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Induction of antigen specific peripheral tolerance by targeting Langerhans cells

Research Project

Project/Area Number 17390312
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionNagoya City University

Principal Investigator

MORITA Akimichi  Nagoya City University, Graduate School of Medical Sciences, Professor And Chair (30264732)

Co-Investigator(Kenkyū-buntansha) SHINTANI Yoichi  Nagoya City University, Graduate School of Medical Sciences, Research Associate (10336688)
YAMAMOTO Ai  Nagoya City University, Graduate School of Medical Sciences, Research Associate (60381802)
小林 桂子  名古屋市立大学, 大学院医学研究科, 助手 (80381789)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,410,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2005: ¥7,900,000 (Direct Cost: ¥7,900,000)
KeywordsULTRAVIOLET / IMMUNE SUPPRESSION / EGURATORY T CELLS / Narrow-band UVB / 制御性T細胞 / ランゲルハンス細胞 / 樹状細胞 / 免疫寛容 / アレルギー疾患 / 皮膚 / 遅延型過敏反応 / 自己免疫疾患
Research Abstract

Phototherapy generally induces a relatively long remission period in patients with psoriasis, which cannot be explained simply by UV-induced apoptosis. Therefore, the role of regulatory T cells should also be considered. We recently reported that narrow-band UVB suppresses delayed-type hypersensitivity (DTH) and contact hypersensitivity by inducing regulatory T cell production. The UV wavelength that induced regulatory T cells to DTH, however, was not known. We irradiated a mouse DTH model using a monochromator to produce several UVB wavelengths (290 nm, 300 nm, 310 nm, and 320 nm). All wavelengths tested significantly suppressed DTH, with 300 nm inducing maximal suppression. Foxp3 expression in lymph node cells from tolerant mice was analyzed by real time polymerase chain reaction (mRNA) and FACS analysis (protein). Foxp3 induction was increased 2-fold at 300 nm compared with controls. Similarly, interleukin (IL)-10 induction was increased 10-fold at 300 nm. Conversely, IL-17, IL-23, and IL-12 were suppressed by 40%, 25%, and 30%, respectively, at 300 nm. These data indicate that 300-nm UV light induces Foxp3-expressing regulatory T cells and suppresses Th-17 cells. Besides inducing Foxp3-expressing regulatory T cells, the suppression of Th-17 cells might be important for the UV light-induced immune suppression. The use of a specific wavelength within the UVB range is a new strategy for the induction of antigen-specific peripheral tolerance and provides a new potential treatment for allergic dermatologic diseases.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (96 results)

All 2008 2007 2006 2005 Other

All Journal Article (65 results) (of which Peer Reviewed: 35 results) Presentation (7 results) Book (24 results)

  • [Journal Article] Ultrastructure of cutaneous collagen alterations in systemic sclerosis by UVAI and PUVA therapy2008

    • Author(s)
      Noriyuki Sakakibara, Shigeru Sugano, and Akimichi Morita
    • Journal Title

      JD 35

      Pages: 35-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Narrowband UVB Radiation Suppresses Contact Hypersensitivity2008

    • Author(s)
      Yoichi Shintani, Yoko Yasuda, Keiko Kobayashi, Akira Maeda, Akimichi Morita
    • Journal Title

      Photodermatol Photoimmunol Photomedicin 24

      Pages: 32-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recent Developments in Phototherapy:Treatment Methods and Devices2008

    • Author(s)
      Akimichi Morita, Mark Weiss, Akira Maeda
    • Journal Title

      Recent Patents on Inflammation & Allergy Drug Discovery (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 光線療法の新たな展開2008

    • Author(s)
      森田 明理
    • Journal Title

      日本医師会雑誌 136

      Pages: 2418-2419

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 光線療法と外用療法のcombination therapy-安全性に対する新たな見解2008

    • Author(s)
      森田 明理
    • Journal Title

      臨床皮膚科増刊号、最近のトピックス2008 62(5)

      Pages: 89-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ultrastructure of cutaneous collagen alterations in systemic sclerosis by UVAI and PUVA therapy2008

    • Author(s)
      Noriyuki, Sakakibara, Shigeru, Sugano, Akimichi, Morita
    • Journal Title

      JD 35

      Pages: 63-69

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Narrowband UVB Radiation Suppresses Contact Hypersensitivity2008

    • Author(s)
      Yoichi, Shintani, Yoko, Yasuda, Keiko, Kobayashi, Akira, Maeda, Akimichi, Morita
    • Journal Title

      Photodermatol Photoimmunol Photomedicin 24

      Pages: 32-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A new target blue light phototherapy for the treatment of acne2007

