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Elucidation of roles of the nitric oxide synthase system on the basis of the development of mice lacing all nitric oxide synthase isoforms

Research Project

Project/Area Number 17390071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

TSUTSUI Masato  University of Occupational and Environmental Health, Japan, School of Medicine, Department of Pharmacology, Associate Professor (70309962)

Co-Investigator(Kenkyū-buntansha) SHIMOKAWA Hiroaki  Tohoku University Graduate School of Medicine, Deparment of Cardiovascular Medicine, Professor (00235681)
UETA Yoichi  University of Occupational&Environmental Health, Japan, School of Medicine, Department of Physiology, Professor (10232745)
YANAGIHARA Nobuyuki  University of Occupational&Environmental Health, Japan, School of Medicine, Department of Pharmacology, Professor (80140896)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥11,770,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsnitric oxide synthase / genetically engineered mice / arteriosclerosis / myocardial infarction / metabolic syndrome / 一酸化窒素 / ノックアウト / 骨 / マウス / 遺伝子改変 / 尿崩症 / メタボリック症候群
Research Abstract

The nitric oxide synthase (NOS) system consists of three isoforms: neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS). The roles of the NOS system in vivo have been widely studied using non-selective NOS inhibitors. However, since the NOS inhibitors possess multiple non-specific actions, the authentic roles of the NOS system in our body remain to be fully elucidated. To address this issue, we have recently developed the NOS system-deficient mice (triply n/i/eN0S^<-/-> mice) (PNAS 2005).
Although the triply NOS^<-/-> mouse was not embryo-lethal fortunately, survival rate was markedly reduced as compared with wild-type mice. Intriguingly, more than half of the triply NOS4^<-/-> mice died due to spontaneous myocardial infarction associated with severe coronary arteriosclerosis.
Notably, although it is well established that eNOS exerts antiarteriosclerotic effects, and although eNOS^<-/-> mice manifest accumulation of cardiovascular risk factors, eNOS^<-/-> mice do not spontaneous … More ly develop arteriosclerotic vascular lesion formation. This inconsistency is explained by a compensatory mechanism by other NOSs that are not genetically disrupted. Thus, our triply NOS^<-/-> mouse is a powerful experimental tool to solve this problem and to investigate the roles of the NOS system.
The triply NOS^<-/-> mice manifested metabolic syndrome, including visceral obesity, hypertension, hypertriglyceridemia, and impaired glucose tolerance. In addition, the triply NOS mice exhibited left ventricular hypertrophy and diastolic dysfunction. Importantly, an increase in plasma angiotensin II level and upregulation of cardiac angiotensin-converting enzyme were noted in the triply NOS^<-/-> mice, suggesting an involvement of activation of the renin-angiotensin system in the pathogenesis of cardiovascular disorders in the triply NOS^<-/-> mice.
These results provide the first direct evidence that genetic disruption of the whole NOS system causes spontaneous myocardial infarction associated with multiple cardiovascular risk factors of metabolic origin in mice in vivo, demonstrating the critical role of the endogenous NOS system in maintaining cardiovascular homeostasis. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (137 results)

All 2008 2007 2006 2005

All Journal Article (76 results) (of which Peer Reviewed: 34 results) Presentation (60 results) Book (1 results)

  • [Journal Article] Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms2008

    • Author(s)
      Nakata S, et. al.
    • Journal Title

      Circulation 117

      Pages: 2211-2223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo2008

    • Author(s)
      Sabanai K, et. al.
    • Journal Title

      J Bone Miner Res 23

      Pages: 633-643

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats2008

    • Author(s)
      Kamezaki F, et. al.
    • Journal Title

      Am J Respir Crit Care Med 177

      Pages: 219-226

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells2008

    • Author(s)
      Tanimoto A, et. al.
    • Journal Title

      J Biol Chem 283

      Pages: 4643-4651

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase 12 is a factor that accelerates the initiation of atheroscle rosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits2008

