
• [Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway : a new therapeautic target. (2005)
  • Author(s): Mashima, T., Oh-hara, T., Sato, S., Mochizuki, M., Sugimoto, Y., Yamazaki K., Hamada, J., Tada, M., Moriuchi, T., Ishikawa, Y., Kato, Y., Tomoda, H., Yamori, T., Tsuruo, T.
  • Journal Title: J Natl Cancer Ins 97 Pages: 765-777
• [Journal Article] Nucleotide sequence variation is frequent in the mitochondrial DNA displacement loop region of individual human tumor cells. (2005)
  • Author(s): Yoneyama, H., Hara, T., Kato, Y., Yamori, T., Matsuura, E.T., Koike, K.
  • Journal Title: Mol Cancer Res 3 Pages: 14-20
• [Journal Article] Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. (2005)
  • Author(s): Lai, Y.Y., Huang, L.J., Lee, K.H., Xiao, Z, Bastow, K.F., Yamori, T., Kuo, S.C.
  • Journal Title: Bioorg Med Chem, 13 Pages: 265-275
• [Journal Article] プロテオミクスによる大腸癌マーカーの探索 (2005)
  • Author(s): 矢守隆夫, 志和美重子
  • Journal Title: GI.Research 13 Pages: 115-121
• [Presentation] Cancer Cell Informatics による抗がん分子標的薬創薬研究-新規PI3K阻害剤開発への応用 (2009)
  • Author(s): 矢守隆夫
  • Organizer: 東邦大学薬学部オープンリサーチセンター第6回老化・老年病研究センター公開セミナー
  • Place of Presentation: 千葉
  • Year and Date: 2009-03-12
• [Presentation] がん細胞による化合物プロフィルの描出法(Cancer Cell lnformatics) : 方法論から分子標的薬開発への応用まで (2009)
  • Author(s): 矢守隆夫
  • Organizer: 第2回和漢薬の科学研究シンポジウム
  • Place of Presentation: 富山
• [Presentation] PT3キナーゼ阻害剤の開発 (2009)
  • Author(s): 矢守隆夫
  • Organizer: 第7回日本臨床腫瘍学会
  • Place of Presentation: 名古屋
• [Presentation] がん細胞による化合物プロフィルの描出法(Cancer Cell Informatics):方法論から分子標的薬開発への応用まで (2009)
  • Author(s): 矢守隆夫
  • Organizer: 第2回和漢薬の科学研究シンポジウム
  • Place of Presentation: 富山
• [Presentation] PI3キナーゼ阻害剤の開発 (2009)
  • Author(s): 矢守隆夫
  • Organizer: 第7回日本臨床腫瘍学会
  • Place of Presentation: 名古屋
• [Presentation] カルボラン含有トリアジン類のトポイソメラーゼ阻害活性 (2009)
  • Author(s): 潘鉱承, 矢守隆夫, Kang S, 中村浩之
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] 定量的標的プロテオミクスを用いた胃癌及び乳癌細胞株における薬剤耐性に関わる候補トランスポーターの同定 (2009)
  • Author(s): 小渕航, 岩瀬怜, 大槻純男, 上家潤一, 矢守隆夫, 寺崎哲也
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
• [Presentation] Cancer Cell Informatics とは-その分子標的治療薬の創薬への応用 (2008)
  • Author(s): 矢守隆夫
  • Organizer: 創薬薬理フォーラム第16回シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-09-19
• [Presentation] Cancer Cell Informatics の開発-そのがん分子標的薬創薬への応用- (2008)
  • Author(s): 矢守隆夫
  • Organizer: 平成20年度神奈川がんセンター臨床研究所・医師の会共催講演会
  • Place of Presentation: 神奈川
  • Year and Date: 2008-07-22
• [Presentation] Cancer Cell Informatics とは-そのがん分子標的治療研究への応用 (2008)
  • Author(s): 矢守隆夫
  • Organizer: 重粒子医科学センター第20回研究交流会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-15
• [Presentation] Cancer Cell Informaticsとは〜その分子標的治療薬の創薬への応用〜 (2008)
  • Author(s): 矢守 隆夫
  • Organizer: 北里大学薬学部公開シンポジウム
  • Place of Presentation: 北里大学
  • Year and Date: 2008-02-22
• [Presentation] Evaluation of antitumor activity of a novel PI3K inhibitor ZSTK474 by various human cancer xenograft models (2008)
  • Author(s): Yamori T, 0kamura M
  • Organizer: The20th EORTC-NCI-AACR symposium
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Antitumor Effect of a PI3-Kinase Inhibitor ZSTK474 in an Orthotopic Brain Tumor Model (2008)
  • Author(s): Yamori T, 0kamura M, Yoshimi H, Yaguchi S, Kawada M
  • Organizer: Targeting the PI3-Kinase Pathway in Cancer(AACR Specia1 Conferences)
  • Place of Presentation: Cambridge, Massachusetts, USA
• [Presentation] A New PI3 Kinase Inhibitor ZSTK 474 identified by JFCR39 Cancer Cell Pane (2008)
  • Author(s): Yamori T
  • Organizer: The 22nd Naito Conference on Chemica1 Biology[I]
  • Place of Presentation: Sapporo
• [Presentation] アカデミアにおける分子標的-薬探索の試み (2008)
  • Author(s): 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ZSTK474, a novel PI3K inhibitor, down-regulates CDC25A and induces G1 phase cell cycle arrest in human cancer cells (2008)
  • Author(s): Dan S, Mukai Y, Yaguchi S, Yamori T.
