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New optical brain imaging in infants by using near-infrared diffuse optical tomography

Research Project

Project/Area Number 17390307
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionKagawa University

Principal Investigator

KUSAKA Takashi  Kagawa University, Maternal Perinatal Center, Faculty of Medicine, Maternal Perinatal Center (50274288)

Co-Investigator(Kenkyū-buntansha) YAMADA Yukio  University of Electro-Communications, Dept. of Mech. Eng. and Intel. Sys, Japan Professor (10334583)
TANIKAWA Yukari  National Institute of Advanced Industrial Science and Technology(AIST), 人間福祉医工学研究部門, Japan (20344202)
NISHIDA Tomoko  Kagawa University, Dept of Pediatrics, Assistant Professor (00243759)
NAMBA Masanori  Kagawa University, Dept of Pediatrics, Japan. Assistant Professor (90237636)
OKUBO Kensuke  Kagawa University, Dept of Pediatrics, Assistant Professor (80335851)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 2006: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2005: ¥6,700,000 (Direct Cost: ¥6,700,000)
KeywordsNear-infrared spectroscopy / Optical tomography / Infant / Hypocapnea / Cerebral blood volume / Periventricular leukomalasia / Time-resolved spectroscopy / Cerebral Hb oxygen saturation / 低出生体重児 / 脳内血液量 / 脳内ヘモグロビン酸素飽和度 / 吸収係数 / 散乱係数 / トモグラフィー / 新生児 / 脳 / 組織Hb酸素飽和度
Research Abstract

An optical 3D imaging method using near-infrared diffuse optical tomography (NIR DOT) to estimate the regional light scattering and absorption properties in infants has been developed. The NIR DOT system is consisted of 16 source-detector fibers, pulsed diode lasers operating at the wavelengths of 759 and 835 nm and time correlated single photon counting units. The image reconstruction algorithm is based on the modified generalized pulsed spectral technique. The time-resolved data were used to estimate for concentration of oxyHb and deoxyHb.
DOT was measured in an infant on 29 days after birth, whose gestational age and birth weight was 23 weeks and 658g, assisted by an artificial respirator. Informed consent in writing was obtained from the parents, and the study was approved by the local ethics committee.
The data under two different state, (A) normocapnea and (B) hypocapnea induced by hyperventilation, were obtained. DOT images showed the Hb concentrations obtained at the state (B) subtracted by (A). The results showed that the total Hb concentration in the most parts of the brain decreased, reflecting the decrease in cerebral blood flow, especially white matter regions. The results demonstrated that NIR DOT is capable of reconstructing the images of Hb concentration with a high spatial resolution in infants at the bedside.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007 2005

All Journal Article (20 results)

  • [Journal Article] Relationship between muscle oxygenation and electromyography activity during sustained isometric contraction2008

    • Author(s)
      Yamada E, Kusaka T, Arima N, Isobe K, Yamamoto T, Itoh S.
    • Journal Title

      Clinical Physiology and Functional Imaging (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Relationship between muscle oxygenation and electromyography activity during sustained isometric contraction.2008

    • Author(s)
      Yamada E, Kusaka T, Arisna N, Isobe H, Yamasnoto T, Itoh S.
    • Journal Title

      Clinical Physialogy and Functionsi Imaging (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Accumulation of triosephosphate is.omerase,with sequence homology to amyloid peptides,in vessel walls of the newborn piglet hippocampus2007

    • Author(s)
      Kusaka T, Ueno M, et. al.
    • Journal Title

      Microscopy Research and Technique Jul;70(7)

      Pages: 648-55

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functional optical hemodynamic imaging of the olfactory cortex2007

    • Author(s)
      Kobayashi E, Kusaka T, Karaki M, et. al.
    • Journal Title

      Laryngoscope Mar;117(3)

      Pages: 541-6

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of prenatal X-irradiation on the developing cerebral cortex of rats.II:A quantitative assessment of glial cells in the somatosensory cortex2007

    • Author(s)
      Miki T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, et. al.
    • Journal Title

      International Journal of Developmental.Neuroscience Aug;25(5)

      Pages: 293-7

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro production of bilirubin photoisomers by light irradiation using neoBLUE2007

    • Author(s)
      Okada H, Abe T, Etoh Y, Yoshino S, Kato I, Iwaki T, Okubo K, Yasuda S, Kawada K, Kusaka T, et. al.
    • Journal Title

      Pediatr Int. Jun;49(3)

      Pages: 318-21

    • NAID

      10019493781

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 拡散光トモグラフィ装.置を用いた未熟児頭部のin vivo測定2007