    • Author(s)
      Yamada S, et. al.
    • Journal Title

      Am J Pathol 172

      Pages: 1419-1429

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Direct inhibition of N-methyl-D-aspartate (NMDA) receptor function by antiglauco matous beta-antagonists2008

    • Author(s)
      Nagata T, et. al.
    • Journal Title

      J Pharmacol Sci 106

      Pages: 423-434

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Copper,zinc superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole2008

    • Author(s)
      Nii H, et. al.
    • Journal Title

      Mutat Res (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.2008

    • Author(s)
      Nakata S, et. al.
    • Journal Title

      Circulation 117

      Pages: 2211-2223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo : Involvement of the renin-angiotensin system.2008

    • Author(s)
      Sabanai K, et. al.
    • Journal Title

      J Bone Miner Res. 25(5)

      Pages: 633-643

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.2008

    • Author(s)
      Kamezaki F, et. al.
    • Journal Title

      Am J Respir Crit Care Med. 177

      Pages: 219-226

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2 -Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells.2008

    • Author(s)
      Tanimoto A, et. al.
    • Journal Title

      J Biol Chem. 283(8)

      Pages: 4643-4651

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Matrix metalloproteinase 12 is a factor that accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits.2008

    • Author(s)
      Yamada S, et. al.
    • Journal Title

      Am J Pathol. 172

      Pages: 1419-1429

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Direct inhibition of N-methyl-D-aspartate(NMDA) receptor function by antiglaucomatous beta-antagonists.2008

    • Author(s)
      Nagata T, et. al.
    • Journal Title

      J Pharmacol Sci. 106

      Pages: 423-434

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Copper, zinc superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido[1, 2-a:3', 2'-d] imidazole.2008

    • Author(s)
      Nii H, et. al.
    • Journal Title

      Mutat Res(Genet Toxicol Environ Mutagen). (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine Hlreceptor and NF-kB signaling pathway2008

    • Author(s)
      Tanimoto A, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 27

      Pages: 1556-1561

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms2008

    • Author(s)
      Sei Nakata
    • Journal Title

      Circulation(※掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo2008

    • Author(s)
      Sabanai K
    • Journal Title

      Journal of Bone and Mineral Research(※掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kB pathway2007

    • Author(s)
      Nakata S, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 27

      Pages: 92-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine H1 receptor and NF-kB signaling pathway2007

    • Author(s)
      Tanimoto A, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 27

      Pages: 1556-1561

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ApoE gene deficiency enhances the reduction of bone formation induced by a high-fatdiet through the stimulation of p53-mediated apoptosis in osteoblastic cells2007

    • Author(s)
      Hirasawa H, et. al.
    • Journal Title

      J Bone Miner Res 22

      Pages: 1020-1030

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dual effects of daidzein,a soy isoflavone,on catecholamine synthesis and secretion incultured bovine adrenal medullary cells2007

    • Author(s)
      Liu M, et. al.
    • Journal Title

      Endocrinology 148

      Pages: 5348-5354

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of resveratrol,a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells2007

    • Author(s)
      Shinohara Y, et. al.
    • Journal Title

      Biochem Pharmacol 74

      Pages: 1608-1618

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medullary cells by milnacipran2007

    • Author(s)
      Shinkai K, et. al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol 375

      Pages: 65-72

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Capsaicin inhibits catecholamine secretion and synthesis by blocking Na^+ and Ca^<2+> influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells2007

    • Author(s)
      Takahashi K, et. al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol 374

      Pages: 107-116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] NO合成酵素完全欠損マウスの開発2007

    • Author(s)
      筒井 正人, 他
    • Journal Title

      Yakugaku Zasshi 127

      Pages: 1347-1355

    • NAID

      110006380720

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Statin treatment upregutates vascular neuronal nitric oxide synthase through Akt/NF-kB pathway.2007

