Molecular mechanisms generating a critical period of thyroid hormone action on brain development and its modulation by environmental chemicals

• Project/Area Number: 17390060
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Gunma University
• Principal Investigator: KOIBUCHI Noriyuki Gunma University, 大学院・医学系研究科, 教授 (80234681)
• Co-Investigator(Kenkyū-buntansha): SHIMOKAWA Noriaki 群馬大学, 大学院・医学系研究科, 准教授 (90235680) ; IWASAKI Toshiharu 群馬大学, 大学院・医学系研究科, 講師 (80375576) ; TAKESHITA Akira 冲中記念成人病研究所, 研究員 (20322646)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,450,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2006: ¥2,800,000 (Direct Cost: ¥2,800,000); Fiscal Year 2005: ¥8,100,000 (Direct Cost: ¥8,100,000)
• Keywords: 甲状腺ホルモン / 甲状腺ホルモン受容体 / 環境化学物質 / 転写共役因子 / 環境医学 / 成長・発達 / 脳発達

Research Abstract

本研究は甲状腺ホルモン(TH)による脳発達の調節機構とPCBなどの環境化学物質のTH系への作用解析を目的とした。そして動物実験と生化学的実験により, 分子から個体レベルまでの解析を目指した。動物実験では, TH作用にはRORなどの他の核内受容体や転写共役因子の発現が必要である事, 生化学的な実験で細胞内でTH受容体(TR)とそれらの物質が複合体を作っている事を明らかにした。また, PCBがTRに対し, "疑似ホルモン"ではなく, 従来とは全く異なった機構で作用している事を明らかにした。

Research Products

• [Journal Article] Identification of the functional doman of thyroid hormond receptor responsible for polychlorinated biphenyl- mediated suppression of its action in vitro (2008)
  • Author(s): Miyazaki W, Iwasaki T, takeshita A, Tohyama C, Koibuchi N
  • Journal Title: Environ Health Perspect 116 Pages: 1231-1236
  • Peer Reviewed
• [Journal Article] Liquid chemiluminescent DNA pull-down assay to measurreceptor-DNA binding in solution (2008)
  • Author(s): Iwasaki T, Miyazaki W, Rokutanda N, Koibuchi N
  • Journal Title: Bio-Techniques 45 Pages: 445-448
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): KoibuchiN
  • Journal Title: The ole f thyroid hormone on cerebellar development 7(Cerebellum) Pages: 530-533
  • Peer Reviewed
• [Journal Article] Hormonal regulation of cerebellar development and plasticity. (2008)
  • Author(s): Koibuchi N
  • Journal Title: Cerebellum 7 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Cerebellum, a target for hormonal signaling (2008)
  • Author(s): Koibuchi N, Kimura-Kuroda J, Ikeda Y, Tsutsui K.
  • Journal Title: Cerebellum 7 Pages: 499-504
  • Peer Reviewed
• [Journal Article] The role of fhyroid hormone on cerebellar development. (2008)
  • Author(s): Koibuchi N
  • Journal Title: Cerebellum 7 Pages: 530-533
  • Peer Reviewed
• [Journal Article] Low-dose morphine induces hyperalgesia through activation of Gas, protein kinase C and L-type Ca2+ channels in rats. (2008)
  • Author(s): Esmaeili-Mahani, S, Shimokawa N, Javan M, Maghsoudi N, Motamedi F, Koibuchi N, Ahmadiani A
  • Journal Title: J Neurosci Res 86 Pages: 471-479
  • Peer Reviewed
• [Journal Article] Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats (2008)
  • Author(s): Seki T, Shimokawa N, Iizuka H, Takagishi K, Koibuchi N.
  • Journal Title: Mol Cell Biochem 312 Pages: 193-199
  • Peer Reviewed
• [Journal Article] Identification of the functional domain of thyroid hormone receptor responsible for polychlorinated biphenyl-mediated suppression of its action in vitro. (2008)
  • Author(s): Miyazaki W, Iwasaki T, Takeshita A, Tohyama C, Koibuchi N.
  • Journal Title: Environ Health Perspect 116 Pages: 1231-1236
  • Peer Reviewed
• [Journal Article] Liquid chemiluminescent DNA pull-down assay to measure nuclear receptor-DNA binding in solution. (2008)
  • Author(s): Iwasaki T, Miyazaki W, Rokutanda N, Koibuchi N.
  • Journal Title: BioTechniques 45 Pages: 445-448
  • Peer Reviewed
• [Journal Article] Augmentation of estrogen receptor - mediated transcription by steroid and xenobiotic receptor (2008)
  • Author(s): Rokutanda N, Iwasaki T, Odawara H, Nagaoka R, Miyazaki W, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, Iino Y, Morishita Y, Koibuchi N.
