Pathogenesis of antiphospholipid antibodies:

• Project/Area Number: 17390286
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Hokkaido University
• Principal Investigator: KOIKE Takao Hokkaido University, Graduate School of Medicine, Professor, 大学院医学研究科, 教授 (80146795)
• Project Period (FY): 2005 – 2006
• Project Status: Completed (Fiscal Year 2006)
• Budget Amount: ¥15,300,000 (Direct Cost: ¥15,300,000); Fiscal Year 2006: ¥7,000,000 (Direct Cost: ¥7,000,000); Fiscal Year 2005: ¥8,300,000 (Direct Cost: ¥8,300,000)
• Keywords: Antiphospholipid syndrome / Thrombosis / proteome / p38 MAPK / Integrin / β_2GPI / 免疫学 / バイオテクノロジー / p38MARK / Tissue Factor(TF) / 抗リン脂質抗体

Research Abstract

The antiphospholipid syndrome (APS) is characterized by thrombosis and the presence of antiphospholipid antibodies (aPL). Tissue factor (TF), the major initiator of the coagulation system, is induced on monocytes by aPL in vitro, explaining, in part, the pathophysiology in this syndrome. Recently, it has been focused the nature of the aPL-induced signal transduction pathways leading to TF expression, and we reported that the mitogen-activated protein kinase (MAPK) pathway played an important role in aPL-induced TF expression on monocytes. In this study, we demonstrate that β_2 glycoprotein I (β_2GPI) interacts with plasma gelsolin that binds to integrin5β1 through fibronectin. The interaction between β_2GPI/monoclonal anti-β_2GPI antibody (β_2GPI dependent anticardiolipin antibodies; aCL/β_2GPI) complex and cell surface enhanced in the presence of plasma gelsolin. Western blotting studies using monocyte cell line (RAW264.7) demonstrated that p38 MAPK protein was phosphorylated by monoclonal aCL/β2GPI treatment, and the phosphorylation was attenuated in the presence of anti-integrinα5β1 antibody. Furthermore, focal adhesion kinase (FAK) that is downstream of fibronectin-integrin signaling pathway was phosphorylated by aPL treatment. These results demonstrated that the integrin-p38 MAPK signaling pathway plays an important role in aPL-induced TF expression on monocytes and suggest that the integrin may be a possible therapeutic target to modify a prothrombotic state in patients with APS

Research Products

• [Journal Article] A polymorphism in the Human Platelet Antigen 6b represents a risk factor for thrombocytopenia in patients with systemic lupus erythematosus. (2007)
  • Author(s): Amengual O, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, Koike T
  • Journal Title: Arthritis Rheum (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid syndrome. (2007)
  • Author(s): Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T
  • Journal Title: Lupus (in press)
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] " Resurrection of Thrombin " in the pathophysiology of the antiphospholipid syndrome. (2007)
  • Author(s): Koike T, Atsumi T
  • Journal Title: Arthritis Rheum 56 Pages: 393-394
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antiphospholipid antibodies : Lessons from the bench (2007)
  • Author(s): Koike T, Bohgaki M, Amengual O, Atsumi T
  • Journal Title: J Autoimmunity 28 Pages: 129-133
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hepatosplenic alpha/beta T cell lymphoma presenting with cold agglutinin disease. (2007)
  • Author(s): Minauchi K, Nishio M, Itoh T, Yamamoto S, Fujimoto K, Sato N, Koike T
  • Journal Title: Ann Hematol 86 Pages: 155-157
  • NAID: 120000973066
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A polymorphism in the Human Platelet Antigen 6b represents a risk factor for thrombocytopenia in patients with systemic lupus erythematosus. (2007)
  • Author(s): Amengual o, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, Koike T.
  • Journal Title: Arthritis Rheum (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid syndrome. (2007)
  • Author(s): Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T.
  • Journal Title: Lupus (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] "Resurrection of Thrombin " in the pathophysiology of the antiphospholipid syndrome. (2007)
  • Author(s): Koike T, Atsumi T.