    • Author(s)
      Nakata S, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 27(1)

      Pages: 92-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells.2007

    • Author(s)
      Hirasawa H, et. al.
    • Journal Title

      J Bone Miner Res 22

      Pages: 1020-1030

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medultary cells.2007

    • Author(s)
      Liu M, et. al.
    • Journal Title

      Endocrinology 148(11)

      Pages: 5348-5354

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of resveratrol, a grape polyphenot, on catecholamine secretion and synthesis in cultured bovine adrenal meduttary cells.2007

    • Author(s)
      Shinohara Y, et. al.
    • Journal Title

      Biochem Pharmacol. 74

      Pages: 1608-1618

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Angiotensin receptor blocker improves coronary flow velocity reserve in hypertensive patients-comparison with calcium channel blocker.2007

    • Author(s)
      Kamezaki F, et. al.
    • Journal Title

      Hypertens Res. 30

      Pages: 699-706

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medutlary cells by milnacipran.2007

    • Author(s)
      Shinkai K, et. al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 375(1)

      Pages: 65-72

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway2007

    • Author(s)
      Sei Nakata
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology 27巻

      Pages: 92-98

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NO合成酵素完全欠損マウスの開発2007

    • Author(s)
      筒井 正人
    • Journal Title

      薬学雑誌 127巻

      Pages: 1347-1355

    • NAID

      110006380720

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway.2007

    • Author(s)
      Sei Nakata
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology 27・1

      Pages: 92-98

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension2006

    • Author(s)
      Suda O, et. al.
    • Journal Title

      J Pharmacol Sci 101

      Pages: 159-165

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis2006

    • Author(s)
      Tasaki H, et. al.
    • Journal Title

      Atherosclerosis 187

      Pages: 131-138

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase2006

    • Author(s)
      Akasaka S, et. al.
    • Journal Title

      Brain Res 1089

      Pages: 1-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomedullary plasma membrane by 17beta-estradiol2006

    • Author(s)
      Yanagihara N, et. al.
    • Journal Title

      Biochem Biophys Res Commun 339

      Pages: 548-553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Crossover trial of intensive monotherapy with atorvastatin and combined therapy with atorvastatin and colestimide for Japanese familial hypercholesterolemia2006

    • Author(s)
      Tasaki H, et. al.
    • Journal Title

      Circ J 70

      Pages: 14-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Development of genetically engineered mice lacking all nitric oxide synthases2006

    • Author(s)
      Tsutsui M, et. al.
    • Journal Title

      J Pharmacol Sci 102

      Pages: 147-154

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Capsaicin inhibits catecholamine secretion and synthesis by blocking Na^+ and Ca^<2+> influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells.2006

    • Author(s)
      Takahashi K, et. al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 374(2)

      Pages: 107-116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension.2006

    • Author(s)
      Suda O, et. al.
    • Journal Title

      J Pharmacot Sci. 101

      Pages: 159-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Heparin-reteased extracettular superoxide dismutase is reduced in patients with coronary artery atherosclerosis.2006

    • Author(s)
      Tasaki H, et. al.
    • Journal Title

      Atherosclerosis 187

      Pages: 131-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The hypothatamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase.2006

    • Author(s)
      Akasaka, et. al.
    • Journal Title

      Brain Res. 1089(1)

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomeduttary plasma membrane by 17beta-estradiol.2006

    • Author(s)
      Yanagihara N, et. al.
    • Journal Title

      Biochem Biophys Res Commun. 339

      Pages: 548-553

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Crossover trial of intensive monotherapy with atorvastatin and combined therapy with atorvastatin and colestimide for Japanese familial hypercholesterotemia.2006

    • Author(s)
      Tasaki H, et. al.
    • Journal Title

      Circ J. 70(1)

      Pages: 14-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of genetically engineered mice lacking all nitric oxide synthases.2006

