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Cohort Study of construction workers in Hokuriku Area regarding non-malignant and malignant asbestos related lung diseases

Research Project

Project/Area Number 17390168
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKochi University (2007-2008)
University of Fukui (2005-2006)

Principal Investigator

SUGANUMA Narufum  Kochi University, 教育研究部医療学系, 教授 (50313747)

Co-Investigator(Kenkyū-buntansha) KUSAKA Yukinori  福井大学, 医学部, 教授 (70135680)
ITOH Harumi  福井大学, 副学長 (40026943)
ISHIZAKI Takeshi  福井大学, 医学部, 教授 (80151364)
MURATA Kiyoshi  滋賀医科大学, 医学部, 教授 (20127038)
HISANAGA Naomi  愛知教育大学, 保健環境センター, 教授 (90111856)
Research Collaborator TABATA Masaji  石川県予防医学協会
NAKANISHI Yutaka  パブリックヘルス診療所
FUJISHIMA Seitarou  慶應義塾大学, 医学部, 講師
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,140,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2006: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywords石綿関連疾患 / 悪性腫瘍 / 胸部単純エックス線 / 胸部CT / 国際分類 / スクリーニング / 社会医学 / 内科 / 放射線 / プロテオーム / 環境 / 石綿関連肺がん / 非悪性石綿関連疾患 / 悪性中皮腫 / 建築業 / 低線量CT / 腫瘍マーカー / 高分解能CT / 分類
Research Abstract

我々が国際共同開発した職業・環境性呼吸器病のためのHRCT分類(ICOERD)を疫学ツールとして用いて、福井県を中心に石綿曝露者である建設作業者3000人の集団を対象にコホートを立トげ、胸部単純X線検査、希望者に対する低線量MDCTによる胸部CT肺癌検診、血清・血漿を採取しての腫瘍マーカー検索を行った。この4年間に6例の肺がん患者と1例の中皮腫患者を発見するに至った。胸部単純では、胸膜プラークは7-10%、不整形陰影は1%未満であった。胸部X線とCTを比較するとCTは約二倍の有所見率であった。腫瘍マーカーの石綿曝露者の健診における有効性は現在検討中である。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (39 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (22 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Reliability of the International Classification of High-Resolution Computed Tomography for Occupational and Environmental Respiratory Diseases2009

    • Author(s)
      Suganuma N, Kusaka Y, Hering KG, Vehmas T, Kraus T, Arakawa H, Parker JE, Kivisaari L, Letourneux M, Gevenois PA, Tuengerthal S, Crane MD, Shida H, Akira M, Henry DA, Nakajima Y, Hiraga Y, Itoh H, Hosoda Y.
    • Journal Title

      J Occup Health 51(3)(published online before print)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Reliability of the International Classification of High-Resolution Computed Tomography for Occupational and Environmental Respiratory Diseases2009

    • Author(s)
      Suganuma N, Kusaka Y, et al.
    • Journal Title

      Journal of Occupational Health 51(In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progression from near normal to End-Stage Lungs in Chronic Interstitial Pneumonia related to silica exposure : Long-term CT observations.2008

    • Author(s)
      Arakawa H, Fujimoto K, Honma K, Suganuma N, et al.
    • Journal Title

      Am J Roentgenology 191(4)

      Pages: 1040-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A flat-panel detector digital radiography and a storage phosphor computed radiography : screening for pneumoconiosis2007

    • Author(s)
      Takashima Y, Suganuma N, Sakurazawa H, Itoh H, Hirano H, Shida H and Kusaka Y.
    • Journal Title

      J Occup Health 49(1)

      Pages: 39-45

    • Related Report
      2008 Final Research Report
  • [Journal Article] A Flat-panel Detector Digital Radiography and a Storage Phosphor Computed Radiography:Screening for Pneumoconioses2007

    • Author(s)
      Takashima Y, Suganuma N, Sakurazawa H, Itoh H, Hirano H, Shida H, Kusaka Y.
    • Journal Title

      J Occup Health 49

      Pages: 39-45

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic Interstitial Pneumonia in silicosis and non-fibrous silicate pneumoconiosis:Comparison with idiopathic pulmonary fibrosis by CT.20072007

    • Author(s)
      Arakawa H, Johkoh T, Saito Y, Honma K, Fukushima Y, Shida H, Suganuma N.
    • Journal Title

      Chest 131(in press)

      Pages: 1870-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A flat-panel detector digital radiography and a storage phosphor computed radiography : screening for pneumocomosis.2007

    • Author(s)
      Takashima Y, Suqanuma N, Sakurazawa H, Itoh H, Hirano H, Shida H, Kusaka Y.
    • Journal Title

