Studies on cortical spreading depression and changes in brain capillary blood flow in acute phase of brain ischemia or aura in acute migraine

• Project/Area Number: 17390255
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Keio University
• Principal Investigator: SUZUKI Norihiro Keio University, 医学部, 教授 (10158975)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Shinichi 慶應義塾大学, 医学部, 准教授 (20236285) ; ITOH Yoshiaki 慶應義塾大学, 医学部, 講師 (90265786) ; ITO Daisuke 慶應義塾大学, 医学部, 講師 (80286450) ; TOMITA Yutaka 慶應義塾大学, 医学部, 助教 (60276251) ; 長田 高志 慶應義塾大学, 医学部, 助教 (30348635)
• Co-Investigator(Renkei-kenkyūsha): OSADA Takashi 慶應義塾大学, 医学部, 助教 (30348635)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥14,900,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2006: ¥6,100,000 (Direct Cost: ¥6,100,000); Fiscal Year 2005: ¥6,200,000 (Direct Cost: ¥6,200,000)
• Keywords: 脳虚血 / 片頭痛 / 脳微小循環 / 大脳皮質拡延性抑制 / 片頭痛前兆 / 皮質拡延性抑制 / 脳血流 / 脳毛細血管

Research Abstract

虚血時の微小循環変化と皮質拡延性抑制(cortical spread depression : CSD)の微小循環変化は類似した表現型を示すが、原因と結果が逆であり発生機序的にまったく異なるものである。CSDにおける微小循環変化は神経細胞脱分極によって二次的に起こる毛細血管血流障害であり、CSDと密接に関連する片頭痛においては血管の一過性の炎症反応を含む異常反応が惹起される可能性がある.

Research Products

• [Journal Article] Ambivalent aspects of interleukin-6 in cerebral ischemia : inflammatory versus neurotrophic aspects. (2009)
  • Author(s): Suzuki S, Tanaka K, Suzuki N
  • Journal Title: J Cereb Blood Flow Metab 29(3) Pages: 464-479
  • Peer Reviewed
• [Journal Article] Automated method for tracking vast numbers of FITC-labeled RBCs in microvessels of rat brain in vivo using a high-speed confocal microscope system (2008)
  • Author(s): Tomita M, Osada T, Schiszler I, Tomita Y, Unekawa M, Toriumi H, Tanahashi N, Suzuki N
  • Journal Title: Microcirculation 15(2) Pages: 163-174
  • Peer Reviewed
• [Journal Article] Frequency distribution function of red blood cell velocities in single capillaries of the rat cerebral cortex using intravital laser-scanning confocal microscopy with high-speed camera (2008)
  • Author(s): Unekawa M, Tomita M, Osada T, Tomita Y, Toriumi H, Tatarishvili J, Suzuki N
  • Journal Title: Asian Biomed. 2(3) Pages: 203-218
  • Peer Reviewed
• [Journal Article] Automated method for tracking vast numbers of FITC-labeled RBCs in microvessels of rat brain in vivo using a high-speed confocal microscope system. (2008)
  • Author(s): Tomita M, Osada T, Schiszler I, Tomita Y, Unekawa M, Toriumi H, Tanahashi N, Suzuki N
  • Journal Title: Microcirculation 15(2) Pages: 163-174
  • Peer Reviewed
• [Journal Article] Frequency distribution function of red blood cell velocities in single Capillaries of the rat cerebral cortex using intravital laser-scanning confocal microscopy with high-speed camera. (2008)
  • Author(s): Unekawa M, Tomita M, Osada T, Tomita Y, Toriumi H, T atarishvili J, Suzuki N
  • Journal Title: Asian Biomed 2(3) Pages: 203-218
  • Peer Reviewed
• [Journal Article] Automated method for tracking vast numbers of FTTC-labeled RBCs in microvessels of rat brain in vivo using a high-speed confocal microscope system. (2008)
  • Author(s): Tomita M, Osada T, Schiszler I, Tomita Y, Unekawa M, Toriumi H, Tanahashi N, Suzuki N.