  • Organizer: The 100-th Am Assoc Cancer Res (AACR) Annual Meeting
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Phosphoproteomic screening of biomarkers for assessing response to a PI3K inhibitor by using SELDI-TOF MS (2008)
  • Author(s): Akashi T, Yaguchi S, Okamura M, Yamori T.
  • Organizer: The 100-th Am Assoc Cancer Res (AACR) Annua 1 Meeting
  • Place of Presentation: San Diego, CA, USA
• [Presentation] ZSTK474 is a specific class I PI3 kinase inhibitor (2008)
  • Author(s): Kong D, Yaguchi S, Yamori T.
  • Organizer: The 100-th Am Assoc Cancer Res (AACR) Annual Meeting
  • Place of Presentation: San Diego, CA, USA
• [Presentation] Evaluation of antitumor activity of a novel PI3K inhibitor ZSTK474 by various human cancer xenograft models (2008)
  • Author(s): Yamori T, Okamura M.
  • Organizer: The 20th EORTC-NCI-AACR symposium
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Anti-angiogenic activity of a novel PI3K inhibitor, ZSTK474 (2008)
  • Author(s): Kong D, Yoshimi H, Yamori T.
  • Organizer: The 20th EORTC-NCI-AACR symposium
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Antitumor Effect of a PI3-Kinase Inhibitor ZSTK474 in an Ortho topic Brain Tumor Model (2008)
  • Author(s): Yamori T, Okamura M, Yoshimi H, Yaguchi S, Kawada M.
  • Organizer: Targeting the PI3-Kinase Pathway in Cancer (AACR Special Conferences)
  • Place of Presentation: Cambridge, Massachusetts, USA
• [Presentation] A New PI3 Kinase Inhibitor ZSTK 474 identified by JFCR39 Cancer Cell Lines Panel (2008)
  • Author(s): Yamori T.
  • Organizer: 第4回日韓シンポジウム
  • Place of Presentation: 鬼怒川
• [Presentation] 新規PI3キナーゼ阻害剤ZSTK474によるG1アレスト誘導 (2008)
  • Author(s): 旦慎吾, 向井由美子, 矢口信一, 矢守隆夫
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
• [Presentation] CDK阻害因子p15I^<NK4b>誘導化合物の探索と新規MEK阻害剤としての同定 (2008)
  • Author(s): 曽根義宏, 山口尚之, 吉田孝行, 掛札れいな, 高木浩一, 小山真, 与五沢真吾, 矢守隆夫, 酒井敏行
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
• [Presentation] 新規PI3K阻害剤ZSTK474の特異性 (2008)
  • Author(s): 孔徳新, 矢口信一, 矢守隆夫
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
• [Presentation] プロテオミクスによるPI3キナーゼ阻害剤感受性因子の探索 (2008)
  • Author(s): 明石哲行, 矢口信一, 矢守隆夫
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
• [Presentation] 含窒素複素環を導入したバンレイシ科アセトゲニン類の合成と癌細胞増殖抑制効果 (2008)
  • Author(s): 小島直人, 矢守隆夫
  • Organizer: 第12回がん分子標的治療研究会
  • Place of Presentation: 東京
• [Presentation] A New PI3 Kinase Inhibitor ZSTK 474 identified by JFCR39 Cancer Cell Pane (2008)
  • Author(s): Yamori T.
