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Epidemiology for exposure limit setting of indium, a potent agent inducing interstitial lung injury

Research Project

Project/Area Number 17390179
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKeio University

Principal Investigator

SANO Yuri  Keio University, Schoolof Medicine, Instructor, 医学部, 助手 (20338023)

Co-Investigator(Kenkyū-buntansha) OMAE Kazuyuki  Keio University, School of Medicine, Professor, 医学部, 教授 (60118924)
KIKUCHI Yuriko  Keio University, School of Medicine, Instructor, 医学部, 助手 (10383720)
YOSHIOKA Noriyuki  Keio University, School of Medicine, Instructor, 医学部, 助手 (70365229)
TANAKA Akiyo  Kyushu University, School of Medicine, Assistant Professor, 大学院医学研究院, 専任講師 (10136484)
HIRATA Miyuki  Kyushu University, School of Medicine, Instructor, 大学院医学研究院, 助手 (30156674)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordsindium / respiratory effect / cross-sectional study / interstitial lung injury / KL-6 / HRCT / spirometry / risk communication
Research Abstract

During the study period (April 2005-March 2007), a research team visited a total of 44 times to 21 indium plants or head quarters (3 in Kyushu area, 2 in Chugoku area, 1 in Kinki area, 12 in Kanto area, and 3 in Tohoku area), and base-line studies, follow-up studies, negotiation for joining our study, exposure information exchanges and risk communication were carried out After the epidemiological studies, the results of individual medical examinations or overall results in the plants were informed to each worker or to company medical staff/plant managers.
In epidemiological studies, indium in serum and whole blood, and job history were measured as an exposure index. Medical history, subjective symptoms on respiratory tracts, spirometry, chest HRCT, KL-6, SP-D, SP-A, etc. were examined as effect indices. In a few plants, immunological and collagen-diseased-related parameters in serum and renal cortex functions were also determined to rule out the possibility of hypersensitive / collagen- … More disease-related pneumonitis and cadmium-like health effects (An atomic number of the indium is the next to the cadmium).
We found 3 new indium lung cases in the base-line studies. Total number of indium-exposed workers examined was ca. 530 and that of referent workers was ca. 150. Results of base-line studies indicated that KL-6 of more than a quarter exposed workers exceeded the reference value ( 500 U/mL) and chest HRCT of ca. one-tenth exposed workers showed interstitial changes of the lung. Both exposure-effect and exposure-response relationships were very sharp between indium exposure indices and effect indices. We concluded that a cause-effect relationship was firmly established.
We think that number of workers examined is enough to establish the exposure limit value for indium and preparation of documentation for an occupational biological exposure limit (OEL-B) of indium is now ongoing.
(On April 25, 2007, the Japan Society for Occupational Health proposed OEL-B of indium in serum as 3 ng/ml at General Meeting of JSOH.) Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (5 results)

All 2007 2006

All Journal Article (5 results)

  • [Journal Article] Interstitial Pulmonary Disease In Indium-Processing Workers2007

    • Author(s)
      Chonan T, Taguchi O, Omae K
    • Journal Title

      European Respiratory Journal 29

      Pages: 317-324

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Interstitial Pulmonary Disease In Indium-Processing Workers.2007

    • Author(s)
      Chonan T, Taguchi O, Omae K.
    • Journal Title

      European respiratory journal 29

      Pages: 317-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] インジウム肺2006

    • Author(s)
      中野真規子, 大前和幸
    • Journal Title

      産業医学ジャーナル 29

      Pages: 123-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Indium lung.2006

    • Author(s)
      Nakano M, Omae K.
    • Journal Title

      Occupational Health Journal (Sangyo Igaku Journal) 29

      Pages: 123-126

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] インジウム肺2006

    • Author(s)
      中野新規子, 大前和幸
    • Journal Title

      産業医学ジャーナル 29

      Pages: 123-126

    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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