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Analyses of calcium-activated potassium channels as novel targets for new drug therapy

Research Project

Project/Area Number 17390045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionNagoya City University

Principal Investigator

IMAIZUMI Yuji  Nagoya City University, Graduate School of Pharmaceutical Sciences, Professor (60117794)

Co-Investigator(Kenkyū-buntansha) OHYA Susumu  Nagoya City University, Graduate School of Pharmaceutical Sciences, Associate Professor (70275147)
YAMAMURA Hisao  Nagoya City University, Graduate School of Pharmaceutical Sciences, Research Associate (80398362)
TOGARI Akihumi  Aichi Gakuin University, School of Dentistry, Professor (80126325)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,100,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2006: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 2005: ¥6,900,000 (Direct Cost: ¥6,900,000)
Keywordscalcium-activated potassium channel / BK channel / SK channel / potassium channel opener / ryanodine receptor / caveolae / drug development / potential sensitive fluorescent / カルシウム活性化カリウムチャネル / TASKチャネル / ピマル酸 / 心筋ミトコンドリア / 心筋保護作用 / 間質細胞 / ペースメーカー細胞
Research Abstract

In excitable cells, such as CNS neurons, negative feedback regulation systems for intracellular Ca^<2+> homeostasis work to prevent Ca^<2+> overlord, when excess excitability and resulting excess Ca^<2+> influx occurs. Activation of Ca^<2+> activated K+ (Kca) channels is know to be one ` of the most important components responsible for the negative feedback regulation of [Ca2^+]_i in excitable cells. This project was undertaken to elucidate the molecular mechanism for the regulation of Kca channel activity and to search changes in the regulation diseases. The goal of this project is to find out molecular seeds targeting on K_ca channels in some diseases. The following development was obtained during the research period. (1) It was found that small conductance K_ca (SK) channel in vascular endothelial cell lines originally derived from bovine blood-brain barrier has significant functional role in endothelial; proliferation stimulated by ATP presumably released from astrocytes in CNS. (J … More BC,2006; J Pharmacol Sci, 104, 2007). (2) The deep impact of ryanodine receptor type2 (RyR2) to the mechanism for negative feedback regulation of [Ca^<2+>], via spontaneous Ca^<2+> release(Ca^<2+> spark) from sarcoplasmic reticulum and subsequent activation of large conductance Kca (BK) channel was found using urinary bladder smooth muscle cells from wild type and RyR2 heterozygous KO mice. A line of evidence indicates that RyR2 contributes to the bladder continent as 'a key molecule regulating resting membrane potential and muscular tonus as well as excitation-contraction coupling (J Physiol, 2007, J Pharmacol Sci, 103, 2007). (3) It was found that potential sensitive oxonol dyes act as potent BK channel openers. It is the first synthesized compound which shows opening property selective to BK81 and 84 subunits over BK62. The oxonol compounds may be a seed of 8 subunit selective BK channel opener (Mol Pharmacol, 2007). (4) It has been known that the contractile responses of isolated large arteries from spontaneously hypertensive rats (SHR) to agonists are markedly potentiated in low pH bathing solution. It was found that the enhanced expression of BK channels in arterial smooth muscles of SHR and its sensitivity to extracellular pH are responsible for the acid pH induced potentiation of contraction (Am J Physiol, 2007). Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (248 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (57 results) (of which Peer Reviewed: 23 results) Presentation (181 results) Book (6 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Ca^<2+>シグナルから膜電位変化ヘシグナル変換する分子集積体としてのトランスポートソームの機能解析2008

    • Author(s)
      今泉 祐治
    • Journal Title

      TRANSPORTSOME 2007冬号

      Pages: 11-14

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Cell-Cycle-Dependent Regulation of Ca^<2+>-activated K^+ Channel in Jurkat T-lymphocyte2007

    • Author(s)
      Takashi Morimoto
    • Journal Title

      J. Pharmacol. Sci 104

      Pages: 94-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characteristics of the ATP-lnduced Ca^<2+>-entry pathway in the t-BBEC 117 Cell Line Derived From Bovine Brain Endothelial Cells2007

    • Author(s)
      Daijyu Yamazaki
    • Journal Title

      J. Pharmacol. Sci 104

      Pages: 103-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle2007

    • Author(s)
      Shingo Hotta
    • Journal Title

      J. Physiol.(Cond.) 582

      Pages: 489-506

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca^<2+>-Activated K^+ channel Activators Selective forβ1 andβ4 but Not for β2 Subunits2007

    • Author(s)
      Takashi Morimoto
    • Journal Title

      Mol. Pharmacol 71

      Pages: 1075-1088

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] C-type natriuretic peptide activates a nonselective cation current in acutely isolated ratcardiac fibroblasts via natriuretic peptide Creceptor mediated signaling2007

    • Author(s)
      Robert A. Rose
    • Journal Title

      J. Physiol.(Cond.) 580

      Pages: 255-274

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Methyl-β-cyclodextrin Prevents Ca^<2+>-induced Ca^<2+> Release in Smooth Muscle Cells of Mouse Urinary Bladder2007

    • Author(s)
      Shingo Hotta
    • Journal Title

      J. Pharmacol. Sci 103

      Pages: 121-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cell-Cycle-Dependent Regulation of Ca^<2+>-activated K^+ Channel in Jurkat T-Iymphocyte2007

    • Author(s)
      Takashi, Morimoto, Susumu, Ohya, Hidetoshi, Hayashi, Kikuo, Onozaki, Yuji, Imaizumi
    • Journal Title

      J. Pharmacol. Sci 104

      Pages: 94-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characteristics of the ATP-Induced Ca^<2+>-entry pathway in the t-BBEC 117 Cell Line Derived From Bovine Brain Endothelial Cells2007

    • Author(s)
      Daiju, Yamazaki, Susumu, Ohya, Kiyofumi, Asai, Yuji, Imaizumi
    • Journal Title

      J. Pharmacol. Sci 104

      Pages: 103-107

    • NAID

      10024314163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ryanodine receptor type 2 deficiency changes excitation- contraction coupling and membrane potential in urinary bladder smooth muscle2007

    • Author(s)
      Shingo, Hotta, Kozo, Morimura, Susumu, Ohya, Katsuhiko, Muraki, Hiroshi, Takesmma, Yuji, Imaizum
    • Journal Title

      J. Physiol. (Lond.) 582

      Pages: 489-506

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca^<2+> -Activated K^+ channel Activators Selective for 131 and 34 but Not for β 2 Subunits2007

    • Author(s)
      Takashi, Morimoto, Kazuho, Sakamoto, Hiroko, Sade, Susumu, Ohya, KatsunlKo, Muraki, Yuji, Imaizumi
    • Journal Title

      Mol.Pharmacol 71

      Pages: 1075-1088

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] C-type natriuretic peptide activates a nonselective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor mediated signaling2007

    • Author(s)
      Robert, A. Rose, Noriyuki, Hatano, Susumu, Ohya, Yuji, Imaizumi, Wayne, R. Giles
    • Journal Title

      J. Physiol. (Lond.) 580

      Pages: 255-274

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Methyl-β-cyclodextrin Prevents Ca^<2+>-induced Caz+ Release in Smooth Muscle Cells of Mouse Urinary Bladder2007

    • Author(s)
      Shingo, Hotta, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Journal Title

      J. Pharmacol. Sci 103

      Pages: 121-126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cell-cycle-dependent regulation of Ca^<2+>-activated K^+ channel in Jurkat T-lymphocyte2007

    • Author(s)
      Morimoto T
    • Journal Title

      J. Pharmacol. Sci. 104

      Pages: 94-98

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of the ATP-Induced Ca^<2+>-entry pathway in the t-BBEC 117 cell line derived from bovine brain endothelial cells2007

