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Diagnosis and pathogenesis of schizophrenia induced by methamphetamine

Research Project

Project/Area Number 17390321
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNihon University

Principal Investigator

KOJIMA Takuya  Nihon University, School of Medicine, Professor, 医学部, 客員教授 (40014203)

Co-Investigator(Kenkyū-buntansha) MATUSHIMA Eisuke  Graduate School of Tokyo Medical and Dental University, Section of Liaison Psychiatry and Palliative Medicine, Associate Professor, 医学部, 助教授 (50242186)
KURACHI Masachika  University of Toyama, Faculty of Medicine, Professor, 医学部, 教授 (80019603)
ITOKAWA Masanari  TOKYO INSTITUTE OF PSYCHIATRY, Schizophrenia Research Project, Project Leader, 統合失調症部門, 部門長 (40332324)
TAKAHASHI Sakae  Nihon University, School of Medicine, Lecturer, 医学部, 講師 (70297802)
ARINAMI Tadao  University Tsukuba, Department of Medical Genetics, Institute of Basic Medical Science, Professor, 大学院・人間総合科学研究所, 教授 (10212648)
大久保 起延  日本大学, 医学部, 講師 (90328716)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2005: ¥9,500,000 (Direct Cost: ¥9,500,000)
KeywordsMethamphetamine psychosis / Schizophrenia induced by methamphetamine / Schizophrenia / Exploratory eye movements / Discriminator of schizophrenia / Responsive search score / Sensitivity gene of schizophrenia / Linkage analysis / 覚醒剤誘発性総合失調症 / 総合失調症 / 総合失調症診断補助装置 / 総合失調症感受性遺伝子 / 覚せい剤誘発性統合失調症 / 脳形態学的変化 / 分子遺伝学
Research Abstract

Introduction : In our country methamphetamine (MAP) psychoses are thought to be caused by repetitive taking in MAP, which are different from schizophrenia. On the other hand, in Europe and America, the type with continuation of hallucination and delusion in the MAP psychoses are diagnosed as schizophrenia induced by MAP. There is a controversy between investigators of Europe and America, and Japan. 1) Study I : It was investigated if there is schizophrenia induced by MAP using exploratory eye movements, evaluation of clinical symptoms, duration of psychotic period, and analysis of schizophrenia candidate genes. Nine MAP psychoses in the Matsuzawa Metropolitan Hospital and 22 normal controls were recruited. The helpful equipment for diagnosis of schizophrenia using exploratory eye movements was used to this study which can discriminated schizophrenia from non-schizophrenia with 75% sensitivity and 80% specificity. If D value of the discrimination formula is minus the subject is decided … More to be schizophrenia, the discrimination formula plus, non-schizophrenia. Six of 9 MAP psychoses was D+. The clinical symptoms was worse in the D+group than in the D-group. The duration of psychotic period was longer in the D+group than the D-group. Genes of neuropeptide Y., reelin, STX were analyzed in 31 cases. The group with each risk alleles was showed higher in D value than the group without risk alleles. Study 2 : Forty nine MAP psychoses, which had recorded in Saitama Mental Health Center, were examined using schizophrenia discriminator with exploratory eye movements. Twenty eight of 49 MAP psychoses were D+ and decided to schizophrenia. Twenty one of 49 MAP psychoses were D- and decided to non-schizophrenia. The value of BPRS was higher in the D+group than in the D-group. The duration of psychotic period was longer in the D+group than in the D-group. Patients with RSS of less than 7 seven were 10 cases in the D+group. They had longest psychotic period, most sever symptoms and lower GAF value. Conclusion Results of study 1 and 2 suggested that there are patients with schizophrenia induced by overuse of methamphetamine in the MAP psychoses Less

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (28 results)

All 2007 2006 2005 Other

All Journal Article (27 results) Book (1 results)

  • [Journal Article] 統合失調症の認知機能,中枢神経回路,感受性遺伝子を基盤にした新しい診断装置の開発2007

    • Author(s)
      小島卓也, 高橋栄, 泰羅雅登, 酒谷薫, 横田正夫, 坂井禎一郎, 大久保起延, 大久保博美, 鈴木正泰, 松田哲也, 松浦雅人, 松島英介
    • Journal Title

      精神医学 49・3

      Pages: 245-252

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Parietal lobe volume deficits in schizophrenia spectrum disorders2007

    • Author(s)
      Shi-yu Zhou, Michio Suzuki, Tsutomu Takahashi, Hirofumi Hagino, Yasuhiro Kawasaki, MieMatsui, Hikaru Seto, Masayoshi Kurachi
    • Journal Title

      Schizophrenia Research 89

      Pages: 35-48

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] PGS4 is not a susceptibility gene for schizophrenia in Japanese : Association study in a large case-control population2007

    • Author(s)
      H.Ishiguro, Y.Horiuchi, M.Koga, T.Inada, N.Iwata, N.Ozaki, H.Ujike, T.Muratake, T.Someya, T.Arinami
    • Journal Title