    • Author(s)
      Tsutsui. M, et. al.
    • Journal Title

      J Pharmacol Sci(Review) 102

      Pages: 147-154

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of genetically engineered mice lacking all three nitric oxide synthases.2006

    • Author(s)
      Masato Tsutsui
    • Journal Title

      Journal of Pharmacological Sciences 102・2

      Pages: 147-154

    • NAID

      10020345313

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension.2006

    • Author(s)
      Osamu Suda
    • Journal Title

      Journal of Pharmacological Sciences 101・2

      Pages: 159-165

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis.2006

    • Author(s)
      Hiromi Tasaki
    • Journal Title

      Atherosclerosis. 187

      Pages: 131-138

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase.2006

    • Author(s)
      Masayoshi Nomura
    • Journal Title

      Brain Res. 1089・1

      Pages: 1-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Stimulation of catecholamine synthesis through unique estrogen receptors in the boving adrenomedullary plasma membrane by 17beta-estradiol.2006

    • Author(s)
      Nobuyuki Yanagihara
    • Journal Title

      Biochem Biophys Res Commun. 339

      Pages: 548-553

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Morishita T, et. al.
    • Journal Title

      Proc Natl Acad Sci USA 70

      Pages: 10616-10621

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis2005

    • Author(s)
      Sasaguri Y, et. al.
    • Journal Title

      Circ Res 96

      Pages: 974-981

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Vascular neuronal nitric oxide synthase is selectively upregulated by platelet-derived growth factor:Involvement of the MEK/ERK pathway2005

    • Author(s)
      Nakata S, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 25

      Pages: 2502-2508

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Granulocyte macrophage-colony stimulating factor increases the expression of histamine and histamine receptors in monocytes/macrophages in relation to arteriosclerosis2005

    • Author(s)
      Murata Y, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 25

      Pages: 430-435

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Extracellular superoxide dismutase overexpression reduces cuff-induced arterial neointimal formation2005

    • Author(s)
      Ozumi K, et. al.
    • Journal Title

      Atherosclerosis 181

      Pages: 265-272

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Stimulation of catecholamine synthesis by environmental estrogenic pollutants2005

    • Author(s)
      Yanagihara N, et. al.
    • Journal Title

      Endocrinology 146

      Pages: 265-272

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells2005

    • Author(s)
      Shinkai K, et. al.
    • Journal Title

      Biochem Pharmacol 70

      Pages: 1389-1397

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus2005

    • Author(s)
      Nomura M, et. al.
    • Journal Title

      Neuroreport 16

      Pages: 413-417

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Selective blockade of nicotinic acetylcholine receptors by pimobendan, a drug for the treatment of heart failure2005

    • Author(s)
      Toyohira Y, et. al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol 371

      Pages: 107-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms.2005

    • Author(s)
      Morishita T, et. al.
    • Journal Title

      Proc Natl Acad Sci USA. 102

      Pages: 10616-10621

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis.2005

    • Author(s)
      Sasaguri Y, et. al.
    • Journal Title

      Circ Res. 96(9)

      Pages: 974-981

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Vascular neuronal nitric oxide synthase is selectively upregulated by platelet-derived growth factor : Involvement of the MEK/ERK pathway.2005

    • Author(s)
      Nakata S, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 25(12)

      Pages: 2502-2508

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Granulocyte macrophage-colony stimulating factor increases the expression of histamine and histamine receptors in monocytes/macrophages in relation to arteriosclerosis.2005

    • Author(s)
      Murata Y, et. al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 25(2)

      Pages: 430-435

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Extracellular superoxide dismutase overexpression reduces cuff-induced arterial neointimal formation.2005

    • Author(s)
      Ozumi K, et. al.
    • Journal Title

      Atherosclerosis 181

      Pages: 55-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Stimulation of catecholamine synthesis by environmental estrogenic pollutants.2005

    • Author(s)
      Yanagihara N, et. al.
    • Journal Title

      Endocrinology 46(1)