    • Author(s)
      Yamazaki D
    • Journal Title

      J. Pharmacol. Sci. 104

      Pages: 103-107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle2007

    • Author(s)
      Hotta S
    • Journal Title

      J. Physiol.(Lond.) 582

      Pages: 489-506

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-sensitive oxonol dyes are novel BK channel activators selective for β1 and β4 but not for β2 subunits2007

    • Author(s)
      Morimoto T
    • Journal Title

      Mol. Pharmacol. 71

      Pages: 1075-1088

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CNP activates a nonselective cation current in acutely isolated rat cardiac fibroblasts via NPR-C receptor mediated signaling2007

    • Author(s)
      Robert A. Rose
    • Journal Title

      J. Physiol.(Lond.) 580

      Pages: 255-274

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methyl-β-cyclodextrin prevents Ca^<2+>-induced Ca^<2+> release in smooth muscle cells of mouse urinary bladder2007

    • Author(s)
      Hotta S
    • Journal Title

      J. Pharmacol. Sci. 103

      Pages: 121-126

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methyl-β-cyclodextrin prevents Ca^<2+>-induced Ca^<2+> release in smooth muscle cells of mouse urinary bladder2007

    • Author(s)
      Hotta S, Yamamura H, Ohya S, Imaizumi Y
    • Journal Title

      J Pharmacol Sci 103(1)

      Pages: 121-126

    • NAID

      10024312258

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Voltage-sensitive oxonol dyes are novel large-conductance Ca^<2+>-activated K^+ channel activators selective for β1 and β4 but not for β2 subunits2007

    • Author(s)
      Morimoto T, Sakamoto K, Sade H, Ohya S, Muraki K, Imaizumi Y
    • Journal Title

      Mol Pharmacol 71(4)

      Pages: 1075-1088

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel functions of small conductance Cat^<2+>-activated K^+ channel in enhanced cell proliferation by ATP in Brain Endothelial Cells2006

    • Author(s)
      Daiju Yamazaki
    • Journal Title

      J. Biol. Chem 281

      Pages: 38430-38439

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Molecular and electrophysiological characteristics of K^+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY and SHR2006

    • Author(s)
      Hidekazu Kiyoshi
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol 291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Voltage-dependent Ca^<2+>-Channel Block by Openers of Intermediate and Small Conductance Ca<2+>-activated K^+ channels in Urinary Bladder Smooth Muscle Cells2006

    • Author(s)
      Kozo Morimura
    • Journal Title

      J. Pharmacol. Sci 100

      Pages: 237-241

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inherent pacemaker function of duodenal GIST2006

    • Author(s)
      Shinji Furuzono
    • Journal Title

      Eur. J. Cancer 42

      Pages: 243-248

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Molecular Mechanisms for Large Conductance Ca^<2+>-Activated K^+ Channel Activation by a Novel Opener, 12, 14-Dichlorodehydroabietic Acid2006

    • Author(s)
      Kazuho Sakamoto
    • Journal Title

      J. Pharmacol. Exp. Ther 316

      Pages: 144-153

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Two-step Ca^<2+> intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes2006

    • Author(s)
      Kozo Morimura
    • Journal Title

      Am. J. Physiol. Cell Physiol 290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Activation of large-conductance, Ca^<2+>-activated K^+ channels by cannabinoids2006

    • Author(s)
      Hiroko Sade
    • Journal Title

      Am. J. Physiol. Cell Physiol 290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 血管に対するチャネル開口薬の作用2006

    • Author(s)
      今泉 祐治
    • Journal Title

      心電図 26

      Pages: 11-19

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new insight into the function of TRPV22006

    • Author(s)
      Muraki K
    • Journal Title

      circulatory organs TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades(Frontiers in Neuroscience)(Wolfgang B. Liedtke, ed.), Chapter 28, CRC Press

      Pages: 389-396

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel functions of small conductance Ca^<2+>-activated K+ channel in enhanced cell proliferation by ATP in Brain Endothelial Cells J. Biol. Chem2006

    • Author(s)
      Daiju, Yamazaki, Mineyoshi, Aoyama, Susumu, Ohya, Katsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Journal Title

      J. Biol. Chem 281

      Pages: 38430-38439

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular and electrophysiological characteristics of K^+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY and SHR2006

    • Author(s)
      Hidekazu, Kiyoshi, Daiju, Yamazaki, Susumu, Ohya, Mika, Kitsukawa, Katsuhiko, Muraki, Shinya, Saito, Yasushi, Ohizumi, Yuji, Imaizumi
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol 291

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Voltage-dependent Ca^<2+>-Channel Block by Openers of Intermediate and Small Conductance Ca^<2+>-activated K+ channels in Urinary Bladder Smooth Muscle Cells2006

    • Author(s)
      Kozo, Morimura, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Journal Title

      J. Pharmacol. Sci 100

      Pages: 237-241

    • NAID

      10018240450

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inherent pacemaker function of duodenal GIST2006

    • Author(s)
      Shinji, Furuzono, Susumu, Ohya, Soichiro, Inoue, Akimasa, Nakao, Yuji, Imaizumi, Shinsuke, Nakayama
    • Journal Title

      Eur. J. Cancer 42

      Pages: 243-248

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular, Mechanisms, for Large, Conductance Ca^<2+>-Activated K+ Channel Activation by a Novel Opener, 12,14-Dichlorodehydroabietic Acid2006

    • Author(s)
      Kazuho, Sakamoto, Taro, Nonomura, Susumu, Ohya, Katsuhiko, Muraki, Tomohiko, Ohwada, Yuji, Imaizumi
    • Journal Title

      J. Pharmacol. Exp. Ther 316

      Pages: 144-153

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Two-step Ca^<2+> intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes2006

    • Author(s)
      Kozo, Morimura, Yoshiaki, Ohi, Hisao, Yamamura, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Journal Title

      Am. J. Physiol. Cell Physiol 290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Activation of large-conductance, Ca^<2+>-activated K^+ channels by cannabinoids Am2006

    • Author(s)
      Hiroko, Sade, Katsuhiko, Muraki, Susumu, Ohya, Noriyuki, Hatano, Yuji, Imaizumi
    • Journal Title

      J. Physiol. Cell Physiol 290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of K^+ channel openers on vasculature Jap2006

    • Author(s)
      Yuji, Imaizumi, Katsuhiko, Muraki
    • Journal Title

      J. of Electrocardiol 26

      Pages: 11-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel functions of small conductance Ca^<2+>-activated K^+ channel in enhanced cell proliferation by ATP in brain endothelial cells2006

    • Author(s)
      Yamazaki D, Aoyama M, Ohya S, Muraki K, Asai K, Imaizumi Y
    • Journal Title

      J Biol Chem 281(50)

      Pages: 38430-38439

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular and electrophysiological characteristics of K^+ conductance sensitive to acidic pH in aortic smooth muscle cells of WKY and SHR2006

    • Author(s)
      Kiyoshi H, Yamazaki D, Ohya S, Kitsukawa M, Muraki K, Saito SY, Ohizumi Y, Imaizumi Y
    • Journal Title

      Am J Physiol Heart Circ Physiol 291(6)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 血管に対するチャネル開口薬の作用2006

    • Author(s)
      今泉祐治, 村木克彦
    • Journal Title

      心電図 26

      Pages: 11-19

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Two-step Ca^<2+> intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes2006

    • Author(s)
      Morimura et al.
    • Journal Title

      American Journal of Physiology 290(2)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Molecular mechanisms for BK channel activation by a novel opener, 12, 14-dichlorodehydroabietic acid2006

    • Author(s)
      Sakamoto et al.
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 316(1)

      Pages: 144-153

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Activation of large-conductance Ca^<2+> activated K^+ channels by cannabinoids2006

    • Author(s)
      Sade et al.
    • Journal Title

      American Journal of Physiology 290(1)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Inherent pacemaker function of duodenal GIST2006

