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Pathophysiological analysis of myocardial dysfunction by observing nanometer ordernanometer-order dynamics of actin-myosin, interaction

Research Project

Project/Area Number 17390231
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNara Medical University

Principal Investigator

SHIMIZU Juichiro  Nara Medical University, Department of Surgery, Associate Professor (80294403)

Co-Investigator(Kenkyū-buntansha) TAKAKI Miyako  Nara Medical University, Department of Physiology II, Professor (00033358)
MOHRI Satoshi  Okayama University, Department of Cardiovascular Physiology, Assistant Professor (00294413)
NAKAMURA Kazuhumi  Okayama University, Department of Cardiovascular Medicine, Associate (10335630)
MIYASAKA Takehiro  Himeji Dokkyo University, Department of Medical Engineering, Professor (60308195)
YAGI Naoto  Japan Synchrotron Radiation Research Institute, Bio-and Soft-material Research Group, Group Leader (80133940)
梶谷 文彦  川崎学園, 医療福祉大学・医療短期大学, 教授 (70029114)
辻岡 克彦  川崎医科大学, 医学部, 教授 (30163801)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,130,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2005: ¥6,700,000 (Direct Cost: ¥6,700,000)
KeywordsSPring-8 / X-ray Diffraction / Hypoxia / Myofilament Lattice / Crossbridge / Contraction / Frank Starling Law / Ca Transient / Heart Rate / Transmural Heterogeneity / X線回折 / 心臓 / 左心室自由壁 / アクチン / ミオシン / クロスブリッジ / ラット
Research Abstract

We have been proceeding to investigate into the cardiac physiology, especially in the myocardial excitation-contraction coupling. We study the cardiac performance in the isolated and in the in situ heart, theoretically analyze the data from the view of mechanoenergetics, and then speculate the myocardial intracellular Ca2+ dynamics and the myofilament crossbridge attach/detach kinetics. Then we found that the left ventricular myocardial intracellular Ca2+ dynamics is independent of the left ventricular volume and the left ventricular myofilament Ca2+ bound/unbound kinetics is also independent of the left ventricular volume. Then we proposed that the volume dependent increase in the cardiac contracting force that is known as Frank-Starling law is greatly dependent on the actin-myosin interaction. Several methods have been reported to investigate the actin-myosin interaction in variable level, most of them are the molecular level experiments. Tb investigate the myocardial actin-myosin in … More teraction in the physiologically contracting preparation, the x-ray diffraction technique is quite useful and reliable using synchrotron radiation. The x-ray provided by the first- and the second-generation synchrotron facilities were not enough strong to penetrate the myocardium and not enough monochromatic to make dear diffraction images. Because of these reasons, the investigators had to use thin papillary muscle and perform summation of diffraction images obtained from thousands of contractions to reduce S/N ratio. Now we can use the third generation synchrotron facility. Because the SPring-8 that is the world largest synchrotron facility can provide the ideal-ray characterized as 1) high photon flux, 2) monochromatic, and 3) collimated, we can analyze the actin-myosin interaction in the excised rat hearts in a single contraction without summation. We aimed to establish the x-ray diffraction analysis in isolated rat hearts and to analyze the relation between the left ventricular pressure and the actin-myosin interaction in the failing heart. The detailed results are in the main part of this report. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (99 results)

All 2008 2007 2006 2005 Other

All Journal Article (40 results) (of which Peer Reviewed: 27 results) Presentation (58 results) Remarks (1 results)

  • [Journal Article] A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system2008

    • Author(s)
      Katsui R
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hypovolemia Does Not Affect Speed Of Isovolumic Left Ventricular Contraction And Relaxation In Excised Canine Heart2008

    • Author(s)
      Mizuno J
    • Journal Title

      Shock 29

      Pages: 395-401

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system.2008

    • Author(s)
      Katsui R, Kojima Y, Kuniyasu H, Shimizu J, Koyama F, Fujii H, Nakajima Y, Takaki M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypovolemia Does Not Affect Speed Of Isovolumic Left Ventricular Contraction And Relaxation In Excised Canine Heart.2008

    • Author(s)
      Mizuno J, Shimizu J, Mohri S, Araki J, Hanaoka K, and YamadaY.
    • Journal Title

      Shock 29

      Pages: 395-401

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of gut pacemaker cell formation from mouse ES cells by the c-kit inhibitor2007

