Investigation into the pathogenesis of amyloidosis using the newly developed animal models.

• Project/Area Number: 17390111
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Shinshu University
• Principal Investigator: HIGUCHI Keiichi Shinshu University, Graduate School of Medicine, Professor (20173156)
• Co-Investigator(Kenkyū-buntansha): MORI Masayuki Shinshu University, Graduate School of Medicine, Associate Professor (60273190) ; SAWASHITA Jinko Shinshu University, Graduate School of Medicine, Assistant Professor (40359732) ; MAEDA Shuichiro University of Yamanashi, Interdisciplinary Graduate School of Medicine and Engineering, Professor (10117244)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥15,630,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥1,230,000); Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2006: ¥4,400,000 (Direct Cost: ¥4,400,000); Fiscal Year 2005: ¥5,900,000 (Direct Cost: ¥5,900,000)
• Keywords: Model animals / Amyloidosis / Transmission / Mouse / Inflammation / Fibril conformation / ApoA-II / Dialysis / モデルマウス / AApoAII / FAP / AAアミロイドーシス / 透析アミロイドーシス

Research Abstract

The amyloidosis is a group of protein misfolding disorders characterized by the accumulation of amyloid fibrils formed from a variety of proteins that, under normal physiological conditions, are harmless and soluble. Here we investigate into the pathogenesis of the transmission/infection of amyloidosis using newly developed animal models of amyloidosis. We used mouse models for AApoAII amyloidosis, ATTR (familial amyloid polyneuropathy; FAP) amyloidosis, AA(reactive) amyloidosis, AB2M (dialysis) amyloidosis and cheetah AA amyloidosis. We developed a new transgenic mouse strain, Apoa2^cTg, Apoa2^c/c which over-expressed amyloidogenic Apoa2^c gene. These strain mice showed very high susceptibility to the injection of exogenous amyloid fibrils. AA amyloidosis is one of the principal causes of mortality in captive cheetahs (Acinonyx jubatus), which are in danger of extinction, We found that show the feces from a cheetah with AA amyloidosis can act as a possible origin to accelerate the transmission of AA amyloidosis. We also tried to induce amyloidosis by the injection of ATTR amyloid fibrils in the transgenic mouse strain (TTRMet30rg, mTtr-/-) which expressed TTR variant of FAP patients. We found that seeding/transmission effect of the amyloid fibrils was not obvious in ATTR deposition in the tissues, but deposition of other amyloid fibrils (ex. AApoAII or AA) induced ATTR deposition. We developed a new transgenic mouse strain (hβ2MTg+/+, mβ2m-/-) which over-expresses human β2 microglobulin (β2M), and is deficient in endogenous β2m gene. Up to date, Aβ2M deposition could not be detected even after the induction by injection with Aβ2M amyloid fibrils. We found that over-expression of heat shock proteins prevented development of AApoAII amyloidosis using HSF1 (heat shock factor 1) transgenic mice. We also investigated the effect of inflammation on amyloidosis using interleukin 6 deficient mice.

Research Products

• [Journal Article] Amyloidosis in transgenic mice expressing murine amyloidgenic apolipo-protein A-II(Apoa2^c). (2007)
  • Author(s): Ge F, et. al.
  • Journal Title: Lab Invest 87(7) Pages: 633-643
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils(AApoAII)and protein A amyloid fibrils(AA). (2007)
  • Author(s): Yan J, et. al.
  • Journal Title: Am J Pathol 171(1): Pages: 172-180
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional polymorphisms of the LSS and Fdftl genes in laboratory rats. (2007)
  • Author(s): Mori M, et. al.
  • Journal Title: Exp Anim 56(2) Pages: 93-101
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice. (2007)
  • Author(s): Otsuki B, et. al.