  • Organizer: The 22^<nd> Naito Conference on "Chemical Biology [I]
  • Place of Presentation: 札幌
• [Presentation] Telomere Fingerprint Database : テロメア動態・薬剤反応性研究のための新たなプラットフォーム (2008)
  • Author(s): 清宮啓之, 村松由起子, 田原栄俊, 上野勝, 矢守隆夫, 鶴尾隆
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ヒト卵巣癌細胞の紡錘糸形成におけるTACC3-TOGpのユニークで必須な役割 (2008)
  • Author(s): 八尾良司, 矢守隆夫, 野田哲生
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] アカデミアにおける分子標的薬探索の試み (2008)
  • Author(s): 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] CDK阻害因子p15^<INK4b>誘導化合物の探索と新規MEK阻害剤としての同定 (2008)
  • Author(s): 曽和義広, 山口尚之, 吉田孝行, 掛札れいな, 高木浩一, 小山真, 与五沢真吾, 矢守隆夫, 酒井敏行
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 時系列イメージングによる39ヒト癌細胞株の遊走性観察 (2008)
  • Author(s): 明石哲行, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ヒト肺癌と大腸癌におけるPTEN遺伝子のメチル化解析 (2008)
  • Author(s): 奥井理予, 矢守隆夫, 山本智理子, 中川健, 石川雄一
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] HTRFアッセイを用いた定量的なPI3キナーゼ活性測定法の構築 (2008)
  • Author(s): 杉田裕宣, 旦慎吾, 孔徳新, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 新規PI3K阻害剤ZSTK474のヒト癌24系 Xenograf を用いた抗腫瘍効果 (2008)
  • Author(s): 岡村睦美, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] JFCR39と in silico COMPARE解析によるPI3K阻害剤とAkt阻害剤の比較 (2008)
  • Author(s): 山崎佳波, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 新規PI3K阻害剤ZSTK474の血管新生阻害作用 (2008)
  • Author(s): 孔徳新, 吉見直, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 新規PI3K阻害剤ZSTK474による抗腫瘍メカニズムの解析 (2008)
  • Author(s): 旦慎吾, 向井由美子, 岡村睦美, 吉見直, 矢口信一, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] インピーダンスによるリアルタイム細胞増殖測定法の開発 (2008)
  • Author(s): 小林雅明, 旦慎吾, 大橋愛美, 矢守隆夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ほ乳類動物細胞におけるTACC3-TOGp依存的な紡錘体形成機構 (2008)
  • Author(s): 八尾良司, 矢守隆夫, 野田哲生
  • Organizer: 第31回日本分子生物学会年会 第81回日本生化学会大会 合同大会
  • Place of Presentation: 神戸
• [Presentation] Identification of candidates for new drug, target and biomarker by mining data sets from a panel of human cancer cell lines : JFCR39 (2007)
  • Author(s): Yamori T
  • Organizer: MBI Chemogenomics Workshop
  • Place of Presentation: Ohio, USA
• [Presentation] Informatics-guided identification of candidates for new drug, target and biomarker based on JFCR39 (2007)
  • Author(s): Yamori T
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] Cancer Cell Informatics による分子標的同定 (2007)
  • Author(s): 矢守隆夫
  • Organizer: 日本薬理学会・シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] Identification of candidates for new drug,target and biomarker by mining data sets from a panel of human cancer cell lines:JFCR39 (2007)
  • Author(s): Yamori T.
  • Organizer: MBI Chemogenomics Workshop
  • Place of Presentation: Ohio,USA
• [Presentation] Epigenetic silencing of the RecQ helicase genes in Japanese lung cancer (2007)
  • Author(s): Okui M, Ishikawa Y, Yamori T, Nakagawa K.
  • Organizer: The 98-th Am Assoc Cancer Res(AACR)Annual Meeting
  • Place of Presentation: Los Angeles,CA,U.S.A.
• [Presentation] Proteomic screening for biomarkers for predicting sensitivity to anticancer drugs by using SELDI-TOF MS (2007)
  • Author(s): Akashi T, Nishimura Y, Shiwa M, Yamori T.