    • Author(s)
      Takaki M
    • Journal Title

      Biochemical and Biophysical Research Communications 359

      Pages: 354-359

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats2007

    • Author(s)
      Kajiya M
    • Journal Title

      Am J Physiol Heart Circ Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.2007

    • Author(s)
      Kajiya M, Hirota M, Inai Y, Kiyooka T, Morimoto T, Iwasaki T, Endo K, Mohri S, Shimizu J, Yada T, Ogsawara Y,
    • Journal Title

      Am J Physiol Heart Circ Physiol 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart slice NMR2007

    • Author(s)
      Uetani T, Yamashita D, Shimizu J, Misawa H, Tatematsu Y, Hamaguchi Y, Miyasaka T, Katanosaka Y, Kato T,
    • Journal Title

      Am J physiol Heart Circ Physiol 292

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of novel histone deacetylase inhibitor,N-(2-aminopheny1)benzamide on a reversible hypertrophy induced by isoproterenol in in situ rat hearts.2007

    • Author(s)
      Kitagawa Y, Tamura Y, Shimizu J, Nakajima-Takenaka C, Taniguchi S, Uesato S, Takaki M
    • Journal Title

      Journal of Pharmacological Sciences 104(2)

      Pages: 167-175

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of gut pacemaker cell formation from mouse ES cells by the c-kit inhibitor.2007

    • Author(s)
      Takaki M, Misawa H, Shimizu J, Kuniyasu H, Horiguchi K
    • Journal Title

      Biochemical and Biophysical Research Communications 359

      Pages: 354-359

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart slice NMR.2007

    • Author(s)
      Uetani T. et al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 292(2)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.2007

    • Author(s)
      Kajiya M. et al.
    • Journal Title

      Am J Physiol Heart Circ Physiol. Epub

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Iris movement mediates vascular apoptosis during rat pupillary membrane regression2006

    • Author(s)
      Morizane Y
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 290(3)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 放射光X線回折法による拍動心臓の収縮蛋白質分子動態のリアルタイム計測とその応用2006

    • Author(s)
      白井 幹康
    • Journal Title

      分子心血管病 7(4)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Starling-effect-independent lusitropism index in canine left ventricle: logistic time constant2006

    • Author(s)
      Mizuno J
    • Journal Title

      Anesth Analg 102(4)

      Pages: 1032-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts2006

    • Author(s)
      Oshima Y
    • Journal Title

      Ann Thorac Surg 81(2)

      Pages: 658-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors2006

    • Author(s)
      Hirota M
    • Journal Title

      J Heart Lung Transplant 25(3)

      Pages: 339-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Measurements of CO_2, lactic acid and sodium bicarbonate secreted by cultured cells using a flow-through type pH/CO_2 sensor system based on ISFET2006

    • Author(s)
      Mohri S
    • Journal Title

      J Heart Lung Transplant 25(3)

      Pages: 339-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High Mechanical efficiency of left ventricular arrhythmic contractions during atrial fibrillation2006

    • Author(s)
      Shimizu J
    • Journal Title

      J Physiological Sciences 56(4)

      Pages: 269-274

    • NAID

      10020331796

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Heart Slice NMR2006

    • Author(s)
      Uetani T
    • Journal Title

      Am J Physiol Heart Circ Physiol 292

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of novel histone deacetylase inhibitor, N-(2-aminophenyl)benzamide on a reversible hypertrophy induced by isoproterenol in in situ rat hearts2006

    • Author(s)
      Kitagawa Y
    • Journal Title

      Journal of Pharmacological Sciences 104(2)

      Pages: 167-175

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High mechanical efficiency of left ventricular arrhythmic contractions during atrial fibrillation.2006

    • Author(s)
      Shimizu J. et al.
    • Journal Title

      JPhusiol Sci. 56(4)

      Pages: 269-74

    • NAID

      10020331796

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Starling-effect-independent lusitropism index in canine left ventricle : logistic time constant.2006

    • Author(s)
      Mizuno J. et al.
    • Journal Title

      Anesth Analg. 102(4)

      Pages: 1032-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated caninenon-heart-beating donors.2006

    • Author(s)
      Hirota M. et al.
    • Journal Title

      J Heart Lung Transplant. 25(3)

      Pages: 339-44

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 放射光X線回折法による拍動心臓の収縮蛋白質分子動態のリアルタイム計測とその応用2006

    • Author(s)
      白井幹康 ら
    • Journal Title

      分子心血管病 7(4)

