| Project/Area Number |
17390327
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAGAWA Keiichi The University of Tokyo, Hospital, Associate Professor (80188896)
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| Co-Investigator(Kenkyū-buntansha) |
UESAKA Mitsuru The University of Tokyo, School of Engineering, Professor (30232739)
AOKI Yukimasa International University of Health and Welfare, 放射線情報科学学科, Professor (40143474)
TAGO Masao The University of Tokyo, Hospital, Lecturer (50282520)
MASUTANI Yoshitaka The University of Tokyo, Hospital, Lecturer (20345193)
ISHIKAWA Masatoshi The University of Tokyo, Graduate School of Information Science and Technology, Professor (40212857)
小野木 雄三 東京大学, 医学部附属病院, 助教授 (90233593)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥9,240,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2005: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Radiation therapy / Lung cancer / Respiratory movement / Tracking irradiation / Diaphragm movement / In-treatment kV CT imaging / Modulated Arc Therapy (IMAT) / Image-Guided Radiation Therapy (IGRT) / 臓器移動 / 定位放射線治療 |
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| Research Abstract |
(1) Four-dimensional lung cancer imaging has been successfully performed by using a multi-detector CT
(2) Real-time fluoroscopic tumor imaging has been achieved by using a flat panel detector for MV x-ray.
(3) A kilovolt x-ray CT imaging technique has been developed by using radiotherapy machine.
(4) A respiratory curve has been derived from the patient diaphragm position obtained by kilovoltage x-ray imaging.
(5) A technique for in-treatment kV cone beam CT imaging has been established.
(6) A method for measuring patient set-up errors has been developed for stereotactic radiotherapy immediately before treatment, during treatment, and immediately after treatment. Clinical study has also been launched.
(7) A real-time tumor tracking system has been developed by detecting the tumor position estimated from the patient diaphragm position using in-treatment kV x-ray imaging.
(8) As for clinical application of large bore CT for radiotherapy. We have applied a 90 cm bore CT to radiotherapy practice.
(9) A tumor tracking algorithm has been developed by increasing MW maximum leaf speed.
(10) Intensity modulated arc therapy has been achieved by successfully controlling dose rate and gantry speed.
(11) We have addressed a problem and proposed a solution to apply previously developed x-band linac to radiotherapy practice.
(12) Real-time tumor tracking using robot arm-mounted linac has been studied from a robot engineering view.
(13) We have designed a next-generation tracking system by combining a linac with a robot arm and a CT imager.
(14) The target and risk organs have been localized immediately before treatment, during treatment and immediately after treatment by using built-in CT imaging unit.
(15) We have discovered that commercially available drug serves as a radiosensitizer, and have revealed its radiobiological mechanism.
(16) Total assessment and clinical application We have obtained significant treatment outcome by applying our results to clinical practice.
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