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Analysis of sequential endoproteolytic process of beta-APP to establish novel therapeutic interventions

Research Project

Project/Area Number 17390318
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionOsaka University

Principal Investigator

TAKEDA Masatoshi  Osaka University, Graduate School of Medicine, Professor (00179649)

Co-Investigator(Kenkyū-buntansha) OKOCHI Masayasu  Osaka University, Graduate School of Medicine, Assistant (90335357)
KUDO Takashi  Osaka University, Graduate School of Medicine, Associate Professor (10273632)
TANAKA Toshihisa  Osaka University, graduate School of Medicine, Lecturer (10294068)
TAGAMI Shinji  Osaka University, Graduate School of Medicine, Assistant (40362735)
MORIHARA Takashi  Osaka University, Graduate School of Medicine, Assistant (90403196)
紙野 晃人  大阪大学, 医学系研究科, 助手 (40307955)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2006: ¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 2005: ¥8,300,000 (Direct Cost: ¥8,300,000)
KeywordsAlzheimer disease / Presenilin / gamma-secretase / Notch signaling / Amyloid-beta peptide / beta-amyloid protein precursor / Notch-1 / gamma-cleavage
Research Abstract

We have revealed detailed processes of sequential endoproteolysis of betaAPP and Notch. We have found that novel compound-W is a second generation gamma-secretase inhibitor which inhibits Abeta generation without perturbing Notch signaling. Moreover, we found that Abeta29-40 peptide has an activity to inhibit beta-secretase. Furthermore, we established ELISA system to measure Nbeta level in vivo. In addition, we accidentally found compound-OSX which inhibit beta-cleavage of betaAPP without inhibiting BACE.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (69 results)

All 2007 2006 2005 Other

All Journal Article (64 results) Book (5 results)

  • [Journal Article] The DYRKIA gene,encoded in chromosome 21 Down syndrome critical region,bridges between beta-amyloid production and tauphosphorylation in Alzheimer disease2007

    • Author(s)
      Kimura R, Kamino K, et. al.
    • Journal Title

      Hum Mol Genet. 16(1)

      Pages: 15-23

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.2007

    • Author(s)
      Kimura R, Kamino K, et. al.
    • Journal Title

      Hum Mol Genet. 16(1)

      Pages: 15-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.2007

    • Author(s)
      Kimura R, Kamino K, et al.
    • Journal Title

      Hum Mol Genet. 16(1)

      Pages: 15-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Secretion of the Notch-1 A β-like peptide 」during Notch signaling2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 28(12)

      Pages: 7890-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      BIOCHEMISTRY 45(15)

      Pages: 4907-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Development of new screening system for Alzheilzer disease,in vitro A・sink ,assay,toidentify the dissociation of soluble A・from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura LM, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease 22(3)

      Pages: 487-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
    • Journal Title

      J Neuroscience 5(26)

      Pages: 3821-3828

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 非ろテロイド性消炎薬(NSAIDs)のA」42産生阻害作用とその応用2006

    • Author(s)
      大河内 正康, 田上 真次, 武田 雅俊
    • Journal Title

      CURRENT THERAPY Vol 24, No.3

      Pages: 33-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease2006

    • Author(s)
      Nakamura K, Ohya W, Funakoshi H, Sakaguchi G, Kato A, Takeda M, Kudo T, Nakamura T.
    • Journal Title

      J Neurosci Res. 84(4)

      Pages: 874-90

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Formation of tauinclusions in knock-in mice with familial Alzheimer disease(FAD)mutation of presenilinl(PSl)2006

    • Author(s)
      Tanemura K, Chui DH, Nakano Y, Kudo T, Takeda M, Takashima A.
    • Journal Title

      J Biol Chem. 281(8)

      Pages: 5037-41

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of・APP in cultured cells2006

    • Author(s)
      Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M
    • Journal Title

      Psychogeriatrics Sep 6

      Pages: 107-113

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antipsychotic medication and cognitive function in schizophrenia2006