  • Journal Title: J Bone Miner Res 22(5) Pages: 675-685
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] アミロイドーシスの伝播. (2007)
  • Author(s): 樋口 京一
  • Journal Title: 細胞工学 26(2) Pages: 177-180
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] アミロイドーシスの発症の分子的機構解明を目指して:現状と展望,夢 (2007)
  • Author(s): 後藤 祐児, 他
  • Journal Title: 細胞工学 26(2) Pages: 181-185
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2^c) (2007)
  • Author(s): Ge, F., Yao, J., Fu, X., Guo, Z., Yan, J., Zhang, B., Zhang, H., Tomozawa, H., Miyazaki, J., Jinko, Sawashita, J., Mori, M., Higuchi, K
  • Journal Title: Lab Invest 87(2) Pages: 633-643
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils (AApoAII) and protein A amyloid fibrils (AA) (2007)
  • Author(s): Yan, I., Fu, X., Ge, F., Zhang, B., Yao, J., Zhang, H., Qian, J., Tomozawa, H., Naiki, H., Sawashita, J., Mori, M., Higuchi, K
  • Journal Title: Am J Pathol 171(1) Pages: 172-180
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional Polymorphisms of the LSS and Fdft1 genes in laboratory rats (2007)
  • Author(s): Mori, M., Sawashita, J., Higuchi, K
  • Journal Title: Exp Anim 56(2) Pages: 93-101
  • NAID: 130000068039
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Quantitative Trait Locus that Determines the Cross-sectional Shape of the Femur in SAMP6 and SAMP2 mice (2007)
  • Author(s): Otsuki, B., Matsumura, T., Shimizu, M., Mori, M., Okudaira, S., Nakanishi, R., Higuchi, K., Hosokawa, M., Tsuboyama, T., Nakamura, T
  • Journal Title: J Bone Miner Res 22(5) Pages: 675-685
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transmission of amyloidosis. (Japanese) (2007)
  • Author(s): Higuchi, K
  • Journal Title: Cell Technology 26(2) Pages: 177-180
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elucidation of molecular mechanism of amyloidosis : the present, future, and dream. (Japanese) (2007)
  • Author(s): Goto, Y., Kuwata, K., Sekishima, Y., Tanaka, M., Naiki, H., Nagai, Y., Matsuzaki, K., Higuchi, K
  • Journal Title: Cell Technology 26(2) Pages: 181-1185
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mouse senile amyloidosis : possible horizontal transmission in the mouse room (2007)
  • Author(s): Fu, X., Korenaga, T., Yan, J., Ge, F., Zhan, B., Qian, J., Naiki, H., Sawashita, J., Mori, M., Higuchi, K
  • Journal Title: in "XIth International Symposium on Amyloidosis". (Skinner M, Berk JL, Connors LH, Seldin DC eds) CRC Press Boca Raton, FL USA Pages: 10-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amyloidosis in the transgenic mice of mouse amyloidgenic apolipoprotein A-II (Apoa2^c) (2007)
  • Author(s): Higuchi, K., Ge, F., Fu, X., Yao, J., Zhan, B., Zhan, H., Qian, J., Sawashita, J., Mori, M.
  • Journal Title: in "XIth International Symposium on Amyloidosis". (Skinner M, Berk JL, Connors LH, Seldin DC eds) CRC Press Boca Raton, FL USA Pages: 143-145
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amyloidosis in transgenic mice expressing muuine amyloidgenic apolipoprotein A-II(Apoa2^c). (2007)
  • Author(s): Ge F, Yao J, Fu X, Guo Z, Yan J, Zhang B, Zhang H, Tomozawa H, Miyazaki J, Sawashita J, Mori M, Higuchi K.
  • Journal Title: Lab Invest 87(7) Pages: 633-643
  • Peer Reviewed
• [Journal Article] Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloidfibrils(AApoAII)and proteom A amyloid fibrils(AA). (2007)
  • Author(s): Yan J, Fu X, Ge F, Zhang B, Yao J, Zhang H, Qian J, Tomozawa H, Naiki H, Sawashita J, Mori M, Higuchi K.
  • Journal Title: Am J Pathol 171(1): Pages: 172-180
  • Peer Reviewed
• [Journal Article] Functional Polymorphisms of the LSS and Fdft1 genes in laboratory rats. (2007)
  • Author(s): Mori M, Sawashita J, Higuchi K.
  • Journal Title: Exp Anim 56(2) Pages: 93-101
  • NAID: 130000068039
  • Peer Reviewed
• [Journal Article] Quantitative Trait Locus that Determines the Cross-sectional Shape of the Femur in SAMP6 and SAMP2 mice. (2007)
  • Author(s): Otsuki B, Matsumura T, Shimizu M, Mori M, Okudaira S, Nakanishi R, Higuchi K, Hosokawa M, Tsuboyama T, Nakamura T.
  • Journal Title: J Bone Miner Res 22(5) Pages: 675-685
  • Peer Reviewed
• [Journal Article] Amyloidosis in trangenic mice expressing murine amyloidogenic apolipoprotein A-II(Apoa2^c). (2007)
  • Author(s): Ge F, Yao J, Fu X, Guo Z, Yan J, Zhang B, Zhang H, Tomozawa H, Miyazaki J, Sawashita J, Mori M, Higuchi K.
