Target-tracking system in the stereotactic radiation therapy for body tumors

• Project/Area Number: 17390327
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAGAWA Keiichi The University of Tokyo, Hospital, Associate Professor (80188896)
• Co-Investigator(Kenkyū-buntansha): UESAKA Mitsuru The University of Tokyo, School of Engineering, Professor (30232739) ; AOKI Yukimasa International University of Health and Welfare, 放射線情報科学学科, Professor (40143474) ; TAGO Masao The University of Tokyo, Hospital, Lecturer (50282520) ; MASUTANI Yoshitaka The University of Tokyo, Hospital, Lecturer (20345193) ; ISHIKAWA Masatoshi The University of Tokyo, Graduate School of Information Science and Technology, Professor (40212857) ; 小野木 雄三 東京大学, 医学部附属病院, 助教授 (90233593)
• Project Period (FY): 2005 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥9,240,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥540,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000); Fiscal Year 2005: ¥4,700,000 (Direct Cost: ¥4,700,000)
• Keywords: Radiation therapy / Lung cancer / Respiratory movement / Tracking irradiation / Diaphragm movement / In-treatment kV CT imaging / Modulated Arc Therapy (IMAT) / Image-Guided Radiation Therapy (IGRT) / 臓器移動 / 定位放射線治療

Research Abstract

(1) Four-dimensional lung cancer imaging has been successfully performed by using a multi-detector CT
(2) Real-time fluoroscopic tumor imaging has been achieved by using a flat panel detector for MV x-ray.
(3) A kilovolt x-ray CT imaging technique has been developed by using radiotherapy machine.
(4) A respiratory curve has been derived from the patient diaphragm position obtained by kilovoltage x-ray imaging.
(5) A technique for in-treatment kV cone beam CT imaging has been established.
(6) A method for measuring patient set-up errors has been developed for stereotactic radiotherapy immediately before treatment, during treatment, and immediately after treatment. Clinical study has also been launched.
(7) A real-time tumor tracking system has been developed by detecting the tumor position estimated from the patient diaphragm position using in-treatment kV x-ray imaging.
(8) As for clinical application of large bore CT for radiotherapy. We have applied a 90 cm bore CT to radiotherapy practice.
(9) A tumor tracking algorithm has been developed by increasing MW maximum leaf speed.
(10) Intensity modulated arc therapy has been achieved by successfully controlling dose rate and gantry speed.
(11) We have addressed a problem and proposed a solution to apply previously developed x-band linac to radiotherapy practice.
(12) Real-time tumor tracking using robot arm-mounted linac has been studied from a robot engineering view.
(13) We have designed a next-generation tracking system by combining a linac with a robot arm and a CT imager.
(14) The target and risk organs have been localized immediately before treatment, during treatment and immediately after treatment by using built-in CT imaging unit.
(15) We have discovered that commercially available drug serves as a radiosensitizer, and have revealed its radiobiological mechanism.
(16) Total assessment and clinical application We have obtained significant treatment outcome by applying our results to clinical practice.

Research Products

• [Journal Article] Enhancement of Antitumor Radiation Efficacy and Consistent Induction of the Abscopal Effect in Mice by ECI301, an Active Variant of Macrophage Inflammatory Protein-1{alpha}. (2008)
  • Author(s): Shiraishi K, Ishiwata Y, Nakagawa K, Yokochi S, Taruki C
  • Journal Title: Clin Cancer Res. 15;14(4) Pages: 1159-1166
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Palliative radiation therapy for advanced gastrointestinal cancer. (2008)
  • Author(s): Murakami N, Nakagawa K, Yamashita H, Nagawa H.
  • Journal Title: Digestion 77suppl1 Pages: 29-35
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of mouse 3t3-swiss albino cells available in Japan: necessity of quality control when used as feeders. (2008)
  • Author(s): Takeuchi T, Wang L, Mori S, Nakagawa K, Yoshikura H
  • Journal Title: Jpn J. Infect Dis. 61(1) Pages: 9-12
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhancement of Antitumor Radiation Efficacy and Consistent Induction of the Abscopal Effect in Mice by ECI301, an Active Variant of Macrophage Inflammatory Protein- 1{alpha} (2008)
  • Author(s): Shiraishi K, Ishiwata Y, Nakagawa K Yokochi S, Taruki C, Akuta T, Ohtomo K, Matsushima K, Tamatani T, Kanegasaki S.
  • Journal Title: Clin Cancer Res 14(4) Pages: 1159-1166
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Palliative radiation therapy for advanced gastrointestinal cancer (2008)
  • Author(s): Murakami N, Nakagawa K, Yamashita H, Nagawa H.
