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Elucidation of protective mechanisms of endogenous low-molecular-weight compounds on neuronal death in central nervous system

Research Project

Project/Area Number 17390157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKyoto University

Principal Investigator

AKAIKE Akinori  Kyoto University, Graduate School of Pharmaceutical Sciences, Professor, 薬学研究科, 教授 (80135558)

Co-Investigator(Kenkyū-buntansha) KATSUKI Hiroshi  Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor, 薬学研究科, 助教授 (40240733)
KUME Toshiaki  Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor, 薬学研究科, 助手 (10303843)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2006: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 2005: ¥9,600,000 (Direct Cost: ¥9,600,000)
KeywordsNeuronal death / Excitotoxicity / Nitric oxide / Serofendic acid / Donepezil / Nicotinic receptor
Research Abstract

We focused on the low-molecular-weight substances that controlled the neuronal death induced by glutamate and radical stress. 1, Serofendic acid, a low-molecular-weight substance of atisane-type diterpenoids derived from fetal calf serum, prevents glutamate-induced apoptosis in cultured cortical neurons by the prevention of loss of mitochondrial membrane potential and the reduction of the process of caspase-3 activation. 2, We investigated the effect of serofendic acid on ischemic injury induced by a transient occlusion of the middle cerebral artery in rats. Serofendic acid significantly reduced total infarct volume, similar to edaravone, a free radical scavenger. These results suggest that intracerebroventricular administration of serofendic acid prevents the neurodegeneration induced by a transient focal cerebral ischemia and reperfusion. 3, We found that donepezil and galanthamine prevented glutamate neurotoxicity through α4-and α7-nAChRs, followed by the PI3K-Akt pathway, and that … More tacrine protected neuronal cells through a different pathway. 4, We examined the mechanisms of thrombin cytotoxicity in the striatum in vivo. Thrombin induced neuronal death and microglial activation around the injection site. Neuronal loss without any sign of nuclear fragmentation was observed. Thrombin-induced damage was partially but significantly reduced by concomitant administration of inhibitors of MAPK pathways. Thus, MAPK pathways and microglial activation may serve as therapeutic targets of pathogenic conditions associated with hemorrhagic stroke. 5, We examined the role of endogenous agonists at the glycine site of NMDA receptors in excitotoxic retinal damage in vivo. Endogenous D-serine is at least in part involved in pathological processes mediated by NMDA receptor over-activation in the retina. The levels of endogenous glycine site agonists influence the severity of NMDA receptor-mediated excitotoxic retinal damage in vivo. Both glycine and D-serine contribute to the excitotoxic processes in the retina. Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (56 results)

All 2006 2005

All Journal Article (56 results)

  • [Journal Article] Preclinical evidence of neuroprotection by cholinesterase inhibitors.2006

    • Author(s)
      Akaike, A.
    • Journal Title

      Alzheimer Dis. Assoc. Disord. 20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures.2006

    • Author(s)
      Fujimoto, S., Katsuki, H., Kume, T., Akaike, A.
    • Journal Title

      Neurobiology of Disease 22

      Pages: 130-142

    • NAID

      120002468469

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Amyloid β-peptide preconditioning reduces glutamate-induced neurotoxicity by pormoting endocytosis of NMDA receptor.2006

    • Author(s)
      Goto, Y., Niidome, T., Akaike, A., Kihara, T., Sugimoto, H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 259-265

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.2006

    • Author(s)
      Hama, Y., Katsuki, H., Tochikawa, Y., Suminaka, C., Kume, T., Akaike, A.
    • Journal Title

      Neurosci. Res. 56

      Pages: 279-285

    • NAID

      10019272913

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A critical role of TRPM2 in neuronal cell death by hydrogen peroxide.2006

    • Author(s)
      Kaneko, S., Kawakami, S., Hara, Y., Wakamori, M., Itoh, E., Minami, T., Takada, Y., Kume, T., Katsuki, H., Mori, Y., Akaike, A.
    • Journal Title

      J. Pharmacol. Sci. 101

      Pages: 66-76

    • NAID

      10018237407

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Serofendic acid, a neuroprotective substance derived from fetal calf serum, inhibits mitochondrial membrane depolarization and caspase-3 activation.2006

    • Author(s)
      Kume, T., Taguchi, R., Katsuki, H., Akao, M., Sugimoto, H., Kaneko, S., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 542

