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Neuroimaging investigation Vascular Depression

Research Project

Project/Area Number 17390320
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHiroshima University

Principal Investigator

YAMAWAKI Shigeto  Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (40230601)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Yasumasa  Graduate School of Biomedical Sciences, Assistant Professor, 大学院医歯薬学総合研究科, 講師 (70314763)
YAMASHITA Hidehisa  Hiroshima University, Hospital, Assistant Professor, 病院・講師 (50294591)
TAKAMI Hiroshi  Hiroshima University, Hospital, Assistant, 病院・助手
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2006: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 2005: ¥9,500,000 (Direct Cost: ¥9,500,000)
KeywordsVascular Depression / Basal ganglia / Apathy / Frontal lobe / long term prognosis / dementia / Rehabilitation / 機能的MRI / 前頭葉機能低下 / 意欲低下 / 認知的リハビリテーション
Research Abstract

Growing evidence has been reported an association between cerebrovascular disease and geriatric depression. The term "vascular depression" has been used to describe a subtype of depression occurring later in, life and characterized by the brain changes that may be related depression onset.
The presence of cerebrovascular change may affect the course of depression in geriatric population. There is lots of literature about the effects of cerebrovascular change on treatment response in geriatric depression. However, few studies addressed the relationship between the presence of cerebrovascular change and long term prognosis of geriatric depression.
We have investigated
1) Relationship between location of cerebrovascular change and clinical features of the depressive symptoms in elderly patients after stroke. 2) The effects of cerebrovascular change on the course of depressive symptoms, rate of dementia and mortality approximately 10 years in geriatric depression, 3) Cerebral brain function in depressed elderly and the relationship between this brain function and the number of depressive episodes using functional magnetic resonance imaging, 4) the effects of depressive mood and loss of interest on physical functional recovery in elderly patients after stroke.
Result
1) The severity of affective depression (SDS score) was associated with left frontal lobe (but not basal ganglia) damage, and that of apathetic depression (AS score) was related to damage to the bilateral basal ganglia (but not to the frontal lobe). 2) The presence of silent cerebral infarction was associated with poor prognosis of depression in long term follow up. 3) Activation in the anterior cingulate cortex was significantly attenuated in patients who had experienced multiple depressive episodes, compared with patients with single depressive episode and control group, 4). The presence of depressive mood and loss of interest decreased physical functional recovery in elderly patients after stroke

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (31 results)

All 2007 2006 2005

All Journal Article (30 results) Book (1 results)

  • [Journal Article] Post-stroke affective or apathetic depression and lesion location : left frontal lobe and bilateral basal ganglia.2007

    • Author(s)
      Hama, S.
    • Journal Title

      European Archives of Psychiatry and Clinical Neuroscience 257

      Pages: 149-152

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Attenuated anterior cingulate activation during a verbal fluency task in elderly patients with a history of multiple-episode depression.2007

    • Author(s)
      Takami, H.
    • Journal Title

      The American Journal of Geriatric Psychiatry (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 認知症予防とうつ病との関連性-特に脳血管性うつ病との関連について-2007

    • Author(s)
      山下英尚
    • Journal Title

      分子精神医学 7

      Pages: 184-185

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 脳卒中後うつ病の治療 SSRIとSNRI2007

    • Author(s)
      山下英尚
    • Journal Title

      成人病と生活習慣病 (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Attenuated Anterior Cingulate Activation During a Verbal Fluency Task in Elderly Patients With a History of Multiple-Episode Depression.2007

    • Author(s)
      Takami H, Okamoto Y, Yamashita H, Okada G, Yamawaki S
    • Journal Title

      Am J Geriatr Psychiatry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Post-stroke affective or apathetic depression and lesion location : left frontal lobe and bilateral basal ganglia.2007

    • Author(s)
      Hama S, Yamashita H, Shigenobu M, Watanabe A, Kurisu K, Yamawaki S, Kitaoka T
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci. 257,3

      Pages: 149152-149152

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Changes in central nerves system with age.2007

    • Author(s)
      Yamashita H, Yamawaki S
    • Journal Title

      Geriatric Medicine

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Treatment of post stroke depression.2007

    • Author(s)
      Yamashita H, Kozuru T, Jitsuiki H, Okada G, Yamawaki S
    • Journal Title

      The journal of adult disease

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Preventio of dementia in patients with elderly depression.2007

    • Author(s)
      Yamashita H, Yamawaki S
    • Journal Title

      Japanese Journal of Molecular Psychiatry 7

      Pages: 184-185

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Brain function in patients with elderly depression, after remission.2007

    • Author(s)
      Takami H, Okamoto Y, Yamashita H, Okada G, Yamawaki S
    • Journal Title

      Japanese Journal of Molecular Psychiatry 7

      Pages: 182-183

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Successful effect of ECT on a case of major depression with Cushing syndrome and uterine cancer.2007

    • Author(s)
      Iwamoto T, Yamashita H, Erabi K, Kobayakawa M, Sentani M, Kozuru T, Okamoto Y, Yamawaki S
    • Journal Title