      Pages: 358-68

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Iris movement mediates vascular apoptosis during rat pupillary membrane regression.2006

    • Author(s)
      Monzane Y, Mohri S, Kosaka J, Tone S, Kiyooka T, Miyasaka T, Shimizu J, Ogasawara Y, Shiraga F, Minatogawa Y, Sasaki J, Ohtsuki H, Kajiya F.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol. 290・3

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Celsior preserved cardiac mechanoenergetics better than popular solutions in canine hearts2006

    • Author(s)
      Oshima Y, Mohri S, Shimizu J, Iribe G, Imaoka T, Fujinaka W, Kiyooka T, Ishino K, Sano S, Kajiya F, Suga H.
    • Journal Title

      Ann Thorac Surg 81・2

      Pages: 658-664

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prediction of functional recovery of 60-minute warm ischemic hearts from asphyxiated canine non-heart-beating donors.2006

    • Author(s)
      Hirota M, Ishino K, Fukumasu I, Yoshida K, Mohri S, Shimizu J, Kajiya F, Sano S.
    • Journal Title

      J Heart Lung Transplant 25・3

      Pages: 339-344

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Positive inotropic effect of nicorandil in in situ adult rats2005

    • Author(s)
      Nakahashi K
    • Journal Title

      J Anesth 19(1)

      Pages: 45-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Calpain inhibitor-1 protects the rat heart from ischemic-reperfusion iniurv: analysis by mechanical work and energetics2005

    • Author(s)
      Yoshikawa Y
    • Journal Title

      Am J Physiol Heart Circ Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Na^+/Ca^<2+> exchange inhibition protects the rat heart from ischemicreperfusion injury by blocking energy-wasting processes2005

    • Author(s)
      Hagihara H
    • Journal Title

      Am J Physiol Heart Circ Physiol 288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Detrimental effects after dobutamine infusion on rat left ventricular function: mechanical work and energetics2005

    • Author(s)
      Nakajima-Takenaka C
    • Journal Title

      Experimental Physiology 90(4)

      Pages: 635-644

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Normal distribution of ventricular pressure-volume area of arrhythmic beats under atrial fibrillation in canine heart2005

    • Author(s)
      Mohri S
    • Journal Title

      Am J Physiol Heart Circ Physiol 288(4)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Direct observation of epicardial coronary capillary hemodynamics during reactive hyperemia and during adenosine administration by intravital video microscopy2005

    • Author(s)
      Kiyooka T
    • Journal Title

      Am J Physiol Heart Circ Physiol 288(3)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regression of capillary network in atrophied soleus muscle induced by hindlimb unweighting2005

    • Author(s)
      Fujino H
    • Journal Title

      J Appl Physiol 98

      Pages: 1407-1413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Predictability of O_2 consumption from contractility and mechanical energy of absolute arrhythmic beats in canine heart2005

    • Author(s)
      Shimizu J
    • Journal Title

      Jpn J Physiol 55(2)

      Pages: 135-142

    • NAID

      10016627439

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Variable unstressed volume keeps normal distributions of canine left ventricular contractility and total mechanical energy under atrial fibrillation2005

    • Author(s)
      Mohri S
    • Journal Title

      Jpn J Physiol 55(5)

      Pages: 255-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Normal distribution of ventricular pressure-volume area of arrhythmic beats under atrial fibrillation in canine heart.2005

    • Author(s)
      Mohri S, Shimizu J, Iribe G, Ito H, Morita T, Yamaguchi H, Sano S, Kajiya F, Suga H.
    • Journal Title

      Am J Physiol Heart Circ Physiol. 288・4

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Regression of capillary network in atrophied soleus muscle induced by hindlimb unweighting.2005

    • Author(s)
      Fujino H, Kohzuki H, Takeda I, Kiyooka T, Miyasaka T, Mohri S, Shimizu J, Kajiya F.
    • Journal Title

      J Appl Physiol. 98・4

      Pages: 1407-1413

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Variable Unstressed Volume Keeps Normal Distributions of Canine Left Ventricular Contractility and Total Mechanical Energy under Atrial Fibrillation.2005

    • Author(s)
      Mohri S, Shimizu J, Ito H, Yamaguchi H, Sano S, Takaki M, Suga H.
    • Journal Title

      Jpn J Physiol. 55・5

      Pages: 255-264

    • NAID

      10018623883

    • Related Report
      2005 Annual Research Report
  • [Presentation] Increasing preload attenuates crossbridge formation under hypoxia2008