    • Author(s)
      Reiko Noborio, Emi Nishida, Mariko Kurokawa, Akimichi Morita
    • Journal Title

      Photoderm Photoimmunol Photomedicin 23

      Pages: 23-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel functions of herbal medicines in dendritic cells-Role of Amomi Semen in tumor immunity2007

    • Author(s)
      Hajime Fukui, Seika Mitsui, Nobue Harima, Mitsuhiko Nose, Kunio Tsujimura, Hajime Mizukami, Akimichi Morita
    • Journal Title

      Microbiol Microimmunol 51

      Pages: 1121-1133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Tobacco smoke causes premature skin aging2007

    • Author(s)
      Akimichi Morita
    • Journal Title

      Journal of Dermatological Science 48

      Pages: 48-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 光老化と光防御2007

    • Author(s)
      森田 明理
    • Journal Title

      平成17年度日本皮膚科学会前実績研修講習会

      Pages: 1-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PUVAとナローバンドUVB2007

    • Author(s)
      森田 明理
    • Journal Title

      日皮会誌 126

      Pages: 126-126

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 乾癬の爪病変に対する局所療法2007

    • Author(s)
      三谷 有史、森田 明理
    • Journal Title

      デルマ 126

      Pages: 19-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 紫外線と眼-PUVA療法,ナローバンドUVB療法からどう眼を保護するか2007

    • Author(s)
      森田 明理
    • Journal Title

      Visual Dermatology 16(10)

      Pages: 1082-1086

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PUVA療法2007

    • Author(s)
      森田 明理
    • Journal Title

      デルマ 132

      Pages: 137-141

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 光線療法の新たな展開-その理論と背景2007

    • Author(s)
      森田 明理
    • Journal Title

      日皮会誌 117

      Pages: 2370-2371

    • NAID

      10027062920

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] アトピー性皮膚炎に対するナローバンドUVB療法2007

    • Author(s)
      森田 明理、山本 あい、澤田 啓生
    • Journal Title

      皮膚の科学 6(増刊9号

      Pages: 26-31

    • NAID

      130004547291

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A new target blue light phototherapy for the treatment of acne2007

    • Author(s)
      Reiko, Noborio, Emi, Nishida, Mariko, Kurokawa, Akimichi, Morita
    • Journal Title

      Photoderm Photoimmunol Photomedicin, 23

      Pages: 32-4

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel functions of herbal medicines in dendritic cells - Role of Amomi Semen in tumor immunity2007

    • Author(s)
      Hajime, Fukui, Seika, Mitsui, Nobue, Harima, Mitsuhiko, Nose, Kunio, Tsujimura, Hajime, Mizukami, Akimichi, Morita
    • Journal Title

      Microbiol Microimmunol 51

      Pages: 1121-1133

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Tobacco smoke causes premature skin aging2007

    • Author(s)
      Akimichi, Morita
    • Journal Title

      Journal of Dermatological Science 48

      Pages: 169-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A new target blue light phototherapy for the treatment of acne2007

    • Author(s)
      Reiko Noborio
    • Journal Title

      Photoderm Photoimmunol Photomedicin 23

      Pages: 32-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tobacco smoke extract induces premature skin aging in mouse skin2007

    • Author(s)
      Hiroshi Tanaka
    • Journal Title

      J Dermatol Sci 46

      Pages: 69-71

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel functions of herbal medicines in dendritic cells - Role of Amomi Semen in tumor immunity2007

    • Author(s)
      Hajime Fukui
    • Journal Title

      Microbiol Microimmunol 51

      Pages: 1121-1133

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructure of cutaneous collagen alterations in systemic sclerosis by UVA1 and PUVA therapy2007

    • Author(s)
      Noriyuki Sakakibara
    • Journal Title

      J Dermatol 51

      Pages: 1121-1133

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Narrowband UVB Radiation Suppresses Contact Hypersensitivity2007

    • Author(s)
      Yoichi Shintani
    • Journal Title

      Photoderm Photoimmunol Photomedicin 51

      Pages: 1121-1133

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new targeted blue light phototherapy for the treatment of acne2007

    • Author(s)
      Reiko Noborio
    • Journal Title

      Photodermatology, Photoimmunology & Photomedicine 23巻1号

      Pages: 32-34

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antigen specific peripheral tolerance induced by opical applicatic of NF-kB decoy oligodeoxynucleotide2006

    • Author(s)
      Iwao Isomura, Kunio Tsujimura, and Akimichi Morita
    • Journal Title

      J invest Dermatol 126

      Pages: 97-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of the efficacy of calcipotriol and maxacalcitol in combination therapy with narrow-band ultraviolet B for treatment of psoriasis vulgaris2006