      Schizophrenia Research 89

      Pages: 161-164

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Parietal lobe volume deficits in schizophrenia spectrum disorders2007

    • Author(s)
      Shi-yu Zhou, Michio Suzuki, Tsutomu Takahashi, Hirofumi Hagino, Yasuhiro Kawasaki, Mie Matsui, Hikaru Seto, Masayoshi Kurachi
    • Journal Title

      Schizophrenia Research 89

      Pages: 35-48

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A New Discriminating Method of Schizophrenia Based on Cognition, Neuronal Circuit, and Genetic Factors2007

    • Author(s)
      KOJIMA Takuya, TAKAHASHI Sakae, TAIRA Masato, SAKATANI Kaoru, YOKOTA Masao
    • Journal Title

      CLINICAL PSYCHIATRY 49 (3)

      Pages: 245-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 視床と眼球運動障害(統合失調症のケース)2006

    • Author(s)
      松田哲也, 鹿中紀子, 小島卓也
    • Journal Title

      Clinical Neuroscience 24・10

      Pages: 1145-1147

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Association Analysis of δ -Opioid Receptor Gene Polymorphisms in Methamphetamine Dependence/Psychosis2006

    • Author(s)
      Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Matsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Msanari Itokawa, Maki Naka, Soishiro Ide, Kazutaka Ikeda, Yohtaro Numashi, Ishiro Sora
    • Journal Title

      American Journal of Medical Genetics Part B 141B

      Pages: 482-486

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association Analysis of δ-Opioid Receptor Gene Polymorphisms in Methamphetamine Dependence/Psychosis2006

    • Author(s)
      Hideaki Kobayashi, Harumi Hata, Hiroshi Ujike, Matsuo Harano, Toshiya Inada, Tokutaro Komiyama, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata, Masaomi Iyo, Norio Ozaki, Msanari Itokawa, Maki Naka, Soishiro Ide, Kazutaka Ikeda, Yohtaro Numashi, Ishiro Sora
    • Journal Title

      American Journal of Medical Genetics Part B 141B

      Pages: 482-286

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia2006

    • Author(s)
      Arai M, Yamada K, Toyota T, Obata N, Haga S, Yoshida Y, Nakamura K, Minabe Y, Ujike H, Sora I, Ikeda K, Mori N, Yoshikawa T, Itokawa M.
    • Journal Title

      Biol Psychiatry in press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A Polymorphism in the PDLIM5 Gene Associated with Gene Expression and Schizophrenia.2006

    • Author(s)
      Horiuchi Y, Arai M, Niizato K, Iritani S, Noguchi E, Ohtsuki T, Koga M, Kato T, Itokawa M, Arinami T.
    • Journal Title

      Biol Psychiatry 59・5

      Pages: 434-439

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes.2006

    • Author(s)
      Iwayama Y, Hashimoto K, Nakajima M, Toyota T, Yamada K, Shimizu E, Itokawa M, Hoshika K, Iyo M, Yoshikawa T.
    • Journal Title

      Neurosci Lett 394・2

      Pages: 101-104

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Correlation between quan titative-EEG alterations and age in patients with interferon-alpha-treated hepatits C.2005

    • Author(s)
      Kamei S, Oga K, Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Sakai T, Ohkubo H, Matsumura H, Moriyama M, Hirayanagi K.
    • Journal Title

      J Clin Neurophysiol Jan-Feb, 22 ・ 1

      Pages: 49-52

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genomewide High-Density SNP Linkage Analysis of 236 Japanese Families Supports the Exixtence of Schizpphrenia Susceptibility Loci on Chromosomes 1p, 14q, and 20p.2005

    • Author(s)
      The Japanese Schuzophrenia Sib-Pair Linkage Group(JSSLG), Arinami T, Ohtsuki T, Ishiguro H, Kojima T, et al.
    • Journal Title

      Am. J. Hum. Genet. 77

      Pages: 937-944

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] World Federation of Societies of Biological Psychiatru (WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 1 : Acute treatment of Schizophrenia.2005

    • Author(s)
      Falkai P, Wobrock T, Lieberman J, Kojima T et al.
    • Journal Title

      The World Jounal of Biological Psyachiatry 6・3

      Pages: 132-191

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Correlation between quan titative-EEG alterations and age in patients with interferon-alpha-treated hepatits C.2005

    • Author(s)
      Kamei S, Oga K, Matsuura M, Tanaka N, Kojima T, Arakawa Y, Matsukawa Y, Mizutani T, Sakai T, Ohkubo H, Matsumura H, Moriyama M, Hirayanagi K.
    • Journal Title

      J Clin Neurophysiol., Jan-Feb 22(1)

      Pages: 49-52

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genomewide High-Density SNP Linkage Analysis of 236 Japanese Families Supports the Exixtence of Schizpphrenia Susceptibility Loci on Chromosomes 1p,14q, and 20p.2005

