| Co-Investigator(Kenkyū-buntansha) |
ENDO Ginji Osaka City University, Graduate School of Medicine, Professor (20160393)
SATO Kyoko Osaka City University, Graduate School of Medicine, Assistant Professor (00381989)
HIKITA Yonezo Osaka City University, Graduate School of Medicine, Lecture (50420724)
YONEDA Takeshi Osaka City University, Graduate School of Medicine, Lecture (90445023)
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| Budget Amount *help |
¥13,700,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2005: ¥8,100,000 (Direct Cost: ¥8,100,000)
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| Research Abstract |
The purpose of this study is to enroll participants in the prospective cohort study designed to clarify the effect of visceral adiposity directly measured by computed tomography (CT) on the risk factors for cardiometabolic diseases, such as type 2 diabetes, hyperlipidemia, hypertension, metabolic syndrome, coronary heart disease. Between 2005 and 2007, we enrolled about 1000 men and women at the Ohtori Health Promotion Center, Osaka, Japan. Baseline variables included fasting plasma glucose, fasting immunoreactive insulin, body mass index; waist circumference; and abdominal, thoracic, and thigh fat areas measured by CT et al. Visceral adiposity was measured as intra-abdominal fat area (IAFA) at the umbilicus level. We examined the association between visceral adiposity measured by CT and the prevalence of impaired fasting glucose, type 2 diabetes, high normal blood pressure, hypertension, hypertriglycemia, and low HDL cholesterol. These associations were as strong as those which have b
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een reported by the Japanese Americans Community Diabetes Study. We will publish these results in a year. We will continue to study this cohort and are also recruiting additional participants, especially women. We are planning to conduct 5-year follow-up examination and 10-year follow-up examination after baseline examination. In the Japanese Americans Community Diabetes Study, we have reported several important manuscripts. We have reported that greater visceral adiposity was associated with an increased risk of metabolic syndrome (Diabetologia 2007) and future insulin resistance (Diabetes 2008). Surprisingly No research has been prospectively performed on whether directly measured visceral fat is associated with an increased risk of future insulin resistance. Ours is the first prospective study to evaluate the relationship of directly measured visceral adiposity to future insulin resistance. We also reported manuscript about the optimal waist and visceral fat values for identifying Japanese Americans at the risk for the metabolic syndrome (Diabetes Care 2007). We have also several manuscripts about the incidence of type 2 diabetes. Less
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