    • Author(s)
      Reiko Noborio, Keiko Kobayashi, Yoichi Shintani, Akimichi Morita
    • Journal Title

      Photoderm Photoimmunol Photomedicin 262

      Pages: 22-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Regulation of NF-kB signaling pathway by decoy oligodeoxynucleotide2006

    • Author(s)
      Iwao Isomura, Akimichi Morita
    • Journal Title

      Microbiol Microimmnol 50(8)

      Pages: 559-563

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 乾癬に対してレーザー治療は有効ですか2006

    • Author(s)
      上尾 礼子、森田 明理
    • Journal Title

      デルマ 115

      Pages: 115-115

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 光線療法の将来に向けて-新しいナローバンドUVBとUVAl2006

    • Author(s)
      森田 明理
    • Journal Title

      デルマ 116

      Pages: 116-116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 掌蹠膿疱症における光線療法2006

    • Author(s)
      磯村 巌、森田 明理
    • Journal Title

      デルマ 115

      Pages: 39-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 乾癬に対するパルスダイレーザー療法2006

    • Author(s)
      上尾 礼子、森田 明理
    • Journal Title

      デルマ 115

      Pages: 63-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PUVAバス療法2006

    • Author(s)
      小林 桂子、森田 明理
    • Journal Title

      デルマ 115

      Pages: 15-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 新しい紫外線療法2006

    • Author(s)
      森田 明理
    • Journal Title

      日本医事新報 4307

      Pages: 49-52

    • NAID

      10016860237

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] ナローバンドUVB治療のひろがり2006

    • Author(s)
      森田 明理
    • Journal Title

      日皮会誌 116

      Pages: 2182-2186

    • NAID

      10027062149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 乾癬治療における光線治療の進歩2006

    • Author(s)
      森田 明理
    • Journal Title

      日皮会誌 116

      Pages: 1899-1903

    • NAID

      10027061490

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Antigen specific peripheral tolerance induced by topical application of NF-kB decoy oligodeoxynucleotide2006

    • Author(s)
      Iwao, Isomura, Kunio, Tsujimura, Akimichi, Morita
    • Journal Title

      J invest Dermatol 126

      Pages: 97-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Comparison of the efficacy of calcipotriol and maxacalcitol in combination therapy with narrow-band ultraviolet B for treatment of psoriasis vulgaris2006

    • Author(s)
      Reiko, Noborio, Keiko, Kobayashi, Yoichi, Shintani, Akimichi, Morita
    • Journal Title

      Photoderm Photoimmunol Photomedicin 22

      Pages: 262-262

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regulation of NF-kB signaling pathway by decoy oligodeoxynucleotide2006

    • Author(s)
      Iwao, Isomura, Akimichi, Morita
    • Journal Title

      Microbiol Microimmnol 50(8)

      Pages: 559-563

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regulation of NF-kB signaling pathway by decoy oligodeoxynicleotide2006

    • Author(s)
      Iwao Isomura
    • Journal Title

      Microbiol Microimmnol 50巻8号

      Pages: 559-563

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antigen specific peripheral tolerance induced by topical application of NF-kB decoy oligodeoxynucleotide2006

    • Author(s)
      Iwao Isomura
    • Journal Title

      J invest Dermatol 126巻

      Pages: 97-104

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Comparison of the efficacy of calcipotriol and maxacalcitol in combination therapy with narrow-band ultraviolet B for treatment of psoriasisvulgaris2006

    • Author(s)
      Reiko Noborio
    • Journal Title

      Photoderm Photoimmunol Photomedicine 5巻

      Pages: 262-262

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular alterations of Decorin Photoaging2006

    • Author(s)
      Yoshihiko Kawashima
    • Journal Title

      J Dermatol Sci 2巻

      Pages: 51-56

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A successful treatment of topical tacrolimus therapy for discoid lupus erythematosus2006

    • Author(s)
      Masayoshi Sugano
    • Journal Title

      J Dermatol 33巻

      Pages: 887-891

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Recombinant cholera toxin B activates dendritic cells and enhances antitumor immunity2005

    • Author(s)
      Iwao Isomura, Yoko Yasuda, Kunio Tochikubo, Akimichi Morita
    • Journal Title

      Microbiol and Immunology 49

      Pages: 79-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dermal mast cells are involved in the incidence ofscratching behavior caused by multiple application of hapten,2,4,6-trinitrochlorobenzene,in mice2005

    • Author(s)
      Hirotaka Yamashita, Yoshiko Michibata, Hajime Mizukami, Yukio Ogihara, Akimichi Morita, Mitsuhiko Nose
    • Journal Title