  • Journal Title: Microcirculation. 15 Pages: 163-174
  • Peer Reviewed
• [Journal Article] Effect of Gosha-jinki-gan, a Kampo medicine, on cortical blood flow of rat brain as observed by hemodilution technique and high-speed confocal microscopy (2007)
  • Author(s): Osada T, Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N
  • Journal Title: Microvasc. Rev. Commun 1 Pages: 16-19
  • NAID: 130004467802
  • Peer Reviewed
• [Journal Article] Sampling rate-dependent RBC velocity in intraparenchymal single capillaries of rat cerebral cortex. Microvasc (2007)
  • Author(s): Unekawa M, Tomita M, Osada T, Tomita Y, Toriumi H, Suzuki N
  • Journal Title: Rev. Commun 1 Pages: 12-15
  • Peer Reviewed
• [Journal Article] Effect of Gosha-jinki-gan,a Kampo medicine,on cortical blood flow of rat brain as observed by hemodilution technique and high-speed confocal microscopy (2007)
  • Author(s): Osada T, Tomita M, Tomita Y, Unekawa M, Torium i H, Suzuki N
  • Journal Title: MVRC 1 Pages: 16-19
  • NAID: 130004467802
  • Peer Reviewed
• [Journal Article] Sampling rate-dependent RBC velocity in intraparenchymal single capillaries of rat cerebral cortex (2007)
  • Author(s): Unekawa M, Tomita M, Osada, T Tomita Y, Toriumi H, Suzuki N
  • Journal Title: MVRC 1 Pages: 12-15
  • Peer Reviewed
• [Journal Article] Novel mutation of the Notch3 gene in a Japanese patient with CADASIL. (2007)
  • Author(s): Oki K, Nagata E, Ishiko A, Tanaka K, Takahashi K, Tabira T, Katayama T, Suzuki N
  • Journal Title: Eur J Neurol 14 Pages: 464-466
  • Peer Reviewed
• [Journal Article] Regeneration of the central nervous system using endogenous repair mechanisms. (2007)
  • Author(s): Okano H, Sakaguchi M, 0ki K, Suzuki N, Sawamoto K
  • Journal Title: J Neurochem 102 Pages: 1459-1465
  • Peer Reviewed
• [Journal Article] Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat. (2007)
  • Author(s): Shimizu T, Toriumi H, Sato H, Shibata M, Nagata E, Gotoh K, Suzuki N:, 2007
  • Journal Title: Brain Res 1173 Pages: 84-91
  • Peer Reviewed
• [Journal Article] Altered levels of serotonin in lymphoblasts derived from migraine patients (2007)
  • Author(s): Nagata E, Hamada J, Shimizu T, Shibata M, Suzuki S, Osada T, Kuwana M, Suzuki N
  • Journal Title: Neurosci Res 57 Pages: 179-183
  • NAID: 10021188602
• [Journal Article] Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression (2006)
  • Author(s): Osada T, Tomita M, Suzuki N
  • Journal Title: Neuroreport 17(12) Pages: 1365-1368
  • Peer Reviewed
• [Journal Article] Astroglial swelling for removed rat brain enlargement incubated in deoxygenated mock cerebrospinal fluid. Clin (2006)
  • Author(s): Osada T, Tomita M, Tanahashi N, Takeda H, Nagai T, Suzuki N
  • Journal Title: Hemorheol. Microcirc 34(1-2) Pages: 223-226
  • Peer Reviewed
• [Journal Article] Flow effect impacts NIRS, jeopardizing quantification of tissue hemoglobin (2006)
  • Author(s): Tomita M, Suzuki N
  • Journal Title: Neuroimage 33 Pages: 13-16
  • Peer Reviewed
• [Journal Article] Contribution of the flow effect caused by shear-dependent RBC aggregation to NIRS spectroscopicsignals (2006)
  • Author(s): Tomita M, Ohtomo M, Suzuki N