  • Journal Title: Lab Invest (in press)
• [Journal Article] Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils (AApoAII) and protein A amyloid fibrils(AA). (2007)
  • Author(s): Yan J, Fu X, Zhang B, Yao J, Zhang H, Qian J, Tomozawa H, Naiki H, Sawashita J, Mori M, Higuchi K.
  • Journal Title: Am J Pathol (in press)
• [Journal Article] アミロイドーシスの伝播 (2007)
  • Author(s): 樋口京一
  • Journal Title: 細胞工学 26・2 Pages: 177-180
• [Journal Article] Transmissibility of mouse AApoAII amyloid fibrils: Inactivation by physical and chemical methods. (2006)
  • Author(s): Zhang H, et. al.
  • Journal Title: FASEB J 20(7) Pages: 1012-1014
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. (2006)
  • Author(s): Yan J, et. al.
  • Journal Title: Exp Gerontol 41(2) Pages: 130-140
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. (2006)
  • Author(s): Korenaga T, et. al.
  • Journal Title: Am J Pathol 168(3) Pages: 898-906
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Lanosterol synthase mutations cause cholesterol deficiency-associated cataractsin the Shumiya cataract rat. (2006)
  • Author(s): Mori M, et. al.
  • Journal Title: J Clin Invest 116(2) Pages: 395-404
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transmissibility of mouse AApoAII amyloid fibrils : inactivation by physical and chemical methods (2006)
  • Author(s): Zhang, H., Sawashita, J., Fu, X., Korenaga, T., Yan, J., Mori, M., Higuchi, K
  • Journal Title: FASEB J 20(7) Pages: 1012-1014
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice (2006)
  • Author(s): Yan, J., Fujii, K., Yao, J., Kishida, H., Hosoe, K., Sawashita, J., Takeda, T., Mori, M., Higuchi, K
  • Journal Title: Exp Gerontol 41(2) Pages: 130-140
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transmission of amyloidosis in offspring of mice with A ApoAII amyloidosis (2006)
  • Author(s): Korenaga, T., Yan, T., Sawashita, J., Matsusita, T., Naiki, H., Hosokawa, M., Mori, M., Higuchi, K., Fu, X
  • Journal Title: Am J Pathol 168(3) Pages: 898-906
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat (2006)
  • Author(s): Mori, M., Li, G., Abe, I., Nakayama, J., Guo, Z., Sawashita, J., Ugawa, T., Nishizono, Serikawa, T., Higuchi, K., Shumiya, S
  • Journal Title: J Clin Invest 116(2) Pages: 395-404
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transmissibility of mouse AApoAII amyloid fibrils : inactivation by physical and chemical methods. (2006)
  • Author(s): Zhang H, Sawashita J, Fu X, Korenaga T, Yan J, Mori M, Higuchi K.
  • Journal Title: FASEB J 20・7 Pages: 1012-1014
• [Journal Article] Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. (2006)
  • Author(s): Yan J, Fujii K, Yao J, Kishida H, Hosoe K, Sawashita J, Takeda T, Mori M, Higuchi K.
  • Journal Title: Exp Gerontol 41・2 Pages: 130-140
• [Journal Article] Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. (2006)
  • Author(s): Korenaga T, Yan J, Sawashita J, Matsusita T, Naiki H, Hosokawa M, Mori M, Higuchi K, Fu X.
  • Journal Title: Am J Pathol 168・3 Pages: 898-906
• [Journal Article] Transmissibility of mouse AApoAII amyloid fibrils : inactivation by physical and chemical methods. (2006)
  • Author(s): Zhang H, Sawashita J, Fu X, Korenaga T, Yan J, Mori M, Higuchi K.
  • Journal Title: FASEB J 印刷中
• [Journal Article] Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis. (2006)
  • Author(s): Korenaga T, Yan J, Sawashita J, Matsusita T, Naiki H, Hosokawa M, Mori M, Higuchi K, Fu X.
  • Journal Title: Am J Pathol 168(3) Pages: 898-906
• [Journal Article] Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat. (2006)
  • Author(s): Mori M, Li G, Abe I, Nakayama J, Guo Z, Sawashita J, Ugawa T, Nishizono S, Serikawa T, Higuchi K, Shumiya S.
  • Journal Title: J Clin Invest 116(2) Pages: 395-404
• [Journal Article] Unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan. (2005)
  • Author(s): Tojo K, et. al.