      J Exp Dermatol 14

      Pages: 438-44

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A Newly Developed Phototherapy for atopic dermatitis2005

    • Author(s)
      Akimichi Morita
    • Journal Title

      Allergology International 54

      Pages: 32-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary 2005 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性光線性皮膚炎2005

    • Author(s)
      森田 明理
    • Journal Title

      アレルギーの臨床 25

      Pages: 193-198

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎の光線治療の今後2005

    • Author(s)
      森田 明理
    • Journal Title

      日本医事新報 4216

      Pages: 105-105

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎の光線療法2005

    • Author(s)
      森田 明理
    • Journal Title

      アレルギー科 19

      Pages: 511-517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] ナローバンドUVB療法2005

    • Author(s)
      森田 明理
    • Journal Title

      マルホ皮膚科セミナー

      Pages: 18-22

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 光線テストの方法2005

    • Author(s)
      森田 明理
    • Journal Title

      朝日メディカル

      Pages: 84-85

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 新しい紫外線療法、(皮膚科セミナリウム)2005

    • Author(s)
      森田 明理
    • Journal Title

      日皮会誌 115

      Pages: 1591-1597

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 陽に当たるのはアトピー性皮膚炎によくないのですか2005

    • Author(s)
      森田 明理
    • Journal Title

      Q&Aでわかるアレルギー疾患1

      Pages: 379-381

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] わかりやすい光線療法の実際2005

    • Author(s)
      森田 明理
    • Journal Title

      日皮会誌 115

      Pages: 2209-2212

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recombinant cholera toxin B activates dendritic cells and enhances antitumor immunity2005

    • Author(s)
      Iwao, Isomura, Yoko, Yasuda, Kunio, Tochikubo, Akimichi, Morita
    • Journal Title

      Microbiol and Immunology 49

      Pages: 79-87

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dermal mast cells are involved in the incidence ofscratching behavior caused by multiple application of hapten, 2, 4, 6-trinitrochlorobenzene, in mice2005

    • Author(s)
      Hirotaka, Yamashita, Yoshiko, Michibata, Hajime, Mizukami, Yukio, Ogihara, Akimichi, Morita, Mitsuhiko, Nose
    • Journal Title

      J Exp Dermatol 14

      Pages: 438-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A Newly Developed Phototherapy for atopic dermatitis2005

    • Author(s)
      Akimichi, Morita
    • Journal Title

      Allergology International 54

      Pages: 175-180

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recombinant cholera toxin B activates dendritic cells and enhances antitumor immunity2005

    • Author(s)
      Iwao Isomura
    • Journal Title

      Microbiol Immunol 49

      Pages: 79-87

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Dermal mast cells are involved in the incidence of scratching behavior caused by multiple application of hapten,2,4,6-trinitrochlorobenzene, in mice2005

    • Author(s)
      Hirotaka Yamashita
    • Journal Title

      J Exp Dermatol 14

      Pages: 438-444

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Antigen specific peripheral tolerance induced by topical application of NF-kB decoy oligodeoxynucleotide2005

    • Author(s)
      Iwao Isomura
    • Journal Title

      J Invest Dermatol 126

      Pages: 97-104

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アトピー性皮膚炎の光線療法2005

    • Author(s)
      森田明理
    • Journal Title

      アレルギー科 19

      Pages: 511-517

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 新しい紫外線療法2005

    • Author(s)
      森田明理
    • Journal Title

      日皮会誌 115

      Pages: 1591-1597

    • NAID

      10016860237

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Recent Developments in Phototherapy: Treatment Methods and Devices

    • Author(s)
      Akimichi, Morita, Mark, Weiss, Akira, Maeda
    • Journal Title

      Recent Patents on Inflammation & Allergy Drug Discovery, in press (June)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 光線療法の新たな展開-その理論と背景2007

    • Author(s)
      森田 明理
    • Organizer
      第106回日本皮膚科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] UVA1 and visible light phototherapy, Photodermatology (Lim, Honingsmann, Hawk, eds)2007

    • Author(s)
      Jean, Krutmann, Akimichi, Morita
    • Organizer
      Taylor & Francis gourpe, LLC
    • Place of Presentation
      MewYork
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Peter Schroder, und Akimichi Morita:Molekulare Mechanismen der Lichtalterung durch UV-Strahlung und andere Noxen, in Hautalterung 2 Auflage: Grundlagen-Pravention-Therapie(Jean Krutmann and Thomas Diepgen, eds)2007

    • Author(s)
      Jean, Krutmann
    • Organizer
      Springer
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Therapeutic photomedicine phototherapy; in Fitzpatrick's Dermatology in general medicine, 7th ed (Freedberg IM, et. al. ed)2007