  • Journal Title: Neuroimage 33 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Capillo-venous flow in the brain : significance of intravascular RBC aggregation for venous flow regulation (2006)
  • Author(s): Tomita M, Tanahashi N, Takeda H, Schiszler I, Osada T, Unekawa M, Suzuki N
  • Journal Title: Clin. Hemorheol. Microcirc 34(1-2) Pages: 51-57
  • Peer Reviewed
• [Journal Article] Oxidative metabolism in cultured rat astroglia : effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation (2006)
  • Author(s): Abe T, Takahashi S, Suzuki N
  • Journal Title: J Cereb Blood Flow Metab 26 Pages: 153-160
  • Peer Reviewed
• [Journal Article] Contribution of the flow effect caused by shear-dependent RBC aggregation to NIRS spectroscopic signals. (2006)
  • Author(s): Tomita M, Ohtomo M, Suzuki N
  • Journal Title: Neuro Image 33 Pages: 1-10
• [Journal Article] Capillo-venous flow in the brain : Singificance of intravascular RBC aggregation for venous flow regulation. (2006)
  • Author(s): Tomita M, Tanahashi N, Takeda H, Schiszler I, Osada T, Unekawa M, Suzuki N
  • Journal Title: Clin Hemorheol Micro 34(1-2) Pages: 51-57
• [Journal Article] Astroglial swelling for removed rat brain enlargement incubated in deoxygenated mock cerebrospinal fluid. (2006)
  • Author(s): Osada T, Tomita M, Tanahashi N, Takeda H, Nagai T, Suzuki N
  • Journal Title: Clin Hemorheol Micro 34(1-2) Pages: 223-226
• [Journal Article] Capillo-venous flow in the brain : significance of intravascular RBC aggregation for venous flow regulation (2006)
  • Author(s): Tomita M, Tanahashi N, Takeda H, Schiszler I, Osada T, Unekawa M, Suzuki N
  • Journal Title: Clin Hemorheol Micro 34 Pages: 51-57
• [Journal Article] Astroglial swelling for removed rat brain enlargement incubated in deoxygenated mock cerebrospinal fluid. (2006)
  • Author(s): Osada T, Tomita M, Tanahashi N, Takeda H, Nagai T, Suzuki N
  • Journal Title: Clin Hemorheol Micro 34 Pages: 223-226
• [Journal Article] Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells. (2006)
  • Author(s): Ito Y, Takaoka R, Ohira M, Abe T, Tnahashi N, Suzuki N
  • Journal Title: Clin Hemorheol Microcirc. 34 Pages: 163-168
• [Journal Article] Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period. (2006)
  • Author(s): Nagata E, Shibata M, Hamada J, Shimizu T, Katoh Y, Gotoh J, Suzuki N
  • Journal Title: Headache 46 Pages: 592-596
• [Journal Article] Metabolic properties of astrocytes differentiated from rat neurospheres. (2006)
  • Author(s): Abe T, Takahashi S, Suzuki N
  • Journal Title: Brain Research 1101 Pages: 5-11
• [Journal Article] A561C polymorphism of E-selectin is associated with ischemic cerebrovascular diseases in Japanese population without diabetes mellitus and hypercholoesterolemia. (2006)
  • Author(s): Hattori H, Sato H, Ito D, Tanahashi N, Murata M, Saito I, Watanabe K, Suzuki N
  • Journal Title: Brain Research 1108 Pages: 221-223
• [Journal Article] Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression. (2006)
  • Author(s): Osada T, Tomita M, Suzuki N
  • Journal Title: Neuro Report 17 Pages: 1365-1368
• [Journal Article] G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke. (2006)
  • Author(s): Hattori H, Sonoda A, Sato H, Ito D, Tanahashi N, Murata M, Saito I, Watanabe K, Suzuki N
  • Journal Title: Brain Research 1121 Pages: 246-249
