Studies on cortical spreading depression and changes in brain capillary blood flow in acute phase of brain ischemia or aura in acute migraine
| Project/Area Number |
17390255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
SUZUKI Norihiro Keio University, 医学部, 教授 (10158975)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shinichi 慶應義塾大学, 医学部, 准教授 (20236285)
ITOH Yoshiaki 慶應義塾大学, 医学部, 講師 (90265786)
ITO Daisuke 慶應義塾大学, 医学部, 講師 (80286450)
TOMITA Yutaka 慶應義塾大学, 医学部, 助教 (60276251)
長田 高志 慶應義塾大学, 医学部, 助教 (30348635)
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| Co-Investigator(Renkei-kenkyūsha) |
OSADA Takashi 慶應義塾大学, 医学部, 助教 (30348635)
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| Project Period (FY) |
2005 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥14,900,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2006: ¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 2005: ¥6,200,000 (Direct Cost: ¥6,200,000)
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| Keywords | 脳虚血 / 片頭痛 / 脳微小循環 / 大脳皮質拡延性抑制 / 片頭痛前兆 / 皮質拡延性抑制 / 脳血流 / 脳毛細血管 |
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| Research Abstract |
虚血時の微小循環変化と皮質拡延性抑制(cortical spread depression : CSD)の微小循環変化は類似した表現型を示すが、原因と結果が逆であり発生機序的にまったく異なるものである。CSDにおける微小循環変化は神経細胞脱分極によって二次的に起こる毛細血管血流障害であり、CSDと密接に関連する片頭痛においては血管の一過性の炎症反応を含む異常反応が惹起される可能性がある.
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Report
(5 results)
Research Products
(93 results)
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[Presentation] Effects of artificial RBCs on murine cerebral ischemia2008
Author(s)
Tomita Y, Toriumi H, Osada T, Tomita M, Unekawa M, Itoh Y, Hoshino H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Suzuki N
Organizer
10th International Symposium on Thrombolysis and Acute Stroke threrapy
Place of Presentation
Budapest
Year and Date
2008-09-23
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[Presentation] Magnetic targeting of nanometric magnetic fluid loaded liposomes to specific intravascular areas a dynamic imaging study and analysis of CBF with KEIO-IS1 software in mice.、東京。2008
Author(s)
Tomita Y, Riviere C, Martina MS, Willhelm C, Tran Dinh A, Menager C, Pinard E, Lesieur S, Gazeau F, Tomita M, Suzuki N, Seylaz J.
Organizer
第33目日本微小循環学会総会
Place of Presentation
東京
Year and Date
2008-02-21
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[Book] 講義録 神経学2007
Author(s)
鈴木 則宏、荒木 信夫(編)
Total Pages
537
Publisher
メジカルレビュー社、東京
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