  • Journal Title: Digestion. 77 Suppl 1 Pages: 29-35
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of mouse 3t3-swiss albino cells available in Japan : necessity of quality control when used as feeders (2008)
  • Author(s): Takeuchi T, Wang L, Mori S, Nakagawa K, Yoshikura H, Kanda T.
  • Journal Title: Jpn J Infect Dis, Jan 61(1) Pages: 9-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Palliative readiation therapy for advanced gastrointestinal cancer (2008)
  • Author(s): Murakami N, Nakagawa K, Yamashita H, Nagawa H.
  • Journal Title: Digestion Supp1 1 Pages: 29-35
  • Peer Reviewed
• [Journal Article] Characterization of mouse 3t3-swiss albino cells available in Japan:neoessity of quality control when used as feeders (2008)
  • Author(s): Takeuchi T, Wang L, Mori S, Nakagawaw K, Yoshikura H, Kanda T.
  • Journal Title: Jpn J Infect Dis 61(1) Pages: 9-12
  • Peer Reviewed
• [Journal Article] Preliminary Stastical Assessment of Intervention by a Palliative Care Team Working in a Japanese General Inpatient Unit. (2007)
  • Author(s): Satoru Iwase, Tadashi Murakami, Yuichiro Saitou, Keiichi Nakagawa
  • Journal Title: American Journal of Hospice & Palliative Medicine Vol.24 No1 Pages: 1-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study. (2007)
  • Author(s): Yamashita H, Nakagawa K, Shiraishi K, Tago M, Igaki H
  • Journal Title: J. Gastroenterol Hepatol 22(4) Pages: 523-527
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A rod matrix compensator for small-field intensity modulated radiation therapy: a preliminary phantom study. (2007)
  • Author(s): Nakagawa K, Yoda K, Masutani Y, Sasaki K, Ohtomo K.
  • Journal Title: IEEE Trans Biomed Eng 54(5) Pages: 943-946
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Exceptionally high incidence of symptomatic grade 2-5 radiation pneumonitis after stereotactic radiation therapy for lung tumors. (2007)
  • Author(s): Yamashita H, Nakagawa K, Nakamura N, Koyanagi H, Tago M, Igaki H
  • Journal Title: Radiat Oncol 7;2 Pages: 21-21
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Evaluation of neutron dosimetry on pancreatic cancer phantom model for application of intraoperative boron neutron-capture therapy. (2007)
  • Author(s): Yanagie H, Sakurai Y, Ogura K, Kobayashi T, Sugiyama H. Ono K. Nakagawa K
  • Journal Title: Biomed Pharmacother 61(8) Pages: 505-514
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. (2007)
  • Author(s): Aoyama H, Tago M, Kato N, Toyoda T, Hirota S, Shioura H, Nakagawa K
  • Journal Title: Int J. Radiat Oncol Biol Phys 1;68(5) Pages: 1388-1395
  • NAID: 120000955794
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pathological Changes in the Gastrointestinal Tract of a Heavily Radiation-exposed Worker at the Tokai-mura Criticality Accident. (2007)
  • Author(s): Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M
  • Journal Title: J. Radiat Res (Tokyo). 49(1) Pages: 55-56
  • NAID: 110006570528
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Free Radical Scavenger Edaravone Suppresses X-ray-induced Apoptosis through p53 Inhibition in MOLT-4 Cells. (2007)
  • Author(s): Sasano N, Enomoto A, Hosoi Y, Y, Shiraishi K, Miyagawa K, Nakagawa K
  • Journal Title: J. Radiat Res (Tokyo) 48(6) Pages: 495-503
  • NAID: 110006452332
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Verification of in-treatment tumor position using kilovoltage cone-beam computed tomography: a preliminary study. (2007)
  • Author(s): Nakagawa K, Yamashita H, Shiraishi K, Igaki H, Terahara A
  • Journal Title: Int J. Radiat Oncol Biol Phys. 15;69(4) Pages: 970-973
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Preliminary Stastical Assessment of Intervention by a Palliative Care Team Working in a Japanese General Inpatient Unit. (2007)
  • Author(s): Satoru Iwase, Tadashi Murakami, Yuichiro Saitou, Keiichi Nakagawa
  • Journal Title: American Journal of Hopsice & Palliative Medicine Vol.24 No1 Pages: 1-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma : Retrospective study (2007)
  • Author(s): Yamashita H, Nakagawa K, Shiraishi K, Tago M, Igaki H, Nakamura N, Sasano N, Siina S, Omata M, Ohtomo K.