• [Journal Article] Oxidative metabolism in cultured rat astroglia : effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation. (2006)
  • Author(s): Abe T
  • Journal Title: J Cereb Blood Flow Metab 26(2) Pages: 153-160
• [Journal Article] Intramicrovascular behavior of platelets in rat brain observed by high speed laser confocal fluorescent microscopy (2005)
  • Author(s): Tanahashi N, Takeda H, Osada T, Oki K, Unekawa M, Tomita M, Suzuki N
  • Journal Title: Microcirculation Annual 21 Pages: 43-44
  • Peer Reviewed
• [Journal Article] Initial oligemia with capillary flow stop followed by hyperemia during K^+-induced cortical spreading depression in rats. (2005)
  • Author(s): Tomita M, Schiszler I, Tomita Y, Tanahashi N, Takeda H, Osada T, Suzuki N
  • Journal Title: J. Cereb. Blood Flow Metab 25(6) Pages: 742-747
  • Peer Reviewed
• [Journal Article] Protective mechanism against excessive contraction of human brain microvascular endothelial cells in response to oxygen stimulus (2005)
  • Author(s): Tomita M, Tanahashi N, Takeda H, Osada T, Suzuki N
  • Journal Title: Microcirculation Annual 21 Pages: 13-14
  • Peer Reviewed
• [Journal Article] RBC velocity in intraparenchymal capillaries of the rat brain and its fluctuation (2005)
  • Author(s): Unekawa M, Tomita M, Tanahashi N, Takeda H, Osada T, Suzuki N
  • Journal Title: Microcirculation Annual 21 Pages: 85-86
  • Peer Reviewed
• [Journal Article] Initial oligemia with capillary flow stop followed by hyperemia during K+-induced cortical spreading depression in rats. (2005)
  • Author(s): Tomita M
  • Journal Title: J Cereb Blood Flow Metab 25(6) Pages: 742-747
• [Journal Article] Software (keio-is2) for automatically tracking red blood cells (RBCs) with calculation of individual RBCvelocities in single capillaries of rat brain. (2005)
  • Author(s): Schiszler I
  • Journal Title: J Cereb Blood Flow Metabol 25
• [Journal Article] Spatial and temporal heterogeneity of single capillary plasma flow and RBC tracking in the rat cerebral cortex (2005)
  • Author(s): Tomita M
  • Journal Title: J Cereb Blood Flow Metabol 25(Suppl)
• [Journal Article] Initial oligemia with capillary flow stop followed by hyperemia during K+-induced cortical spreading depression in rats. (2005)
  • Author(s): Tomita M
  • Journal Title: J Cereb Blood Flow Metabol 25(6) Pages: 742-747
• [Journal Article] Perturbation of intraparenchymal arterioles during K+-induced cortical spreading depression in cats. (2005)
  • Author(s): Osada T
  • Journal Title: J Cereb Blood Flow Metabol 25(Suppl)
• [Journal Article] Cortical microflow quantitative measurements with high spatial and temporal resolution over 1 month after focal cerebral ischemia in mice. (2005)
  • Author(s): Tomita Y
  • Journal Title: J Cereb Blood Flow Metab 25(Suppl)
• [Journal Article] Changes of flow velocity and rbc tracking in single capillaries and capillary densities during severe hypotension in rat brain. (2005)
  • Author(s): Takeda H
  • Journal Title: J Cereb Blood Flow Metab 25(Suppl)
• [Journal Article] Intramicrovascular behavior of platelets in rat brain observed by high-speed laser confocal fluorescence microscopy. (2005)
  • Author(s): Tanahashi N
  • Journal Title: J Cereb Blood Flow Metab 25(Suppl)