    • Author(s)
      Furuzono et al.
    • Journal Title

      European Journal of Cancer 42(2)

      Pages: 243-248

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sulphonylurea receptors differently modulate ICC pacemaker Ca^<2+> activity and smooth muscle contractility2005

    • Author(s)
      Shinsuke Nakayama
    • Journal Title

      J.Cell Sci 118

      Pages: 4167-4173

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cardioprotective effects of estradiol include the activation of large-conductance Ca^<2+>-activated K^+ channels in cardiac mitochondria2005

    • Author(s)
      Susumu Ohya
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol 289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] K^+ Currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts2005

    • Author(s)
      Lisa Chilton
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ca^<2+> Releasing Channels2005

    • Author(s)
      Yuji Imaizumi
    • Journal Title

      Pulmonary Vascular Smooth Muscle Cells Ion Channels in the Pulmonary Vasculature, Chapter7, CRC Press

      Pages: 147-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cardioprotective effects of estradiol include the activation of large-conductance Ca^<2+>-activated K^+ channels in cardiac mitochondria2005

    • Author(s)
      Susumu, Ohya, Yukiko, Kuwata, Kazuho, Sakamoto, Katsuhiko, Muraki, Yuji, Imaizumi
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol 289

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Sulphonylurea receptors differently modulate ICC pacemaker Ca^<2+> activity and smooth muscle contractility2005

    • Author(s)
      Shinsuke, Nakayama, Susumu, Ohya, Hong-Nian, Liu, Toshiya, Watanabe, Shinji, Furuzono, Jing, Wang, Yuji, Nishizawa, Masahiro, Aoyama, Naruhiko, Murase, Tatsuaki, Matsubara, Yasushi, Ito, Yuji, Imaizumi, Shunichi, Kajioka
    • Journal Title

      J. Cell Sci 118

      Pages: 4163-4173

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] K^+ Currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts2005

    • Author(s)
      Lisa, Chilton, Susumu, Ohya, Darren, H., Freed, Eric, George, Vanja, Drobic, Yoshiyuki, Shibukawa, K., Andrew Mac, Cannell, Yuji, Imaizumi, Robert, B. Clark, Ian, M. C., Dixon, Wayne, R. Giles
    • Journal Title

      Am. J. Physiol. Heart Circ. Physiol 288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cardioprotective effects of estradiol include the activation of large-conductance Ca^<2+>-activated K^+ channels in cardiac mitochondria2005

    • Author(s)
      Ohya et al.
    • Journal Title

      American Journal of Physiology 289(4)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Sulphonylurea receptors differently modulate ICC pacemaker Ca^<2+> activity and smooth muscle contractility2005

    • Author(s)
      Nakayama et al.
    • Journal Title

      Journal of Cell Science 118(18)

      Pages: 4163-4173

    • Related Report
      2005 Annual Research Report
  • [Journal Article] K^+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts2005

    • Author(s)
      Chilton et al.
    • Journal Title

      American Journal of Physiology 288(6)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle

    • Author(s)
      Hotta S, Kozo M, Ohya S, Muraki K, Takeshima H, Imaizumi Y
    • Journal Title

      J Physiol (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CNP activates a nonselective cation current in acutely isolated rat cardiac fibroblasts via NPR-C receptor mediated signaling

    • Author(s)
      Rose RA, Hatano N, Ohya S, Imaizumi Y, Giles WR
    • Journal Title

      J Physiol (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 脳血管内皮細胞において内向き整流性K^+チャネル(Kir2.1)の活性化により生じる過剰な過分極は細胞死を引き起こす2009

    • Author(s)
      山崎 大樹
    • Organizer
      生体機能と創薬シンポジウム
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional roles of voltage-gated K^+ channels in RINm5F cells2008

    • Author(s)
      Takuya, Kimura, Susumu, Ohya, Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 128th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RINm5F細胞における電位依存性K^+チャネルの機能的役割2008

    • Author(s)
      木村拓哉
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] BKチャネルのDiBAC_4(3)によるβサブユニット選択的活性化分子機構の解明2008

    • Author(s)
      藤高 啓右
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 末梢組織ペースメーカーモデルにおける細胞間電気シグナル伝播機構の解明2008

    • Author(s)
      橋爪 圭吾
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] RINm5F細胞における電位依存陸K^+チャネルの機能的役割2008

    • Author(s)
      木村 拓哉
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The subunit selective activation mechanism of BK channel by DiBAC4(3)2008

    • Author(s)
      Keisuke, Fujitaka, Takashi, Morimoto, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 128th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intercellular electrical coupling in ICC-like pacemaker cells2008

    • Author(s)
      Keigo, Hashidume, Taisuke, Kimura, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 128th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 平滑筋におけるカルモジュリン様タンパク質及びCa^<2+>/カルモジュリン依存性キナーゼHによる早期不活性化K^+チャネル制御2008

    • Author(s)
      大矢 進
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular basis for the regulation of rapidly-inactivating, A-type K^+ channels by CaM-like proteins and CaMKII in smooth muscles2008

    • Author(s)
      Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 85^th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-03-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 平滑筋におけるカルモジュリン様タンパク質及びCa^<2+>/カルモジュリン依存性キナーゼIIによる早期不活性化K^+チャネル制御2008

    • Author(s)
      大矢進
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血管平滑筋細胞におけるBKチャネルの一分子動態解析2008

    • Author(s)
      山村 寿男
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] テストステロンによる扁桃体の大コンダクタンスCa^<2+>活性化K^+チャネル発現調節2008

    • Author(s)
      大野 晃稔
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Single-molecule imaging of BK channels in vascular smooth muscle cells2008

    • Author(s)
      Hisao, Yamamura, Chikako, Ikeda, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-03-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of Large conductance Ca^<2+> activated K^+ channels expression in rat amygdala by testosterone2008

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-03-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+>交換輸送体(NCX)高発現膀胱における自発収縮充進の機構解析2008

    • Author(s)
      村田 秀道
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular imaging analyses of functional interaction between ion channels and regulatory proteins in subplasmalemmalmicrodomains2008

    • Author(s)
      Yuji, Imaizumi, Chikako, Ikeda, Hisao, Yamamura
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional analysis of Na^+/Ca^<2+> exchanger (NCX) for spontaneous contractions in urinary bladder smooth muscle2008

    • Author(s)
      Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+>交換輸送体(NCX)高発現膀胱における自発収縮亢進の機構解析2008

    • Author(s)
      村田秀道
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 平滑筋細胞における局所Ca^<2+>変動のTIRF画像解析2008

    • Author(s)
      山村 寿男
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 松果体細胞における大コンダクタンスCa^<2+>活性化K^+チャネルの生理的意義の解明2008

    • Author(s)
      水谷 浩也
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] BKチャネル分子のTIRF画像解析2008

    • Author(s)
      池田 知佳子
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CD3およびCD28刺激によるJurkat T細胞におけるkv1.3電流の調節2008

    • Author(s)
      松下 雄一朗
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 微小膜ドメインにおけるイオンチャネル協関制御分子機構の可視化2008

    • Author(s)
      今泉 祐治
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] TIRF imaging of local Ca^<2+> transients in smooth muscle cells2008

    • Author(s)
      Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Physiological roles of large-conductance Ca^<2+>-activated K+ channel in rat pinealocytes2008

    • Author(s)
      Hiroya, Mizutani, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TIRF imaging of BK channel molecules2008

    • Author(s)
      Chikako, Ikeda, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulation by CD3/CD28 activation on Kv1.3 K^+ current in human leukemia Jurkat cells2008

    • Author(s)
      Yuichiro, Matsushita, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dahl食塩感受性高血圧ラット腎動脈平滑筋におけるK^+チャネル機能変化2008