      Pages: 265-272

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells.2005

    • Author(s)
      Shinkai K, et. al.
    • Journal Title

      Biochem Pharmacol. 70(9)

      Pages: 1389-1397

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus.2005

    • Author(s)
      Nomura M, et. al.
    • Journal Title

      Neuroreport 16(4)

      Pages: 413-417

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Selective blockade of nicotinic acetytcholine receptors by pimobendan, a drug for the treatment of heart failure : reduction of catecholamine secretion and synthesis in adrenal medullary cells.2005

    • Author(s)
      Toyohira Y, et. al.
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 371(2)

      Pages: 107-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Morishita T, et al.
    • Journal Title

      Proc Natl Acad Sci USA. 102

      Pages: 10616-10621

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Vascular neuronal nitric oxide synthase is selectively upregulated by platelet-derived growth factor2005

    • Author(s)
      Nakata S, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 25

      Pages: 2502-2508

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis2005

    • Author(s)
      Sasaguri Y, et al.
    • Journal Title

      Circ Res 96(6)

      Pages: 974-981

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Granulocyte macrophage-colony simulating factor increases the expression of histamine and histamine receptors in monocytes/macrophages in relation to arteriosclerosis2005

    • Author(s)
      Murata Y, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol 25(2)

      Pages: 430-435

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stimulation of catecholamine synthesis by environmental estrogenic pollutants2005

    • Author(s)
      Yanagihara N, et al.
    • Journal Title

      Endocrinology 146(1)

      Pages: 265-272

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Selective blockade of nicotinic acetylcholine receptors by pimobendan, a drug for the treatment of heart failure2005

    • Author(s)
      Toyohira Y, et al.
    • Journal Title

      Naunyn-Schmiedeberg's Arch Pharmacol 371(2)

      Pages: 107-113

    • Related Report
      2005 Annual Research Report
  • [Presentation] 心血管病とNO:NO合成酵素完全欠損マウスから得られた新知見2008

    • Author(s)
      筒井 正人
    • Organizer
      日本心脈管作動物質学会シンポジウム
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2008-02-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Statin treatment ameliorates metabolic syndrome in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Important role of renin-angiotensin system in the pathogenesis of myocardial infarction in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Abnormal lipoprotein metabolism in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Severe dyslipidemia and lipid-rich atherosclerotic lesion formation in mice lacking all nitric oxide synthases fed a high-cholesterol diet2007

    • Author(s)
      Yatera Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Disruption of whole nitric oxide synthase system causes impaired glucose tolerance and insulin resistance in mice in vivo2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gender difference of arteriosclerotic cardiovascular diseases in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthases system-Lessons from mice lacking all nitric oxide synthase isoforms-2007

    • Author(s)
      Takaki A, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      米国オーランド
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Statin treatment ameliorates metabolic syndrome in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Important role of renin-angiotensin system in the pathogenesis of myocardial infarction in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Abnormal lipoprotein metabolism in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Severe dyslipidemia and lipid-rich atherosclerotic lesion formation in mice lacking all nitric oxide synthases fed a high-cholesterol diet2007

    • Author(s)
      Yatera Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] aL Disruption of whole nitric oxlde synthase system causes impaired glucose tolerance and insulin resistance in mice in vivo2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Gender difference of arteriosclerotic cardiovascular diseases in mice lacking all nitric oxide synthase isoforms2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthases system-Lessons from mice lacking all nitric oxide synthase isoforms-2007

    • Author(s)
      Takaki A, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2007
    • Place of Presentation
      Orlando, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Abnormal behaviors of mice lacking all nitric exide synthase isofbrms2007

    • Author(s)
      Yanagihara N, et. al.
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Abnormal behaviors of mice lacking all nitric exide synthase isofbrms2007