  • Journal Title: Arthritis Rheum 56 Pages: 393-394
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antiphospholipid antibodies : Lessons from the bench. (2007)
  • Author(s): Koike T, Bohgaki M, Amengual 0, Atsumi T.
  • Journal Title: J Autoimmunity 28 Pages: 129-133
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hepatosplenic alpha/beta T cell lymphoma presenting with cold agglutinin disease. (2007)
  • Author(s): Minauchi K, Nishio M, Itoh T, Yamamoto S, Fujimoto K, Sato N, Koike T.
  • Journal Title: Ann Hematol. 86 Pages: 155-157
  • NAID: 120000973066
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] "Resurrection of Thrombin" in the pathophysiology of the antiphospholipid syndrome. (2007)
  • Author(s): Koike T, Atsumi T.
  • Journal Title: Arthritis Rheum. 56 (2) Pages: 393-394
• [Journal Article] A polymorphism in the Human Platelet Antigen 6b represents a risk factor for thrombocytopenia in patients with systemic lupus erythematosus. (2007)
  • Author(s): Amengual O, Atsumi T, Komano Y, Kataoka H, Horita T, Yasuda S, Koike T.
  • Journal Title: Arthritis Rheum (in press)
• [Journal Article] Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid syndrome (2007)
  • Author(s): Horita T, Ichikawa K, Kataoka H, Yasuda S, Atsumi T, Koike T.
  • Journal Title: Lupus (in press)
• [Journal Article] International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. (2006)
  • Author(s): Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RHWM, de Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA
  • Journal Title: J Thromb Haemost 4 Pages: 295-306
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transient antiphospholipid antibodies associated with acute infections in children : a report of three cases and a review of the literature. (2006)
  • Author(s): Mizumoto H, Maihara T, Hiejima E, Shiota M, Hata A, Seto S, Atsumi T, Koike T, Hata D
  • Journal Title: Eur J Pediatr 165 Pages: 484-488
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A novel mutation of WFS1 gene in a Japanese man of Wolfram syndrome with positive diabetes-related antibodies. (2006)
  • Author(s): Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Tanizawa Y, Koike T
  • Journal Title: Diabetes Res Clin Pract. 73 Pages: 215-217
  • NAID: 120000959864
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A case of reversed pituitary dysfunction with intrasellar mass. (2006)
  • Author(s): Nagai S, Shimizu C, Kimura Y, Umetsu M, Taniguchi S, Takeuchi J, Atsumi T, Yoshioka N, Kubo M, Koike T
  • Journal Title: J Endocrinol Invest 29 Pages: 367-372
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Pathophysiology of the antiphospholipid syndrome : roles of anticardiolipin antibodies in thrombosis and fibrinolysis. (2006)
  • Author(s): Amengual O, Atsumi T, Koike T
  • Journal Title: APLAR J Rheumatol 9 Pages: 377-386
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] One novel and one recurrent mutation in the PROS1 gene cause type l protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis. (2006)
  • Author(s): Mizukami K, Nakabayashi T, Naitoh S, Takeda M, Tarumi T, Mizoguchi I, Ieko M, Koike T
  • Journal Title: Am J Hematol 81 Pages: 787-797
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Factor Xa inhibitors : new anti-thrombotic agents and their characteristics. (2006)
  • Author(s): Ieko M, Tarumi T, Nakabayashi T, Yoshida M, Naito S, Koike T
  • Journal Title: Frontiers in Bioscience 11 Pages: 232-248
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] TRAIL-mediated cytotoxicity : Impacts of sTRAIL and vTRAIL microvesicles. (2006)
  • Author(s): Furusaki A, Judo S, Yamashita Y, Amasaki Y, Atsumi T, Koike T
  • Journal Title: J Biol Sci. 6 Pages: 150-159