    • Author(s)
      荻原 和信
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト由来軟骨肉腫細胞(OUMS-27)に対するニフルミ酸の作用2008

    • Author(s)
      船橋 賢司
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Modulated functions of K^+ channels in renal artery smooth muscles of Dahl salt-sensitive rat2008

    • Author(s)
      Kazunobu, Ogiwara, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of niflumic acid on ion channels in human chondrosarcoma cell line (OUMS-27)2008

    • Author(s)
      Kenji, Funahashi, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 81st Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-03-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dah1食塩感受性高血圧ラット腎動脈平滑筋におけるK^+チャネル機能変化2008

    • Author(s)
      荻原和信
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2008-03-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Visualization of local Ca^<2+> transients in smooth muscle cells using total internal refection fluorescence microscope2008

    • Author(s)
      Hisao Yamamura
    • Organizer
      Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences(The 4th US-Japan Joint Conference)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-02-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Visualization of local Ca^<2+> transients in smooth muscle cells using total internal reflection fluorescence microscope2008

    • Author(s)
      Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences (The 4th US-Japan Joint Conference)
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-02-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TIRF imaging of Ca^<2+>-induced Ca^<2+> release in smooth muscle cells2008

    • Author(s)
      Hisao Yamamura
    • Organizer
      Biophysical Society-52th Annual Meeting
    • Place of Presentation
      Long Beach, USA
    • Year and Date
      2008-02-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TIRF imaging of Ca^<2+>-induced Ca^<2+> release in smooth muscle cells2008

    • Author(s)
      Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      Biophysical Society -52th Annual Meeting-
    • Place of Presentation
      Long Beach, USA
    • Year and Date
      2008-02-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 食塩感受性高血圧モデルラット腎動脈平滑筋におけるK^+チャネル機能変化2007

    • Author(s)
      荻原 和信
    • Organizer
      第112回日本薬理学会近畿部会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 大動脈平滑筋細胞におけるBKチャネルの一分子動態可視化解析2007

    • Author(s)
      山村 寿男
    • Organizer
      第17回日本循環薬理学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Single-molecule imaging of BK channels in aortic smooth muscle cells2007

    • Author(s)
      Hisao, Yamamura, Chikako, Ikeda, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 17th Annual Meeting of Japanese Associations of Cardiovascular Pharmacology
    • Place of Presentation
      Osaka
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Modulated functions of K+ channels in renal artery smooth muscles of Dahl salt-sensitive rat2007

    • Author(s)
      Kazunobu, Ogiwara, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 112th Kinki Branch Meeting of The Japanese Pharmacological Society in Osaka
    • Place of Presentation
      Osaka
    • Year and Date
      2007-11-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms underlying β subunit selective activation of BK channel by DiBAC_4(3)2007

    • Author(s)
      Yuji Imaizumi
    • Organizer
      5th Annual Discovery on Target
    • Place of Presentation
      Boston, USA
    • Year and Date
      2007-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms underlying βsubunit selective activation of BK channel by DiBAC4(3)2007

    • Author(s)
      Yuji, Imaizumi, Takashi, Morimoto, Keisuke, Fujitaka, Susumu, Ohya
    • Organizer
      5th Annual Discovery on Target
    • Place of Presentation
      Boston, USA
    • Year and Date
      2007-10-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanisms underlying β subunit selective activation of BK channel by DiBAC_4(3)2007

    • Author(s)
      Yuji Imaizumi
    • Organizer
      5th Annual Discovery on Target.
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2007-10-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト前立腺癌におけるCa^<2+>活陸化K^+チャネル遺伝子発現2007

    • Author(s)
      丹羽 里実
    • Organizer
      第17回日本医療薬学会
    • Place of Presentation
      群馬
    • Year and Date
      2007-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gene expression of Ca^<2+>-activated K^+ channels in human prostate cancer2007

    • Author(s)
      Satomi, Niwa, Susumu, Ohya, Akitoshi, Ohno, Yoshiyuki, Kojima, Syoichi, Sasaki, Kenjiro, Kori, Yuji, Imaizumi
    • Organizer
      The 17th Annual Metting of Japanese Society of Pharmaceutical Health Care and Sciences
    • Place of Presentation
      Gunma
    • Year and Date
      2007-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト前立腺癌におけるCa^<2+>活性化K^+チャネル遺伝子発現2007

    • Author(s)
      丹羽里実
    • Organizer
      第17回 日本医療薬学会
    • Place of Presentation
      群馬
    • Year and Date
      2007-09-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 全反射蛍光顕微鏡を用いたBKチャネルの一分子可視化解析2007

    • Author(s)
      池田 知佳子
    • Organizer
      生体機能と創薬シンポジウム2007
    • Place of Presentation
      金沢
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 平滑筋Ca^<2+>誘発性Ca^<2+>遊離のTIRF画像解析2007

    • Author(s)
      山村 寿男
    • Organizer
      生体機能と創薬シンポジウム2007
    • Place of Presentation
      金沢
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Single molecule imaging of BK channels using total internal reflection fluorescence microscopy2007

    • Author(s)
      Chikako, Ikeda, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      Biofunction and Drug Discovery Symposium 2007
    • Place of Presentation
      Kanazawa
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TIRF imaging of Ca^<2+>-induced Ca^<2+> release in smooth muscle cells2007

    • Author(s)
      Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      Biofunction and Drug Discovery Symposium 2007
    • Place of Presentation
      Kanazawa
    • Year and Date
      2007-09-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 平滑筋興奮の多様性と興奮収縮連関2007

    • Author(s)
      今泉 祐治
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Diversity of membrane excitability in smooth muscles and excitation-contraction coupling [Educational Lecture]2007

    • Author(s)
      Yuji, Imaizumi
    • Organizer
      The 49th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Nara
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管平滑筋細胞の静止時Ca^<2+>動態制御機構におけるNa^+/Ca^<2+>交換輸送体の役割2007

    • Author(s)
      村田 秀道
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2007-07-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 生殖器平滑筋のテストステロンによる大コンダクタンスCa^<2+>活性化K^+チャネルとリアノジン受容体の発現変化2007

    • Author(s)
      大野 晃稔
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2007-07-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Roles of Na^+/Ca^<2+> exchanger on resting Ca^<2+> mobilization in vascular smooth muscle cells2007

    • Author(s)
      Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Imaizumi
    • Organizer
      The 49th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Nara
    • Year and Date
      2007-07-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in expression of large-conductance Ca^<2+>-activated K+ channel and ryanodine receptor by testosterone2007

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 49th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Nara
    • Year and Date
      2007-07-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 松果体細胞におけるニコチン誘発性の細胞内Ca^<2+>シグナルとCa^<2+>感受性チャネルの機能解析2007

    • Author(s)
      水谷 浩也
    • Organizer
      第111回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ヒト由来軟骨肉腫細胞株(OUMS-27)におけるイオンチャネルの機能解析2007

    • Author(s)
      舩橋 賢司
    • Organizer
      第111回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Functional roles of ion channels involved in nicotinic ACh receptor-mediated Ca^<2+> signal in rat pinealocytes2007

    • Author(s)
      Hiroya, Mizutani, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 111th Kinki Branch Meeting of The Japanese Pharmacological Society in Nagoya
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional characterization of ion channels expressed in human chondrosarcoma cell line, OUMS-272007

    • Author(s)
      Kenji, Funahashi, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 111th Kinki Branch Meeting of The Japanese Pharmacological Society in Nagoya
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 短期培養cardiac fibroblastにおけるATP誘発クロライド電流2007

    • Author(s)
      波多野紀行
    • Organizer
      第111回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] ウサギ洞房結節細胞におけるSIP受容体作動薬ONO-WE-061の作用2007

    • Author(s)
      岩浪 真
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 抗アンドロゲン薬によるラット精管平滑筋のリアノジン受容体機能・発現変化2007