    • Author(s)
      Jean, Krutmann, Akimichi, Morita
    • Organizer
      McGraw-Hill
    • Place of Presentation
      NewYork
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Premature skin aging by infrared radiation, tobacco smoke, ozone and other enviornmental pollutans; in Skin aging, (J. Krutmann, B Gilchrest)2006

    • Author(s)
      Peter, Schroeder, Stefan, M., Schieke, Akimichi, Morita
    • Organizer
      Springer
    • Place of Presentation
      New York
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] tobacco smoke effect on skin function and apperance; Cigarette Smoke and Oxidative stress2006

    • Author(s)
      Akimichi, Morita
    • Organizer
      Springer-Verlag
    • Place of Presentation
      NewYork
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Phototherapy for Atopic Dermatitis, Handbook of Atopic Eczema, 2nd edition ; Eds. Ring, Ruzicka and Przybilla2005

    • Author(s)
      Jean, Krutmann, Akimichi, Morita
    • Organizer
      Springer-Verlag
    • Place of Presentation
      Heidelberg
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 今日の治療指針2008

    • Author(s)
      森田 明理
    • Total Pages
      2
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 最新皮膚科学大系2008

    • Author(s)
      森田 明理
    • Total Pages
      10
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚科サブスペシャルティーシリーズ2008

    • Author(s)
      榊原 茂、森田 明理
    • Total Pages
      2
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚科サブスペシャルティーシリーズ2008

    • Author(s)
      森田 明理
    • Total Pages
      36
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚科サブスペシャルティーシリーズ2008

    • Author(s)
      森田 明理、前田 晃
    • Total Pages
      2
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚科サブスペシャルティーシリーズ2008

    • Author(s)
      前田 晃、森田 明理
    • Total Pages
      4
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] EBM皮膚疾患の治療2008

    • Author(s)
      森田 明理
    • Total Pages
      6
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Photodermatology2007

    • Author(s)
      Jean Krutmann and Akimichi Morita
    • Total Pages
      12
    • Publisher
      Taylor & Francis gourpe,LLC
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Hautalterung 2 Auflage2007

    • Author(s)
      Jean Krutmann, Peter Schroder, and Akimichi Morita
    • Total Pages
      21
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Fitzpatrick's Dermatology in general medicine2007

    • Author(s)
      Jean Krutmann and Akimichi Morita
    • Total Pages
      7
    • Publisher
      McGraw-Hill
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 小児アレルギーシリーズ、アトピー性皮膚炎2007

    • Author(s)
      森田 明理
    • Total Pages
      4
    • Publisher
      診断と治療社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚科診療プラクティス2007

    • Author(s)
      森田 明理、山口 裕史
    • Total Pages
      6
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Fitzpatrick's Dermatology in general medicine, 7th ed2007

    • Author(s)
      Jean Krutmann and Akimichi Morita
    • Total Pages
      7
    • Publisher
      McGraw-Hill
    • Related Report
      2007 Annual Research Report
  • [Book] Photodermatology2007

    • Author(s)
      Jean Krutmann, Akimichi Morita
    • Total Pages
      12
    • Publisher
      Inhorma Healthcare
    • Related Report
      2006 Annual Research Report
  • [Book] Skin aging2006

    • Author(s)
      Peter Schroeder, Stefan M Schieke, Akimichi Mo rita
    • Total Pages
      9
    • Publisher
      Springer
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Cigarette Smoke and Oxidative stress2006

    • Author(s)
      Akimichi Morita
    • Total Pages
      6
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] What's New in 皮膚科学2006

    • Author(s)
      森田 明理
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚疾患最新の治療2006

    • Author(s)
      森田 明理
    • Total Pages
      2
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Handbook of Atopic Eczema2005

    • Author(s)
      Jean Krutmann and Aki michi Morita
    • Total Pages
      4
    • Publisher
      Springer-Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 今日の治療指針2005

    • Author(s)
      森田 明理
    • Total Pages
      1
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 皮膚科診療プラクティス2005

    • Author(s)
      森田 明理、上尾 礼子
    • Total Pages
      2
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 難治性皮膚疾患の病態と治療2005

    • Author(s)
      森田 明理
    • Total Pages
      7
    • Publisher
      順天堂大学医学部皮膚科
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 先端医療シリーズ38、皮膚疾患2005

    • Author(s)
      森田 明理
    • Total Pages
      4
    • Publisher
      先端医療技術研究所
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Immune Machanisms of Allergic Contact Dermatitis2005

    • Author(s)
      Akira Takashima
    • Publisher
      Landes Bioscience
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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