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinical analysis of cognitive function in diabetic patients by MMSE and SPECT (2006)
  • Author(s): Niwa H, Koumoto C, Shiga T, Takeuchi J, Mishima S, Segawa T, Atsumi T, Shimizu C, Koike T, Yoshioka N
  • Journal Title: Diabetes Res Clin Pract. 72 Pages: 142-147
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Acute schizophrenic symptoms as the initial manifestation of HIV infection that respond to highly active antiretroviral therapy. (2006)
  • Author(s): Hashimoto T, Nishio M, Sakai T, Fujimoto K, Sato N, Endo T, Koike T
  • Journal Title: Clinical Infectious Diseases 42 Pages: 1653-1655
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Protective effect of pravastatin on vascular endothelium in patients with System Sclerosis : a pilot study (2006)
  • Author(s): Furukawa S, Yasuda S, Amengual O, Horita T, Atsumi T, Koike T
  • Journal Title: Ann Rheum Dis 65 Pages: 1118-1120
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Hypogammaglobulinemmia with a selective delayed recovery inmemory B cells and an impaired Isotype expression after rituximab administration as an adjuvant to autologous stem cell transplantation for non-Hodgkin lymphoma. (2006)
  • Author(s): Nishio M, Fujimoto K, Yamamoto S, Endo T, Sakai T, Obara M, Kumano K, Minauchi K, Yamaguchi K, Takeda Y, Sato N, Koizumi K, Mukai M, Koike T
  • Journal Title: Eur J Haemato. 77 Pages: 226-232
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. (2006)
  • Author(s): Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RHWM, de Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA.
  • Journal Title: J Thromb Haemost. 4 Pages: 295-306
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transient antiphospholipid antibodies associated with acute infections in children : a report of three cases and a review of the literature. (2006)
  • Author(s): Mizumoto H, Maihara T, Hiejima E, Shiota M, Hata A, Seto S, Atsumi T, Koike T, Hata D.
  • Journal Title: Eur J Pediatr. 165 Pages: 484-488
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel mutation of WFSI gene in a Japanese man of Wolfram syndrome with positive diabetes-related antibodies. (2006)
  • Author(s): Nakamura A, Shimizu C, Nagai S, Taniguchi S, Umetsu M, Atsumi T, Wada N, Yoshioka N, Ono Y, Tanizawa Y, Koike T.
  • Journal Title: Diabetes Res Clin Pract. 73 Pages: 215-217
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A case of reversed pituitary dysfunction with intrasellar mass. (2006)
  • Author(s): Nagai S, Shimizu C, Kimura Y, Umetsu M, Taniguchi S, Takeuchi J, Atsumi T, Yoshioka N, Kubo M, Koike T.
  • Journal Title: J Endocrinol Invest. 29 Pages: 367-372
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pathophysiology of the antiphospholipid syndrome : roles of anticardiolipin antibodies in thrombosis and fibrinolysis (2006)
  • Author(s): Amengual O, Atsumi T, Koike T.
  • Journal Title: APLAR J Rheumatol 9 Pages: 377-386
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] One novel and one recurrent mutation in the PROS1 gene cause type I protein S deficiency in patients with pulmonary embolism associated with deep vein thrombosis. (2006)
  • Author(s): Mizukami K, Nakabayashi T, Naitoh S, Takeda M, Tarumi T, Mizoguchi I, leko M, Koike T.
  • Journal Title: Am J Hematol. 81 Pages: 787-797
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Factor Xa inhibitors : new anti-thrombotic agents and their characteristics. (2006)
  • Author(s): leko M, Tarumi T, Nakabayashi T, Yoshida M, Naito S, Koike, T.
  • Journal Title: Frontiers in Bioscience. 11 Pages: 232-248
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TRAIL-mediated cytotoxicity : Impacts of sTRAIL and vTRAIL microvesicles. (2006)
  • Author(s): Furusaki A, Judo S, Yamashita Y, Amasaki Y, Atsumi T, Koike T.