    • Author(s)
      大野 晃稔
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of ONO-WE-061, a novel agonist for S1P receptor, in rabbit sinus node cells2007

    • Author(s)
      Makoto, Iwaanmi, Katsuhiko, Muraki, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 127th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in function and expression of ryanodine receptor in rat vas deferens smooth muscles by anti-androgen drug2007

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 127th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト前立腺癌におけるイオンチャネル遺伝子発現プロファイル2007

    • Author(s)
      丹羽 里実
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 平滑筋細胞におけるCa^<2+>誘発性Ca^<2+>遊離機構のTIRF画像解析2007

    • Author(s)
      山村 寿男
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gene profiles of ion channels in human prostate cancer2007

    • Author(s)
      Satomi, Niwa, Susumu, Ohya, Akitoshi, Ohno, Yoshiyuki, Kojima, Syoichi, Sasaki, Kenjiro, Kori, Yuji, Imaizumi
    • Organizer
      The 127th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] TIRF imaging of Ca^<2+>-induced Ca^<2+> release in smooth muscle cells2007

    • Author(s)
      Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 127th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 全反射顕微鏡を利用した平滑筋Ca^<2+>誘発性Ca2÷遊離機構の可視化解析2007

    • Author(s)
      山村 寿男
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Visualization of Ca^<2+>-induced Ca^<2+> release in smooth muscle cells using total internal reflection fluorescence microscope2007

    • Author(s)
      Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Kir2.1活性化による過剰な過分極は脳血管内皮細胞死を引き起こす2007

    • Author(s)
      山崎 大樹
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] P19CL6細胞株の筋小胞体とミトコンドリアにおいて観察される自発性Ca^<2+>トランジェントの解析2007

    • Author(s)
      堀 優子
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管平滑筋におけるNa^+/Ca^<2+>交換輸送体の収縮調節機構への寄与2007

    • Author(s)
      村田 秀道
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット培養肺動脈平滑筋細胞におけるCa^<2+>活性化Clチャネルの機能発現2007

    • Author(s)
      井戸 田晴奈
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The excess membrane hyperpolarization induced by Kir2.1 activation causes brain capillary endothelial cell death2007

    • Author(s)
      Daiju, Yamazaki, Hisao, Yamamura, Susumu, Ohya, Ktsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous Ca^<2+> transients fromsarcoplasmic reticulum and mitochondria in P19CL6 cells2007

    • Author(s)
      Yuko, Hori, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of TheJapanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional roles of Na+/Ca^<2+> exchanger on the regulation of Ca^<2+> activated K^+ channels in vascular smooth muscle2007

    • Author(s)
      Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional expression of Ca^<2+> activated Cl channels in cultured smooth muscle cells of rat pulmonary artery2007

    • Author(s)
      Haruna, Itoda, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+>交換輸送体(NCX)過剰発現膀胱平滑筋における細胞内Ca^<2+>動態の変化2007

    • Author(s)
      堀田 真吾
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DiBAC4(3)によるβサブユニット選択的BKチャネル活性化の分子機構2007

    • Author(s)
      森本 岳
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒスタミンはヒト由来軟骨肉腫細胞(OUMS-27)においてCa^<2+>活性化K^+チャネルによる過分極を引き起こす2007

    • Author(s)
      舩橋 賢司
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト前立腺癌におけるK^+及びCa^<2+>チャネル遺伝子発現2007

    • Author(s)
      大矢 進
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in Ca^<2+> mobilization in urinary bladder smooth muscle overexpressing Na+/ Ca^<2+> exchanger (NCX)2007

    • Author(s)
      Shingo, Hotta, Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular mechanism of 13 subunit-selective BK channel activation by DiBAC4(3)2007

    • Author(s)
      Takashi, Morimoto, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Histamine induces membrane hyperpolarization via stimulation of Ca^<2+> activated K^+ channels in Human chondrosarcoma cell line (OUMS-27)2007

    • Author(s)
      Kenji, Funahashi, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of K^+ and Ca^<2+> channel genes in human prostate cancer2007

    • Author(s)
      Susumu, Ohya, Satomi, Niwa, Akitoshi, Ohno, Kojima, Shoichi, Sasaki, Kenjiro, Kohri, Yuji, Imaizumi
    • Organizer
      The 80th Annual Meeting of the Pharmacological Society of Japan
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] methyl-β-cyclodextrinの膀胱平滑筋におけるCICR機構への影響2006

    • Author(s)
      堀田 真吾
    • Organizer
      平成18年度日本薬学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] BKチャネルに対するオキソノール系化合物の構造と活性について2006

    • Author(s)
      森本 岳
    • Organizer
      平成18年度日本薬学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 抗アンドロゲン剤の精管平滑筋K^+チャネル活性への影響2006

    • Author(s)
      大野 晃稔
    • Organizer
      平成18年度日本薬学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of methyl-β-cyclodextrin on CICR mechanism in urinary bladder smooth muscle2006

    • Author(s)
      Shingo, Hotta, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      Tokai Brunch Meeting of The Japanese Pharmaceutical Society 2006
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Structure-activity of voltage-sensitive oxonol dyes as BK channel openers2006

    • Author(s)
      Takeshi, Morimoto, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      Tokai Brunch Meeting of The Japanese Pharmaceutical Society 2006
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of anti-androgen drug on ion channel activity in rat vas deferens smooth muscle2006

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      Tokai Brunch Meeting of The Japanese Pharmaceutical Society 2006
    • Place of Presentation
      Nagoya
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管平滑筋におけるNa^+/Ca^<2+>交換輸送体の生理的意義の解明2006

    • Author(s)
      村田 秀道
    • Organizer
      第16回循環薬理学会
    • Place of Presentation
      東京
    • Year and Date
      2006-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Physiological roles of Na^+/Ca^<2+> exchanger in vascular smooth muscles2006

    • Author(s)
      Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, iwamoto, Yuji, Imaizumi
    • Organizer
      The 16th Annual Meeting of Japanese Associations of Cardiovascular Pharmacology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-12-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット精管平滑筋におけるテストステロンによる電位依存性K^+チャネル発現2006

    • Author(s)
      大矢 進
    • Organizer
      第110回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Year and Date
      2006-11-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規大コンダクタンスCa^<2+>活性化K^+チャネル開口薬の薬理学的解析と創薬への応用2006

    • Author(s)
      森本 岳
    • Organizer
      第110回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Year and Date
      2006-11-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of voltage-gated K^+ channel expression in rat vas deferens by testosterone2006

    • Author(s)
      Takasaki, Japan, Susumu, Ohya, Akitoshi, Ohno, Yuji, Imaizumi
    • Organizer
      The 110th Kinki Branch Meeting of the Pharmacological Society of Japan in Kyoto
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pharmacological analysis of novel large-conductance Ca^<2+> activated K^+ channel openers2006

    • Author(s)
      Takeshi, Morimoto, Kazuho, Sakamoto, Hiroko, Sade, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 110th Kinki Branch Meeting of the Pharmacological Society of Japan in Kyoto
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-11-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 男性ホルモンによる精管平滑筋K^+チャネル発現調節2006

    • Author(s)
      大矢 進
    • Organizer
      第34回薬物活性シンポジウム
    • Place of Presentation
      高崎
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Testosterone regulation of ion channel expression in vas deferens2006

    • Author(s)
      Susumu, Ohya, Akitoshi, Ohno, Satomi, Niwa, Katsutoshi, Ito, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 34th Symposium on Drug Activity
    • Place of Presentation
      Takasaki, Japan
    • Year and Date
      2006-09-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Na^+/Ca^<2+>交換輸送体(NCX)過剰発現膀胱平滑筋における生理機能変化2006