  • Journal Title: J Gastroenterol Hepatol 22(4) Pages: 523-527
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A rod matrix compensator for small-field intensity modulated radiation therapy a preliminary phantom study (2007)
  • Author(s): Nakagawa K, Yoda K, Masutani Y, Sasaki K, Ohtomo K.
  • Journal Title: IEEE Trans Biomed Eng. 54(5) Pages: 943-946
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Exceptionally high incidence of symptomatic grade 2-5 radiation pneumonitis after stereotactic radiation therapy for lung tumors (2007)
  • Author(s): Yamashita H, Nakagawa K, Nakamura N, Koyanagi H, Tago M, Igaki H, Shiraishi K, Sasano N, Ohtomo K.
  • Journal Title: Radiat Oncol 2 Pages: 21-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evaluation of neutron dosimetry on pancreatic cancer phantom model for application of intraoperative boron neutron-capture therap (2007)
  • Author(s): Yanagie H, Sakurai Y, Ogura K, Kobayashi T, Furuya Y, Sugiyama H, Kobayashi H, Ono K, Nakagawa K, Takahashi H, Nakazawa M, Eriguchi M.
  • Journal Title: Biomed Pharmacother 61(8) Pages: 505-514
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone (2007)
  • Author(s): Aoyama H, Tago M, Kato N, Toyoda T, Kenjyo M, Hirota S, Shioura H, Inomata T, Kunieda E, Hayakawa K, Nakagawa K, Kobashi G, Shirato H.
  • Journal Title: Int J Radiat Oncol Biol Phys. 68(5) Pages: 1388-1395
  • NAID: 120000955794
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pathological Changes in the Gastrointestinal Tract of a Heavily Radiation-exposed Worker at the Tokai-mura Criticality Accident (2007)
  • Author(s): Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K.
  • Journal Title: J Radiat Res (Tokyo) 49(1) Pages: 55-56
  • NAID: 110006570528
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Free Radical Scavenger Edaravone Suppresses X-ray-induced Apoptosis through p53 Inhibition in MOLT-4 Cells (2007)
  • Author(s): Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K.
  • Journal Title: J Radiat Res (Tokyo) 48(6) Pages: 495-503
  • NAID: 110006452332
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Verification of in-treatment tumor position using kilovoltage cone-beam computed tomography : a preliminary study (2007)
  • Author(s): Nakagawa K, Yamashita H, Shiraishi K, Igaki H, Terahara A, Nakamura N, Ohtomo K, Saegusa S, Shiraki T, Oritate T, Yoda K.
  • Journal Title: Int J Radiat Oncol Biol Phys 69(4) Pages: 970-973
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Experimental verification of the utility of positron emitter nuclei generated by photonuclear reactions for X-ray beam monitoring in a phantom (2007)
  • Author(s): Nishio T, Inaniwa T, Inoue K, Miyatake A, Nakagawa K Yoda K, Ogino T.
  • Journal Title: Radiat Med. 25(10) Pages: 516-522
  • NAID: 10020177787
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A rod matrix compensator for small-field intensity modulated radiation therapy:a preliminary phantom study (2007)
  • Author(s): Nakagawa K, Yoda K, Masutani Y, Sasaki K, Ohtomo K
  • Journal Title: IEEE Trans Biomed Eng 54(5) Pages: 943-946
  • Peer Reviewed
• [Journal Article] Radiotherapy ofr lymph node metastases in with hepatocellular carcinoma: Retrospective study (2007)
  • Author(s): Yamashita H, Nalcagawa K, Shraishi K,
  • Journal Title: J Gastreenterol Hepatol 22(4) Pages: 523-527
  • Peer Reviewed
• [Journal Article] Exceptionally high incidence of sympotmatic grade 2-5 radiation pneumonitis after sterotactic radiation therapy for lung tumors (2007)
  • Author(s): Yamashita H, Nakagawa K, Nakamura N, Kbyanagi H, Tago M,
  • Journal Title: Radiat Oncol 7(2) Pages: 21-21
  • Peer Reviewed
• [Journal Article] Patholoaical Changes in the Gestrointeatinal Tract of a Heavily Readiation-exposed Worker at the Tokai-mura Criticality Accdent (2007)
  • Author(s): Igaki H, Nakagawa K, Uozaki E, Akahane M, Hosoi Y, Ohtomo K
  • Journal Title: J Radiat Res 49(1) Pages: 55-56
  • Peer Reviewed
• [Journal Article] Saegusa S, Shiraki T, 0ritate T, Yoda K. Verification of in-treatment tumor position using kilovoltage cone-beam computed tomography:apreliminary study (2007)
  • Author(s): Nakagawa K, Yamashita H, Shiraishi K, Terahara A, Ohtomo K,
  • Journal Title: Int J Radiat Oneel Biol Phys 15:69(4) Pages: 970-973
  • Peer Reviewed
• [Journal Article] Experimental verfication of the utility of positron emitter nuclei generated by photonuclear reactions for X-ray bean monitoring in a phantom (2007)
  • Author(s): Nishio T, Inaniwa T, Miyatake A, Nakagawa k, Yoda K, Ogino T.