  • Journal Title: J Biol Sci. 6 Pages: 150-159
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical analysis of cognitive function in diabetic patients by MMSE and SPECT. (2006)
  • Author(s): Niwa H, Koumoto C, Shiga T, Takeuchi J, Mishima S, Segawa T, Atsumi T, Shimizu C, Koike T, Yoshioka N.
  • Journal Title: Diabetes Res Clin pract. 72 Pages: 142-147
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Acute schizophrenic symptoms as the initial manifestation of HIV infection that respond to highly active antiretroviral therapy. (2006)
  • Author(s): Hashimoto T, Nishio M, Sakai T, Fujimoto K, Sato N, Endo T, Koike T.
  • Journal Title: Clinical Infectious Diseases. 42 Pages: 1653-1655
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protective effect of pravastatin on vascular endothelium in patients with System Sclerosis : a pilot study. (2006)
  • Author(s): Furukawa S, Yasuda S, Amengual 0, Horita T, Atsumi T, Koike T.
  • Journal Title: Ann Rheum Dis. 65 Pages: 1118-1120
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hypogammaglobulinemmia with a selective delayed recovery inmemory B cells and an impaired Isotype expression after rituximab administration as an adjuvant to autologous sterr cell transplantation for non-Hodgkin lymphoma. (2006)
  • Author(s): Nishio M, Fujimoto K, Yamamoto S, Endo T, Sakai T, Obara M, Kumano K, Minauchi K, Yamaguchi K, Takeda Y, Sato N, Koizumi K, Mukai M, Koike T.
  • Journal Title: Eur J Haemato. 77 Pages: 226-232
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] β 2-glycoprotein I and anti-β 2-glycoproteinl antibodies " Hughes Syndrome : Antiphospholipid Syndrome" second edition, Khamashta MA ed (2006)
  • Author(s): Yasuda, S., Atsumi, T., Koike, T.
  • Pages: 307-318
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transient antiphospholipid antibodies associated with acute infections in children : a report of three cases and a review of the literature (2006)
  • Author(s): Mizumoto H, Maihara T, Hiejima E, Shiota M, Hata A, Seto S, Atsumi T, Koike T, Hata D.
  • Journal Title: Eur J Pediatr. 165 Pages: 484-488
• [Journal Article] Pathophysiology of the antiphospholipid syndrome : roles of anticardiolipin antibodies in thrombosis and fibrinolysis (2006)
  • Author(s): Amengual O, Atsumi T, Koike T.
  • Journal Title: APLAR J Rheumatol. 9 Pages: 377-386
• [Journal Article] Protective effect of pravastatin on vascular endothelium in patients with System Sclerosis : a pilot study (2006)
  • Author(s): Furukawa S, Yasuda S, Amengual O, Horita T, Atsumi T, Koike T
  • Journal Title: Ann Rheum Dis 65(8) Pages: 1118-1120
• [Journal Article] Factor Xa inhibitors : new anti-thrombotic agents and their characteristics. (2006)
  • Author(s): Ieko, M.
  • Journal Title: Frontiers in Bioscience 11 Pages: 232-248
• [Journal Article] Significance of valine/leucine^<247> polymorphism of β 2-glycoprotein I in antiphospholipid syndrome : increased reactivity of anti-β 2-glycoprotein I autoantibodies to the valine^<247>β 2-glycoprotein I variant (2005)
  • Author(s): Yasuda S.Atsumi T., Matsuura, E, Kaihara.K., Yamamoto, D., Ichikawa, K., Koike, T.
  • Journal Title: Arthritis Rheum 52 Pages: 212-218
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  • Author(s): Kataoka, H., Takahashi, S., Takase, K., Yamasaki, S., Yokosuka, T., Koike, T., Saito,T.
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cutting Edge : Fas Ligand (CD178) Cytoplasmic Tail Is a Positive Regulator of Fas Ligand-Mediated Cytotoxicity. (2005)
  • Author(s): Jodo, S., Pidiyar, VJ., Xiao, S., Furusaki, A., Sharma, R., Koike, T., Ju,ST.