    • Author(s)
      堀田 真吾
    • Organizer
      第48回日本平滑筋学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in physiological function in urinary bladder smooth muscles overexpressing Na^+/Ca^<2+> exchanger (NCX)2006

    • Author(s)
      Shingo, Hotta, Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Iwamoto
    • Organizer
      The 48th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Okayama
    • Year and Date
      2006-07-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The contribution of ryanodine receptor type 2 to E-C coupling and the regulation of resting tone in urinary bladder mvocvtes2006

    • Author(s)
      Shingo Hotta
    • Organizer
      IUPHAR-15th World Congress of Pharmacology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The contribution of ryanodine receptor type 2 to E℃ coupling and the regulation of resting tone in urinary bladder myocytes2006

    • Author(s)
      Shingo, Hotta, Kozo, Morimura, Susumu, Ohya, Katsuhiko, Muraki, Hiroshi, Takeshima, Yuji, Imaizumi
    • Organizer
      IUPHAR -15th World Congress of Pharmacology-
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sarcoplasmic reticulum and membrane events in smooth muscle cells2006

    • Author(s)
      Yuji Imaizumi
    • Organizer
      IUPHAR-15th World Congress of Pharmacology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two different types of K^+ channels regulated cell proliferation and cell death in bovine brain endothelial cells2006

    • Author(s)
      Daiju Yamazaki
    • Organizer
      IUPHAR-15th World Congress of Pharmacology
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sarcoplasmic reticulum and membrane events in smooth muscle cells [Invited Speaker]2006

    • Author(s)
      Yuji, Imaizumi
    • Organizer
      IUPHAR -15th World Congress of Pharmacology-
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two different types of K^+ channels regulated cell proliferation and cell death in bovine brain endothelial cells2006

    • Author(s)
      Daiju, Yamazaki, Susumu, Ohya, Katsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Organizer
      IUPHAR -15th World Congress of Pharmacology-
    • Place of Presentation
      Beijing, China
    • Year and Date
      2006-07-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] フルタミドによる精管平滑筋K^+チャネル機能変化2006

    • Author(s)
      大野 晃稔
    • Organizer
      第109回日本薬理学会近畿部会
    • Place of Presentation
      倉敷
    • Year and Date
      2006-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マウス大動脈平滑筋細胞におけるNa^+/Ca^<2+>交換輸送体の電気生理学的解析2006

    • Author(s)
      村田 秀道
    • Organizer
      第109回日本薬理学会近畿部会
    • Place of Presentation
      倉敷
    • Year and Date
      2006-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of flutamide on functional properties of vas deferens ion channels2006

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Hisao, Yamamura, Yuji, Imaizumi
    • Organizer
      The 109th Kinki Branch Meeting of The Pharmacological Society of Japan In Kurashiki
    • Place of Presentation
      Kurashiki
    • Year and Date
      2006-06-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Electrophysiological analysis of Na+/Ca+2+ exchanger in murine aortic smooth muscle cells2006

    • Author(s)
      Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Imaizumi
    • Organizer
      The 109th Kinki Branch Meeting of The Pharmacological Society of Japan In Kurashiki
    • Place of Presentation
      Kurashiki
    • Year and Date
      2006-06-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ピマル酸による電位依存性K^+チャネル開口作用と結合部位の探索2006

    • Author(s)
      坂本 多穂
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification and functional characterization of pimaric actid binding motifs involving in voltage-gated K^+ channel opening2006

    • Author(s)
      Kazuho, Sakamoto, Susumu, Ohya, Katsuhiko, Muraki, Tomohiko, Ohwada, Yuji, Imaizumi
    • Organizer
      The 126th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2006-03-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 中コンダクタンスCa^<2+>活性化K^+チャネルにおける開口薬結合部位の同定2006

    • Author(s)
      柳 文乃
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular identification of binding domains of intermediate-conductance Ca^<2+> -activated K^+ channel openers2006

    • Author(s)
      Ayano, Yanagi, Satomi, Niwa, Hisao, Yamamura, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 126th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2006-03-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒトHCN3チャネルの酸性pHによる活性化2006

    • Author(s)
      山村 寿男
    • Organizer
      日本薬学会第126年会
    • Place of Presentation
      仙台
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Activation of the human HCN3 channel by acidic pH2006

    • Author(s)
      Hisao, Yamamura, Naomi, Itazu, Yoko, Matsuoka, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 126th Annual Meeting of The Pharmaceutical Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2006-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 電位依存性Ca^<2+>チャネルβ3サブユニット欠損マウスの平滑筋における中コンダクタンスCa^<2+>活性化K^+チャネルの発現低下2006

    • Author(s)
      森村 浩三
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 去勢ラット精管平滑筋における大コンダクタンスCa^<2+>活性化K^+チャネル減少の自発収縮への影響2006

    • Author(s)
      大野 晃稔
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Jurkat細胞における小コンダクタンスCa^<2+>活性化K^+チャネルの細胞周期に伴う機能調節2006

    • Author(s)
      森本 岳
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ピマル酸による電位依存性K^+チャネルの制御と結合領域の推定2006

    • Author(s)
      坂本 多穂
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒトHCN3チャネルのpH感受性2006

    • Author(s)
      山村 寿男
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Down-regulation of intermediate conductance Ca^<2+> activated K^+ channel in smooth muscle of voltage dependent Ca2+ channel(32)subunit deficient mouse2006

    • Author(s)
      Kozo, Morimura, Susumu, Ohya, Hisao, Yamamura, Manabu, Murakami, katsuhiko, muraki, Kazuo, Nunoki, Teruyuki, Yanagisawa, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The regulation of large conductance Ca^<2+> -activated K^+ channel expressions brings spontaneous contractions in vas deference from castrated-rat2006

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cell-cycle dependent regulation of small-conductance Ca^<2+> -activated K^+ channel activity in Jurkat T-lymphocytes2006

    • Author(s)
      Takeshi, Morimoto, Susumu, Ohya, Hidetoshi, Hayashi, Katsuhiko, Muraki, Kikuo, Onozaki, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Pimaric acid modulate, voltage-gated K^+ channels by binding its activation gate2006

    • Author(s)
      Kazuho, Sakamoto, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Activation of the human HCN3 channel by acidic pH2006

    • Author(s)
      Hisao, Yamamura, Naomi, Itazu, Yoko, Matsuoka, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-10
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット大動脈平滑筋細胞における細胞内Ca^<2+>濃度と膜電流へのTrpV4活性化薬である4α-phorbol12, 13-didecanoateの影響2006

    • Author(s)
      田中 良一
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of 4a-Phorbol 12,13-dide-canoate, a potent activator of Trpv4, on intracellular Ca^<2+> concentration and membrane currents in rat aortic myocytes2006

    • Author(s)
      Ryoichi, Tanaka, Katsuhiko, Muraki, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膀胱平滑筋における2型リアノジン受容体を介したCa^<2+>動態の解明2006

    • Author(s)
      堀田 真吾
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ウシ脳血管内皮細胞において内向き整流性K^+チャネルは細胞死を制御する2006

    • Author(s)
      山崎 大樹
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ca^<2+> mobilization via ryanodine receptor type 2 in urinary bladder smooth muscle2006

    • Author(s)
      Shingo, Hotta, Kozo, Morimura, Susumu, Ohya, Katsuhiko, Muraki, Hiroshi, Takeshima, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inward rectifier K^+ channel regulates cell death in bovine capillary endothelial cells2006

    • Author(s)
      Daiju, Yamazaki, Susumu, Ohya, Katsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Organizer
      The 79th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of IP_3 formation in voltage-dependent regulation of Ca^<2+> concentration in coronary arterial smooth muscle cells2006

    • Author(s)
      Hisao Yamamura
    • Organizer
      Biophysical Society-50th Annual Meeting
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2006-02-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Involvement of IP_3 formation in voltage-dependent regulation of Ca^<2+> concentration in coronary arterial smooth muscle cells2006