  • Journal Title: Endocrine 33 Pages: 305-316
  • Peer Reviewed
• [Journal Article] ポリ塩化ビフェニルによる器官の発達,機能維持への影響-甲状腺ホルモンを介するPCB類の作用機構 (2008)
  • Author(s): 鯉淵典之,岩崎俊晴
  • Journal Title: ビオフイジア 1 Pages: 26-29
• [Journal Article] Low-dose morphine induces hyperalgesia through activation of Gαs, protein kinase C and L-type Ca2+ channels in rats. (2008)
  • Author(s): Esmaeili-Mahani S, Shimokawa N, Javan M, Maghsoudi N, Motamedi F, Koibuchi N, Ahmadiani A.
  • Journal Title: J Neurosci Res 86 Pages: 471-479
• [Journal Article] ぽり塩化ビフェニルによる器官の発達,機脳維持への影響-甲状線ホルモンを介するPCB類の作用機構- (2008)
  • Author(s): 鯉淵 典之, 岩崎 俊晴
  • Journal Title: ビオフィリア 1 Pages: 26-29
• [Journal Article] Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer- type retinoic acid receptor-related orphan receptor alpha mutation (2007)
  • Author(s): Qiu C-H, Shimokawa N, Iwasaki T, Parhar IS, Koibuchi N
  • Journal Title: Endocrinology 148 Pages: 1745-1753
  • Peer Reviewed
• [Journal Article] Alteration of cerebellar neurotrophin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan orphan receptor-〓 mutation. (2007)
  • Author(s): Qiu C-H Shimokawa N, Iwasaki T, Parhar IS, Koibuchi N.
  • Journal Title: Endocrinology 148 Pages: 1745-1753
• [Journal Article] PCB affects on DNA binding domain of thyroid hormone recepors. (2007)
  • Author(s): Miyazaki W, Iwasaki T, Koibuchi N.
  • Journal Title: Ocganohalogen Compounds 69 Pages: 1773-1775
• [Journal Article] Low dose hydroxylated PCB disrupt Ca2+ homeostasis and plasma membrane potential. (2007)
  • Author(s): Londono MB, Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N.
  • Journal Title: Organohalogen Compounds 69 Pages: 1776-1778
• [Journal Article] Symptomatic hyponatremia after voluntary excessive water ingestion in a patient without psychiatric problems. (2007)
  • Author(s): Hiramatsu R, Takashita A, Taguchi M, Takeuchi Y.
  • Journal Title: Endocr J 54 Pages: 643-645
• [Journal Article] Fibroblast growth factor (FGF)23 in patients with acromegaly. (2007)
  • Author(s): Ito N, Fukumoto S, Taguchi M, Takeshita A, Takeuchi Y, Yamada S, Fujita T.
  • Journal Title: Endocr J 54 Pages: 481-484
  • NAID: 130004770047
• [Journal Article] Tamoxifen activates CYP3A4 and MDR-1 genes through steroid and xenobiotic receptor in breast cancer cells. (2007)
  • Author(s): Nagaoka R, Iwasaki T, Rokutanda N, Takeshita A, Koibuchi Y, Horiguchi J, Shimokawa N, lino Y, Morishita Y, Koibuchi N
  • Journal Title: Endocrine (印刷中)
• [Journal Article] Alteration of cerebellar neurotrophin messenger ribonucleic acids and the lack of thyroid hormone augmentation by staggerer- type retinoic acid receptor-related orphan receptor-a mutation. (2007)
  • Author(s): Qiu C-H, Shimokawa N, Iwasaki T, Parhar IS, Koibuchi N.
  • Journal Title: Endocrinology 148(印刷中)
• [Journal Article] Regulation of brain development by thyroid hormone and its modulation by environmental chemicals (2006)
  • Author(s): Koibuchi N, Iwasaki T
  • Journal Title: Endocrine J 53 Pages: 295-303
  • NAID: 10018177799
  • Peer Reviewed
• [Journal Article] The interaction of TR・1-N- terminus with SRC-1 serves a fulltranscriptional activation function of SRC-1 (2006)
  • Author(s): Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N
  • Journal Title: Endocrinlogy 147 Pages: 1452-1457
  • Peer Reviewed
• [Journal Article] Low dose hydroxylated PCB induces c-Jun expression in PC12 cells (2006)
  • Author(s): Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N
  • Journal Title: Neurotoxicology 27 Pages: 176-183
  • Peer Reviewed
• [Journal Article] The endocrine disrupting chemical. dietlhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells (2006)
  • Author(s): Takeshita A, Inagaki K, Igarashi-Migitaka J, Ozawa Y, Koibuchi N
  • Journal Title: J Edocrinol 190 Pages: 897-902
  • Peer Reviewed
• [Journal Article] Neuronal expression of nuclear transcription factor MafG in the rat medulla oblongata after baroreceptor stimulation. (2006)
  • Author(s): Kumaki I, Yang D, Koibuchi N, Takayama K.