  • Journal Title: J Immunol 174 Pages: 4470-4474
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  • Description: 「研究成果報告書概要(和文)」より
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  • Author(s): Imai, Y., Chou, T., Tobinai, K., Tanosaki, R., Morishima, Y., Ogura, M., Shimazaki, C., Taniwaki, M., Hiraoka, A., Tanimoto, M., Koike, T., Kogawa, K., Hirai, H., Yoshida, T., Tamura, K., Kishi,K., Hotta,T
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  • Journal Title: Clin Cancer Res 11 Pages: 5784-5792
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis (2005)
  • Author(s): Atsumi, T., Furukawa, S., Amengual, O., Koike,T.
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  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Up regulated expression of tumour necrosis factor a converting enzyme in peripheral monocytes of patients with early systemic sclerosis. (2005)
  • Author(s): Bohgaki, T., Amasaki, Y., Nishimura, N., Bohgaki, M., Yamashita, Y., Nishio, M., awada, KI., Jodo, S., Atsumi, T., Koike,T.
  • Journal Title: Ann Rheum Dis 64 Pages: 1165-1173
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Research around β 2-glycoprotein I : A major target for antiphospholipid antibodies. (2005)
  • Author(s): Atsumi, T., Amengual, O., Yasuda, S., Matsuura, E., Koike,T
  • Journal Title: Autoimmunity 38 Pages: 377-381
  • Description: 「研究成果報告書概要(和文)」より
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• [Journal Article] Antiphospholipid antibodies and cell activation : crucial role of p38 MAPK pathway (2005)
  • Author(s): Koike, T., Atsumi, T.
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• [Journal Article] Pathogenesis of antiphospholipid antibodies : impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway (2005)
  • Author(s): Yasuda, S., Bohgaki, M., Atsumi, T., Koike,T.
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  • Journal Title: J Endocrinol Invest 28 Pages: 464-468
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Persistent panhypogammaglobulinemia with selected loss of memory B cells and impaired isotype expression after rituximab therapy for post-transplant EBV-associated autoimmune hemolytic anemia. (2005)
  • Author(s): Nishio, M., Endo, T., Fujimoto, K., Sato, N., Sakai, T., Obara, M., Kumano, K., Minauchi, K., Koike,T.
  • Journal Title: Eur J Haematol 75 Pages: 527-529
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Cat-eye syndrome with isolated idiopathic hypogonadotropic hypogonadism. (2005)
  • Author(s): Matsumoto, R., Shimizu, C., Nagai, S., Taniguchi, S., Umetsu, M., Kimura, Y., Atsumi, T., Yoshioka, N., Kubo, M., Koike,T.
  • Journal Title: Internal Med 44 Pages: 1069-1073
  • NAID: 130000085271
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Significance of valine/leucine247 polymorphism of β 2-glycoprotein I in antiphospholipid syndrome : increased reactivity of anti-β 2-glycoprotein I autoantibodies to the valine247β 2-glycoprotein I variant. (2005)
  • Author(s): Yasuda S.Atsumi T., Matsuura, E, Kaihara.K., Yamamoto, D., Ichikawa, K., Koike, T.
  • Journal Title: Arthritis Rheum 52 Pages: 212-218
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD25^+CD4^+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4. (2005)
  • Author(s): Kataoka, H., Takahashi, S., Takase, K., Yamasaki, S., Yokosuka, T., Koike, T., Saito, T.
  • Journal Title: Int Immnol 17 Pages: 421-427
  • NAID: 10016485662
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cutting Edge : Fas Ligand (CD178) Cytoplasmic Tail Is a Positive Regulator of Fas Ligand-Mediated Cytotoxicity. (2005)
  • Author(s): Jodo, S., Pidiyar, VJ., Xiao, S., Furusaki, A., Sharma, R., Koike, T., Ju, ST.
