Molecular bases of cerebral cortical development controlled by Cajal-Retzius cells

• Project/Area Number: 17390086
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Osaka University (2007-2008); Mitsubishi Kagaku Institute of Life Sciences (2005-2006)
• Principal Investigator: TANABE Yasuto Osaka University, 大学院・生命機能研究科, 准教授 (10311309)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Fujio 大阪大学, 大学院・生命機能研究科, 教授 (20089882)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,980,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥1,680,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000); Fiscal Year 2005: ¥4,500,000 (Direct Cost: ¥4,500,000)
• Keywords: 分子・細胞神経科学 / 発生 / 大脳皮質 / 皮質投射ニューロン / 神経細胞 / 細胞移動 / 分化 / 神経細胞分化 / 細胞分裂 / Cajal-Retzius細胞

Research Abstract

本研究課題においては、Cajal-Retzius細胞によって発生制御を受ける皮質投射ニューロンに発現されている転写因子Meis2に主眼をおいて解析を進めてきた。これまでの解析結果から、転写因子Meis2は皮質構築過程において(A)神経細胞への運命決定・分化(B)神経細胞の脳室帯から皮質板への細胞移動調節(C)皮質前駆細胞の細胞分裂調節のおもに3つの発達素過程に重要な役割を果たすことを明らかにした。

Research Products

• [Journal Article] Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing (2008)
  • Author(s): Atsushi Tamada, Tatsuro Kumada, Yan Zhu, Tomoko Matsumoto, Yumiko Hatanaka, Keiko Muguruma, Zhe Chen, Yasuto Tanabe, Makio Torigoe, Kenta Yamauchi, Hiroshi Oyama, Kazuhiko Nishida, Fujio Murakami
  • Journal Title: Neural Development 3,9
  • Peer Reviewed
• [Journal Article] Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing (2008)
  • Author(s): Tamada A., et al
  • Journal Title: Neural Development 8 Pages: 29-46
  • Peer Reviewed
• [Journal Article] Cajal-Retzius 細胞と大脳皮質形成 (2005)
  • Author(s): 田辺康人
  • Journal Title: 脳21 8 Pages: 240-245
• [Presentation] Transcriptional Control of Neocortical Neurogenesis by TALE-family Homeodomain Factor, Meis 2 (2009)
  • Author(s): Yasuto Tanabe
  • Organizer: 国際シンポジウム
  • Place of Presentation: Awaji Yumebutai (兵庫)
  • Year and Date: 2009-10-09
• [Presentation] Meis2 activities in the control of three distinct developmental steps during the corticogenesis (2008)
  • Author(s): Yasuto Tanabe
  • Organizer: 国際シンポジウム
  • Place of Presentation: 神戸理研 (神戸)
  • Year and Date: 2008-03-24
• [Presentation] Meis2 転写因子の大脳皮質発達素過程における機能的役割 (2008)
  • Author(s): 田辺康人
  • Organizer: 「大脳皮質の発生と可塑性」基礎生物学研究所研究会
  • Place of Presentation: 基礎生物学研究所 (岡崎)
  • Year and Date: 2008-03-07
• [Presentation] Meis2 activities in the control of three distinct developmental steps during the corticogenesis (2007)
  • Author(s): 田辺康人
  • Organizer: 第30回日本神経科学学会
  • Place of Presentation: パシフィコ横浜 (横浜)
  • Year and Date: 2007-09-11
• [Presentation] Meis2 activities in the control of three distinct developmental steps during the corticogenesis (2007)
  • Author(s): 田辺康人
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] Characterization of Cajal-Retzius Cell Development in the Cerebral Cortex (2006)
  • Author(s): 田辺康人
  • Organizer: シンポジウム招待講演「大脳皮質の発生と機能構築」基礎生物学研究所研究会
  • Place of Presentation: 基礎生物学研究所 (岡崎)
  • Year and Date: 2006-03-17
• [Presentation] Development of Cajal-Retzius Cells in the Cerebral Cortex (2006)
  • Author(s): Yasuto Tanabe
  • Organizer: 国際シンポジウム招待講演
  • Place of Presentation: 慶慮義塾大学 (東京)
  • Year and Date: 2006-01-30
• [Presentation] Ontogenic and Molecular Characterization of Cajal-Retzius Cells in the Developing Cerebral Cortex (2005)
  • Author(s): Yasuto Tanabe
  • Organizer: 国際シンポジウム招待講演
  • Place of Presentation: 大阪大学 (大阪)