      J Occup Health 49

      Pages: 39-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selection of Reference films and reliability of a proposed Classification of HRCT for Pneumoconioses2006

    • Author(s)
      Suganuma N, Kusaka Y, Hering Vehmas T, Kraus T, Parker JE, Shida H.
    • Journal Title

      Int Arch Occup Environ Health 79

      Pages: 472-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Is CT screening for asbestos-related diseases rational?2006

    • Author(s)
      Suganuma N, Kusaka Y, Itoh H.
    • Journal Title

      Occup Environ Dis J (1)

      Pages: 9-16

    • Related Report
      2008 Final Research Report
  • [Journal Article] Selection of Reference films and reliability of a proposed Classification of HRCT for Pneumoconioses.2006

    • Author(s)
      Suqanuma N, Kusaka Y. et al.
    • Journal Title

      Int Arch Occup Environ Health 79

      Pages: 472-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selection of Reference films and reliability of a proposed Classification of HRCT for Pneumoconioses.2006

    • Author(s)
      Suganuma N, Kusaka Y.et al.
    • Journal Title

      Int Arch Occup Environ Health (Epub ahead of print)

      Pages: 1-5

    • Related Report
      2005 Annual Research Report
  • [Presentation] 石綿曝露者の腫瘍マーカーによる中皮腫スクリーニングの可能性の検討2009

    • Author(s)
      松本純子, 中西久, 弘田量二, 藤島清太郎, 日下幸則, 菅沼成文
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] モニター診断における解像度の差による読影結果への影響の検討2009

    • Author(s)
      菅沼成文, 濱田典彦, 窪田哲也, 森田賢
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] International Classification of HRCT for Occupational and Environmental Diseases : Viewer.2009

    • Author(s)
      Suganuma. N, et al.
    • Organizer
      International Congress of Occupational Health
    • Place of Presentation
      Cape Town International Convention Centre
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 石綿曝露者の腫瘍マーカーによる中皮腫スクリーニングの可能性の検討2009

    • Author(s)
      松本純子, 中西久, 弘田量一, 藤島清太郎, 梅村朋弘, 日下幸則, 菅沼成文
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡市
    • Related Report
      2008 Final Research Report
  • [Presentation] モニター診断における解像度の差による読影結果への影響の検討2009

    • Author(s)
      菅沼成文, 濱田典彦, 窪田哲也, 森田賢
    • Organizer
      第82回日本産業衛生学
    • Place of Presentation
      福岡市
    • Related Report
      2008 Final Research Report
  • [Presentation] Assessing and Improving Physician's skill in reading Pneumoconioses CXR2009

    • Author(s)
      Nlandu N, Suzuki S, Hirota R, Kusaka Y, Suganuma N.
    • Organizer
      第82回日本産業衛生学会
    • Place of Presentation
      福岡市
    • Related Report
      2008 Final Research Report
  • [Presentation] Itoh H. International Classification of HRCT for Occupational and Environmental Respiratory Diseases (ICOERD): Viewer2009

    • Author(s)
      Suganuma N, Kusaka Y, Arakawa H, Akira M, Onda H, Murao K, Matsumoto T.
    • Organizer
      International Congress of Occupational Health
    • Place of Presentation
      Cape Town
    • Related Report
      2008 Final Research Report
  • [Presentation] Assessing and Improving Physician's skill in reading Pneumoconioses CXR2009

    • Author(s)
      Nlandu N, Suzuki S, Hirota R, Kusaka Y, Suganuma N.
    • Organizer
      International Congress of Occupational Health
    • Place of Presentation
      Cape Town
    • Related Report
      2008 Final Research Report
  • [Presentation] Validity of International Classification of HRCT for Occupational and Environmental Respiratory Diseases on the basis of ILO 2000 International Classification of Radiograph of Pneumoconioses2009

    • Author(s)
      Suganuma N, Kusaka Y, Itoh H, Tamura T, Hirano H, Takashima Y.
    • Organizer
      23rd International Congress of Occupational Health
    • Place of Presentation
      Cape Town(526)
    • Related Report
      2008 Final Research Report
  • [Presentation] A Supplement to International Classification of HRCT for Occupational and Environmental Respiratory Diseases on Malignant Mesothelioma2009

    • Author(s)
      Kusaka Y, Suganuma N, Tamura T, Kumagai S, Akira M, Arakawa H, Itoh H.
    • Organizer
      23rd International Congress of Occupational Health
    • Place of Presentation
      Cape Town(525)
    • Related Report
      2008 Final Research Report
  • [Presentation] 尼崎に集積した胸膜中皮腫の症例集に関する放射線医学的検討2008