    • Author(s)
      上野 雅範, 福沢 遼, 大川 晋平, 山田 幸生, 日下 隆, 西田 智子, 磯部 健一, 谷川 ゆかり, 高 峰, 佐藤 知絵, 星 詳子
    • Journal Title

      第19回バイオエンジニアリン「グ講演会講演論文集

      Pages: 338-339

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo measurement of premature neonato head using diffuse optical tomography.2007

    • Author(s)
      Masanori Ueno, Ryo Fukuzawa, Shinpei Okawa, Yultio Yamada, Takasbi Kusaka, Tomoko Nisbida, Kenichi Isobe, Yukaxi Tanikawa, Feng Gao, Chie Sato, Yoko Hoshi.
    • Journal Title

      Proceedings of the 19th Bioengineering Conference (in Japanese)

      Pages: 338-339

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vivo measurement of premature neonate head using diffuse optical tomography.2007

    • Author(s)
      Masanori Ueno, Ryo Fukuzawa, Shinpei Okawa, Yukio Yasnada, Takashi Kusaka, Tomoko Nishida, Kenichi bobs, Yukari Tanikawa, Feng Gao, Cbie Sato, Yoko Hoshi.
    • Journal Title

      3rd Asian and Pacific Rim Sympoaium an Biophotonics & Biophetonica Downunder II, Besk of Abstract

      Pages: 43-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Study for diffuse optical tomographyby using nearinfrared time-resolved method. Dept. of Mech. Rug. and Intel.2007

    • Author(s)
      Masanori Ueno.
    • Journal Title

      Sys., Graduate school of Universiiy of Riectro-Communicatisna Japan. A graduation thesis (in Japanese)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Study for diffuse optical tomography in premature infant. Dept of Mech. Rug. end Intel.2007

    • Author(s)
      Ryo Fukuzawa.
    • Journal Title

      Sys., University of Electro-Commusicatione, Japan. A graduation thesis (in Japanese)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Accumulation of triosephosphate isomerass, with sequence homology to amyloid peptides, in vessel walls of the newborn piglet hippocampue.2007

    • Author(s)
      Kusaka T, Ueno M, Mulci T, Kanenishi K, Nagai Y, Huang CL, Okamoto Y, Ogawa T, Onodera hi, Itoh S, Altiguchi I, Sakamoto H.
    • Journal Title

      Microscopy Research and Technique 70(7)

      Pages: 648-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functional optical hemodynarnic imaging of the olfactory cortex.2007

    • Author(s)
      Kobayasbi E, Kusaka T, Karaki M, Kobayashi R, Itoh S, Men N.
    • Journal Title

      Laryngoscope 117(3)

      Pages: 541-6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The effect of prenatal lliirradiation on the developing cerebral cortex of rate. II : A quantitative assessment of glial cells in the somatosensory cortex.2007

    • Author(s)
      Multi T, Yokoyama T, Sumitani K, Wang ZY, Yang W, Kusaka T, Matsumeto Y, Warita K, Lee NS, Fukui Y, Takeuchi Y, et. al.
    • Journal Title

      International Journal of Developmental Neurescience. 25(5)

      Pages: 293-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] In vitro production of bilirubin photaisomers by light ircadiation using neoBLUE.2007

    • Author(s)
      Okada H, Abe T, Etoh Y, Yosbino S, Kate I, Iwaki T, Okubo K, Yasuda S, Kawada K, Kusaka T, Nemba M, Nisbitla T, Imai T, Isobe K, Itoh S.
    • Journal Title

      irediatr tnt. 49(3)

      Pages: 318-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 拡散光トモグラフィ装置を用いた未熟児頭部のin vivo測定2007

    • Author(s)
      上野雅範, 福沢遼, 大川晋平, 日下隆 等
    • Journal Title

      第19回バイオエンジニアリング講演会講演論文集 06-05

      Pages: 338-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Accumulation of triosephosphate isomerase, with sequence homology to beta amyloid peptides, in vessel walls of the newborn piglet hippocampus.2007

    • Author(s)
      Kusaka T, Ueno M, Miki T, et al.
    • Journal Title

      Microsc Res Tech (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Functional optical hemodynamic imaging of the olfactory cortex2007

    • Author(s)
      Kobayashi E, Kusaka T, Karaki M, et al.
    • Journal Title

      Laryngoscope 117(3)

      Pages: 541-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Developmental changes of optical properties in neonates determined by near-infrared time-resolved spectroscopy.2005

    • Author(s)
      Ijichi S, Kusaka T, Isobe K, et al.
    • Journal Title

      Pediatric Research 58

      Pages: 568-573

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia.2005

    • Author(s)
      Ijichi S, Kusaka T, Isobe K, et al.
    • Journal Title

      Journal of Biomedical Optics 10

      Pages: 24026-24026

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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