  • Journal Title: J Immunol 174 Pages: 4470-4474
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation (2005)
  • Author(s): Nishio, S., Hatano, M., Nagata, M., Horie, S., Koike, T., Tokuhisa, T., Mochizuki, T.
  • Journal Title: J Clin Invest 115 Pages: 910-918
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. (2005)
  • Author(s): Kochi, Y., Yamada, R., Suzuki, A., Harley, JB., Shirasawa, S., Sawada, T., Bae, SC., Tokuhiro, S., Chang, X., Sekine, A., Takahashi, A., Tsunoda, T., Ohnishi, Y., Kaufman, KM., Kang, CP., Kang, C., Otsubo, S., Yumura, W., Mimori, A., Koike, T., Nakamura, Y., Sasazuki, T., Yamamoto, K.
  • Journal Title: Nat Genet 37 Pages: 478-485
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isolation and transplantation of highly purified autologous peripheral CD34+ progenitor cells : purging efficacy, hematopoietic reconstitution in non-Hodgkin's lymphoma (NHL) : results of Japanese phase II study (2005)
  • Author(s): Imai, Y., Chou, T., Tobinai, K., Tanosaki, R., Morishima, Y., Ogura, M., Shimazaki, C., Taniwaki, M., Hiraoka, A., Tanimoto, M., Koike, T., Kogawa, K., Hirai, H., Yoshida, T., Tamura, K., Kishi, K., Hotta, T, CliniMACS Study Group.
  • Journal Title: Bone Marrow Transpl 35 Pages: 479-487
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer. (2005)
  • Author(s): Bando, H., Atsumi, T., Nishio, T., Niwa, H., Mishima, S., Shimizu, C., Yoshioka, N., Bucala, R., Koike, T
  • Journal Title: Clin Cancer Res 11 Pages: 5784-5792
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis. (2005)
  • Author(s): Atsumi, T., Furukawa, S., Amengual, O., Koike, T.
  • Journal Title: Lupus 14 Pages: 499-504
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Up regulated expression of tumor necrosis factor a converting enzyme in peripheral monocytes of patients with early systemic sclerosis. (2005)
  • Author(s): Bohgaki, T., Amasaki, Y., Nishimura, N., Bohgaki, M., Yamashita, Y., Nishio, M., awada, KI., Jodo, S., Atsumi, T., Koike, T.
  • Journal Title: Ann Rheum Dis. 64 Pages: 1165-1173
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Research around β 2-glycoprotein I : A major target for antiphospholipid antibodies. (2005)
  • Author(s): Atsumi, T., Amengual, O., Yasuda, S., Matsuura, E., Koike, T.
  • Journal Title: Autoimmunity. 38 Pages: 377-381
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Butyrate suppresses tumor necrosis factor a production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element. (2005)
  • Author(s): Fukao, J., Amasaki, Y., Yamashita, Y., Bohgaki, T., Yasuda, S., Jodo, S., Atsumi, T., Koike, T.
  • Journal Title: Arthritis Rheum. 52 Pages: 2697-2707
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antiphospholipid antibodies and cell activation : crucial role of p38 MAPK pathway. (2005)
  • Author(s): Koike, T., Atsumi, T.
  • Journal Title: Lupus 14 Pages: 799-801
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 isoforms in adipocytes and their potential role in glycolytic regulation. (2005)
  • Author(s): Atsumi, T., Nishio, T., Niwa, H., Takeuchi, J., Bando, H., Shimizu, C., Yoshioka, N., Bucala, R., Koike, T.
  • Journal Title: Diabetes 54 Pages: 3349-3357
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Antiaenic structures recoanized by anti-B2-alvconrotein I autn-antihnriips (2005)
  • Author(s): Kasahara, H., Matsuura, E., Kaihara, K., Yamamoto, D., Kobayashi, K., Inagaki, J., Ichikawa, K., Tsutsumi, A., Yasuda, S., Atsumi, T., Yasuda, T., Koike, T.