    • Author(s)
      Shimizu J
    • Organizer
      第72回日本循環器学会総会、学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increasing preload attenuates crossbridge formation under hypoxia2008

    • Author(s)
      Shimizu, J
    • Organizer
      The 72rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-03-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increasing preload attenuates crossbridge formation under hypoxia2008

    • Author(s)
      Juichiro Shimizu, Yamato Tamura, Takehiro Miyasaka, Daisuke Takeshita, Miako Takaki,
    • Organizer
      第72回日本循環器学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of NCX in increased O_2 consumption in hypertrophiedrat hearts2008

    • Author(s)
      Ito H
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Decrease in oxygen cost of left ventricular contractility by SERCA2a overexpression2008

    • Author(s)
      Sakata S
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increasing preload attenuates crossbridge formation under hypoxia2008

    • Author(s)
      Shimizu J
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of NCX in increased O2 consumption in hypertrophied rat hearts2008

    • Author(s)
      Ito, H
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Decrease in oxygen cost of left ventricular contractility by SERCA2a overexpression2008

    • Author(s)
      Sakata, S
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Increasing preload attenuates crossbridge formation under hypoxia2008

    • Author(s)
      Shimizu, J
    • Organizer
      The 85th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Role of NCX in increased O2 consumption in hypertrophied rat hearts.2008

    • Author(s)
      Ito H, Shimizu J, Matsuoka S, Kim B, Takeuchi A, Nakajima-Takenaka C, Yamashita D, Sakata S, Takaki M
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Decrease in oxygen cost of left ventricular contractility by SERC A2a overexpression.2008

    • Author(s)
      Sakata S, Sakata N, Sakata Y, Nakajima-Takenaka C, Shibata M, Misawa H, Ito H, Shimizu J, Takaki M:
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Increasing preload attenuates crossbridge formation under hypoxia.2008

    • Author(s)
      Shimizu J, Yagi N, Miyasaka T, Sakata S, Nakajima-Takenaka C, Misawa H, Takaki M
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス胚性幹細胞から分化誘導された腸管におけるc-kit陽性細胞(ICC)の形成の対するGIST治療薬2008

    • Author(s)
      高木 都、三澤 裕美、清水 壽一郎、国安 弘基、堀口 和秀
    • Organizer
      第4回日本消化管学会総会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス胚性幹細胞から分化誘導された腸管におけるc-kit陽性細胞(ICC)の形成の対するGIST治療薬グリベックの効果2008

    • Author(s)
      高木 都
    • Organizer
      第4回日本消化管学会総会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibition of c-kit positive gut pacemaker cell formation from mouse ES cells by the GIST treatment drug, Glivec2008

    • Author(s)
      Takaki, M
    • Organizer
      The 4th Annual Meeting of the Japanese Gastroenterological Association
    • Place of Presentation
      Osaka
    • Year and Date
      2008-02-07
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 健常ラット心臓へのSERCA2a遺伝子導入は、左室収縮性の酸素コストを低下させる2008

    • Author(s)
      坂田 進
    • Organizer
      第18回日本病態生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 低酸素環境下での前負荷増大による心機能低下と心筋分子モータの挙動異常2008

    • Author(s)
      柴田 宗孝
    • Organizer
      第18回日本病態生理学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] SERCA2a gene transfer to normal rat heart reduces oxygen cost of left ventricular contraction2008

    • Author(s)
      Sakata, S
    • Organizer
      The 17rd Annual Scientific Meeting of the Japanese Society of Pathophsiology
    • Place of Presentation
      Kobe
    • Year and Date
      2008-01-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cardiac dysfunction and attenuated myocardial molecular motor function with increasing preloadunder hypoxia2008

    • Author(s)
      Shibata, M
    • Organizer
      The 17rd Annual Scientific Meeting of the Japanese Society of Pathophsiology
    • Place of Presentation
      Kobe
    • Year and Date
      2008-01-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シックハウス症候群関連化学物質ホルムアルデヒドの心機能に及ぼす影響2007

    • Author(s)
      竹下 大輔、清水 壽一郎、中島 千香子、高木 都
    • Organizer
      第54回中部日本生理学会・第100回近畿生理学談話会合同大会
    • Place of Presentation
      三重
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 選択的β1プロッカーランジオロールの特性:血液交叉灌流摘出ラット心臓を用いるメカノエナジェティクスからのアプローチ2007