  • Journal Title: Radiat Med 25(10) Pages: 516-522
  • Peer Reviewed
• [Journal Article] Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6. (2006)
  • Author(s): Yoko Matsumoto, Shunsuke Nakagawa, Tetsu Yano, Keiichi Nakagawa
  • Journal Title: Journal of Medical Virology 78(4) Pages: 501-507
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. (2006)
  • Author(s): Li Z, Hosoi Y, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Nakagawa K
  • Journal Title: Biochem and Biophys Res Commun 341(2): Pages: 363-368
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Taste dysfunction in patients receiving radiotherapy. (2006)
  • Author(s): Yamashita H. Nakagawa K, Nakamura N, Shiraishi K
  • Journal Title: Head Neck 28(6) Pages: 508-516
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. (2006)
  • Author(s): Takizawa S, Nagasaka K, Nakagawa S, Yano T, Nakagawa K
  • Journal Title: Genes Cells 11(4) Pages: 453-464
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma: report of seven cases. (2006)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Igaki H, Shiraishi X
  • Journal Title: J. Obstet Gynaecol Res 32(2) Pages: 235-242
  • NAID: 10018118675
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. (2006)
  • Author(s): Norio Tonotsuka, Yoshio Hosoi, Shukichi Miyazaki, Keiichi Nakagawa,
  • Journal Title: Internationa1 Journal of Molecular Medicine 18(3) Pages: 441-447
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. (2006)
  • Author(s): Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M
  • Journal Title: JAMA 295(21) Pages: 2535-2536
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Treatment results of chemoradiation therapy for localized aggressive lymphomas: a retrospective 20-year study (2006)
  • Author(s): Yamashita H, Nakamura N, Shiraishi K, Kurokawa M, Igaki H, Nakagawa K.
  • Journal Title: Ann Hematol 85(8) Pages: 523-529
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] External beam radiotherapy to treat intra-and extra-hepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation. (2006)
  • Author(s): Yamashita H, Nakagawa K, Shiraishi K, Tago M, Igaki H, Nakamura N
  • Journal Title: J. Gastroenterol Hepatol 21(10) Pages: 1555-1560
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from Gl to S phase by localizing at the basolateral membrane in epithelial cells. (2006)
  • Author(s): Nagasaka K, Nakagawa S, Yano T, Takizawa S, Matsumoto Y
  • Journal Title: Cancer Sci 97(11) Pages: 1217-1225
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer. (2006)
  • Author(s): Yamashita H, Nakagawa K, Nakamura N, Abe K, Asakage T, Ohmoto M
  • Journal Title: Int J. Radiat Oncol Biol Phys 1;66(5) Pages: 1422-1429
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The intergroup/RTOG 85-01 concurrent chemoradiation regimen for Japanese esophageal cancer. (2006)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Nakamura N
  • Journal Title: Hepatogastroenterology 53(72): Pages: 863-868
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Retrospective Study of Radiotherapy for Spinal Bone Metastases from Hepatocellular Carcinoma (HCC). (2006)
  • Author(s): Nakamura N, Igaki H, Yamashita H, Shiraishi K, Sasano N, Nakagawa K.