    • Author(s)
      Hisao, Yamamura, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      Biophysical Society -50th Annual Meeting-
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2006-02-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Testosterone regulates the large-conductance Ca^<2+>-activated K^+ channel expression in ratvas deferens smooth muscle cells2006

    • Author(s)
      Akitoshi Ohno
    • Organizer
      Biophysical Society-50th Annual Meeting
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2006-02-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Testosterone regulates the large-conductance Ca^<2+>-activated K^+ channel expression in rat vas deferens smooth muscle cells2006

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      Biophysical Society -50th Annual Meeting-
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2006-02-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マウス大動脈平滑筋細胞におけるNa^+/Ca^<2+>交換輸送体の機能解析2006

    • Author(s)
      村田 秀道
    • Organizer
      生体機能と創薬シンポジウム
    • Place of Presentation
      福岡
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The contribution of inward-rectifier Kir2.1 K^+ channel regulation in the mechanisms underlying the brain endothelial cell death by excess ATP2006

    • Author(s)
      Daiju, Yamazaki, Susumu, Ohya, katsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Organizer
      Biofunction and Drug Discovery Symposium 2006
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Physiologycal roles of Na^+/Ca^<2+> exchanger in mouse aorta smooth muscle cells2006

    • Author(s)
      Hidemichi, Murata, Hisao, Yamamura, Susumu, Ohya, Takahiro, Iwamoto, Yuji, Imaizumi
    • Organizer
      Biofunction and Drug Discovery Symposium 2006
    • Place of Presentation
      Fukuoka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A New Insight into the Function of TRPV2 in Circulatory Organs2006

    • Author(s)
      Katsuhiko, Muraki, Munekazu, Shigekawa, Yuji, Imaizumi
    • Organizer
      TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades (Frontiers in Neuroscience) (Wolfgang B. Liedtke, ed.), Chapter 28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 電位依存性Ca^<2+>チャネルβ3サブユニット欠損マウスにおける平滑筋での中コンダクタンスCa^<2+>活性化K^+チャネルの発現変化2005

    • Author(s)
      森村 浩三
    • Organizer
      平成17年度日本薬学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in intermediate-conductance Ca^<2+> -activated K^+ channel expression in smooth muscles of voltage-gated Ca^<2+> channel β3 subunit null mice2005

    • Author(s)
      Kozo, Morimura, Susumu, Ohya, Hisao, Yamamura, Manabu, Murakami, Katsuhiko, Muraki, Kazuo, Nunoki, Teruyuki, Yanagisawa, Yuji, Imaizumi
    • Organizer
      Tokai Brunch Meeting of The Japanese Pharmaceutical Society 2005
    • Place of Presentation
      Nagoya
    • Year and Date
      2005-12-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Twotypes of K^+ channel regulate cell proliferation and damage in bovine brain capillary endothelial cells2005

    • Author(s)
      Daiju Yamazaki
    • Organizer
      Neuroscience 2005-SfN 35th Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two types of K^+ channel regulate cell proliferation and damage in bovine brain capillary endothelial cells2005

    • Author(s)
      Daiju, Yamazaki, Mineyoshi, Aoyama, Susumu, Ohya, Katsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Organizer
      Neuroscience 2005 -SfN 35th Annual Meeting-
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2005-11-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] P19CL6胚性腫瘍細胞における心筋分化に伴う細胞内Ca^<2+>シグナル制御機構の変化2005

    • Author(s)
      堀 優子
    • Organizer
      生体機能と創薬シンポジウム2005
    • Place of Presentation
      広島
    • Year and Date
      2005-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 消化管ペースメーカー細胞モデルの構築-リアノジン受容体とCa^<2+>活性化K^+チャネルの共発現系を用いて2005

    • Author(s)
      木村 泰介
    • Organizer
      生体機能と創薬シンポジウム2005
    • Place of Presentation
      広島
    • Year and Date
      2005-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 心筋ミトコンドリアにおけるBKチャネルβ1サブユニットの発現とBKチャネル開口薬による心筋細胞保護作用2005

    • Author(s)
      大矢 進
    • Organizer
      生体機能と創薬シンポジウム2005
    • Place of Presentation
      広島
    • Year and Date
      2005-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in functional expression of voltage-dependent Ca^<2+> channel and the ryanodine receptor during cardiac myocytes differentiation in P19CL6 cells2005

    • Author(s)
      Yuko, Hori, Kaori, Kato, Asuka, Ogawa, Kozo, Morimura, Shingo, Hotta, Hisao, Yamamura, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      Biofunction and Drug Discovery Symposium 2005
    • Place of Presentation
      Hiroshima
    • Year and Date
      2005-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Imaizumi A model for electrical pacemaker cells of the gut〜Functional coupling between ryanodine receptor and Ca^<2+>-activated K^+ channel〜2005

    • Author(s)
      Taisuke, Kimura, Hisao, Yamamura, Aid, Yamada, Takayo, Goto, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      Biofunction and Drug Discovery Symposium 2005
    • Place of Presentation
      Hiroshima
    • Year and Date
      2005-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression of BK channel β1 subunit in cardiac mitochondria and cardioprotective effects of BK channel openers2005

    • Author(s)
      Susumu, Ohya, Kazuho, Sakamoto, Yukiko, Kuwata, Katsuhiko, Muraki, Tomohiko, Ohwada
    • Organizer
      Biofunction and Drug Discovery Symposium 2005
    • Place of Presentation
      Hiroshima, Japan
    • Year and Date
      2005-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two step mechanism of induced release in excitation-contraction coupling2005

    • Author(s)
      Yuji Imaizumi
    • Organizer
      University of Oxford Meeting on Ion channels, genes and regulation in smooth muscle
    • Place of Presentation
      Oxford. UK
    • Year and Date
      2005-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Two step mechanism of Ca^<2+> induced Ca^<2+> release in excitation-contraction coupling [Invited Speaker]2005

    • Author(s)
      Yuji, Imaizumi
    • Organizer
      University of Oxford Meeting on Ion channels, genes and regulation in smooth muscle.
    • Place of Presentation
      Oxford. UK
    • Year and Date
      2005-09-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Physiological functions of ryanodine receptor type2 (RyR2) at resting state and during excitation-contraction coupling in urinary bladder smooth muscle2005

    • Author(s)
      Shingo Hotta
    • Organizer
      University of Oxford Meeting on Ion channels, genes and regulation in smooth muscle
    • Place of Presentation
      Oxford. UK
    • Year and Date
      2005-09-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Physiological functions of ryanodine receptor type 2 (RyR2) at resting state and during excitation-contraction coupling in urinary bladder smooth muscle2005

    • Author(s)
      Shingo, Hotta, Kozo, Morimura, Susumu, Ohya, Katsuhiko, Muraki, Hiroshi, Takeshima, Yuji, Imaizumi
    • Organizer
      University of Oxford Meeting on Ion channels, genes and regulation in smooth muscle.
    • Place of Presentation
      Oxford. UK
    • Year and Date
      2005-09-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Large-conductance Ca^<2+>-activated K^+ channel β1 subunit in cardiac mitochondria and cardioprotective effects of BK channel openers2005

    • Author(s)
      SusumuOhya
    • Organizer
      US-Japan Conference on Drug Development & Rational Drug Design
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2005-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Testosterone regulation of large-conductance Cat^<2+>-activated K^+ channel expression in ratvas deferens smooth muscle cells2005

    • Author(s)
      Akitoshi Ohn
    • Organizer
      US-Japan Conference on Drug Development & Rational Drug Design
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2005-08-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Testosterone regulation of large-conductance Ca^<2+>-activated K^+ channel expression in rat vas deferens smooth muscle cells2005

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      US-Japan Conference on Drug Development & Rational Drug Design
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2005-08-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ウシ脳血管内皮細胞におけるSOCの特性2005