      Pages: 69-76

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons.2006

    • Author(s)
      Nakatsu, Y., Kotake, Y., Komasaka, K., Hakozaki, H., Taguchi, R., Kume, T., Akaike, A., Ohta, S.
    • Journal Title

      Toxicol. Sci. 89

      Pages: 235-242

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation.2006

    • Author(s)
      Niidome, T., Morimoto, N., Iijima, S., Akaike A., Kihara, T., Sugimoto, H.
    • Journal Title

      Eur. J. Pharmacol. 548

      Pages: 1-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] c-jun N-terminal kinase inhibition and α-tocopherol protect midbrain dopaminergic neurons from interferon-g/lipopolysaccharide-induced injury without affecting nitric oxide production.2006

    • Author(s)
      Shibata, H., Katsuki, H., Okawara, M., Kume, T., Akaike, A.
    • Journal Title

      J. Neruosci. Res. 83

      Pages: 102-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons.2006

    • Author(s)
      Shirakawa, H., Katsuki, H., Kume, T., Kaneko, S., Akaike, A.
    • Journal Title

      British J. Pharmacol. 147

      Pages: 729-736

    • NAID

      120002468468

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Nitric oxide-mediated effect of nipradilol, α - and β-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.2006

    • Author(s)
      Taguchi, R., Shirakawa H., Yamaguchi, T., Kume, T., Katsuki, H., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 535

      Pages: 86-94

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.2006

    • Author(s)
      Takada-Takatori, Y., Kume, T., Sugimoto, M., Katsuki, H., Niidome, T., Sugimoto, H., Fujii, T., Okabe, S., Akaike A.
    • Journal Title

      Eur. J. Pharmacol. 549

      Pages: 19-26

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade.2006

    • Author(s)
      Takada-Takatori, Y., Kume, T., Sugimoto, M., Katsuki, H., Sugimoto, H., Akaike, A.
    • Journal Title

      Neuropharmacology 51

      Pages: 474-486

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Effects of selegiline on antioxidant systems in the nigrostriatum in rat.2006

    • Author(s)
      Takahata, K., Shimazu, S., Katsuki, H., Yoneda, F., Akaike, A.
    • Journal Title

      J. Neural Transm. 113

      Pages: 151-158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes.2006

    • Author(s)
      Takeda, T., Akao, M., Matsumoto-Ida, M., Kato, M., Takenaka, H., Kihara, Y., Kume, T., Akaike, A., Kita, T.
    • Journal Title

      J. American College. Cardiology 47

      Pages: 1882-1890

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Synthesis and neuroprotective effects of serofendic acid analogues.2006

    • Author(s)
      Terauchi, T., Doko, T., Yonaga, M., Kajiwara, A., Niidome, T., Taguchi, R., Kume, T., Akaike, A., Sugimoto, H.
    • Journal Title

      Bioorg. Med. Chem. Lett. 16

      Pages: 5080-5083

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embroyonic stem cells.2006

    • Author(s)
      Yanagisawa, D., Qi, M., Kim, D., Kitamura, Y., Inden, M., Tsuchiya, D., Takata, K., Taniguchi, T., Yoshimoto, K., Shimohama, S., Akaike, A., Sumi, S., Inoue, K.
    • Journal Title

      Neurosci. Lett. 407

      Pages: 74-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture.2006

    • Author(s)
      Katsuki, H., Okawara, M., Shibata, H., Kume, T., Akaike, A.
    • Journal Title

      J. Neurochem. 97

      Pages: 1232-1242

    • NAID

      120002468470

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Amyloid b-peptide preconditioning reduces glutamate-induced neurotoxicity by pormoting endocytosis of NMDA receptor.2006

    • Author(s)
      Goto, Y., Niidome, T., Akaike, A.Kihara, T., Sugimoto, H
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 259-265

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Mechanisms of cell death of neural progenitor cells caused by trophic support deprivation.2006

    • Author(s)
      Niidome, T., Morimoto, N., Iijima, S., Akaike, A., Kihara, T., Sugimoto, H.
    • Journal Title

      Eur. J. Pharmacol. 548

      Pages: 1-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] c-jun N-terminal kinase inhibition and a-tocopherol protect midbrain dopaminergic neurons from interferon-g/lipopolysaccharide-induced injury without affecting nitric oxide production.2006

    • Author(s)
      Shibata, H., Katsuki, H., Okawara, M., Kume, T., Akaike, A.
    • Journal Title

      J. Neruosci. Res. 83

      Pages: 102-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Nitric oxide-mediated effect of nipradilol, a- and b-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.2006