  • Journal Title: Int Immunol 17 Pages: 1533-1542
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pathogenesis of antiphospholipid antibodies : impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway. (2005)
  • Author(s): Yasuda, S., Bohgaki, M., Atsumi, T., Koike, T.
  • Journal Title: Immunobiology 210 Pages: 775-780
  • NAID: 120000959527
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein C Sapporo (protein C Glu 25 →Lys) : A heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor. (2005)
  • Author(s): Nakabayashi, T., Mizukami, K., Naitoh, S., Takeda, M., Shikamoto, Y., Nakagawa, T., Kaneko, H., Tarumi, T., Mizoguchi, I., Mizuno, H., leko, M., Koike, T.
  • Journal Title: Thromb Haemost 94 Pages: 942-950
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effective in vivo purging with rituximab and autologous peripheral blood stem cell transplantation in a woman with CD5 positive primary cutaneous diffuse large B-cell lymphoma. (2005)
  • Author(s): Goto, H., Nishio, M., Endo, T., Sato, N., Koizumi, K., Fujimoto, K., Sakai, T., Kumano, K., Obara, M., Koike, T.
  • Journal Title: Eur J Haematol. 74 Pages: 526-528
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A rare case of Gitelman's syndrome presenting with hypocalcemia and osteopenia. (2005)
  • Author(s): Nakamura, A., Simizu, C., Nagai, S., Taniguchi, S., Umetsu, M., Atsumi, T., Yoshioka, N., Ono, Y., Tajima, T., Kubo, M., Koike, T.
  • Journal Title: J Endocrinol Invest 28 Pages: 464-468
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Persistent panhypogammaglobulinemia with selected loss of memory B cells and impaired isotype expression after rituximab therapy for post-transplant EBV-associated autoimmune hemolytic anemia. (2005)
  • Author(s): Nishio, M., Endo, T., Fujimoto, K., Sato, N., Sakai, T., Obara, M., Kumano, K., Minauchi, K., Koike, T.
  • Journal Title: Eur J Haematol. 75 Pages: 527-529
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cat-eye syndrome with isolated idiopathic hypogonadotropic hypogonadism. (2005)
  • Author(s): Matsumoto, R., Shimizu, C., Nagai, S., Taniguchi, S., Umetsu, M., Kimura, Y., Atsumi, T., Yoshioka, N., Kubo, M., Koike, T.
  • Journal Title: Internal Med 44 Pages: 1069-1073
  • NAID: 130000085271
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Significance of valine/leucine^<247> polymorphism of β2-glycoprotein I in antiphospholipid syndrome : increased reactivity of anti-β2-glycoprotein I autoantibodies to the valine^<247> β2-glvcoprotein I variant (2005)
  • Author(s): Yasuda S
  • Journal Title: Arthritis Rheum 51・2 Pages: 212-218
• [Journal Article] CD25^+CD4^+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4. (2005)
  • Author(s): Kataoka, H.
  • Journal Title: Int Immnol 17・4 Pages: 421-427
• [Journal Article] Cutting Edge : Fas Ligand (CD178) Cytoplasmic Tail Is a Positive Regulator of Fas Ligand-Mediated Cytotoxicity. (2005)
  • Author(s): Jodo, S
  • Journal Title: J.Immunol 174・8 Pages: 4470-4474
• [Journal Article] Pkdl regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. (2005)
  • Author(s): Nishio, S.
  • Journal Title: J Clin Invest 115・4 Pages: 910-918
• [Journal Article] A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. (2005)
  • Author(s): Kochi, Y.
  • Journal Title: Nat Genet 37・5 Pages: 478-485
• [Journal Article] CliniMACS Study Group. Isolation and transplantation of highly purified autologous peripheral CD34+ progenitor cells : purging efficacy, hematopoietic reconstitution in non-Hodgkin's lymphoma (NHL) : results of Japanese Phase II study. (2005)
  • Author(s): Imai, Y.