  • Journal Title: Life Sci 78 Pages: 1760-1766
• [Journal Article] The interaction ofTRβ1-N-terminus with SRC-1 serves a full transcriptional activation function of SRC-1. (2006)
  • Author(s): Iwasaki T, Takeshita A, Miyazaki W, Chin ww, Koibuchi N.
  • Journal Title: Endocrinology 147 Pages: 1452-1457
• [Journal Article] Low dose hydroxylated PCB induces c-Jun expression in PC12 cells. (2006)
  • Author(s): Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N
  • Journal Title: Neurotoxicology 27 Pages: 176-183
• [Journal Article] The adrenal gland is a source of stress-induced circulating IL-18. (2006)
  • Author(s): Sugama S, Wang N, Ohata H, Shimokawa N, Koibuchi N, Hashimoto M, Conti B.
  • Journal Title: J Neuroimmunol 172 Pages: 59-65
• [Journal Article] The endocrine disrupting chemical, diethylhexyl phthalate, activates MDR1 gene expression in human colon cancer LS174T cells. (2006)
  • Author(s): Takeshita A, Inagaki K, Igarashi-Migitaka J, Ozawa Y, Koibuchi N.
  • Journal Title: J Endocrinol 190 Pages: 897-902
• [Journal Article] 内分泌撹乱物質の甲状腺及び神経に対する影響 (2006)
  • Author(s): 岩崎俊晴, 鯉淵典之
  • Journal Title: ホルモンと臨床 54 Pages: 215-220
• [Journal Article] 甲状腺ホルモンによる脳発達の調節機構と環境化学物質による修飾 (2006)
  • Author(s): 鯉淵典之, 下川哲昭, 岩崎俊晴
  • Journal Title: 神経研究の進歩 50 Pages: 833-841
• [Journal Article] Postnatal changes of steroid receptor coactivator-1 immunoreactivity in rat cerebellar cortex (2005)
  • Author(s): Yousefi B, Jingu H, Ohta M, Umezu M, Koibuchi N
  • Journal Title: Thyroid 15 Pages: 314-319
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata (2005)
  • Author(s): Okada J, Shimokawa N, Koibuchi N
  • Journal Title: Int J Biochem Cell Biol 37 Pages: 1368-1374
  • Peer Reviewed
• [Journal Article] Extracelluar acidifactivity of MafG-FosB heterodimer (2005)
  • Author(s): Shimokawa N, Kumaki I, Qiu C-H, Ohmiya Y, Takayama K, Koibuchi N
  • Journal Title: J Cell Physiol 205 Pages: 77-85
  • Peer Reviewed
• [Journal Article] Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator (2005)
  • Author(s): Iwasaki T KoibuchiN, Cin WW
  • Journal Title: Endocrinology 146 Pages: 3892-3899
  • Peer Reviewed
• [Journal Article] Retinoid-related receptor (ROR)a mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms. (2005)
  • Author(s): Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff DW
  • Journal Title: Endorine 26 Pages: 25-32
• [Journal Article] Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata (2005)
  • Author(s): Okada J, Shimokawa N, Koibuchi N
  • Journal Title: Int J Biochem Cell Biol 31 Pages: 1368-1374
• [Journal Article] Monitoring synaptogenesis in the developing mouse cerebellum with an original oligonucleotide microarray (2005)
  • Author(s): Takahashi M, Kondoh Y, Tashiro H, Koibuchi N, Kuroda Y, Tashiro T
  • Journal Title: J Neurosci Res 80 Pages: 777-788
• [Journal Article] Functional characterization of JMJD2A, a histone deacetlyase- and retinoblastoma-binding protein (2005)
  • Author(s): Grey SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F.