    • Author(s)
      Yanagihara N, et. al.
    • Organizer
      The 71st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dyslipidemia lipid-rich atherosclerotic lesion formation, and sudden death in mice lacking all nitric oxide synthases fed a high-cholesterol diet2007

    • Author(s)
      Yatera Y, et. al.
    • Organizer
      The 71st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases2007

    • Author(s)
      Yamamoto K, et. al.
    • Organizer
      The 71st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hyper-10w-density-lipoproteinemia in mice lacking all nitric oxide synthases2007

    • Author(s)
      Nakata S, et. al.
    • Organizer
      The 71st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthases system -Lessons from mice lacking all nitric oxide synthase isoforms-2007

    • Author(s)
      Takaki A, et. al.
    • Organizer
      The 71st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Derivatives of reactive oxygen species metabolites correlated with high-sensitivity C-reaetive protein2007

    • Author(s)
      Kamezaki F, et. al.
    • Organizer
      The 71st Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic disruption of all nitric oxide synthase isoforms markedly reduces survivaldue to myocardial infarction in male mice2006

    • Author(s)
      Morishita T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Metabolic syndrome in mice lacking all nitric oxide synthase isoforms2006

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Accelerated vascular lesion formation in mice lacking all nitric oxide synthases in vivo2006

    • Author(s)
      Morishita T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases2006

    • Author(s)
      Shibata K, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hyper-low-density-lipoproteinemia in mice lacking all nitric oxide synthases2006

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Severe dyslipidemia,lipid-rich atherosclerotic lesion formation,and sudden death in mice lacking all nitric oxide synthases fed a high cholesterol diet2006

    • Author(s)
      Yatera Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Long-term treatment with an angiotensin II type 1 receptor blocker ameliorates metabolic syndrome in mice lacking all nitric oxide synthases2006

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthases system-Lessons from mice lacking all nitric oxide synthase isoforms-2006

    • Author(s)
      Takaki A, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      米国シカゴ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of mice lacking all nitric oxide synthase isoforms2006

    • Author(s)
      Tsutsui M
    • Organizer
      The 15th International Union of Pharmacology (IUPHAR)Congress
    • Place of Presentation
      中国北京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic disruption of all nitric oxide synthase isoforms markedly reduces survival due to myocardial infarction in male mice2006

    • Author(s)
      Morishlta T, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Metabolic syndrome in mice lacking all nitric oxide synthase isoforms2006

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Accelerated vascular lesion formation in mice lacking all nitric oxjde synthases in vjvo2006

    • Author(s)
      Morishita T, et. al.
    • Organizer
      J American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases2006

    • Author(s)
      Shibata K, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Severe dyslipidemia, lipid-rich atherosclerotic lesion formation, and sudden death in mice lacking all nitric oxide synthases fed ahigh cholesterol diet2006

    • Author(s)
      Yatera Y, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Long-term treatment with an angiotensin II type l receptor blocker ameliorates metabolic syndrome in mice lacking all nitric oxide synthases2006

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthases system -Lessons from mice lacking all nitric oxide svnthase isoforms-2006

    • Author(s)
      Takaki A, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2006
    • Place of Presentation
      Chicago, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Angiotensin Receptor Blocker lmproves Coronary Flow Velocity Reserve in Hypertensive Patient2006

    • Author(s)
      Kamezaki F, et. al.
    • Organizer
      The 21st Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Fukuok, Janan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic disruption of all nitric oxide synthase isoforms abolishes EDHF-mediated responses in mice2006

    • Author(s)
      Takaki A, et. al.
    • Organizer
      The 21st Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Fukuok, Janan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic disruption of all nitric oxide synthase isoforms enhances bone turnover and bone mineral density in mice in vivo2006

    • Author(s)
      Sabanai K, et. al.
    • Organizer
      The 21st Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Fukuok, Janan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of mice lacking all nitric oxide synthase lsofbrms2006