• [Journal Article] Implication of augumented vasogenic leakage in the mechanism of persistent aura in sporadic hemiplegic migraine. (2005)
  • Author(s): Iizuka T
  • Journal Title: Cephalalgia 26 Pages: 332-335
• [Presentation] 脳虚血周辺部微小血管の血管新生-経時的形態的変化と赤血球流速よりみたアプローチ. 2009. (2009)
  • Author(s): 冨田稔, Tatarishvili J, 鳥海春樹, 冨田裕, 畝川美悠紀, 服部英典, 鈴木則宏
  • Organizer: 第34 回日本卒中学会総会
  • Place of Presentation: 島根
  • Year and Date: 2009-03-19
• [Presentation] マウス板間静脈の血流特異性と週齢に伴う構造変化の検討 (2008)
  • Author(s): 鳥海春樹, 清水利彦, 冨田稔, 冨田裕, 畝川美悠紀, Tatarishvili Jemal, 長田高志, 鈴木則宏
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-06
• [Presentation] マウス脱血出血性ショック時の人工赤血球投与による脳酸素分圧への影響 (2008)
  • Author(s): 冨田裕, 鳥海春樹, Tatarishvili Jemal, 冨田稔, 畝川美悠紀, 酒井宏水, 土田英俊, 堀之内宏久, 小林紘一, 鈴木則宏
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-06
• [Presentation] Time for remodeling of the micro vascular structure after MCA occlusion in mice (2008)
  • Author(s): Tatarishvili Jemal, 冨田稔, 冨田裕, 長田高志, 畝川美悠紀, 鳥海春樹, 鈴木則宏
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-06
• [Presentation] 一酸化窒素の急速静注血圧下降に対する脳血流(血液希釈法)と脳組織毛細血管内赤血球速度の変化 (2008)
  • Author(s): 畝川美悠紀, 冨田稔, 冨田裕, 長田高志, 鳥海春樹, Tatarishvili Jemal, 鈴木則宏
  • Organizer: 第20回日本脳循環代謝学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-06
• [Presentation] Effect of artificial RBCs on raurine hemorrhagic shock model (2008)
  • Author(s): Tomita Y, Toriumi H, Tatarishvili J, Tomita M, Unekawa M, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Suzuki N
  • Organizer: 6th Current Issues on Blood Substitute Research
  • Place of Presentation: 東京
  • Year and Date: 2008-10-24
• [Presentation] RBC exelusion from capillaries in k+-induced cortical spreading depression and MCA occlusion-induced ischemia in rodents. (2008)
  • Author(s): Tomita M, Toraita Y, Osada T, Unekawa M, Toriumi H, Tatarishvili J, Suzuki N
  • Organizer: Symposium, Asian Congress for Microcirculation
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-10-17
• [Presentation] High RBC velocities in single capillaries of the rat cerebral cortex. (2008)
  • Author(s): Tomita M
  • Organizer: Asian Congress for Microcirculation (invited lecture)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2008-10-17
• [Presentation] In vivo visualization of astrocytic elements surrounding micro vessels with flowing FITC-labelled RBCs in mice (2008)
  • Author(s): Tomita Y, Tomita M, Osada T, Unekawa M, Toriumi H, Tatarishvili J, Suzuki N
  • Organizer: 6th World stroke Congress
  • Place of Presentation: Wien, Austria
  • Year and Date: 2008-09-24
• [Presentation] Periodic disappearance of RBC from focal capillary network during K+-induced cortical spreading depression in rodents (2008)
  • Author(s): Tomita M, Tomita Y, Osada T, Unekawa M, Toriumi T, Tatarishvili J, Suzuki N
  • Organizer: 25th Conference of the European Society for Microcirculation
  • Place of Presentation: Budapest
  • Year and Date: 2008-09-23
• [Presentation] Effects of artificial RBCs on murine cerebral ischemia (2008)
  • Author(s): Tomita Y, Toriumi H, Osada T, Tomita M, Unekawa M, Itoh Y, Hoshino H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Suzuki N
  • Organizer: 10th International Symposium on Thrombolysis and Acute Stroke threrapy