  • Journal Title: J Biol Chem 280 Pages: 28507-28518
• [Journal Article] Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. (2005)
  • Author(s): Iwasaki T, Koibuchi N, Chin WW
  • Journal Title: Endocrinology 146 Pages: 3892-3899
• [Journal Article] Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis (2005)
  • Author(s): Igarashi-Migitaka J, Takeshita A, Koibuchi N, Yamada S, Ohtani-Kaneko R, Hirata K
  • Journal Title: Eur J Endocrinol 153 Pages: 595-604
• [Journal Article] 甲状腺ホルモンの中枢作用に及ぼす内分泌かく乱物質の影響 (2005)
  • Author(s): 鯉淵典之, 岩崎俊晴, 宮崎航, 岡田淳一, 下川哲昭, 竹下彰, 黒田洋一郎
  • Journal Title: ホルモンと臨床 53 Pages: 75-80
  • NAID: 10014290940
• [Journal Article] 臨床分子内分泌学3 -甲状腺・副甲状腺・骨内分泌代謝系-I.甲状腺ホルモン 薬理作用と生理差量 脳の発達と機能維持に対する作用 (2005)
  • Author(s): 鯉淵典之
  • Journal Title: 日本臨床 63 Pages: 78-83
• [Journal Article] 小脳の疾患と治療 甲状腺ホルモンと小脳障害 (2005)
  • Author(s): 鯉淵典之
  • Journal Title: Clinical Neurosecience 23 Pages: 1419-1421
• [Presentation] 環境ホルモン研究-最近の進歩 (2008)
  • Author(s): 鯉淵典之
  • Organizer: 第23回日本医科大学内分泌懇話会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-30
• [Presentation] The role of thyroid hormone on cerebellar development (2008)
  • Author(s): Koibuchi N
  • Organizer: Inaugural Cerebellar Symposium
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2008-07-11
• [Presentation] 甲状腺ホルモン受容体におけるPCB作用部位の解析 (2008)
  • Author(s): 宮崎 航, 岩崎 俊晴, 竹下 彰, 遠山 千春, 鯉淵 典之
  • Organizer: 第4回環境生理学プレコングレス
  • Place of Presentation: 東京
  • Year and Date: 2008-03-24
• [Presentation] Mecha- nism of suppression of thyroid hormone receptor- mediated transcription by low dose bromo- related compounds (2008)
  • Author(s): Ibhazehiebo K, Iwaski T, Londono MB, Hirooka K, Shimokawa N, Koibuchi N
  • Organizer: 第11回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] Effect of hydroxylated PCB on Ca^<2+> oscillations and membrane potential in cultured neurons (2008)
  • Author(s): Shimokawa N, Londono M, Miyazaki W, Iwasaki T, Koibuchi N
  • Organizer: 第11回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] 神経細胞発達に及ぼす甲状腺ホルモンの作用と環境化学物質による修飾 (2008)
  • Author(s): 鯉淵典之
  • Organizer: 第51回日本甲状腺学会
  • Place of Presentation: 宇都宮(鎮目レクチャー)
• [Presentation] The effect of thyroid hormone on brain development and its disruption by environmental factors (2008)
  • Author(s): Koibuchi N
  • Organizer: XVII Seminar National Ikatan Ahli Ilmu Faal Indonesia
  • Place of Presentation: Indonesia (Plenary Lecutre)
• [Presentation] Effects of brominated compound on thyroid hormone receptor-mediated transcription (2008)
  • Author(s): Koibuchi N, Ibhazehiebo K, Miyazaki W, Iwasaki T
  • Organizer: 6th Forum of European Neuroscince
  • Place of Presentation: Geneva, Switzrland
• [Presentation] Differential effects of briminated fframe retardant on TR-mediated transcription (2008)
  • Author(s): Ibhazeiebo Kingsley, 岩崎俊晴, 宮崎航, 鯉淵典之
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Presentation] TRBP-CoAA/ CoAM- SRAによる新たな核内ホルモン受容体転写制御機構 (2008)
  • Author(s): 岩崎俊晴, ロンドーニョマリーナ, 宮崎航, 下川哲昭, 鯉淵典之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] Effects of brominated compound on thyroid hormone receptor-mediated transcription. (2008)
  • Author(s): Koibuchi N, Ibhazehiebo K, Miyazaki W, Iwasaki T.