    • Author(s)
      Hori, H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Tadahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kungi H.
    • Journal Title

      Schizophr Res 86

      Pages: 138-146

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Discrepancy of performance among working memory related tasks in autism spectrum disorders was caused by task characteristics except working memory which could interfere with task execution2006

    • Author(s)
      Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekipama R, Ukai S, Ishii, R, Ishigami W, Rajimoto O, Yamashita K, Hashimoto R, Shimizu A, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 312-318

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multiple anti-Alzheimer disease activities of non-steroidal anti-inflammatory drugs2006

    • Author(s)
      Morihara T, Cole GM, Tanii H, Tanaka T, Kudo T, Takeda M
    • Journal Title

      Psychogeriatrics March;6(1)

      Pages: 1-3

    • NAID

      10019375931

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease2006

    • Author(s)
      Tanaka T, Isoe-Wada K, Yamamori H, Kato K, Nessa BN, Sadik GM, Takeda M.
    • Journal Title

      Acta Neurol Taiwan 15

      Pages: 68-71

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurl substrates of emotionally valenced epidodec memory:A PET study using film stimuli2006

    • Author(s)
      Masaki Y, Nishikawa T, Ikejiri Y, Tokunaga H, Hatta N, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60 Suppl 1

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neural substrates of emotional habituation:A PET study using film stimuli2006

    • Author(s)
      Hatta N, Nishikawa T, Ikejiri Y, Tokunaga H, Masaki Y, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60 Suppl 1

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Toll-like receptor 3 mediated ρhyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. 60 Suppl 1

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia2006

    • Author(s)
      Takeda M, Kudo T, Tanaka T, Kamino K, Okochi M, Tagami S
    • Journal Title

      Functional and Moleculart Imaging of Strokeka dn Dementia

      Pages: 101-107

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Effect of valine on the efficiency and precision a cleavage of the Notch-1 transmembrane domain2006

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M
    • Journal Title

      J Neurosci Res. Sep;84(4)

      Pages: 918-25

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in ρAlzheimer's disease2006

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
    • Journal Title

      Psychogeriatrics Dec 6:

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
    • Journal Title

      Biochem Biophys Res Commun Jun2:344(2)

      Pages: 525-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] セクレターゼ阻害薬2006

    • Author(s)
      福森 亮雄, 田上 真次, 大河内 正康, 武田 雅俊
    • Journal Title

      Pharma Medica Vol.24 No.7

      Pages: 4-4

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006

    • Author(s)
      Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Thhyama M, Tabira T, Takeda M.
    • Journal Title

      Biochem Biophys Res Commun. 2

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry. 18

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H.
    • Journal Title

      J Neurosci. 5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tauin human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. Apr60 Suppi 1

      Pages: 527-33

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils.2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R.
    • Journal Title

      Neurobiol Dis. 22(3)

      Pages: 487-95

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. 24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease.2006

    • Author(s)
      Nakamura K, Ohya W, Funakoshi H, Sakaguchi G Kato A, Takeda M. Kudo T, Nakamura T.
    • Journal Title

      I Neurosci Res. 84(4)

      Pages: 874-90

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of /3 APP in cultured cells.2006

    • Author(s)
      Fukumori A, Jiang J ; Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S. Okochi M, Takeda M
    • Journal Title

      Psychogeriatrics.

      Pages: 107-113

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antipsychotic medication and cognitive function in schizophrenia.2006

    • Author(s)
      Hon H, Noguchi H, Hashimoto R, Nakabayashi T, Omori Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada Saitoh O, Iwase M, Kajimoto 0, Takeda M, Okabe S, Kunugi H.
    • Journal Title

      Schizophr Res 86

      Pages: 138-146

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Multiple anti-Alzheimer disease activities of non-steroidal anti-inflammatory drugs.2006

    • Author(s)
      Moriliara 1', Cole GM, Tanii H, Tanaka T, Kudo T, Takeda M
    • Journal Title

      Psychogeriatrics 6(1)