  • Journal Title: Amyloid 12(2) Pages: 103-108
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A locus for eosinophilia in the MES rat is on Chromosome 19. (2005)
  • Author(s): Li G, et. al.
  • Journal Title: Mamm Genom 16(7) Pages: 516-523
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 制御不能タンパク質が引き起こす病態 (2005)
  • Author(s): 樋口 京一
  • Journal Title: 実験医学 23 Pages: 167-173
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan (2005)
  • Author(s): Tojo, K., Tokuda, T., Hoshii, Y., Fu, X., Higuchi, K., Matsui, T.,Kametani, F., Ikeda, S
  • Journal Title: Amyloid 12(2) Pages: 103-108
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A locus for eosinophilia in the MES rat is on Chromosome 19 (2005)
  • Author(s): Li, G., Guo, Z., Higuchi, K., Kawakubo, M., Matsumoto, K., Mori, M
  • Journal Title: Mamm Genome 16(7) Pages: 516-523
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Degenerative disorders caused by uncontrollable conformation of proteins. (Japanese) (2005)
  • Author(s): Higuchi, K
  • Journal Title: Experimental Medicine 23(15) Pages: 167-173
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transmission of Mouse AApoAII Amyloidosis by the Amyloid Fibrils ; Inhibitory Effects on Transmission by the Denaturation / Degradation of Amyloid Fibrils (2005)
  • Author(s): Sawashita, J., Zhang, H., Fu, X., Korenaga, T., Mori, M., Higuchi, K
  • Journal Title: In "Amyloid and Amyloidosis" (Grateau G, Kyle RA, Skinner M eds) CRC Press, Boca Raton USA Pages: 457-459
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transmission of Mouse AApoAII Amyloidosis from Mother to Pups (2005)
  • Author(s): Korenaga, T., Fu, X., Mori, M., Sawashita, J., Naiki, H., Matsushita, T., Higuchi, K
  • Journal Title: In "Amyloid and Amyloidosis" (Grateau G, Kyle RA, Skinner M eds.), CRC Press, Boca Raton USA Pages: 460-462
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Amyloidosis and transmission. (Japanese) (2005)
  • Author(s): Higuchi, K., Fu, X
  • Journal Title: In "Basic and Clinical Medicine of Amyloidosis" (Ikeda S, Ishihara T, eds), Kanehara-shuppan, Tokyu, Japan Pages: 82-87
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Mouse senile amyloidosis. (Japanese) (2005)
  • Author(s): Higuchi, K
  • Journal Title: In "Basic and Clinical Medicine of Amyloidosis" (Ikeda S, Ishihara T, eds), Kanehara-shuppan, Tokyu, Japan Pages: 197-202
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan. (2005)
  • Author(s): Tojo K, Tokuda T, Hoshii Y, Fu X, Higuchi K, Matsui T, Kametani F, Ikeda S.
  • Journal Title: Amyloid 12(2) Pages: 103-108
• [Journal Article] Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. (2005)
  • Author(s): Yan J, Fujii K, Yao J, Kishida H, Hosoe K, Sawashita J, Takeda T, Mori M, Higuchi K.
  • Journal Title: Exp Gerontol 41(2) Pages: 130-140
• [Journal Article] A locus for eosinophilia in the MES rat is on Chromosome 19. (2005)
  • Author(s): Li G, Guo Z, Higuchi K, Kawakubo M, Mtsumoto K, Mori M.
  • Journal Title: Mamm Genom 16(7) Pages: 516-523
• [Presentation] ブドウ種子由来ポリフェノールのアミロイドーシス発症抑制効果の解析 (2007)
  • Author(s): 川上 佳紀、 他
  • Organizer: 第30回日本分子生物学会年会、第80回日本生化学会合同大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of the preventive effect of polyphenols of grape seeds against amyloidosis (Japanese) (2007)
  • Author(s): Kawakami, Y., et. al.
  • Organizer: 30th Annual Meeting of the Molecular Biology Society of Japan and 80th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Yokohama Japan
  • Year and Date: 2007-12-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] マウス老化アミロイドーシスでの骨格筋へのアミロイド沈着 (2007)
  • Author(s): 銭 金澤, 他
  • Organizer: 第2回臨床ストレス応答学会大会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-11-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Amyloid deposition in the muscle in mouse AApoAII amyloidosis. (Japanese) (2007)
  • Author(s): Quin, J., et. al.