  • Organizer: 6th Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Effect of polychlorinated biphenyl (PCB) on thyroid hormone receptor (TR) - retinoic acid-related orphan receptor (ROR) crosstalk and its mechanism in developing brain. (2008)
  • Author(s): Iwasaki T, Qiu CH, Amano Miyazaki W, Shimokawa N, Koibuchi N
  • Organizer: 6th Forum of European Neuroscience
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Competency-based medical education at Gunma University (2008)
  • Author(s): Koibuchi N
  • Organizer: XVII Seminar National. Ikatan. Ahli IlmuFaal Indonesia (インドネシア生理学会)
  • Place of Presentation: Medan, Indonesia
• [Presentation] The effect of thyroid hormone on brain development and its di sruption by environmental factors. (2008)
  • Author(s): Medan, Indonesia
  • Organizer: XVII Seminar National. Ikatan. Ahli IlmuFaal Indonesia (インドネシア生理学会)
  • Place of Presentation: Medan, Indonesia
• [Presentation] SXR, a new predictive factor for the prognosis of breast cancer. (2008)
  • Author(s): Koibuchi N
  • Organizer: III Curso de biologia, molecular y symposio patologias endocrinas de enfoque multidisplinario
  • Place of Presentation: Bogota, Colombia
• [Presentation] Differential effects of briminated fframe retardant on TR-Imediated transcription. (2008)
  • Author(s): Ibhazehiebo Kingsley,岩崎俊晴,宮崎航,鯉淵典之
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Presentation] 新たな機序によるcoactivator modulator(CoAM)による核内ホルモン受容体を介する転写の抑制 (2008)
  • Author(s): 岩崎俊晴,Marina Londno, 宮崎航,下川哲昭 鯉淵典之
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Presentation] 神経細胞発達に及ぼす甲状腺ホルモンの作用と環境化学物質による修飾 (2008)
  • Author(s): 鯉淵典之
  • Organizer: 第51回日本甲状腺学会
  • Place of Presentation: 宇都宮
• [Presentation] Effect of brominated flame retardant on TR-mediated transcription and brain development. (2008)
  • Author(s): キングスレイ・イブハゼヒエボ.岩崎俊晴,宮崎航,鯉淵典之
  • Organizer: 第51回日本甲状腺学会
  • Place of Presentation: 宇都宮
• [Presentation] 新規転写抑制因子brain-derived repressive modulator (B-ReM)の同定 (2008)
  • Author(s): 岩崎俊晴,マリーナ・ロンドーニョ,宮崎航,鯉淵典之
  • Organizer: 第51回日本甲状腺学会
  • Place of Presentation: 宇都宮
• [Presentation] Mechanism of suppression of thyroid hormone receptor-mediated transcription by low dose bromo-related compounds. (2008)
  • Author(s): Ibhazehiebo K, Iwaski T, Londono MB, Hirooka K, Shimokawa N, Koibuchi N
  • Organizer: 第11回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] Effect of hydroxylated PCB on Ca2+ oscillations and membrane potential in cultured neurons. (2008)
  • Author(s): Shimokawa N, Londono M, Miyazaki W, Iwasaki T, Koibuchi N
  • Organizer: 第11回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] PCBのTRシグナリングに対する影響の性差 (2008)
  • Author(s): 岩崎俊晴,Sajdle-Sulkowska E M,尾川陽,菊池拓,Ibhazehiebo K,廣岡和美 下川哲昭,鯉淵典之
  • Organizer: 第11回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] Teaching Physiology:Japanese Experience(招待演者) (2008)
  • Author(s): Koibuchi N
  • Organizer: XVI Seminar National Ikatan AhliIlmu Faal Indonesia(インドネシア生理学会)
  • Place of Presentation: Bandung,Indonesia
• [Presentation] CIN85欠損マウスにおける表現型の解析 (2008)
  • Author(s): 下川 哲昭, 邸 春紅, ロンドーニョ マリーナ, 鯉淵 典之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] TrkAの分解はCBLやNEDD4によるユビキチン化によって制御されている (2008)
  • Author(s): 森田 晶人, マハニサイード, マハニシーマ, ロンドーニョマリーナ, 下川 哲昭, 鯉淵 典之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] レチノイン酸受容体関連オーファン受容体αのApoA1及びMalic Enzyme遺伝子発現に対する影響 (2008)
  • Author(s): 加藤 雅世, 須田 真千子, 岩崎 俊晴, 邸 春紅, 天野 出月, ロンドーニョ マリーナ, 宮崎 航, 下川 哲昭, 鯉淵 典之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] CIN85欠損マウスにおける保育能力と泌乳機能の検討 (2008)