  • Organizer: The 98-th Am Assoc Cancer Res(AACR)Annual Meeting
  • Place of Presentation: Los Angeles,CA,U.S.A.
• [Presentation] EGFR signal pathways selectively activated in lung adenocarcinoma (2007)
  • Author(s): Hiramatsu M, Ninomiya H, Inamura K, Okui M, Satoh Y, Fujiwara M, Yamori T, Kitagawa T, Ishikawa Y.
  • Organizer: The 98-th Am Assoc Cancer Res(AACR)Annual Meeting
  • Place of Presentation: Los Angeles,CA,U.S.A.
• [Presentation] Informatics-guided identification of candidates for new drug,target and biomarker based on JFCR39 (2007)
  • Author(s): Yamori T.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] Proteomic screening for signaling proteins involved in PI3-kinase pathways by using SELDT-TOF MS (2007)
  • Author(s): Akashi T, Yaguchi S, Yamorit.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] Promoter methylation of WRN gene in cancer (2007)
  • Author(s): Okui M, Yamori T, Nakagawa K, Ishikawa Y.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] ZSTK474 inhibits class I PI3 kinase isoforms competitively with ATP (2007)
  • Author(s): Kong D, Yaguchi S, Yamori T.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] MELl cooperates with c-ski to repress TGF-beta signal in gingastric cancer cells (2007)
  • Author(s): Takahata M, Koinuma D, inazawa J, Yamori T, Miyazawa K, Miyazono K, Imamura T.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] PI3K inhibitor,down-regulates CDC25A and induces G_1,phase cell cycle arrest in human cancer cells (2007)
  • Author(s): Dan S, Mukai Y, Yaguchi S, Yamori T.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] PIK3CA mutations in JFCR-39 human cancer cell lines. (2007)
  • Author(s): Sugita H, Dan S, Nakamura H, Yamori T.
  • Organizer: 66-th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] 新規PI3キナーゼ阻害剤ZSTK474による抗腫瘍効果の分子機構の解析 (2007)
  • Author(s): 旦 慎吾, 向井 由美子, 矢口 信一, 矢守 隆夫
  • Organizer: 第11回がん分子標的治療研究会総会
  • Place of Presentation: 大阪
• [Presentation] 新規PI3K阻害剤ZSTK474の分子薬理機序の解析 (2007)
  • Author(s): 孔 徳新, 矢守 隆夫
  • Organizer: 第11回がん分子標的治療研究会総会
  • Place of Presentation: 大阪
• [Presentation] 山菜のシゲト(モミジガサ)から単離されたピサボラン型セスキテルペ'ンエンドパーオキサイドの抗癌活性 (2007)
  • Author(s): 西川 耕司, 山田 京平, 土屋 英子, 矢守 隆夫, 木村 賢一
  • Organizer: 第11回がん分子標的治療研究会総会
  • Place of Presentation: 大阪
• [Presentation] PI3キナーゼを標的とする新規分子標的薬候補ZSTK474 (2007)
  • Author(s): 矢守 隆夫
  • Organizer: 第16回日本がん転移学会総会
  • Place of Presentation: 富山
• [Presentation] PI3キナーゼを分子標的にした新しいがん治療法の開発 (2006)
  • Author(s): 矢守隆夫
  • Organizer: 文部科学省科学研究費補助金「特定領域研究」がん研究に係わる特定領域研究・公開シンポジウム
  • Place of Presentation: 東京
• [Book] 分子標的薬の基礎および研究動向.(山本重夫編集「バイオ医薬の開発技術とシーズ」) (2009)
  • Author(s): 矢守隆夫
  • Total Pages: 384
  • Publisher: シーエムシー出版