  • Place of Presentation: Budapest
  • Year and Date: 2008-09-23
• [Presentation] Periodic disappearance of RBC from focal capillary network during K+-induced cortical spreading depression in rodents (2008)
  • Author(s): Tomita M, Tomita Y, Osada T, Unekawa M, Toriumi T, Tatarishvili J, Suzuki N
  • Organizer: 25th Conference of the European Society for Microcirculation(rodents. J. Vasc. Res., 2008. 45(supple 2) : 49)
  • Place of Presentation: Budapest
  • Year and Date: 2008-09-22
• [Presentation] Facilitation of FITC-labeled RBC movement along single capillaries : role of glia? (2008)
  • Author(s): Tomita M, Tomita Y, Osada T, Unekawa M, Toriumi H, Tatarishvili J, Suzuki N
  • Organizer: Gordon Conference, Brain Energy Metabolism and Blood Flow
  • Place of Presentation: New Hampshire, USA
  • Year and Date: 2008-08-20
• [Presentation] Facilitation of FITC-labeled RBC movement along single capillaries : role of glia? (2008)
  • Author(s): Tomita M, Tomita Y, Osada T, Unekawa M, Toriumi H, Tatarishvili J, Suzuki N
  • Organizer: 2008. Gordon Conference, Brain Energy Metabolism and Blood Flow
  • Place of Presentation: New Hampsher, USA
  • Year and Date: 2008-07-21
• [Presentation] Cell swelling-membrane depolarization-loss of osmotic gradient layer in the cell membrane and changes in light scattering of red blood cells (2008)
  • Author(s): Tomita M, Tomita Y, Osada T, Unekawa M, Toriumi H, Tatarishvili J, Suzuki N
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] マウス脳血管内への選択的な物質移送の検討 (2008)
  • Author(s): 冨田裕, 冨田稔, 鈴木則宏, Seylaz J
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] マウス板間静脈の経週齢的発達と消退-頭痛との関連について- (2008)
  • Author(s): 鳥海春樹, 清水利彦, 冨田稔, 冨田裕, 柴田護, 長田高志, 畝川美悠紀, Jemal Tatalishvili, 後藤京子, 鈴木則宏
  • Organizer: 第49回日本神経学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] マウス脳虚血急性期における虚血部の赤血球標的血流とプラスマ標的血流の乖離(2008 3月20-22日,京都. (2008)
  • Author(s): 長田 高志、冨田 稔、冨田 裕、畝川 みゆき、Tatarishvili Jemal、鳥海 春樹、鈴木 則宏.
  • Organizer: 第33回日本脳卒中学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-20
• [Presentation] 7T-MRIによるマウス中大脳動脈閉塞後の頭部MRI、MRAの反復撮影および梗塞体積測定の試み(2008,3月20-22日、京都。 (2008)
  • Author(s): 冨田 裕、鳥海 春樹、Tatarishvfli Jemal、米山 操、青木 伊知男、長田 高志、畝川 美悠紀、冨田 稔、菅野 巌、鈴木 則宏.
  • Organizer: 第33回日本脳卒中学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-20
• [Presentation] Magnetic targeting of nanometric magnetic fluid loaded liposomes to specific intravascular areas a dynamic imaging study and analysis of CBF with KEIO-IS1 software in mice.、東京。 (2008)
  • Author(s): Tomita Y, Riviere C, Martina MS, Willhelm C, Tran Dinh A, Menager C, Pinard E, Lesieur S, Gazeau F, Tomita M, Suzuki N, Seylaz J.
  • Organizer: 第33目日本微小循環学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-21
• [Presentation] Effect of single capillary lengths in optically sliced thin layer of the rat cerebral cortex on frame-rate dependency of RBC velocity. (2008)
  • Author(s): Unekawa M, Tomita M, Osada T, Tomita Y, Toriumi H, Tatarishvili J, Suzuki N
  • Organizer: 第33回日本微小循環学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-21
• [Presentation] A new"Y-Type"orecortical arteriolo-arteriolar microanastomosis in the micrvascular network of MCA. (2008)
  • Author(s): Tatarishvili J, Tomita M, Tomita Y, Osada T, Unekawa M, Tbriumi H, Suzuki N.