  • Organizer: 2nd Annual Meeting of the Biomedical Society for Stress Response
  • Place of Presentation: Fukuoka Japan
  • Year and Date: 2007-11-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Senescence-Accelerated Mouse (SAM) strains have a spontaneous mutation in the Abcbla gene. (Japanese) (2007)
  • Author(s): Zhang, G., et. al.
  • Organizer: 24th Annual Meeting of the Japanese Society of Animal Models for Human Diseases
  • Place of Presentation: Tsukuba Japan
  • Year and Date: 2007-09-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] SAM系マウスは多剤耐性Abcbla遺伝子に機能喪失突然変異を持つ (2007)
  • Author(s): 張 国紅、 他
  • Organizer: 第24回日本疾患モデル学会総会
  • Place of Presentation: つくば市
  • Year and Date: 2007-09-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アミロイドーシス発症要因としての伝播 (2007)
  • Author(s): 樋口 京一
  • Organizer: 厚生労働省科学研究費補助金・難治性疾患克服研究事業、アミロイドーシスに関する調査研究班、アミロイドーシスの画期的診断・治療法に関する研究班 夏のワークショップ2007
  • Place of Presentation: 宇部市
  • Year and Date: 2007-08-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Transmission of Amyloidosis. (Japanese) (2007)
  • Author(s): Higuchi, K
  • Organizer: 2007 Summer Workshop of Research Committees for Amyloidosis and for Epochal Diagnosis and Treatment of Amyloidosis in Japan in Intractable Disease Division, the Ministry of Health, Labor and Welfare
  • Place of Presentation: Ube. Japan
  • Year and Date: 2007-08-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] マウス老化アミロイドーシスでの骨格筋へのアミロイド沈着 (2007)
  • Author(s): 銭 金澤, 他
  • Organizer: 第22回老化促進モデルマウス研究協議会
  • Place of Presentation: 酒田市
  • Year and Date: 2007-07-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Apolipoprotein A-IIの多型とマウス老化アミロイドーシス:Apoa2 congenic マウスを用いた解析 (2007)
  • Author(s): 張 倍茹、 他
  • Organizer: 第22回老化促進モデルマウス研究協議会
  • Place of Presentation: 酒田市
  • Year and Date: 2007-07-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Amyloid deposition in the muscle in mouse senile amyloidosis. (Japanese) (2007)
  • Author(s): Quin, J., et. al.
  • Organizer: 22th Annual Meeting of the Council for SAM Research
  • Place of Presentation: Sakata Janan
  • Year and Date: 2007-07-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Amyloidosis and polymorphism of apolipoprotein A-II. (Japanese) (2007)
  • Author(s): Zhang, B., et. al.
  • Organizer: 22th Annual Meeting of the Council for SAM Research
  • Place of Presentation: Sakata Japan.
  • Year and Date: 2007-07-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Apolipoprotein A-II の多型とマウス老化アミロイドーシス:Apoa2fcongenicマウスを用いた解析 (2007)
  • Author(s): 張 倍茄、他
  • Organizer: 第22回老化促進モデルマウス研究協議会
  • Place of Presentation: 酒田市
  • Year and Date: 2007-07-26
• [Presentation] チーターのAAアミロイドーシス (2007)
  • Author(s): 樋口京一、 他
  • Organizer: 第51回日本実験動物学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cheetah AA amyloidosis. (Japanese) (2007)
  • Author(s): Higuchi, K., et. al.
  • Organizer: 51th Conference for Laboratory Animal Science
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2007-05-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Reduced Coenzyme Q10 supplementation decelerates senescence insenescence accelerated SAMP1 mice. (2007)
  • Author(s): Higuchi K
  • Organizer: 5th Conference of International Coenzyme Q10 Association.
  • Place of Presentation: Kobe, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Reduced Coenzyme Q10 supplementation decelerates senescence in senescence accelerated SAMP1 mice (2007)
  • Author(s): Higuchi, K
  • Organizer: 5th Conference of International Coenzyme Q10 Association
  • Place of Presentation: Kobe, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] チーターのAAアミロイドーシス (2006)
  • Author(s): 張 倍茹、 他
  • Organizer: 第1回臨床ストレス応答学会
  • Place of Presentation: 京都市
  • Year and Date: 2006-11-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis: Possible horizontal transmission in the mouse room. (2006)
  • Author(s): Fu X, et. al.
  • Organizer: XIth International Symposium on Amyloidosis
  • Place of Presentation: Woods Hole, USA
  • Year and Date: 2006-11-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Amyloidosis in the transgenic mice of mouse amyloidogenic apolipoprotein A-II(Apoa2c). (2006)
  • Author(s): Higuchi K, et. al.
