Research Project
Grant-in-Aid for Scientific Research (B)
Alcohol drinking behavior results from an intricate interplay between genes and environmetal factors, but there remains little understanding of how drinking onset and housing conditions interact to influence on late alcohol drinking behavior. Expression of uncoupling protein-1 (UCP1) in brown adipose tissue (BAT) was studied in young and rats. Mitocondrial UCP1 in BAT is an important key molecule for non-shivering thermogenesis. IP injection of EtOH (2g/kg) caused a decreased expression of BAT UCP1 mRNA in both young and aged rats, but the magnitude of UCP1 mRNA decrease was larger in aged rats than in young rats. Alcohol drinking behavior depends on age of drinking onset and the sensitivity to alcohol associated with functions of ACC DA and 5-HT releases during the process of aging. Mice were injected s.c. with 5, 10 and 20 mg/kg mCPP for 15 days, respectively. Daily intakes of water and 10% ethanol were measured to evaluate alcohol preference (AP) (%) and an alcohol consumption score (g/kg/day).The levels of dopamine (DA) and serotonin (5-H')were analyzed by ECD-HPLC in. the frontal cortex (FC), lateral hypothalamus (LH) and striatum (C/P). MCPP increased AP in a dose-dependently manner. Positive and negative relationships were noted between alcohol consumption score and food intake and mCPP, respectively. MCPP (20mg/kg) increased the level of DA in LH and C/P. The relationship between the levels of 5-HT and mCPP showed a positive correlation in the LH and C/P. The ratios of DOPAC/DA and 5-HIAA/5-HT showed negative correlations with mCPP. It was suggested that the development of alcohol dependence was associated with the down-regulation of 5-HT2c receptor function.Possible underlying reasons for different alcohol drinking behavior in adults include reduced sensitivity to alcohol in the rewarding system and altered responses of the autonomic nerves associated with 5-HT2 receptor functions, e.g., energy dissipation and the stress of housing conditions.
All 2008 2007 2006 2005
All Journal Article (32 results) (of which Peer Reviewed: 4 results) Presentation (1 results)
Trends in Developmental Biology 2
Pages: 45-50
Neuroscience Letter 436
Pages: 167-170
Develop. Neurobiol 67(8)
Pages: 1059-1078
J Neurochem 101(6)
Pages: 1491-1504
Neurosci. Res 59
Pages: 101-106
Develop. Neurobiol. 67
Neurosci. Res. 59
J. Neurochem 101
Tohoku J. Exp. Med 208
Pages: 321-326
10017969062
Mach Ageing Dev 127
Pages: 628-632
Neurobiol Dis 24
Pages: 144-158
Pshchopharmacology 189
Pages: 249-258
Neuroscience Letter 407
Pages: 74-79
J Pharmacol Sci 102
Pages: 243-247
Tohoku J Exp Med 208
ech Ageing Dev 127
Psychopharmacology 189
Neurosci Lett 407
Neuropathology 25
Pages: 54-65
Clin Exp Pharmacol Physiol 32(1-2)
Pages: 91-93
Neuroscience letter 385
Pages: 82-86
Neuroscience 135
Pages: 395-402
Nurosci Lett 387
Pages: 151-156
Neurochem Res 30(12)
Pages: 1607-13
Clin.Exp.Pharmacol.Physiol. 32(1-2)
Neuroscience Letter 385
Neuroscience Letter 387
Neurochem.Res. 30(12)
Pages: 1607-1613