  • Journal Title: Jpn J. Clin Oncol 37(1) Pages: 38-43
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6 (2006)
  • Author(s): Yoko Matsumoto, Shunsuke Nakagawa, Tetsu Yano, Shin Takizawa Kazunori Nagasaka, Keiichi Nakagawa, Takeo Minaguchi, Osamu Wada, Hajime Ooishi, Koji Matsumoto, Toshiharu Yasugi, Tadahito Kanda, Jon M Huibregtse, Yuji Taketani
  • Journal Title: Journal of Medical Virology 78(4) Pages: 501-507
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation (2006)
  • Author(s): Li Z, Hosoi Y, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
  • Journal Title: Biochem and Biophys Commun 341(2) Pages: 363-368
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Taste dysfunction in patients receiving radiotherapy (2006)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Nakamura N, Shiraishi K, Eda M, Nakata H, Nagamatsu N, Yokoyama R, Onimura M, Ohtomo K
  • Journal Title: Head Neck 28(6) Pages: 508-516
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli (2006)
  • Author(s): Takizawa S, Nagasaka K, Nakagawa S, Yano T, Nakagawa K, Yasugi T, Takeuchi T, Kanda T, Huibregtse JM, Akiyama T, Taketani Y
  • Journal Title: Genes Cells. 11(4) Pages: 453-464
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma : report of seven cases (2006)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Igaki H, Shiraishi K, Nakamura N, Sasano N, Yamakawa S, Ohtomo K
  • Journal Title: J Obstet Gynaecol Res. 32(2) Pages: 235-242
  • NAID: 10018118675
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium (2006)
  • Author(s): Norio Tonotsuka, Yoshio Hosoi, Shukichi Miyazaki, Go Miyata, Ko Sugawara, Takahiro Mori, Noriaki Ouchi, Susumu Satonii, Yoshihisa Matsumoto, Keiichi Nakagawa, Kiyoshi Miyagawa, Tetsuya Ono
  • Journal Title: International Journal of Molecular Medicine 18(3) Pages: 441-447
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases : a randomized controlled trial (2006)
  • Author(s): Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G.
  • Journal Title: JAMA 295(21) Pages: 2535-2536
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Treatment results of chemoradiation therapy for localized aggressive lymphomas : a retrospective 20-year study (2006)
  • Author(s): Yamashita H, Izutsu K, Nakamura N, Shiraishi K, Chiba S, Kurokawa M, Tago M, Igaki H, Ohtomo K, Nakagawa K.
  • Journal Title: Ann Hematol 85(8) Pages: 523-529
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] External beam radiotherapy to treat intra- and extra-hepatic dissemination of.hepatocellular carcinoma after radiofrequency thermal ablation (2006)
  • Author(s): Yamashita H, Nakagawa K, Shiraishi K, Tago M, Igaki H, Nakamura N, Sasano N, Shiina S, Omata M, Ohtomo K.
  • Journal Title: J Gastroenterol Hepatol 21(10) Pages: 1555-1560
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radiophotoluminescence Dosimetry Using A Small Spherical Glass : A Preliminary phantom Study (2006)
  • Author(s): Nakagawa K, Yoda K, Shiraki T, Sasaki K, Miyazawa M, Ishidoya T, Ohtomo K, Hamada M.
  • Journal Title: Radiat Prot Dosimetry 11
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human homolog of Drosophila tumor suppressor Scribble negatively regulates call-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells (2006)
  • Author(s): Nagasaka K, Nakagawa S, Yano T, Takizawa S, Matsumoto Y, Tsuruga T, Nakagawa K, Minaguchi T, Oda K, Hiraike-Wada O, Ooishi H, Yasugi T, Taketani Y.
  • Journal Title: Cancer Sci 97(11) Pages: 1217-1225
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Yamakawa S, Ohtomo K. Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer (2006)
  • Author(s): Yamashita H, Nakagawa K, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, Hosoi Y, Sasano N,
  • Journal Title: Int J Radiat Oncol Biol Phys 66(5) Pages: 1422-1429
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The intergroup/RTOG 85-01 concurrent chemoradiation regimen for Japanese esophageal cancer (2006)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Nakamura N, Shiraishi K, Mafune K, Kaminishi M, Ohtomo K.
  • Journal Title: Hepatogastroenterology 53(72) Pages: 863-868
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Retrospective Study of Radiotherapy for Spinal Bone Metastases from Hepatocellular Carcinoma (HCC) (2006)
  • Author(s): Nakamura N, Igaki H, Yamashita H, Shiraishi K, Tago M, Sasano N, Shiina S, Omata M, Makuuchi M, Ohtomo K, Nakagawa K.