  • Organizer: XIth International Symposium on Amyloidosis
  • Place of Presentation: Woods Hole, USA
  • Year and Date: 2006-11-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis : Possible horizontal transmission in the mouse room (2006)
  • Author(s): Fu, X., et. al.
  • Organizer: XIth International Symposium on Amyloidosis
  • Place of Presentation: Woods Hole, USA
  • Year and Date: 2006-11-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Amyloidosis in the transgenic mice of mouse amyloidogenic apolipoprotein A-II (Apoa2^c) (2006)
  • Author(s): Higuchi, K., et. al.
  • Organizer: XIth International Symposium on Amyloidosis
  • Place of Presentation: Woods Hole, USA
  • Year and Date: 2006-11-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2^c) (2006)
  • Author(s): Ge, F., et. al.
  • Organizer: 21th Annual Meeting of the Council for SAM Research
  • Place of Presentation: Nagoya Japan
  • Year and Date: 2006-07-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ApoA-II transgenicマウス(apoa2^cTg)の開発と老化アミロイドーシス (2006)
  • Author(s): 葛 鳳霞、 他
  • Organizer: 第21回老化促進モデルマウス研究協議会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-06-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis; possible transmission in the mouse room. (2006)
  • Author(s): Fu X, et. al.
  • Organizer: 2006 Conference of Korean Society for Gerontology and The 6th Korean-Japan Gerontologist joint Meeting
  • Place of Presentation: Chuncheon, Korea
  • Year and Date: 2006-06-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis Possible transmission in the mouse room (2006)
  • Author(s): Fu, X., et. al.
  • Organizer: 2006 Conference of Korean Society for Gerontology and The 6th Korean-Japan Gerontologist joint Meeting
  • Place of Presentation: Chuncheon, Korea
  • Year and Date: 2006-06-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 活性型hHSF1トランスジェニックマウスにおけるAApoAIIアミロイドーシスの抑制 (2006)
  • Author(s): 張 倍茹、 他
  • Organizer: 第29回日本基礎老化学会
  • Place of Presentation: 長崎
  • Year and Date: 2006-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Cheetah AA amyloidosis. (Japanese) (2006)
  • Author(s): Zhang, B., et. al.
  • Organizer: 1st Annual Meeting of the Japan Society for Biomedical Gerontology
  • Place of Presentation: Nagasaki Japan
  • Year and Date: 2006-06-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prevention of AApoAII amyloidosis in transgenic mice of activated hHSF1. (Japanese) (2006)
  • Author(s): Zhang, B., et. al.
  • Organizer: 29th Annual Meeting of the Japan Society for Biomedical Gerontology
  • Place of Presentation: Nagasaki Japan
  • Year and Date: 2006-06-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] やさしい実験動物の遺伝学 (2006)
  • Author(s): 森 政之
  • Organizer: 第64回信州実験動物研究会・勉強会
  • Place of Presentation: 伊奈市
  • Year and Date: 2006-03-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Basic genetics of experimental animals (2006)
  • Author(s): Mori, M., et. al.
  • Organizer: 64th Seminar of the Shinshu Council for Laboratory Animal Science
  • Place of Presentation: Ina Japan
  • Year and Date: 2006-03-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 活性化hHSF1トランスジェニックマウスにおけるAApoAIIアミロイドーシスの抑制 (2005)
  • Author(s): 張 〓茹、他
  • Organizer: 第10回臨床ストレス蛋白質研究会
  • Place of Presentation: 熊本
  • Year and Date: 2005-11-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Prevention of AApoAII amyloidosis in transgenic mice of activated hHSF1. (Japanese) (2005)
  • Author(s): Zhang, B., et. al.
  • Organizer: The 10th Clinical Conference on Stress Proteins
  • Place of Presentation: Kumamoto Japan
  • Year and Date: 2005-11-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Amyloid fibril formation by the two distinctive sequences of apolipoprotein A-II associated with the mouse senile amyloidosis. (2005)
  • Author(s): Sawashita J, et. al.
  • Organizer: 文化省特定領域研究 タンパク質の一生 国際会議
  • Place of Presentation: 淡路
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis in the transgenic mice of apolipoprotein A-II(Apoa2^c) (2005)
  • Author(s): Yao J, et. al.