  • Organizer: 第33回日本微小循環学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-21
• [Presentation] Repeated in vivo imaging with cellular resolution of bone marrow cells tran splanted into the ischemic brain of a mouse. (2007)
  • Author(s): Tomita Y, Tran Dinh A, Kubis N, Karaszewski B, Seylaz J, Pinard E, Tomita M, Suzuki N
  • Organizer: 21st Century Center of Excellence(COE)Program In ternational symposium 2007 Basic Study and Clinical Application of the Human Stem Cell Biology and I mmunology.
  • Place of Presentation: 東京
  • Year and Date: 2007-11-29
• [Presentation] 共焦点レーザー顕微鏡を用いたげっ歯小動物大脳皮質実質内毛細血管とダリア細胞および赤血球挙動の観療法(2007,10月25-26日,Morioka. (2007)
  • Author(s): 長田 高志、冨田 稔、冨田 裕、畝川 みゆき、鳥海 春樹、鈴本 則宏.
  • Organizer: 第19回日本脳循環代謝学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2007-10-25
• [Presentation] マウス脳梗塞モデルヘの人工赤血球投与の試み (2007)
  • Author(s): 冨田 裕、鳥海 春樹、長田 高志、冨田 稔、畝川 美悠紀、酒井 宏水、土田 英俊、堀之内 宏之、小林 紘一、鈴木 則宏
  • Organizer: 第19回日本脳循環代謝学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2007-10-25
• [Presentation] Fusion of thrombin induced fibrinogen gel by rt-PA on the surface of cultured human brain microvascular endothelial cells.2007,Sep.27-28,Kyoto. (2007)
  • Author(s): Osada T, Tomita M, Tanahashi N, Suzuki N.
  • Organizer: The 2nd Meeting of Asian Stroke Forum.
  • Place of Presentation: 京都
  • Year and Date: 2007-09-27
• [Presentation] ln vivo staining of astrocytic elements surrounding microvessels with flowing RBCs in mice.J Cereb Blood Row Metab 2007:27(Suppl),BP-3M (2007)
  • Author(s): Yutaka Tomita, Minoru Tbmita, Takashi Osada, Miyuki Unekawa, Haruki Toriumi, Ban Mihara, NoriMro Suzuki.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] Chestnut(Amaguri)method to visualize vessels in the dura and kull bone in mice.J Cereb Blood Flow Metab 2007:27(Suppl),BP59-5H. (2007)
  • Author(s): Haruki Toriumi, Minoru Tomita, Yutaka Tomita, Takashi Osada, Miyuki Unekawa, Toshihiko Shimizu, Norihiro Suzuki.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] RBC Exclusion without capillary diametric change during passage of k+induced cortical spreading depression in rats.J Cereb Blood Flow Metab 2007:27(Suppl),BO4-7. (2007)
  • Author(s): Takashi Osada, Minoru Tbmita, Yutaka Tomita, Miyuki Unekawa, Haruki Toriumi, Norihiro Suzuki.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] Pitfalls in NIR-spectroscopy and fMBI for measuring brain oxidativ e metabolism:with special remarks on a-v shunts.J Cereb Blood Flow Metab 2007:27(Suppl),BO3-7. (2007)
  • Author(s): Minoru Tomita, Yutaka Tomita, Takashi Osada, Miyuki Unekawa, Haruki Toriumi, Norihiro Suzuki.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] Extraordinary high flow capillaries in the cerebral microvascular network.J Cereb Blood Flow Metab 2007:27(Suppl),BP2-5U. (2007)
  • Author(s): Miyuki Unekawa, Minoru Tomita, Yutaka Tomita, Takashi Osada, Haruki Toriumi, Norihiro Suzuki.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] Intramicrovascular behavior of leukocytes in mouse brain observed by high speed laser confocal fluorescence microscopy.J Cereb Blood Flow Metab 2007:27(Suppl),BO12-6. (2007)
  • Author(s): Tanahashi N, Hattori K, Araki N, Shimazu K, Saitoh T, Tbmita M.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] Platelet behavior and thrombus formation in mouse brain microva sculature observed on high speed laser confocal fluorescence micros cope.J Cereb Blood Flow Metab 2007:27(Suppl),BO12-7 (2007)
  • Author(s): Hattori K, Tanahasbi N, Araki N, Shimazu K, Saitoh T, Tomita M.