    • Author(s)
      吉川 義朗
    • Organizer
      第60回日本胸部外科学会定期学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] シックハウス症侯群関連化学物質ホルムアルデヒドの心機能に及ぼす影響2007

    • Author(s)
      竹下 大輔
    • Organizer
      第54回中部日本生理学会、第100回磯生理学談話会合同大会
    • Place of Presentation
      三重
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of selective β 1-blocker, landiolol : approach from mechanoenergetics view usingcross-circulating blood perfused rat heart preparations.2007

    • Author(s)
      Yoshikawa, Y
    • Organizer
      The 60th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery
    • Place of Presentation
      Sendai
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of Formaldehyde that is one of thechemical agents causing sick house syndrome on cardiac function.2007

    • Author(s)
      Takeshita, D
    • Organizer
      54th Chubu Nippon and 100th Kinki Combined Physiological Meeting
    • Place of Presentation
      Mie
    • Year and Date
      2007-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 選択的β1ブロッカーランジオロールの特性:血液交叉灌流摘出ラット心臓を用いるメカノエナジェティ2007

    • Author(s)
      吉川 義朗、多林 伸起、辻 毅嗣、藤根 潔枝、清水 壽一郎、谷口 繁樹、高木 都
    • Organizer
      第60回日本鵬外科学会定期学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-10-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nano-order dynamics of molecular motors in rat left ventricle2007

    • Author(s)
      Shimizu J
    • Organizer
      BBSRC Japan Partnering Programme 2007-2011
    • Place of Presentation
      Oxford
    • Year and Date
      2007-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 突発性肺動脈高血圧症患者の肺動脈平滑筋細胞における力学特性ならびに増殖能の検討2007

    • Author(s)
      中村 一文
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      橿原
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of mechanical property and proliferating ability of pulmonary artery smooth muscle cells derived from explanted lung of patients of idiopathic pulmonary hypertension.2007

    • Author(s)
      Nakamura, K
    • Organizer
      The 50th Annual Meeting of Japan Society of Smooth Muscle Research
    • Place of Presentation
      Kashihara
    • Year and Date
      2007-07-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 突発性肺動脈高血圧症患者の肺動脈平滑筋細胞における力学特性ならびに増殖能の検討2007

    • Author(s)
      中村 一文、松原 弘己、清水 壽一郎、草野 研吾、伊達 洋至、大江 透
    • Organizer
      第49回日本平滑筋学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2007-07-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 高い心拍数ではアクチン-ミオシンの架橋形成は減少する2007

    • Author(s)
      清水 壽一郎
    • Organizer
      第46回日本生体医工学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2007-04-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2007

    • Author(s)
      Shimizu, J
    • Organizer
      The 45th Annual Conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      Sendai
    • Year and Date
      2007-04-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2007

    • Author(s)
      Shimizu J
    • Organizer
      第84回日本生理学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Left ventricular lusitropic dysfunction of isoproterenol-induced hypertrophied rat heart2007

    • Author(s)
      Nakajima-Takenaka C
    • Organizer
      第84回日本生理学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Left ventricular lusitropic dysfunction of isoproterenol-induced hypertrophied rat heart2007

    • Author(s)
      Nakajima-Takenaka, C
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2007

    • Author(s)
      Shimizu, J
    • Organizer
      The 84th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      Osaka
    • Year and Date
      2007-03-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2007

    • Author(s)
      Shimizu J
    • Organizer
      第71回日本循環器学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-03-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2007

    • Author(s)
      Shimizu, J
    • Organizer
      The 71rd Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Kobe
    • Year and Date
      2007-03-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高い心拍数では心筋アクチンるミオシン架橋形成は減少する2007

    • Author(s)
      清水 壽一郎
    • Organizer
      第17回日本病態生理学会
    • Place of Presentation
      沖縄
    • Year and Date
      2007-01-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2007

    • Author(s)
      Shimizu, J
    • Organizer
      The 17rd Annual Scientific Meeting of the Japanese Society of Pathophsiology
    • Place of Presentation
      Okinawa
    • Year and Date
      2007-01-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 高い心拍数では心筋アクチン、ミオシン架橋形成は減少する2006

    • Author(s)
      清水 壽一郎
    • Organizer
      筋生理の集い
    • Place of Presentation
      東京
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Higher heart rate attenuates the actin-myosin interaction in LV free wall2006