  • Organizer: 文化省特定領域研究 タンパク質の一生 国際会議
  • Place of Presentation: 淡路
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Initiation and fibrillization of AA amyloidosis by MRP-14 amyloid fibril. (2005)
  • Author(s): Yan J, et. al.
  • Organizer: 文化省特定領域研究 タンパク質の一生 国際会議
  • Place of Presentation: 淡路
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis: The possible transmission in the mouse room. (2005)
  • Author(s): Fu X, et. al.
  • Organizer: 文化省特定領域研究 タンパク質の一生 国際会議
  • Place of Presentation: 淡路
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Amyloid fibril formation by the two distinctive sequences of apolipoprotein A-II associated with the mouse senile amvloidosis (2005)
  • Author(s): Sawashita, J., et. al.
  • Organizer: International Symposium on Life of Proteins
  • Place of Presentation: Awaji Japan
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Initiation and fibrillization of AA amyloidosis by MRP-14 amvloid fibril (2005)
  • Author(s): Yan, J., et. al.
  • Organizer: International Symposium on Life of Proteins
  • Place of Presentation: Awaji Japan
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mouse senile amyloidosis in the transgenic mice of apolipoprotein A-II (Apoa2^c) (2005)
  • Author(s): Yao, J., et. al.
  • Organizer: International Symposium on Life of Proteins
  • Place of Presentation: Awaji Japan
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mouse senile amyloidosis : The possible transmission in the mouse mom (2005)
  • Author(s): Fu, X., et. al.
  • Organizer: International Symposium on Life of Proteins
  • Place of Presentation: Awaji Japan
  • Year and Date: 2005-10-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mouse senile amyloidosis in the transgenic mice of apolipoprotein A-II(Apoa2^c).. (2005)
  • Author(s): Ge F, et. al.
  • Organizer: The 4th Asia-Pacific IAP Congress(IAP2005)
  • Place of Presentation: Beijing China.
  • Year and Date: 2005-08-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Transmission of mouse systemic amyloidosis. Transmission of mouse systemic amyloidosis. (2005)
  • Author(s): Higuchi K.
  • Organizer: The 4th Asia-Pacific IAP Congress(IAP2005)
  • Place of Presentation: Beijing China.
  • Year and Date: 2005-08-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis in the transgenic mice of apolipoprotein A-II (Apoa2^c) (2005)
  • Author(s): Ge, F, et. al.
  • Organizer: The 4th Asia-Pacific International Academy of Pathology Congress (IAP2005)
  • Place of Presentation: Beijing China
  • Year and Date: 2005-08-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Transmission of mouse systemic amyloidosis. Transmission of mouse systemic amyloidosis (2005)
  • Author(s): Higuchi, K
  • Organizer: The 4th Asia-Pacific International Academy of Pathology Congress (IAP2005)
  • Place of Presentation: Beijing China
  • Year and Date: 2005-08-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 遺伝子解析 (2005)
  • Author(s): 森 政之
  • Organizer: 第20回老化促進モデルマウス研究協議会
  • Place of Presentation: 東京
  • Year and Date: 2005-07-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic analysis. (Japanese) (2005)
  • Author(s): Mori, M
  • Organizer: 20th Annual Meeting of the Council for SAM Research
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2005-07-30
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] SAMP1マウスを用いた還元型CoenzymeQ10の抗老化作用の解析 (2005)
  • Author(s): 厳 景民、他
  • Organizer: 第20回老化促進モデルマウス研究協議会
  • Place of Presentation: 東京
  • Year and Date: 2005-07-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス老化アミロイドーシス;飼育室における伝播の可能性. (2005)
  • Author(s): 付 笑影、他
  • Organizer: 第20回老化促進モデルマウス研究協議会
  • Place of Presentation: 東京
  • Year and Date: 2005-07-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス老化アミロイドーシスにおけるアミロイド線維形成関連apoA-IIアミノ酸配列の解析 (2005)
  • Author(s): 澤下 仁子、他
  • Organizer: 第20回老化促進モデルマウス研究協議会
  • Place of Presentation: 東京
  • Year and Date: 2005-07-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. (Japanese) (2005)
  • Author(s): Yan, J., et. al.
  • Organizer: 20th Annual Meeting of the Council for SAM Research
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2005-07-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mouse senile amyloidosis : the possible transmission in the mouse room. (Japanese) (2005)
  • Author(s): Fu, X., et. al.
  • Organizer: 20th Annual Meeting of the Council for SAM Research
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2005-07-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Amyloid fibril formation by the two distinctive sequences of apolipoprotein A-II. (Japanese) (2005)
  • Author(s): Sawashita, J., et. al.