  • Journal Title: Jpn J Clin Oncol. 37(1) Pages: 38-43
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Taste dysfunction in patients receiving radiotherapy (2006)
  • Author(s): Yamashita H, Nakagawa K, 他
  • Journal Title: Head Neck Jun;28(6) Pages: 508-516
• [Journal Article] Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma : report of seven cases (2006)
  • Author(s): Yamashita, H, Nakagawa K, 他
  • Journal Title: J Obster Gynaecol Res Apr;32(2) Pages: 235-242
  • NAID: 10018118675
• [Journal Article] Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases : a randomized controlled trial (2006)
  • Author(s): Nakagawa K, 他
  • Journal Title: JAMA 7:295(21) Pages: 2535-2536
• [Journal Article] External beam radiotherapy to treat intra- and extra-hepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation (2006)
  • Author(s): Yamashita H, Nakagawa K, 他
  • Journal Title: J Gastroenterol Hepatol Oct;21(10) Pages: 1555-1560
• [Journal Article] Radiophotoluminescence Dosimetry Using A Small Spherical Glass : A Preliminary phantom Study (2006)
  • Author(s): Nakagawa K, 他
  • Journal Title: Radiat Prot Dosimetry Sep Pages: 11-11
• [Journal Article] Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer (2006)
  • Author(s): Yamashita H, Nakagawa K, 他
  • Journal Title: Int J Rabiat Oncol Biol Phys Dec 1;66(5) Pages: 1422-1429
• [Journal Article] A Packed Building-Block Compensator (-TETRIS-RT) for IMRT Delivery. (2005)
  • Author(s): Nakagawa K, Fukuhara N, Kawakami H
  • Journal Title: Medical Physics 32(7) Pages: 2231-2235
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Salvage radiotherapy for postoperative loco-regional recurrence of esophageal cancer. (2005)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Nakamura N, Shiraishi K, Ohtomo K
  • Journal Title: Dis Esophagus 18(4) Pages: 215-220
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Treatment results and prognostic analysis of radical radiotherapy for locally a dvanced cancer of the uterine cervix. (2005)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Shiraishi K, Nakamura N, Ohtomo K.
  • Journal Title: Br J. Radiol. 78(933) Pages: 821-826
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A radiophotoluminescent glass plate system for medium-sized field dosimetry. (2005)
  • Author(s): Keiichi Nakagawa, Hiroki Koyanagi, Takashi shiraki, Shigeki Saegusa,
  • Journal Title: review of scientific instruments 76 Pages: 106104-106107
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] High-Dose Conformal Radiotherapy for Supratentorial Malignant Glioma. (2005)
  • Author(s): Minoru Tanaka, Yasushi Ino, Keiichi Nakagawa, Masao Tago
  • Journal Title: Lancet Oncology 6(12) Pages: 953-960
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Radiation therapy for portal venous invasion by hepatocellular carcinoma. (2005)
  • Author(s): Nakagawa K, Yamashita H, Shiraishi K, Nakamura N, Tago M, Igaki H,
  • Journal Title: World J. Gastroenterol 14;11(46): Pages: 7237-7241
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Packed Building-Block Compensator (TETRIS-RT) for IMRT Delivery (2005)
  • Author(s): Nakagawa K, Fukuhara N, Kawakami H
  • Journal Title: Medical Physics 32(7) Pages: 2231-2235
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Salvage radiotherapy for postoperative loco-regional recurrence of esophageal cancer (2005)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Nakamura N, Shiraishi K, Ohtomo K.
  • Journal Title: Dis Esophagus. 18(4) Pages: 215-220
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Treatment results and prognostic analysis of radical radiotherapy for locally advanced cancer of the uterine cervix (2005)
  • Author(s): Yamashita H, Nakagawa K, Tago M, Shiraishi K, Nakamura N, Ohtomo K.
  • Journal Title: Br J Radiol. 78(933) Pages: 821-826
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A radiophotolumineseent glass plate system for medium-sized field dosimetry (2005)
  • Author(s): Keiichi Nakagawa, Hiroki Koyanagi, Takashi Shiraki, Shigeki Saegusa, Katsutake Sasaki, Takashi Oritate, Kazuo, Mima, Masanori Miyazawa, Tatsuyo Ishidoya, Kuni Ohtomo, Kiyoshi Yoda
  • Journal Title: review of scientiic instruments 76 Pages: 106104-106107
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High-Dose Conformal Radiotherapy for Supratentorial Malignant Glioma (2005)
  • Author(s): Minoru Tanaka, Yasushi Ino, Keiichi Nakagawa, Masao Tago, and Tomoki Todo