  • Journal Title: Bone Marrow Transpl 35・5 Pages: 479-487
• [Journal Article] Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer. (2005)
  • Author(s): Bando, H.
  • Journal Title: Clin Cancer Res 11 Pages: 5784-5792
• [Journal Article] Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis (2005)
  • Author(s): Atsumi, T.
  • Journal Title: Lupus 14 Pages: 499-504
• [Journal Article] Up regulated expression of tumour necrosis factor aconverting enzyme in peripheral monocytes of patients with early systemic sclerosis. (2005)
  • Author(s): Bohgaki, T.
  • Journal Title: Ann Rheum Dis. 64 Pages: 1165-1173
• [Journal Article] Research around β2-glycoprotein I : A major target for antiphospholipid antibodies. (2005)
  • Author(s): Atsumi, T.
  • Journal Title: Autoimmunity 38・5 Pages: 377-381
• [Journal Article] Butyrate suppresses tumor necrosis factor a production by regulating specific messenger RNA degradation mediated through a cis-acting AU-rich element. (2005)
  • Author(s): Fukae, J.
  • Journal Title: Arthritis Rheum 52・9 Pages: 2697-2707
• [Journal Article] Antiphospholipid antibodies and cell activation : crucial role of p38 MAPK pathway (2005)
  • Author(s): Koike, T.
  • Journal Title: Lupus 14・10 Pages: 799-801
• [Journal Article] Expression of inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 isoforms in adipocytes and their potentioal role in glycolytic regulation. (2005)
  • Author(s): Atsumi, T.
  • Journal Title: Diabetes 54・12 Pages: 3349-3357
• [Journal Article] Antigenic structures recognized by anti-B2-glycoprotein I auto-antibodies (2005)
  • Author(s): Kasahara, H.
  • Journal Title: Int immunol 17・12 Pages: 1533-1542
• [Journal Article] Pathogenesis of antiphospholipid antibodies : impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway (2005)
  • Author(s): Yasuda, S.
  • Journal Title: Immunobiology 210 Pages: 775-780
• [Journal Article] Protein C Sapporo (protein C Glu 25→Lys) : A heterozygous missense mutation in the Gla domain provides new insight into the interaction between protein C and endothelial protein C receptor. (2005)
  • Author(s): Nakabayashi, T.
  • Journal Title: Thromb Haemost 94 Pages: 942-950
• [Journal Article] Effective in vivo purging with rituximab and autologous peripheral blood stem cell transplantation in a woman with CD5 positive primary cutaneous diffuse large B-cell lymphoma. (2005)
  • Author(s): Goto, H.
  • Journal Title: Eur J Haematol 74・6 Pages: 526-528
• [Journal Article] A rare case of Gitelman's syndrome presenting with hypocalcemia and osteopenia. (2005)
  • Author(s): Nakamura, A.
  • Journal Title: J Endocrinol Invest 28 Pages: 464-468
• [Journal Article] Persistent panhypogammaglobulinemia with selected loss of memory B cells and impaired isotype expression after rituximab therapy for post-transplant EBV associated autoimmune hemolytic anemia. (2005)
  • Author(s): Nishio, M.
  • Journal Title: Eur J Haematol. 75・6 Pages: 527-529
• [Journal Article] Cat-eye syndrome with isolated idiopathic hypogonadotropic hypogonadism. (2005)
  • Author(s): Matsumoto, R.
  • Journal Title: Internal Med 44・10 Pages: 1069-1073
• [Book] β 2-glycoprotein I and anti-β 2-glycoproteinl antibodies" Hughes Syndrome : Antiphospholipid Syndrome" second edition, Khamashta MA ed (2006)
  • Author(s): Yasuda, S., Atsumi, T., Koike, T.
  • Publisher: Sringer
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 内科学 XIV免疫・結合組織・アレルギー疾患 (2006)
  • Author(s): 小池 隆夫
  • Total Pages: 598
  • Publisher: 医学書院