  • Author(s): 池澤 淳, 青塚 伸孝, 伊藤 元治, 茶山 和敏, 下川 哲昭, 鯉淵 典之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 甲状腺ホルモン調節機構のかく乱とその分子メカニズム(シンポジスト) (2008)
  • Author(s): 鯉淵 典之
  • Organizer: 第78回日本衛生学会総会シンポジウム「環境化学物質の毒性とその分子標的の探索」
  • Place of Presentation: 熊本
• [Presentation] 受容体の膜輸送と分解を制御するCIN85の機能解析 (2007)
  • Author(s): 下川 哲昭, ロンドーニョ マリーナ, 邱 春紅, 鯉淵 典之
  • Organizer: 第80回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] 鯉淵典之臭素化芳香族化合物による甲状腺ホルモン受容体による転写への影響 (2007)
  • Author(s): Kingsley Ibhazehiebo, 岩崎俊晴, 宮崎航
  • Organizer: 環境ホルモン学会第10回研究発表会
  • Place of Presentation: 大宮
• [Presentation] Current trends and perspectives for in vivo/in vitro researches of environmental chemicals (2007)
  • Author(s): Koibuchi N
  • Organizer: International symposium on the environmental risksof hemicals
  • Place of Presentation: Japan (Invited Speaker)
• [Presentation] PCB, and thyroid hormone action (2007)
  • Author(s): Koibuchi N
  • Organizer: 8th Iternational Workshop on Resistance to Thyroid Hormone and Action
  • Place of Presentation: Ponta Delgada, S. Migruel, Azores, Portugal
• [Presentation] げっ歯類小脳における周産期甲状腺機能低下症による発達異常とその分子機構 (2007)
  • Author(s): 鯉淵典之, 邱春紅, 下川哲昭, 岩崎俊晴
  • Organizer: 第80回日本内分泌学会学術総会シンポジウム「甲状腺ホルモンと脳の発達機構」
  • Place of Presentation: 東京
• [Presentation] 発達期小脳における甲状腺ホルモンの作用 (2007)
  • Author(s): 鯉淵典之, 邱春紅, 宮崎航, 岩崎俊晴, 下川哲昭
  • Organizer: 第84回日本生活生理学会大会シンポジウム「ホルモン標的器官としての小脳」
  • Place of Presentation: 大阪(シンポジウムオーガナイザー)
• [Presentation] 環境化学物質は甲状腺ホルモン受容体のDNA結合ドメインに影響を及ぼす (2007)
  • Author(s): 宮崎航, 岩崎俊晴, 鯉淵典之
  • Organizer: 第84回日本生活生理学会大会
  • Place of Presentation: 大阪
• [Presentation] Thyroid hormone action in the developing brain and its modulation by environmental chemicals (2007)
  • Author(s): Koibuchi N
  • Organizer: 8th CongrAsia and Oceania Thyroid Association
  • Place of Presentation: Manila, Philippine (Symposist)
• [Presentation] Effect of environmental chemicals(environmental hormones) on nuclear hormone receptor signaling.(招待演者) (2007)
  • Author(s): Koibuchi N
  • Organizer: XVI Seminar National Ikatan Ahli Ilmu Faal Indonesia(インドネシア生理学会)
  • Place of Presentation: Bandung,Indonesia
• [Presentation] PCB and thyroid hormone action.(招待演者) (2007)
  • Author(s): Koibuchi N
  • Organizer: 8th International Workshop on Resistance to Thyroid Hormone and Action
  • Place of Presentation: Ponta Delgada,S.Migruel,Azores,Portugal
• [Presentation] The mechanism of thytoid hormone-mediated gene expression in developing brain and its modulation by enVironmental chemicals.(招待演者) (2007)
  • Author(s): Koibuchi N
  • Organizer: 11th IBRO-Asia Pacific Region Committee School of Neuroscience "Hormone, Brain and Behavior"
  • Place of Presentation: Kuala Lumpur,Malaysia
• [Presentation] Current trends and perspectives for in vivo/in vitro researches of environmental chemicals.(招待演者) (2007)
  • Author(s): Koibuchi N
  • Organizer: International symposium on the enVironmental risks of chemicals
  • Place of Presentation: Ohlniya,Japan
• [Presentation] げっ歯類小脳における周産期甲状腺機能低下症による発達異常とその分子機構.(シンポジウムオーガナイザー,シンポジスト) (2007)
  • Author(s): 鯉淵 典之, 邸 春紅, 下川 哲昭, 岩崎 俊晴
  • Organizer: 第80回日本内分泌学会学術総会シンポジウム「甲状腺ホルモンと脳の発達機構」
  • Place of Presentation: 東京
• [Presentation] 発光標識核酸による「タンパク-タンパク-DNA結合」検出のためのin vitroアッセイの開発とそれを用いたER-SMRT結合の解析 (2007)
  • Author(s): 岩崎 俊晴, 六反田 奈和, 宮崎 航, 鯉淵 典之
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 環境化学物質の甲状腺ホルモン受容体のDNA結合領域への作用 (2007)
  • Author(s): 宮崎 航, 岩崎 俊晴, 鯉淵 典之
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] TSH産生腫瘍における骨代謝の特徴 (2007)