  • Journal Title: Lancet Oncology 6(12) Pages: 953-960
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Radiation therapy for portal venous invasion by hepatocellular carcinoma (2005)
  • Author(s): Nakagawa K, Yamashita H, Shiraishi K, Nakamura N, Tago M, Igaki H, Hosoi Y, Shiina S, Omata M, Makuuchi M, Ohtomo K
  • Journal Title: World J Gastroenterol 11(46) Pages: 7237-7241
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Packed Building-Block Compensator (TETRIS-RT) for IMRT Delivery (2005)
  • Author(s): Nakagawa K, 他
  • Journal Title: Medical Physics 32(7) Pages: 2231-2235
• [Journal Article] Salvage radiotherapy for postoperative loco-regional recurrence of esophageal cancer. (2005)
  • Author(s): Yamashita H, Nakagawa K, 他
  • Journal Title: Dis Esophagus 18(4) Pages: 215-220
• [Journal Article] Treatment results and prognostic analysis of radical radiotherapy for locally advanced cancer of the uterine cervix. (2005)
  • Author(s): Yamashita H, Nakagawa K, 他
  • Journal Title: Br J Radiol. 78(933)2 Pages: 821-826
• [Journal Article] A radiophotoluminescent glass plate system for medium-sized field dosimetry. (2005)
  • Author(s): Keiichi Nakagawa, 他
  • Journal Title: review of scientific instruments 76 Pages: 106104-106107
• [Journal Article] High-Dose Conformal Radiotherapy for Supratentorial Malignant Glioma. (2005)
  • Author(s): Minoru Tanaka, Yasushi Ino, Keiichi Nakagawa, 他
  • Journal Title: Lancet Oncology Dec;6(12): Pages: 953-960
• [Journal Article] Radiation therapy for portal venous invasion by hepatocellular carcinoma. (2005)
  • Author(s): Nakagawa K, 他
  • Journal Title: World J Gastroenterol. Dec14;11(46) Pages: 7237-7241
• [Presentation] 治療用X線と診断用X線の同時照射システムと強度変調原体照射の組み合わせ (2007)
  • Author(s): 中川恵一
  • Organizer: 第20回日本放射線腫瘍学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エレクタシナジーを用いたIGRTの臨床経験と将来展望 (2007)
  • Author(s): 中川恵一
  • Organizer: 第20回日本放射線腫瘍学会 ランチョンセミナー
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Three-dimensional conformal radiotherapy for hepatocellular carcinoma with infe rior vena cava invasion. (2007)
  • Author(s): Igaki H, Nakagawa K, Shiraishi K, Tago M, Nakamura N
  • Organizer: 2007 Gastrointestinal Cancers Symposium
  • Place of Presentation: Orlando, FL
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、中川恵一、, 他
  • Organizer: 第9回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良市ならまちセンター
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エレクタ社Synergyを用いたkVポート、MVポートの同時照射とその応用 (2007)
  • Author(s): 中川恵一、, 他
  • Organizer: 第66回日本医学放射線学会
  • Place of Presentation: パシフィコ横浜
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、中川恵一、, 他
  • Organizer: 第46回日本医学放射線学会生物部会学術大会
  • Place of Presentation: つくば国際会議場
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、中川恵一、, 他
  • Organizer: 第50回日本放射線影響学会
  • Place of Presentation: 幕張メッセ国際会議場 (ポスター)
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、中川恵一、, 他
  • Organizer: 第20回日本放射線腫瘍学会
  • Place of Presentation: 福岡国際会議場
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Three-dimensional conformal radiotherapy for hepatocellular carcinoma with inferior vena cava invasion (2007)
  • Author(s): Igaki H, Nakagawa K, Shiraishi K, Tago M, Nakamura N, Yamashita H, Sasano N, Asari T, Ohtomo K.
  • Organizer: 2007 Gastrointestinal Cancers Symposium
  • Place of Presentation: Orlando, FL
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] エレクタ社Synergyを用いたkVボ-ト、MVポートの同時照射とその応用 (2007)
  • Author(s): 中川 恵一
  • Organizer: 日本医学放射線学会
  • Place of Presentation: 横浜
• [Presentation] 治療用X線と診断用X線の同時照射システムと強度変調原体照射の組み合わせ (2007)
  • Author(s): 中州 恵一
  • Organizer: H本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡
• [Presentation] 肺腫瘍に対する定位放射線治療 (2006)
  • Author(s): 中川恵一
  • Organizer: 第59回日本胸部外科学会定期学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2006-10-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] エダラボンの放射線防護効果 (2006)
  • Author(s): 笹野仲史、中川恵一、, 他
  • Organizer: 第49回日本放射線影響学会
  • Place of Presentation: 札幌・北海道大学高等教育機能開発センター
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 4次元CTと超小型リニアックによる高精度同期照射システムの提案 (2006)
  • Author(s): 中川恵一
  • Organizer: 第19回日本放射線腫瘍学会
  • Place of Presentation: 仙台国際センター
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] eMIP, a derivative of MIP-lalpha enhances the efficacy of radiation in cancer. (2005)
  • Author(s): Shiraishi K, Nakagawa K, Yamashita H, Nakamura N, Tago M, Ohtomo K.
  • Organizer: 1st Asian Congress of Radiation Research.