      Psychiatry 9

      Pages: 440-446

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Post-stroke affective or apathetic depression and lesion location : left frontal lobe and bilateral basal ganglia2007

    • Author(s)
      Hama, S.
    • Journal Title

      European Archives of Psychiatry and Clinical Neuroscience (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 認知症予防とうつ病との関連性-特に脳血管性うつ病との関連について-2007

    • Author(s)
      山下英尚
    • Journal Title

      分子精神医学 (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Anticipation of affective image modulates visual evoked magnetic fields (VEF).2006

    • Author(s)
      Onoda, K.
    • Journal Title

      Experimantal Brain Research 175

      Pages: 536-543

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A case of bipolar disorder with Scleroderma.2006

    • Author(s)
      Fuchikami M, Okamoto Y, Shinohara K, Takami H, Yamashita H, Yamawaki S, Kumagai K
    • Journal Title

      Japanese Journal of Psychiatry 48,11

      Pages: 1233-1236

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Functional MRI investigation of cognitive impairment of depression and cognitive behavior therapy.2006

    • Author(s)
      Kinoshita A, Okamoto Y, Ueda K, Matsunaga M, Suzuki S, Yshimura S, Shishida K, Mantani T, Yamashita H, Okada G, Yamawaki S
    • Journal Title

      Annual Report of Psychiatry and Pharmacotherapy 38

      Pages: 48-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Organic mood disorder.2006

    • Author(s)
      Yamashita H, Yamawaki S
    • Journal Title

      Japanese Journal of Psychiatry Treatment 20, suppl

      Pages: 46-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neuroimaging Studies by fMRI about the Brain Mechanism of Emotion and Behavior : Toward Elucidatin of Pathophysiology in Depression2006

    • Author(s)
      Okamoto Y, Okada G, Ueda K, Asahi S, Shishida K, Kinoshita A, Mantani T, Yamashita H, Yamawaki S, Tanaka S, DoYa K
    • Journal Title

      Japanese Journal of Psychosomatic Medicine 45,6

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Distorted Images of One's Own Body Activates the Prefrontal Cortex and Limbic/Paralimbic System in Young Women : A Functional Magnetic Resonance Imaging Study.2006

    • Author(s)
      Kurosaki M
    • Journal Title

      Biolgical Psychiatry 59・4

      Pages: 380-386

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Factors related to prognosis of vascular depression.2005

    • Author(s)
      Yamashita H, Okada G, Shishida K, Takami H, Fujikawa T, Okamoto Y, Morinobu S, Yamawaki S
    • Journal Title

      Japanese Journal of Molecular Psychiatry 5,2

      Pages: 200-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Diagnosis of vascular depression from dementia.2005

    • Author(s)
      Yamashita H, Yamawaki S
    • Journal Title

      The Japanese journal of clinical and experimental medicine 3

      Pages: 432-435

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Present state and feature theme of geriatric depression.2005

    • Author(s)
      Yamashita H, Yamawaki S
    • Journal Title

      Gerontology : new horizon 17,1

      Pages: 71-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Liaison Psychiatry for the elderly.2005

    • Author(s)
      Yamashita H, Yamawaki S
    • Journal Title

      Geriatric Psychiatry, 226-232, 2005, Nagai Shoten Publisher, Japan,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Visual emotional stimuli modulation of auditory sensory gating studied by magnetic P50 suppression.2005

    • Author(s)
      Yamashita H
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci. 255・2

      Pages: 99-103

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Influence of aging on the improvement of subjective sleep quality by atypical antipsychotic drugs in patients with schizophrenia. -comparison of middle-aged and older adults-2005

    • Author(s)
      Yamashita H
    • Journal Title

      Am J Geriatr Psychiatry. 13・5

      Pages: 377-384

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 高齢うつ病の現状と課題2005

    • Author(s)
      山脇成人
    • Journal Title

      ジェロントロジーニューホライズン 17・1

      Pages: 71-75

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 脳血管性うつ病の予後に関連する要因についての研究2005

    • Author(s)
      山下英尚
    • Journal Title

      分子精神医学 5・2

      Pages: 200-201

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 血管性うつ病と痴呆の鑑別2005

    • Author(s)
      山下英尚
    • Journal Title

      臨床と研究 82・3

      Pages: 432-435

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 器質性気分障害2005

    • Author(s)
      山下英尚
    • Journal Title

      精神科治療学 20・増刊

      Pages: 46-47

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 情動・行動の脳内機序に関する研究の進展 情動・行動の脳内機構に関するfMRI研究 うつ病の病態解明に向けて2005

    • Author(s)
      岡本泰昌
    • Journal Title

      心身医学 45・6

      Pages: 439-447

    • Related Report
      2005 Annual Research Report
  • [Book] 現代老年精神医療2005

    • Author(s)
      山下英尚
    • Total Pages
      7
    • Publisher
      永井書店
    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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