    • Author(s)
      菅沼成文, 日下幸則, 車谷典男, 熊谷信二, 伊藤春海
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] アスベスト関連疾患の胸部レントゲン写真の比較読影 : 従来法とデジタルエックス線写真2008

    • Author(s)
      中西久, 菅沼成文, 伊藤春海, 日下幸則
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2008-06-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] International Classification of HRCT for Occupational and Environmental Respiratory Diseases(ICOERD) : Viewer2007

    • Author(s)
      Suganuma N, Kusaka Y, Arakawa H, Akira M, Onda H, Murao K, Matsumoto T, Itoh H.
    • Organizer
      Radiologic Society of North America
    • Place of Presentation
      Chicago
    • Related Report
      2008 Final Research Report
  • [Presentation] アスベスト関連疾患の胸部レントゲン写真の比較読影 : 従来法とデジタルエックス線写真2007

    • Author(s)
      中西久, 菅沼成文, 玉地義弘, 日下幸則
    • Organizer
      第50回日本産業衛生学会北陸甲信越地方会総会
    • Place of Presentation
      金沢市
    • Related Report
      2008 Final Research Report
  • [Presentation] Serum osteopontin level among carpenters in Fukui, Japan2007

    • Author(s)
      Suganuma N, Kusaka Y, Horiguchi S.
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] Serum Osteopontin level among the construction workers in Fukui,Japan2007

    • Author(s)
      Suganuma N, Horiguchi S, Kusaka Y.
    • Organizer
      ATS 2007
    • Place of Presentation
      San Francisco
    • Related Report
      2007 Annual Research Report
  • [Presentation] International Classification of HRCT for Occupational and Environmental Respir atory Diseases2007

    • Author(s)
      Suganuma N, Kusaka Y, Arakawa H, Akira M, Onda H, Murao K, Matumoto T, Itoh H
    • Organizer
      RSNA 2007
    • Place of Presentation
      Chicago
    • Related Report
      2007 Annual Research Report
  • [Presentation] Early asbestsis in medical screening of asbestos exposed workers by HRCT2006

    • Author(s)
      Suganuma N, Kusaka Y, Itoh H.
    • Organizer
      28^<th> International Congress on Occupational Health
    • Place of Presentation
      Milan
    • Related Report
      2008 Final Research Report
  • [Presentation] Prevalence of radiographic asbestos-related diseases among construction workers in Fukui, Japan2006

    • Author(s)
      Suganuma N, Kusaka Y, Itoh H, Ishizaki T, Tanaka T.
    • Organizer
      28^<th> International Congress on Occupational Health
    • Place of Presentation
      Milan
    • Related Report
      2008 Final Research Report
  • [Presentation] 石綿曝露者のCT検診は正当化されるか?2006

    • Author(s)
      菅沼成文
    • Organizer
      第79回日本産業衛生学会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 環境起因性および職業性呼吸器疾患のための国際HRCT基準 : アスベスト胸部CT検診への応用2006

    • Author(s)
      日下幸則, 菅沼成文
    • Organizer
      第13回日本CT検診学会
    • Place of Presentation
      千葉
    • Related Report
      2008 Final Research Report
  • [Presentation] Merit and Limitation of the HRCT-Classification2005

    • Author(s)
      Suganuma N
    • Organizer
      10^<th> International Conference on Occupational Respiratory Diseases(ICORD)
    • Place of Presentation
      Beijin
    • Related Report
      2008 Final Research Report
  • [Book] International Classification of HRCT for Occupational and Environmental Respiratory Diseases2005

    • Author(s)
      Kusaka Y, Hering KG, Parker JE(eds)
    • Publisher
      Tokyo : Springer
    • Related Report
      2008 Final Research Report
  • [Book] Application of the International Classification of CT for the Occupational Lung Diseases.(In : Kusaka Y, Hering KG, Parker JE, editors.)(International Classification of HRCT for Occupational and Environmental Respiratory Diseases.)2005

    • Author(s)
      Suganuma N, Kusaka Y.
    • Total Pages
      145
    • Publisher
      Springer-Verlag
    • Related Report
      2005 Annual Research Report
  • [Remarks] 菅沼成文 : 福井県の建設作業者の石綿肺・胸膜肥厚と肺癌・悪性中皮腫に関する横断調査. 平成16年度産業保健調査研究報告書. 401-404, 2005, 3.

    • Related Report
      2008 Final Research Report
  • [Remarks] Suganuma N.

    • URL

      http://www.cdc.gov/niosh/docs/2008-139/pdfs/Manuscript-Suganuma-ImageParameters.pdf

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~ff_evrnm/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.kochi-ms.ac.jp/~ff_evrnm/kenkyu.htm

    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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