  • Organizer: Brain 07
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-21
• [Presentation] Software (KEIO-IS2) for automatically tracking red blood cells (RBCs) with calculation of individual RBC velocities in single capillaries of rat brain (2005)
  • Author(s): Schiszler I, Takeda H, Tomita M, Tomita Y, Osada T, Unekawa M, Tanahashi N, Suzuki N
  • Organizer: International Symposium on Cerebral Blood Flow, Metabolism & Function(J. Cereb. Blood Flow Metab., 2005. 25 : S541. 22nd)
  • Place of Presentation: Amsterdam
  • Year and Date: 2005-06-05
• [Book] 講義録 神経学 (2007)
  • Author(s): 鈴木 則宏、荒木 信夫(編)
  • Total Pages: 537
  • Publisher: メジカルレビュー社、東京
• [Book] 脳血管の自律支配神経.Annual Review 神経2007 (2007)
  • Author(s): 清水利彦, 鈴木則宏
  • Publisher: 中外医学社(東京)
• [Book] ペインコントロール(山口徹, 北原光夫, 福井次矢 編)(2007今日の治療指針-私はこう治療している-) (2007)
  • Author(s): 鈴木則宏
  • Publisher: 医学書院(東京)
• [Book] 脳血管の解剖;動脈系、静脈系(井林雪郎編)(ファーマナビゲーター脳卒中編) (2006)
  • Author(s): 高橋一司, 鈴木則宏
  • Publisher: メディカルビュー社(東京)
• [Book] 特殊な脳血管障害-MELASを中心として(篠原幸人 監修)(永山正雄, 濱田潤一 編)(神経救急・集中治療ハンドブック) (2006)
  • Author(s): 飯塚高浩, 鈴木則宏
  • Publisher: 医学書院(東京)
• [Book] 南山堂医学大辞典.改訂19版.群発頭痛、血管性頭痛、後頭神経痛、神経痛、中枢性疼痛、頭痛、内臓反射性疼痛、翼口蓋神経節神経痛. (2006)
  • Author(s): 鈴木則宏
  • Publisher: 南山堂(東京)
• [Book] Cluster Headache. Chapter 87. Anatomy and Pathology of Cluster Headache. The Headaches. Third Edition(Eds.Olesen J, Goadsby PJ, Ramadan NM Tfelt-Hansen P, Welch KMA) (2006)
  • Author(s): Hardebo JE, Suzuki N
  • Publisher: Lippincott, Williams & Willkins, New York,
• [Book] 脳出血.循環器疾患最新の治療2006-2007.(山口 徹、 堀 正二、編集) (2006)
  • Author(s): 武田英孝
  • Publisher: 南江堂、東京
• [Book] 神経伝達物質.脳神経外科大系 1.神経科学(山浦 晃、河瀬 斌、編集) (2006)
  • Author(s): 清水利彦, 鈴木則宏
  • Publisher: 中山書店、東京
• [Book] Chapter 5, Increased intracranial pressure and brain edema. Pathology & Genetics, Structure and functions of CNS blood vessels, Cerebrovascular Diseases(Hannu Kalimo ed.) ISN Book Series (2005)
  • Author(s): Tomita M
  • Publisher: ISN Neuropath Press, Basel
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/medicine/neurology/
• [Remarks]
  • URL: http://web.sc.itc.keio.ac.jp/medicine/neurology/
• [Remarks]
  • URL: http://mtomita.jp/home004.html
• [Patent(Industrial Property Rights)] 片頭痛の診断マーカーとその利用 (2006)
  • Inventor(s): 永田栄一郎、鈴木則宏
  • Industrial Property Rights Holder: 永田栄一郎、鈴木則宏
  • Filing Date: 2006-09-14