    • Author(s)
      The Japanese Schuzophrenia Sib-Pair Linkage Group(JSSLG), Arinami T, Ohtsuki T, Ishiguro H, Kojima T, et al.
    • Journal Title

      Am.J.Hum.Genet. 77

      Pages: 937-944

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] World Federation of Societies of Biological Psychiatru(WFSBP) Guidelines for Biological Treatment of Schizophrenia, Part 1 : Acute treatment of Schizophrenia.2005

    • Author(s)
      Falkai P, Wobrock T, Lieberman J, Kojima T et al.
    • Journal Title

      The World Journal of Biological Psyachiatry 6(3)

      Pages: 132-191

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 【統合失調症の情報処理】統合失調症の認知機能障害と注意2005

    • Author(s)
      松田哲也, 小島卓也
    • Journal Title

      Schizophrenia Frontier 6(2)

      Pages: 97-101

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 眼球運動からみた脳機能(2)2005

    • Author(s)
      松島英介, 松田哲也, 小島卓也
    • Journal Title

      臨床脳波 47(8)

      Pages: 525-531

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 精神医療の新しい潮流-内科心療のために・統合失調症の新しい診断装置の開発2005

    • Author(s)
      小島卓也, 高橋栄, 大久保起延, 大久保博美, 鈴木正泰, 安芸竜彦, 松島英介, 松浦雅人, 松由哲也
    • Journal Title

      綜合臨床 Vol.54,No.12

      Pages: 3034-3037

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 統合失調症の認知障害と眼球運動異常2005

    • Author(s)
      松島英介, 小島卓也
    • Journal Title

      臨床脳波 47巻9号

      Pages: 568-572

    • Related Report
      2005 Annual Research Report
  • [Journal Article] A 200-kb region of human chromosome 22q11confers schizophrenia-related behavioral abnormalities in mice.2005

    • Author(s)
      Hiroi N, Zhu H, Lee MS, Funke B, Sawamura T, Arai M, Itokawa M, Kucherlapati R, Morrow B, Agatsuma S.
    • Journal Title

      Proc Natl Acad Sci U S A 102

      Pages: 19132-19137

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Japanese Schizophrenia Sib-Pair Linkage Group. Genome-wide High-Density SNP Linkage Analysis of 236 Japanese Families Supports the Existence of Schizophrenia Susceptibility Loci on Chromosomes1p, 14q, and 20p.2005

    • Author(s)
      Arinami T, Ohtsuki T, Ishiguro H, Ujike H, Tanaka Y, Morita Y, Mineta M, Takeichi M, Yamada S, Imamura A, Ohara K, Shibuya H, Ohara K, Suzuki Y, Muratake T, Kaneko N, Someya T, Inada T, Yoshikawa T, Toyota T, Yamada K, Kojima T, Takahashi S, Osamu O, Shinkai T, Nakamura M, Fukuzako H, Hashiguchi T, Niwa SI, Ueno T, Tachikawa H, Hori T, Asada T, Nanko S, Kunugi H, Hashimoto R, Ozaki N, Iwata N, Harano M, Arai H, Ohnuma T, Kusumi I, Koyama T, Yoneda H, Fukumaki Y, Shibata H, Kaneko S, Higuchi H, Yasui-Furukori N, Numachi Y, Itokawa M, Okazaki Y
    • Journal Title

      Am J Hum Genet 77

      Pages: 937-944

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels.2005

    • Author(s)
      Yamada K, Ohnishi T, Hashimoto K, Ohba H, Iwayama-Shigeno Y, Toyoshima M, Okuno A, Takao H, Toyota T, Minabe Y, Nakamura K, Shimizu E, Itokawa M, Mori N, Ito M, Yoshikawa T.
    • Journal Title

      Biol Psychiatry 57

      Pages: 1493-1503

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Abnormal effective connectivity of dopamine D2 receptor binding in schizophrenia.2005

    • Author(s)
      Yasuno F, Suhara T, Okubo Y, Ichimiya T, Takano A, Sudo Y, Inoue M.
    • Journal Title

      Psychiatry Res 138(3)

      Pages: 197-207

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Random numbear generation evaluation in patient with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability.

    • Author(s)
      Matsukawa Y, Nagashima M, Kamei S, Tanabe E, Takahashi S, Kojima T, Taira M, Morita K, Matsuura M, Sawada S
    • Journal Title

      Scandinavian journal of Rheumatology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Random numbear generation evaluation in patient with systemic lupus erythematosus indicates a heterogeneous nature of central nervous system vulnerability.

    • Author(s)
      Matsukawa Y, Nagashima M, Kamei S, Tanabe E, Takahashi S, Kojima T, Taira M, Morita K, Matsuura M, Sawada S
    • Journal Title

      Scandinavian journal of Rheumatology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 統合失調症(論文タイトル名:7.精神生理学から)2005

    • Author(s)
      小島卓也(編:風祭元, 山下格)
    • Total Pages
      16
    • Publisher
      日本評論社
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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