      Pages: 1-3

    • NAID

      10019375931

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease.2006

    • Author(s)
      Tanaka T, Isoe-Wada K, Yamamori H, Kato K, Nessa BN Sadik GM, Takeda M.
    • Journal Title

      ActaNeurol Taiwan 15

      Pages: 68-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] S46-51 Tanii H, Tanaka T, Oku N, Takeda M. Neural substrates of emotionally valenced episodic memory : A PET study using film stimuli.2006

    • Author(s)
      Masaki Y, Nishikawa T, Ikejiri Y, Tokunaga H, Haifa N, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N.
    • Journal Title

      Psychiatry Clin Neurosci(Suppl 1) 60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease.2006

    • Author(s)
      Nakamura K, Ohya W, Funakoshi H, Sakaguchi G, Kato A, Takeda M, Kudo T, Nakamura T.
    • Journal Title

      J Neurosci Res. 84(4)

      Pages: 874-890

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1)2006

    • Author(s)
      Tanemura K, Chui DH, Nakano Y, Kudo T, Takeda M, Takashima A.
    • Journal Title

      J Biol Chem. 281(8)

      Pages: 5037-5041

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease 22(3)

      Pages: 487-495

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.2006

    • Author(s)
      Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, Takeda M
    • Journal Title

      Psychogeriatrics Sep 6

      Pages: 107-113

    • NAID

      10019375803

    • Related Report
      2006 Annual Research Report
  • [Journal Article] セクレターゼ阻害薬2006

    • Author(s)
      福森亮雄, 田上真次, 大河内正康, 武田雅俊
    • Journal Title

      Pharma Medica Vol.24 No.7

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006

    • Author(s)
      Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci. 60 Suppl 1

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Cliem. Mar24;281(12)Epub

      Pages: 7890-7898

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006

    • Author(s)
      Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      Biochemistry. Apr18;45(15)

      Pages: 4907-4914

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M
    • Journal Title

      J Neurosci Res. Sep;84(4)

      Pages: 918-925

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
    • Journal Title

      Psychogeriatrics. Dec6:(SUPPL.2)

    • NAID

      10025860692

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antipsychotic medication and cognitive function in schizophrenia.2006

    • Author(s)
      Hori H, Noguchi H, Hashimoto R, Nakabayashi T, Omori M, Takahashi S, Tsukue R, Anami K, Hirabayashi N, Harada S, Saitoh O, Iwase M, Kajimoto O, Takeda M, Okabe S, Kunugi H.
    • Journal Title

      Schizophr Res 86

      Pages: 138-146

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Discrepancy of performance among working memory related tasks in autism spectrum disorders was caused by task characteristics except working memory which could interfere with task execution.2006

    • Author(s)
      Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekiyama R, Ukai S, Ishii, R, Ishigami W, Kajimoto O, Yamashita K, Hashimoto R, Shimizu A, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 312-318

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multiple anti-Alzheimer disease activities of non-steroidal anti-inflammatory drugs.2006

    • Author(s)
      Morihara T, Cole GM, Tanii H, Tanaka T, Kudo T, Takeda M.
    • Journal Title

      Psychogeriatrics March;6(1)

      Pages: 1-3

    • NAID

      10019375931

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neurobiological studies of dementia-biological markers and neuroprotective strategies for Alzheimer disease.2006

    • Author(s)
      Tanaka T, Isoe-Wada K, Yamamori H, Kato K, Nessa BN, Sadik GM, Takeda M.
    • Journal Title

      Acta Neurol Taiwan 15

      Pages: 68-71

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neural substrates of emotionally valenced episodic memory : A PET study using film stimuli.2006

    • Author(s)
      Masaki Y, Nishikawa T, Ikejiri Y, Tokunaga H, Hatta N, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60 Suppl 1

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neural substrates of emotional habituation : A PET study using film stimuli.2006

    • Author(s)
      Hatta N, Nishikawa T, Ikejiri Y, Tokunaga H, Masaki Y, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60 Suppl 1

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006

    • Author(s)
      Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
    • Journal Title