  • Place of Presentation: International Conference Center Hiroshima
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ロッドコンペンセータによる"簡単な"IMRT (2005)
  • Author(s): 中川恵一
  • Organizer: 第18回日本放射線腫瘍学会
  • Place of Presentation: 川越プリンスホテル
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] eMIP, a derivative of MIP-lalpha enhances the efficacy of radiation in cancer (2005)
  • Author(s): Shiraishi K, Nakagawa K, Yamashita H, Nakamura N, Tago M, Ohtomo K.
  • Organizer: 1st Asian Congress of Radiation. Research
  • Place of Presentation: International Conference Center Hiroshima
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 「がんのひみつ」 (2008)
  • Author(s): 中川恵一
  • Total Pages: 168
  • Publisher: 朝日出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 「ドクター中川の"がんを知る"」 (2008)
  • Author(s): 中川恵一
  • Total Pages: 128
  • Publisher: 毎日新聞社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] がんのひみつ (2008)
  • Author(s): 中川 恵一
  • Total Pages: 167
  • Publisher: 朝日出版
• [Book] ドクター中川の"がんを知る (2008)
  • Author(s): 中川 恵一
  • Total Pages: 126
  • Publisher: 毎日新聞社
• [Book] 「切らずに治すがん治療」 (2007)
  • Author(s): 中川恵一
  • Total Pages: 231
  • Publisher: 法研
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 「がん!放射線治療のススメ」 (2007)
  • Author(s): 中川恵一
  • Total Pages: 210
  • Publisher: 三省堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 「がん 生きたい患者と救いたい医者」 (2007)
  • Author(s): 鎌田實・中川恵一
  • Total Pages: 203
  • Publisher: 三省堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 命と向き合う (2007)
  • Author(s): 中川 恵一・養老 孟司・和田 秀樹
  • Total Pages: 158
  • Publisher: 小学館
• [Book] がん!放射線治療のススメ (2007)
  • Author(s): 中川 恵一
  • Total Pages: 210
  • Publisher: 三省堂
• [Book] 切らずに治すがん治療 (2007)
  • Author(s): 中川 恵一
  • Total Pages: 231
  • Publisher: 法研
• [Book] がん 生きたい患者と救いたい医者 (2007)
  • Author(s): 鎌田 實・中川 恵一
  • Total Pages: 203
  • Publisher: 三省堂
• [Book] 「命と向き合う-老いと日本人とがんの壁」 (2006)
  • Author(s): 中川恵一、和田秀樹、養老孟司
  • Total Pages: 160
  • Publisher: 小学館
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 「ビジュアル版がんの教科書」 (2006)
  • Author(s): 中川恵一
  • Total Pages: 157
  • Publisher: 三省堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ビジュアル版がんの教科書 (2006)
  • Author(s): 中川恵一
  • Total Pages: 157
  • Publisher: 三省堂
• [Book] 自分を生ききる-日本のがん治療と死生観- (2005)
  • Author(s): 中川恵一、養老孟司
  • Total Pages: 159
  • Publisher: 小学館
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 自分を生ききる-日本のがん治療と死生観- (2005)
  • Author(s): 中川恵一, 養老孟司
  • Total Pages: 159
  • Publisher: 小学館
• [Patent(Industrial Property Rights)] 放射線増感剤 (2008)
  • Inventor(s): 中川恵一
  • Industrial Property Rights Holder: 東京大学総長
  • Industrial Property Number: 2007-030115
  • Filing Date: 2008-02-12
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 治療用X線照射中の腫瘍位置を画像化する方法 (2007)
  • Inventor(s): 中川恵一
  • Industrial Property Rights Holder: 東京大学総長
  • Industrial Property Number: 2007-154112
  • Filing Date: 2007-06-11
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 放射線治療システム (2006)
  • Inventor(s): 中川恵一
  • Industrial Property Rights Holder: 東京大学総長
  • Filing Date: 2006-12-25
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 放射線照射用コンペンセータおよびコンペンセータ配列照合装置 (2006)
  • Inventor(s): 中川恵一
  • Industrial Property Rights Holder: 東京大学総長
  • Acquisition Date: 2006-06-22
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 球状蛍光ガラス線量測定素子の積算吸収線量測定方法、球状蛍光ガラス線量測定素子、及び積算吸収線量測定用装置」 (2005)
  • Inventor(s): 中川恵一
  • Industrial Property Rights Holder: 東京大学総長
  • Industrial Property Number: 2005-239423
  • Filing Date: 2005-08-22
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 球状蛍光ガラス線量測定素子 (2005)
  • Inventor(s): 中川 恵一
  • Industrial Property Rights Holder: 中川 恵一
  • Industrial Property Number: 2005-239423
  • Filing Date: 2005-08-22