    • Author(s)
      山崎 大樹
    • Organizer
      第28回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2005-07-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of SOC in bovine brain endothelial cells2005

    • Author(s)
      Daiju, Yamazaki, Susumu, Ohya, Katsuhiko, Muraki, Kiyofumi, Asai, Yuji, Imaizumi
    • Organizer
      The 28th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2005-07-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脂質メディエーターによる血管の機能調節と臨床応用2005

    • Author(s)
      村木 克彦
    • Organizer
      第47回日本平滑筋学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2005-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 膀胱平滑筋収縮時におけるRyR2機能の重要性2005

    • Author(s)
      堀田 真吾
    • Organizer
      第47回日本平滑筋学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2005-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Functional regulation of vasculacture by lipid mediators and their clinical use [Symposium]2005

    • Author(s)
      Katsuhiko, Muraki, Susumu, Ohya, Yuji, Imaizumi
    • Organizer
      The 47th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Sendai
    • Year and Date
      2005-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Significance of RyR2 in EC coupling in urinary bladder2005

    • Author(s)
      Shingo, Hotta, Kozo, Morimura, Susumu, Ohya, Katsuhiko, Muraki, Hiroshi, Takeshima, Yuji, Imaizumi
    • Organizer
      The 47th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Sendai
    • Year and Date
      2005-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット大動脈平滑筋細胞に対するEDG受容体活性化薬の効果とEDG受容体の発現変化2005

    • Author(s)
      田中 良一
    • Organizer
      第47回日本平滑筋学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2005-07-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effects of EDG receptor activators in rat aortic smooth muscle cells and changes in expression of EDG receptors by them2005

    • Author(s)
      Ryoichi, Tanaka, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 47th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Sendai
    • Year and Date
      2005-07-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規大コンダクタンスCa^<2+>活性化K^+チャネル開口薬による虚血心筋保護機構の解明2005

    • Author(s)
      坂本 多穂
    • Organizer
      平成17年度日本薬学会東海支部会例会
    • Place of Presentation
      岐阜
    • Year and Date
      2005-07-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Mechanisms for cardioprotective effects of a novel opener of large-conductance Ca^<2+>-activated K^+ channels2005

    • Author(s)
      Kazuho, Sakamoto, Susumu, Ohya, Katsuhiko, Muraki, Tomohiko, Ohwada, Yuji, Imaizumi
    • Organizer
      Tokai Brunch Meeting of The Japanese Pharmaceutical Society in 2005
    • Place of Presentation
      Gifu
    • Year and Date
      2005-07-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 去勢ラット精管平滑筋におけるK^+チャネル発現変化2005

    • Author(s)
      大野 晃稔
    • Organizer
      第107回日本薬理学会近畿部会
    • Place of Presentation
      金沢
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット大動脈初代培養平滑筋細胞におけるEDG受容体の発現変化2005

    • Author(s)
      田中 良一
    • Organizer
      第107回日本薬理学会近畿部会
    • Place of Presentation
      金沢
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in ion channel expression in vas deferens smooth muscles of castrated rats2005

    • Author(s)
      Akitoshi, Ohno, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 107th Kinki Branch Meeting of The Japanese Pharmacological Society In Kanazawa
    • Place of Presentation
      Kanazawa
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Changes in EDG receptor expressions in rat aortic smooth muscle cells in primary culture2005

    • Author(s)
      Ryoichi, Tanaka, Susumu, Ohya, Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      The 107th Kinki Branch Meeting of The Japanese Pharmacological Society In Kanazawa
    • Place of Presentation
      Kanazawa
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 2型リアノジン受容体異型接合型欠損マウス膀胱平滑筋におけるCa^<2+>働態の変化2005

    • Author(s)
      堀田 真吾
    • Organizer
      第82回日本生理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2005-05-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intracellular Ca^<2+> mobilization in urinary bladder of RyR2 heterozygous KO mice2005

    • Author(s)
      Shingo, Hotta, Kozo, Morimura, Susumu, Ohya, Katsuhiko, Muraki, Hiroshi, Takeshima, Yuji, Imaizumi
    • Organizer
      The 82nd Annual Meeting of The Physiological Society of Japan
    • Place of Presentation
      Sendai
    • Year and Date
      2005-05-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel mechanism for enhancement of Ca^<2+> response to ATP in bovine brain capillary endothelial cells2005

    • Author(s)
      Yuji Imaizumi
    • Organizer
      The 35th Congress of the International Union of Physiological Sciences(IUPS)
    • Place of Presentation
      SanDiego, USA
    • Year and Date
      2005-04-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel mechanism for enhancement of Ca^<2+> response to ATP in bovine brain capillary endothelial cells2005

    • Author(s)
      Yuji, Imaizumi, Daiju, Yamazaki, Mineyoshi, Aoyama, Susumu, Ohya, Katsuhiko, Muraki, Kiyofumi, Asai
    • Organizer
      The 35th Congress of the International Union of Physiological Sciences (IUPS)
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2005-04-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 7. Ca^<2+> Releasing Channels in Pulmonary Vascular Smooth Muscle Cells2005

    • Author(s)
      Yuji, Imaizumi, Katsuhiko, Muraki
    • Organizer
      Ion Channels in the Pulmonary Vasculature
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ion channels in vascular smooth muscle cells and remodeling2005

    • Author(s)
      Katsuhiko, Muraki, Yuji, Imaizumi
    • Organizer
      Recent Progress in Ion Channel Reserch-update
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] A new insight into the function of TRPV2 in circulatory organs TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades(Frontiers in Neuroscience)(Wolfgang B. Liedtke, ed.), Chapter 282006

    • Author(s)
      Muraki K
    • Publisher
      CRC Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] A new insight into the function of TRPV2 in circulatory organs. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades (Frontiers in Neuroscience)(Wolfgang B. Liedtke, ed.), Chapter 282006

    • Author(s)
      Muraki K, Shigekawa M, Imaizumi Y
    • Publisher
      CRC Press
    • Related Report
      2006 Annual Research Report
  • [Book] Ca^<2+> Releasing Channels in Pulmonary Vascular Smooth Muscle Cells Ion Channels in the Pulmonary Vasculature, Chapter72005

    • Author(s)
      Yuji Imaizumi
    • Publisher
      CRC Press
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 血管平滑筋細胞イオンチャネルとリモデリング(改訂)別冊・医学のあゆみ2005

    • Author(s)
      村木 克彦
    • Publisher
      医歯薬出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Ca^<2+> releasing channels in pulmonary vascular smooth muscle cells (Ion channels in the pulmonary vasculature, edited by Yuan Jason X.-J.)2005

    • Author(s)
      Imaizumi Y, Muraki K.
    • Publisher
      Marcel Dekker Inc
    • Related Report
      2005 Annual Research Report
  • [Book] 血管平滑筋細胞イオンチャネルとリモデリング(イオンチャネル最前線update、倉智嘉久編集)2005

    • Author(s)
      村木克彦, 今泉祐治
    • Publisher
      医歯薬出版
    • Related Report
      2005 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.phar.nagoya-cu.ac.jp/hp/ysg/index.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.phar.nagoya-cu.ac.jp/hp/ysg/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] カリウムチャネル開口薬2007

    • Inventor(s)
      今泉 祐治, 大矢 進, 森本 岳
    • Industrial Property Rights Holder
      有限会社チャネロサーチテクノロジー
    • Industrial Property Number
      2007-108474
    • Filing Date
      2007-04-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] カリウムチャネル開口薬2007

    • Inventor(s)
      今泉祐治, 大矢 進, 森本 岳
    • Industrial Property Rights Holder
      有限会社チャネロサーチテクノロジー
    • Industrial Property Number
      2007-108474
    • Filing Date
      2007-04-17
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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