      J Biol Chem. Epub

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006

    • Author(s)
      Fukumori A, Okochi M.Tagami S.Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
    • Journal Title

      BIOCHEMISTRY in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Development of new screening system for Alzheimer disease, in vitro Aβ slnk assay, to identify the dissociation of soluble Aβ from fibrils2006

    • Author(s)
      Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R
    • Journal Title

      Neurobiology of Disease. Epub

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The protease active site domain of γ-secretase contributes to substrate identification2006

    • Author(s)
      Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H
    • Journal Title

      J Neuroscience in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻幸作用とその応用2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Journal Title

      CURRENT THERAPY Vol.24 No.3

      Pages: 33-37

    • Related Report
      2005 Annual Research Report
  • [Journal Article] アミロイドβタンパク質産生の異常がアルツハイマー病につなが2005

    • Author(s)
      大河内 正康
    • Journal Title

      アルツハイマー病:治療の可能性を探る2005第.19回「大学と科学」公開シンポジウム講演抄録集 単行本

      Pages: 13-13

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Inhibition of Aβ42 production by NSAIDS

    • Author(s)
      Okochi M, Tagami S, Takeda M
    • Journal Title

      CURRENT THERAPY 24(3)

      Pages: 33-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Takashima A.Formation of tau inclusions in knock-in mice with familial Alzheimer disease(FAD) mutation of presenilin 1(PS1)

    • Author(s)
      Tanemura K, Chui DH,. Nakano Y, Kudo T, Takeda M, Takashima A.
    • Journal Title

      J Biol Chem. 281(8)

      Pages: 5037-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Psychiatry Clin Neurosci Discrepancy of performance among working memory related tasks in autism spectrum disorders was caused by task characteristics except working memory which could interfere with task execution.

    • Author(s)
      Nakahachi T, Iwase M, Takahashi H, Honaga E, Sekiyama R, Ukai S. Ishii, R, Ishigami W, Kajimoto 0, Yamashita K, Hashimoto R Shimizu A, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci 60

      Pages: 312-318

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neural substrates of emotional habituation : A PET study using film stimuli.

    • Author(s)
      Hatta N, Nishikawa T, Ikejiri Y, Tokunaga H, Masaki Y, Uema T, Kazui H, Doronbekov TK, Ogino A, Miyoshi N, Tanii H, Tanaka T, Oku N, Takeda M.
    • Journal Title

      Psychiatry Clin Neurosci(Suppl 1) 60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia

    • Author(s)
      Takeda M, Kudo T, TanakaT, Karnino K, Okochi M, Tagami S
    • Journal Title

      Functional and Moleculart Imaging of Strokeka dn Dementia

      Pages: 101-107

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain

    • Author(s)
      Tanii H, Jiang J, Fukumori A, Tagami S. Okazaki Y, Okochi M, Takeda M
    • Journal Title

      J Neurosci Res. 84(4)

      Pages: 918-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease

    • Author(s)
      Tagami S, Tsujimoto Y, Akaike A, TakashimaA, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K Okochi M Takeda M.
    • Journal Title

      Psychogeriatrics. 6

    • NAID

      10025860692

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 老年期認知症ナビゲーター2006

    • Author(s)
      大河内 正康, 田上 真次, 武田 雅俊
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 脳と循環2006

    • Author(s)
      大河内 正康, 田上 真次, 武田 雅俊
    • Total Pages
      13
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 老年期認知症ナビゲーター2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Total Pages
      2
    • Publisher
      メディカルレビュー社
    • Related Report
      2006 Annual Research Report
  • [Book] 脳と循環2006

    • Author(s)
      大河内正康, 田上真次, 武田雅俊
    • Total Pages
      13
    • Publisher
      メディカルレビュー社
    • Related Report
      2006 Annual Research Report
  • [Book] アルツハイマー病:治療の可能性を探る 2005 第19回「大学と科学」公開シンポジウム講演抄録集2005

    • Author(s)
      大河内正康
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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