• [Book] Mebio Oncology, 5(1) (2008)
  • Author(s): 矢守隆夫
  • Publisher: Cancer Cell Informatics の活用と分子標的薬の探索評価
• [Book] 癌細胞に関する増殖因子の測定法.(日本がん転移学会編集「がん転移研究の実験手法」) (2008)
  • Author(s): 矢守隆夫
  • Total Pages: 362
  • Publisher: 金芳堂
• [Book] Cancer Cell Informatics と分子標的薬剤.(鶴尾隆編集「がんの分子標的治療」) (2008)
  • Author(s): 旦慎吾, 矢守隆夫
  • Total Pages: 441
  • Publisher: 南山堂
• [Book] 蛋白質核酸酵素, 52(13) (2007)
  • Author(s): 矢守隆夫
  • Publisher: Cancer Cell Informaticsとケミカルバイオロジー
• [Book] 新規PI3キナーゼ阻害剤ZSTK474の抗がん活性 (2007)
  • Author(s): 矢口 信一, 矢守 隆夫
  • Publisher: 細胞The CELL
• [Book] 分子標的治療薬の開発と発展 (2007)
  • Author(s): 矢守 隆夫
  • Publisher: 日本病院薬剤師会雑誌
• [Book] クリニカルプラクティス (2007)
  • Author(s): 矢守 隆夫
  • Publisher: 分子標的治療薬
• [Book] Cancer Cell Informaticsとケミカルバイオロジー (2007)
  • Author(s): 矢守 隆夫
  • Publisher: 蛋白質核酸酵素
• [Book] 分子標的治療薬とは (2007)
  • Author(s): 矢守 隆夫
  • Publisher: 月刊薬事
• [Book] 特集・制がん剤の分子標的スクリーニング成績「化学療法基盤情報支援班」報告-制がん候補物質のスクリーニング成績・第12報- (2007)
  • Author(s): 矢守 隆夫, 上原 至雅, 吉田 稔, 井上 正哉, 清宮 啓之, 水上 民夫, 川田 学, 長田 裕之, 松浦 正明
  • Publisher: 癌と化学療法
• [Book] 特集・制がん剤の分子標的スクリーニング成績「新しい戦略による抗がん剤のスクリーニングのための委員会」報告-制がん候補物質のスクリーニング成績・第11報- (2007)
  • Author(s): 矢守 隆夫, 安藤 俊夫, 上原 至雅, 小野 真弓, 河野 通明, 済木 育夫, 内藤 幹彦, 早川 洋一, 鶴尾 隆, 吉田 稔, 杉本 芳一, 馬島 哲夫
  • Publisher: 癌と化学療法
• [Book] 分子標的治療薬 (2007)
  • Author(s): 矢守隆夫
  • Publisher: クリニカルプラクティス
• [Book] 分子標的治療薬の開発と発展 (2007)
  • Author(s): 矢守隆夫
  • Publisher: 日本病院薬剤師会雑誌
• [Book] 分子標的治療法の開発と発展 (2006)
  • Author(s): 矢守隆夫
  • Publisher: 血液フロンティア
• [Book] 分子標的治療薬のオーバービュー (2006)
  • Author(s): 矢守隆夫
  • Publisher: Drug Delivery System
• [Patent(Industrial Property Rights)] PI3キナーゼ阻害剤の効果判定法 (2007)
  • Inventor(s): 明石哲行、矢守隆夫、岡村睦美
  • Industrial Property Rights Holder: 財団法人癌研究会
  • Filing Date: 2007-08-24
• [Patent(Industrial Property Rights)] PI3キナーゼ阻害剤の効果判定方法 (2007)
  • Inventor(s): 明石 哲行、矢守 隆夫、岡村 睦美
  • Industrial Property Rights Holder: 財団法人癌研究会
  • Industrial Property Number: 2007-218234
  • Filing Date: 2007-08-24
• [Patent(Industrial Property Rights)] PI3キナーゼ阻害剤に対する感受性予測方法 (2006)
  • Inventor(s): 明石哲行、西村由美子、矢守隆夫
  • Industrial Property Rights Holder: 財団法人癌研究会
  • Filing Date: 2006-08-14
• [Patent(Industrial Property Rights)] PI3キナーゼ阻害剤の効果判定法 (2006)
  • Inventor(s): 且慎吾、矢守隆夫
  • Industrial Property Rights Holder: -財-団法人癌研究会
  • Filing Date: 2006-08-25
• [Patent(Industrial Property Rights)] PI3キナーゼ阻害剤に対する感受性予測方法 (2006)
  • Inventor(s): 明石哲行, 西村由美子, 矢守隆夫
  • Industrial Property Rights Holder: 財団法人癌研究会
  • Industrial Property Number: 2006-221146
  • Filing Date: 2006-08-14
• [Patent(Industrial Property Rights)] PI3キナーゼ阻害剤の効果判定法 (2006)
  • Inventor(s): 旦慎吾, 矢守隆夫
  • Industrial Property Rights Holder: 財団法人癌研究会
  • Industrial Property Number: 2006-229568
  • Filing Date: 2006-08-25