  • Organizer: 20th Annual Meeting of the Council for SAM Research.
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2005-07-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] マウス老化(AApoAII)アミロイドーシス;飼育室における伝播 (2005)
  • Author(s): 付 笑影、他
  • Organizer: 第28回日本基礎老化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マウス老化アミロイドーシスにおけるアミロイド線維形成関連apoA-IIアミノ酸配列の解析 (2005)
  • Author(s): 澤下 仁子、他
  • Organizer: 第28回日本基礎老化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] SAMP1マウスを用いた還元型CoenzymeQ10の抗老化作用の解析 (2005)
  • Author(s): 厳 景民、他
  • Organizer: 第28回日本基礎老化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Mouse senile amyloidosis : the possible transmission in the mouse room. (Japanese) (2005)
  • Author(s): Fu, X., et. al.
  • Organizer: 28th Annual Meeting of the Japan Society for Biomedical Gerontology
  • Place of Presentation: Nagasaki Japan
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Amyloid fibril formation by the two distinctive sequences of apolipoprotein A-II. (Japanese) (2005)
  • Author(s): Sawashita, J., et. al.
  • Organizer: 28th Annual Meeting of the Japan Society for Biomedical Gerontology
  • Place of Presentation: Nagasaki Japan
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice. (Japanese) (2005)
  • Author(s): Yan, J., et. al.
  • Organizer: 28th Annual Meeting of the Japan Society for Biomedical Gerontology.
  • Place of Presentation: Nagasaki Japan
  • Year and Date: 2005-06-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] XIth International Symposium on Amyloidosis. Amyloidosis in the transgenic mice of mouse amyloidgenic apolipoprotein A-II(Apoa2^c). (2007)
  • Author(s): Higuchi K, et. al.
  • Publisher: CRC Press(Boca Raton, FL USA)Skinner M, Berk JL, Connors LH. eds
  • Description: 「研究成果報告書概要(和文)」より
• [Book] XIth International Symposium on Amyloidosis. Mouse senile amyloidosis: possible horizontal transmission in the mouse room. (2007)
  • Author(s): Fu X, et. al.
  • Publisher: CRC Press(Boca Raton, FL USA)Skinner M, Berk JL, Connors LH. eds
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Amyloid and Amyloidosis. Transmission of mouse AApoAII amyloidosis from mother to pups. (2007)
  • Author(s): Sawashita J, et. al.
  • Publisher: CRC Press(Boca Raton, FL USA)Grateau G, Kyle RA, Skinner M. eds
  • Description: 「研究成果報告書概要(和文)」より
• [Book] XIth International Symposium on Amyloidosis. Amyloidosis in the transgenic mice of mouse amyloidgenic apolipoprotein A-II(Apoa2^c). (2007)
  • Author(s): Higuchi K, et. al.
  • Publisher: CRC Press(Boca Raton, FL USA)Grateau G, Kyle RA, Skinner M. eds
  • Description: 「研究成果報告書概要(和文)」より
• [Book] XIth International Symposium on Amyloidosis.(Skinner M, Berk JL, Connors LH) Amyloidosis in the transgenic mice of mouse amyloidgenic apolipoprotein A-II (Apoa2C). (2007)
  • Author(s): Higuchi K, 他
  • Publisher: CRC Press(Boca Raton, FL USA)
• [Book] XIth International Symposium on Amyloidosis. (Skinner M, Berk JL, Connors LH) Mouse senile amyloidosis: possible horizontal transmission in the mouse room. (2007)
  • Author(s): Fu X, 他
  • Publisher: CRC Press(Boca Raton, FL USA)
• [Book] アミロイドーシスの基礎と臨床(2-5, アミロイドーシスと伝播) (2005)
  • Author(s): 樋口 京一、他
  • Publisher: 金原出版(東京)監修:石原得博、編集:池田修一)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] アミロイドーシスの基礎と臨床(3-7, マウス老化アミロイドーシス) (2005)
  • Author(s): 樋口 京一
  • Publisher: 金原出版(東京)監修:石原得博、編集:池田修一)
  • Description: 「研究成果報告書概要(和文)」より
• [Book] アミロイドーシスの基礎と臨床(2-5,アミロイドーシスと伝播、3-7,マウス老化アミロイドーシス) (2005)
  • Author(s): 監修:石原得博, 編集:池田修一, 著者:樋口京一
  • Total Pages: 294
  • Publisher: 金原出版