    • Author(s)
      Shimizu, J
    • Organizer
      Annual meeting of muscle physiology
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-12-09
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Left ventricular function of isoproterenol-induced hypertrophied rat heart: mechanical work and energetics2006

    • Author(s)
      Nakajima-Takenaka C
    • Organizer
      The 23rd Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      幕張
    • Year and Date
      2006-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Left ventricular function of isoproterenol-induced hypertrophied rat heart : mechanical work and energetics2006

    • Author(s)
      Nakajima-Takenaka, C
    • Organizer
      The 23rd Annual Meeting of ISHR Japanese Section
    • Place of Presentation
      Makuhari
    • Year and Date
      2006-12-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 左室容積増大に伴う筋線維格子間隔の狭小化はアクチン、ミオシンの相互作用を増強する2006

    • Author(s)
      清水 壽一郎
    • Organizer
      第99回近畿生理学談話会
    • Place of Presentation
      大阪
    • Year and Date
      2006-09-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イソプロテレノール誘導ラット肥大心の心筋スライス酸素消費量2006

    • Author(s)
      中島 千香子
    • Organizer
      第99回近畿生理学談話会
    • Place of Presentation
      大阪
    • Year and Date
      2006-09-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reducing myocardial interfilament spacing resulted of increasing left ventricular volume augments actin-myosin interaction2006

    • Author(s)
      Shimizu, J
    • Organizer
      99th Knki Physiological Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2006-09-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Oxygen consumption in myocardial slice preparation of isoproterenol induced hypertrophied heart2006

    • Author(s)
      Nakajima-Takenaka, C
    • Organizer
      99th Knki Physiological Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2006-09-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transmural changes of nano-order myofilament lattice spacing and actin -myosin interaction with increasing left ventricular volume2006

    • Author(s)
      Shimizu J
    • Organizer
      7th Korea-Japan BME Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2006-08-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transmural changes of nano-order myofilament lattice spacing and actin-myosin interaction with increasing left ventricular volume2006

    • Author(s)
      Shimizu, J
    • Organizer
      7th Korea-Japan BME Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2006-08-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Possible Interaction of myocytes and coronary microcirculation-View from Transmural difference of nano-order structure and dynamics of left ventricular cardiac myofilaments2006

    • Author(s)
      Shimizu J
    • Organizer
      5th World Congress of Biomechanics
    • Place of Presentation
      Munich
    • Year and Date
      2006-07-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Strategy for rescue of failing hearts from mechanoenergetic window2006

    • Author(s)
      Takaki M
    • Organizer
      2nd World Congress of International Academy of Cardiovascular Sciences 2006
    • Place of Presentation
      札幌
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Strategy for rescue of failing hearts from mechanoenergetic window2006

    • Author(s)
      Takaki, M
    • Organizer
      2nd World Congress of International Academy of Cardiovascular Sciences 2006 Symposium
    • Place of Presentation
      Sapporo
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規ヒストン脱アセチル化酵素阻害薬N-(2-aminophenyl)benzamideはイソプロテレノール誘導可逆的心肥大および左室機能障害を抑制しない2006

    • Author(s)
      田村 大和
    • Organizer
      第27回日本循環制御医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] イソプロテレノール誘導心肥大の機能評価:3および7日間投与モデルの比較2006

    • Author(s)
      北川 豊
    • Organizer
      第45回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2006-05-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット摘出心におけるクロスブリッジ動態と筋線維格子間隔の貫壁性の変化について2006

    • Author(s)
      清水 壽一郎
    • Organizer
      第83回日本生理学会大会
    • Place of Presentation
      群馬
    • Year and Date
      2006-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transmurally different changes in nano-order myofilament lattice spacing and crossbridge dynamics with increasing left ventricular volume2006

    • Author(s)
      Shimizu J
    • Organizer
      The 50th Biophysical Society Annual Meeting
    • Place of Presentation
      Salt Lake City
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transmural difference in myocardial crossbridge dynamics and myofilament lattice spacing2005

    • Author(s)
      Juichiro Shimizu
    • Organizer
      第22回国際心臓研究学会(ISHR)日本部会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2005-12-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 単色光による冠微小循環とナノオーダー心筋分子モータの解析2005

    • Author(s)
      清水 壽一郎
    • Organizer
      第26回日本レーザー医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2005-09-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.naramed-u.ac.jp/~2phy/Gyoseki.htm

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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