    • Author(s)
      Tsutsui M
    • Organizer
      The 15th lnternational Union of Pharmacology(IUPHAR) Congress
    • Place of Presentation
      Beijing, China
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Metabolic syndrome in mice lacking all nitric oxide synthase isoforms2006

    • Author(s)
      Nakata S, et. al.
    • Organizer
      The 70th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous development of systemic arteriosclerosis in mice lacking all nitric oxide synthase isoforms2006

    • Author(s)
      Tsutsui M, et. al.
    • Organizer
      The 70th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Vasculoprotectjve Role of the Nitric Oxide Synthases System against Vascular Lesion Formation in Mice in Vivo2006

    • Author(s)
      Morishita T, et. al.
    • Organizer
      The 70th Annual Scientific Meeting ofthe Japanese Circulation Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic Disruptlon of All Nitric Oxide Synthase Isoforms Markedly Reduces Survival in Mice2006

    • Author(s)
      Morishita T, et. al.
    • Organizer
      The 70th Annual Scientific Meeting ofthe Japanese Circulation Society
    • Place of Presentation
      Nagoya, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Atorvastatin upregulates vascular neuronal nitric oxide synthase through the Akt/NF-κB pathway2005

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2005
    • Place of Presentation
      米国ダラス
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A new animal model of multiple risk factor syndrome:Mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Nakata S, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2005
    • Place of Presentation
      米国ダラス
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous development of systemic arteriosclerosis in mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Nagasaki M, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2005
    • Place of Presentation
      米国ダラス
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic disruption of all nitric oxide synthase isoforms abolishes EDHF-mediated responses in mice2005

    • Author(s)
      Tekes E, et. al.
    • Organizer
      American Heart Association Scientific Sessions 2005
    • Place of Presentation
      米国ダラス
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Atorvastatin upregulates vascular neuronal nitric oxide synthase through the Akt/NF-kB pathway2005

    • Author(s)
      Nakata S, et. al.
    • Organizer
      The American Heart Association, Scientific Sessions 2005
    • Place of Presentation
      Dallas USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A new animal model of multiple risk factor syndrome : Mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Nakata S, et. al.
    • Organizer
      The Amerlcan Heart Association, scientitic Sessions 2005
    • Place of Presentation
      Dallas, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Spontaneous development of systemic arteriosclerosis in mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Nagasaki M, et. al.
    • Organizer
      The Amerlcan Heart Association, scientitic Sessions 2005
    • Place of Presentation
      Dallas, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic disruption of all nitric oxide synthase isoforms abolishes EDHF-mediated responses in mice2005

    • Author(s)
      Tekes E, et. al.
    • Organizer
      The Amerlcan Heart Association, scientitic Sessions 2005
    • Place of Presentation
      Dallas, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The involvement of nitric oxide synthase in EDHF-mediated responses in mice2005

    • Author(s)
      Tekes E, et. al.
    • Organizer
      The Amerlcan Heart Association, scientitic Sessions 2005
    • Place of Presentation
      Dallas, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms2005

    • Author(s)
      Morishita T, et. al.
    • Organizer
      The 69th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Vascular neuronal nitric oxide synthase expression is upregulated in response to platelet-derived growth factor through the MEK/ERK pathway2005

    • Author(s)
      Nakata S, et. al.
    • Organizer
      The 69th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Atorvastatin upregulates vascular neuronal nitric oxide synthase expression through the Akt/NF-kB pathway2005

    • Author(s)
      Nakata S, et. al.
    • Organizer
      The 69th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cuff-induced neointimal formation is reduced by extracellular superoxide dismutase2005

    • Author(s)
      Ozumi K, et. al.
    • Organizer
      The 69th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Upregulation ofvascular superoxide dismutase in patients with congestive heart failure2005

    • Author(s)
      Miyamoto M, et. al.
    • Organizer
      The 69th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 動脈硬化:最新の基礎と臨床2006

    • Author(s)
      筒井 正人, 他
    • Publisher
      永井書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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