    • Author(s)
      Taguchi, R., Shirakawa, H., Yamaguchi, T., Kume, T., Katsuki, H., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 535

      Pages: 86-94

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.2006

    • Author(s)
      Takada-Takatori, Y., Kume, T., Sugimoto, M., Katsuki, H., Niidome, T., Sugimoto, H., Fujii, T., Okabe, S., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 549

      Pages: 19-26

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Amyloid β-peptide preconditioning reduces glutamate-induced neurotoxicity by pormoting endocytosis of NMDA2006

    • Author(s)
      Goto, Y., Niidome, T., Akaike, A., Kihara, T., Sugimoto, H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 259-265

    • Related Report
      2006 Annual Research Report
  • [Journal Article] c-jun N-terminal kinase inhibition and α-tocopherol protect midbrain dopaminergic neurons from interferon-g/lipopolysaccharide-induced injury without affecting nitric oxide production.2006

    • Author(s)
      Shibata, H., Katsuki, H., Okawara, M., Kume, T., Akaike
    • Journal Title

      J. Neruosci. Res. 83

      Pages: 102-109

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nitric oxide-mediated effect of nipradilol, α - and β-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.2006

    • Author(s)
      Taguchi, R., Shirakawa, H., Yamaguchi, T., Kume, T., Katsuki, H., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 535

      Pages: 86-94

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity.2006

    • Author(s)
      Takada-Takatori, Y., Kume, T., Sugimoto, M., Katsuki, H., Niidome, T., Sugimoto, H., Fujii, T., Okabe, S., Akaike.A.
    • Journal Title

      Eur. J. Pharmacol. 549

      Pages: 19-26

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of selegiline on antioxidant systems in the nigrostriatum in rat.2006

    • Author(s)
      Takahata, K., Shimazu, S., Katsuki, H., Yoneda, F.
    • Journal Title

      J. Neural Transm. 113

      Pages: 151-158

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes.2006

    • Author(s)
      Takeda, T., Akao, M., Matsumoto-Ida, M., Kato, M., Takenaka, H., Kihara, Y., Kume, T., Akaike, A., Kita.T.
    • Journal Title

      J. American College. Cardiology 47

      Pages: 1882-1890

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Synthesis and neuroprotective effects of serofendic acid analogues.2006

    • Author(s)
      Terauchi, T., Doko, T., Yonaga, M., Kajiwara, A., Niidome, T., Taguchi, R., Kume, T., Akaike, A., Sumimoto.H.
    • Journal Title

      Bioorg. Med. Chem. Lett. 16

      Pages: 5080-5083

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nitric oxide-producing microglia mediate thrombin-induced degeneration of dopaminergic neurons in rat midbrain slice culture.2006

    • Author(s)
      Katsuki, H., Okawara, M., Shibata, H., Kume, T., Akaike
    • Journal Title

      J. Neurochem 97

      Pages: 1232-1242

    • NAID

      120002468470

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of R-(-)-BPAP on the expressions of neurotrophins and their receptors in mesencephalic slices.2005

    • Author(s)
      Hirami, C., Takahata, K., Shimazu, S., Yoneda, F., Hayashi, K., Katsuki, H., Akaike, A.
    • Journal Title

      Biol. Pharm. Bull. 28

      Pages: 1524-1526

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] p-Quinone mediates 6-hydroxydopomine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.2005

    • Author(s)
      Izumi, Y., Sawada, H., Sakka, N., Yamamoto, N., Kume, T., Katsuki, H., Shimohama, S., Akaike, A.
    • Journal Title

      J. Neurosci. Res. 79

      Pages: 849-860

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.2005

    • Author(s)
      Izumi, Y., Sawada, H., Yamamoto, N., Kume, T., Katsuki, H., Shimohama, S., Akaike, A.
    • Journal Title

      J. Neurosci. Res. 82

      Pages: 126-137

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.2005

    • Author(s)
      Katsuki, H., Akaike, A.
    • Journal Title

      Neuroreport 16

      Pages: 1157-1161

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures.2005

    • Author(s)
      Katsuki, H., Shinohara, A., Fujimoto, S., Kume, T., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 508

      Pages: 85-91

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.2005

    • Author(s)
      Kume, T., Kawai, Y., Yoshida, K., Nakamizo, T., Kanki, R., Sawada, H., Katsuki, H., Shimohama, S., Sugimoto, H., Akaike, A.
    • Journal Title