  • Author(s): 清水 裕一郎, 田口 学, 竹下 章, 竹内 靖博, 大山 健一, 山田 正三, 宮川 めぐみ
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 原発性副甲状腺機能元進症における術後の骨密度上昇率の予測因子 (2007)
  • Author(s): 田口 学, 三浦 大周, 竹下 章, 竹内 靖博
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 健常成人におけるビタミンD不足の臨床指標としてのintactPTH測定の有用性 (2007)
  • Author(s): 木下 祐加, 田口 学, 竹下 章, 戸来 孝, 米山 彰子, 竹内 靖博
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 乳癌細胞におけるPCBによる核内ホルモン受容体を介する転写の活性化 (2007)
  • Author(s): 小田原 宏樹, 堀口 淳, 岩崎 俊晴, 鯉淵 幸生, 六反田 奈和, 長岡 りん, 宮崎 航, 飯野 佑一, 鯉淵 典之, 竹吉 泉
  • Organizer: 第15回日本乳癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 発達期小脳における甲状腺ホルモン受容体とRORαの相互作用 (2007)
  • Author(s): 邱 春紅, 下川 哲昭, 宮崎 航, 岩崎 俊晴, 鯉淵 典之
  • Organizer: 第34回日本神経内分泌学会
  • Place of Presentation: 前橋
• [Presentation] Malic enzymeプロモーター領域における甲状腺ホルモン転写制御こおけうPCBの影響 (2007)
  • Author(s): 天野 出月, 岩崎 俊晴, 宮崎 航, 下川 哲昭, 鯉淵 典之
  • Organizer: 第50回日本甲状腺学会
  • Place of Presentation: 神戸
• [Presentation] 甲状腺ホルモン受容体及びretinoic acid receptor-related orphan receptor(ROR)を介する転写へのPCBの影響 (2007)
  • Author(s): 岩崎 俊晴, 邱 春紅, 天野 出月, 加藤 雅世, 須田 真千子, マリーナ・ロンドーニョ, 宮崎 航, 下川 哲昭, 鯉淵 典之
  • Organizer: 環境ホルモン学会第10回研究発表会
  • Place of Presentation: 大宮
• [Presentation] 臭素化芳香族化舗による甲状腺ホルモン受容体lrよる転写への影響 (2007)
  • Author(s): Kingsley Ibhazehiebo, 岩崎 俊晴, 宮崎 航, 鯉淵 典之
  • Organizer: 環境ホルモン学会第10回研究発表会
  • Place of Presentation: 大宮
• [Presentation] TRBFC-AAIC-AM-SRAによる新たな核内ホルモン受容体転写制御機構 (2007)
  • Author(s): 岩崎 俊晴, ロンドーニョ マリーナ, 宮崎 航, 下川 哲昭, 鯉淵 典之
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] 鯉淵典之低用量水酸化PCBはPC12細胞において膜電位とCa2+動能を変化させる (2006)
  • Author(s): ロンドーニョマリーナ、下川哲昭、鯉淵典之
  • Organizer: 第9回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] 「タンパク-核酸」結合解析のための新規アッセイ法の樹立 (2006)
  • Author(s): 岩崎俊晴、宮崎航、鯉淵典之
  • Organizer: 第9回環境ホルモン学会研究発表会
  • Place of Presentation: 東京
• [Presentation] Crosstalk between thyroid hormone receptor and retinoid receptor-related orphan receptor (ROR)・, and its modulation by polychlorinated biphenyl (2006)
  • Author(s): Koibuchi N, Qiu C-H, Miyazaki W, Shimokawa N, Iwasaki T
  • Organizer: 36th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Atlanta, GA
• [Presentation] 発達期中枢神経系における甲状腺ホルモン作用の分子基盤 (2006)
  • Author(s): 岩崎俊晴, 鯉淵典之
  • Organizer: 第29回日本神経科学大会シンポジウム「甲状腺ホルモン系と脳発達-環境影響から気分障害まで」
  • Place of Presentation: 京都
• [Presentation] The interaction between TR・1-N-terminus and SRC-1 serves a full transcriptional activation function of SRC-1 (2006)
  • Author(s): Iwasaki T, Takeshita A, Miyazaki W, Koibuchi N
  • Organizer: 88th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston
• [Presentation] TRβ1N末端とSRC-1相互作用 (2006)
  • Author(s): 岩崎俊晴, 竹下彰, 宮崎航, 六反田奈和, 長岡りん, 鯉淵典之
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
• [Presentation] PCBによる脳機能発達の修飾作用 (2006)
  • Author(s): 鯉淵典之
  • Organizer: 第83回日本生理学会大会シンポジウム「環境問題における生理学研究外来性化学物質に対する生体機能の脆弱性」
  • Place of Presentation: 前橋(シンポジスト)
• [Presentation] 甲状腺ホルモンによる能発達の調節機構と環境化学物質による修飾 (2006)
  • Author(s): 鯉淵典之
  • Organizer: 第41回脳のシンポジウム
  • Place of Presentation: 前橋
• [Presentation] Alteration of mRNA levels of neurotrophins and their receptors in decerebellum of Staggerer, an ROR・ mutant mouse. (2005)
  • Author(s): Qiu C, Shimokawa N, Koibuchi N
  • Organizer: 35th Annual Meeting of the Society for Neuroscence
  • Place of Presentation: 2005
• [Presentation] Differential action of PCB and dioxins on TR-mediated transcription : is dioxin more toxic thatn PCB? (2005)
  • Author(s): Iwasaki T, Miyazaki W, Amani I, Rokutanda N, Nagaorka R, Taeshita A, Aoki Y, Tohyama C, Kuroda Y, koibuchi N.