      Neurosci. Lett. 383

      Pages: 199-202

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons.2005

    • Author(s)
      Kume, T., Sugimoto, M., Takada, Y., Yamaguchi, T., Yonezawa, A., Katsuki, H., Sugimoto, H., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 527

      Pages: 77-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons.2005

    • Author(s)
      Shirakawa, H., Katsuki, H., Kume, T., Kaneko, S., Akaike, A.
    • Journal Title

      Eur. J. Neurosci. 21

      Pages: 2329-2335

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.2005

    • Author(s)
      Inden, M., Kitamura, Y., Kondo, J., Hayashi, K., Yanagida, T., Takata, K., Tsuchiya, D., Yanagisawa, D., Nishimura, K., Taniguchi, T., Shimohama, S., Sugimoto.H., Akaike.A.
    • Journal Title

      J. Neurochem. 95

      Pages: 950-961

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serofendic acid promotes survival of auditory hair cells and neurons of mice.2005

    • Author(s)
      Kita, T., Nakagawa, T., Kim, T., Iwai, K., Takebayashi, S., Akaike, A., Ito, J.
    • Journal Title

      NeuroReport 16

      Pages: 689-692

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stimulation of nicotinic acetylcholine receptors protects motor neurons.2005

    • Author(s)
      Nakamizo, T., Kawamata, J., Yamashita, H., Kanki, R., Kihara, T., Sawada, H., Akaike, A., Shimohama, S.
    • Journal Title

      Biochem. Biophys. Res. Com. 330

      Pages: 1285-1289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons.2005

    • Author(s)
      Kume, T., Sugimoto, M., Takada, Y., Yamaguchi, T., Yonezawa, A.Katsuki, H., Sugimoto, H., Akaike, A.
    • Journal Title

      Eur. J. Pharmacol. 527

      Pages: 77-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.2005

    • Author(s)
      Inden, M., Kitamura, Y., Kondo, J., Hayashi, K., Yanagida, T., Takata, K., Tsuchiya, D., Yanagisawa, D., Nishimura, K., Taniguchi, T., Shimohama, S., Sugimoto, H., Akaike, A.
    • Journal Title

      J. Neurochem. 95

      Pages: 950-961

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons.2005

    • Author(s)
      Kume T.et al.
    • Journal Title

      European Journal of Pharmacology 527・1-3

      Pages: 77-85

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats.2005

    • Author(s)
      Inden M. et al.
    • Journal Title

      Journal of Neurochemistry 95・4

      Pages: 950-961

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.2005

    • Author(s)
      Izumi Y.et al.
    • Journal Title

      Journal of Neuroscience Research 82・1

      Pages: 126-137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Effects of R-(-)-BPAP on the expressions of neurotrophins and their receptors in mesencephalic slices.2005

    • Author(s)
      Hirami C. et al.
    • Journal Title

      Biological and Pharmaceutical Bulletin 28・8

      Pages: 1524-1526

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.2005

    • Author(s)
      Katsuki H., Akaike A.
    • Journal Title

      Neuroreport 16・11

      Pages: 1157-1161

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.2005

    • Author(s)
      Kume T.et al.
    • Journal Title

      Neuroscience Letters 383・3

      Pages: 199-202

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons.2005

    • Author(s)
      Shirakawa H. et al.
    • Journal Title

      European Journal of Neuroscience 21・9

      Pages: 2329-2335

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serofendic acid promotes survival of auditory hair cells and neurons of mice.2005

    • Author(s)
      Kita T.et al.
    • Journal Title

      Neuroreport 16・7

      Pages: 689-692

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stimulation of nicotinic acetylcholine receptors protects motor neurons.2005

    • Author(s)
      Nakamizo T. et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 330・4

      Pages: 1285-1289

    • Related Report
      2005 Annual Research Report
  • [Journal Article] p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin.2005

    • Author(s)
      Izumi Y. et al.
    • Journal Title

      Journal of Neuroscience Research 79・6

      Pages: 849-860

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures.2005

    • Author(s)
      Katsuki H. et al.
    • Journal Title

      European Journal of Pharmacology 508・1-3

      Pages: 85-91

    • Related Report
      2005 Annual Research Report
  • [Journal Article] ニューロンのアポトーシスを制御する内在性保護因子2005

    • Author(s)
      赤池昭紀, 香月博志, 久米利明
    • Journal Title

      日本神経精神薬理学雑誌 25・5

      Pages: 245-250

    • NAID

      10016851917

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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