  • Organizer: 35th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington D.C
• [Presentation] Decrease in circadian locomotor activity in congenital hypothyroid rdwrats (2005)
  • Author(s): Yousefi B, Umezu M, Jingu H, Koibuchi N
  • Organizer: 35th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington D.C
• [Presentation] Endocrine disrupters and thyroid hormone interactin (2005)
  • Author(s): Koibuchi N
  • Organizer: The 13th International Thyroid Congress
  • Place of Presentation: Buenos Aires, Argentina. (Symposist)
• [Presentation] 甲状腺ホルモンによる脳発達の調節機構と環境化学物質による修飾機構 (2005)
  • Author(s): 鯉淵典之
  • Organizer: 第78回日本内分泌学会学術総会
  • Place of Presentation: 東京(研究奨励賞受賞講演)
• [Presentation] 環境化学物質の多様性-神経細胞膜への作用と転写の修飾機構シンポジウム「内分泌撹乱物質脳機能-新たな標的としての可能性」 (2005)
  • Author(s): 鯉淵典之
  • Organizer: 第82回日本生理学会大会
  • Place of Presentation: 仙台(オーガナイザー,シンポジスト)
• [Presentation] ゼネラルリプレッサーcoactivator modulator(CoAM)による転写抑制機構 (2005)
  • Author(s): 岩崎俊晴, 宮崎航, Chin Willam W., 鯉淵典之
  • Organizer: 第82回日本生理学会大会
  • Place of Presentation: 仙台
• [Book] 内分泌・栄養・代謝系In : (岡田隆夫編)カラーイラストで学ぶ集中講義生理学 (2008)
  • Author(s): 鯉淵典之
  • Publisher: メジカルビュー
• [Book] カラーイラストで学ぶ集中講義生理学 (2008)
  • Author(s): 岡田隆夫(編)
  • Total Pages: 347
  • Publisher: メジカルビュー
• [Book] 解剖生理学クリアブック (2007)
  • Author(s): 鯉淵 典之, 他
  • Total Pages: 214
  • Publisher: 医学書院
• [Book] 体の内部環境を一定に保つしくみIn : 医学を学ぶ(後藤文雄編) (2006)
  • Author(s): 鯉淵典之
  • Publisher: 南江堂
• [Book] Thyroid hormone action in developing brain and its modulation by polyhalogenated aromatic hydrocarbons. In : C. Kubo, T. Kuboki (eds) (2006)
  • Author(s): Koibuchi N
  • Publisher: Psycho- somatic Medicine, International Congress Series
• [Book] 医学を学ぶ (2006)
  • Author(s): 後藤文夫, 高田邦昭, 鯉淵典之 他
  • Total Pages: 214
  • Publisher: 南江堂
• [Book] 症例問題から学ぶ生理学(鰹淵典之 監訳) (2006)
  • Author(s): Linda S Constanzo著
  • Total Pages: 369
  • Publisher: 丸善株式会社
• [Book] 胎児と新生児の生理学(訳)In : オックスフォード生理学(植村慶一ed.) (2005)
  • Author(s): 鯉淵典之
  • Publisher: 丸善
• [Book] 甲状腺の発達と脳機能-内分泌撹乱の蓋然性-In : 生体統御システムと内分泌撹乱(井口,井上編) (2005)
  • Author(s): 鯉淵典之
  • Publisher: シュプリンガー・フェアラーク東京
• [Book] 生体統御システムと内分泌撹乱 (2005)
  • Author(s): 鯉淵典之
  • Total Pages: 321
  • Publisher: シュプリンガー・フェアラーク東京
• [Patent(Industrial Property Rights)] タンパク質-標的物質の結合検出方法 (2006)
  • Inventor(s): 岩崎俊晴, 鯉淵典之
  • Industrial Property Rights Holder: 岩崎俊晴, 鯉淵典之
  • Filing Date: 2006-03-09