Prognostic factors system for personalized treatment associated with response to radiotherapy in advanced cervical cancer
| Project/Area Number |
17390339
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
HARIMA Yoko Kansai Med.Univ., Faculty of Medicine, Associate Professor, 医学部, 助教授 (80140276)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHIMA Hiromi Kyushu Univ., Faculty of Medicine, Professor, 医学部, 教授 (40140917)
IMADA Hajime Occupational and Environmental Health Univ., Faculty of Medicine, Associate Professor, 医学部, 助教授 (50223326)
HIRAKI Yoshiyuki Kagoshima Univ., Faculty of Medicine, Assistant Professor, 医学部, 講師 (90264423)
寒川 光治 関西医科大学, 医学部, 講師 (10154684)
今井 正浩 関西医科大学, 医学部, 講師 (40268339)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2006: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2005: ¥6,100,000 (Direct Cost: ¥6,100,000)
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| Keywords | cancer / Radiotherapy / genome / protein / translational research / トランスレーチョナルリサーチ / 子宮頸癌 / 放射線治療 / 治療効果予測因子 |
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| Research Abstract |
Improvement of management of advanced cervical cancer after radiotherapy requires a better understanding of its biological behavior. In our previous study, some of these genes correlated with response to radiotherapy were already known to be associated with apoptosis (BIK, TEGT, SSI-3), hypoxia-inducible gene (HIF1A, CA12), and tumor cell invasion and metastasis (CTSL, CTSB, PLAU, CD44). In this series, we were analyzed to identify a set of genes related to radiosensitivity of cervical carcinoma and to establish a predictive method using real-time PCR methods. Next, we were evaluated to identify a set of genes related to metastasis of cervical carcinoma and to establish a predictive method using a cDNA microarray. Some of these genes were associated with chromosomal instability (TTK/hMps1), carcinogenesis (PPPIR7), and oncogene (USP6). We developed a "Predictive Score" system that could clearly separate the metastasis-positive group from the metastasis-negative one. These results may eventually lead to the achievement of "personalized therapy" for this disease.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Angiosarcoma of the scalp treated with curative radiotherapy plus recombinant interleukin-2 immunotherapy.2005
Author(s)
Takayuki Ohguri, Hajime Imada, Satoshi Nomoto, Katsuya Yahara, Masanori Hisaoka, Hiroshi Hashimoto, Yoshiki Tokura, Katsumasa Nakamura, Yoshiyuki Shioyama, Hiroshi Honda, Hiromi Terashima, Yoiichi Moroi, Masutaka Furue, Yukunori Korogi
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Journal Title
Int. J. Radiat. Oncol. Biol. Phys. 61 (5)
Pages: 1446-1453
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx.2005
Author(s)
Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda
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Journal Title
Int. J. Radiat. Oncol. Biol. Phys. 62 (3)
Pages: 680-683
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Stereotactic radiotherapy for lung and liver tumor using a body cast system; Setup accurady and preliminary clinical outcome.2005
Author(s)
Yoshiyuki Shioyama, Katsumasa Nakamura, Shigeo Anai, Tomonari Sasaki, Saiji Ooga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Takashi Toba, Hiromi Terashima, Hiroshi Honda
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Journal Title
Radiation Medicine 23 (6)
Pages: 407-413
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Angiosarcoma of the scalp treated with curative radiotherapy plus recombinant interleukin-2 immunotherapy.2005
Author(s)
Takayuki Ohguri, Hajime Imada, Satoshi Nomoto, Katsuya Yahara, Masanori Hisaoka, Hiroshi Hashimoto, Yoshiki Tokura, Katsumasa Nakamura, Yoshiyuki Shioyama, Hiroshi Honda, Hiromi Terashima, Yoiichi Moroi, Masutaka Furue, Yukunori Korogi.
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Journal Title
Int.J.Radiat.Oncol.Biol.Phys. 61(5)
Pages: 1446-1453
Description
「研究成果報告書概要(欧文)」より
Related Report
-
[Journal Article] Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx.2005
Author(s)
Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda.
-
Journal Title
Int.J.Radiat.Oncol.Biol.Phys. 62(3)
Pages: 680-683
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
[Journal Article] Stereotactic radiotherapy for lung and liver tumor using a body cast system ; Setup accurady and preliminary clinical outcome.2005
Author(s)
Yoshiyuki Shioyama, Katsumasa Nakamura, Shigeo Anai, Tomonari Sasaki, Saiji Ooga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Takashi Toba, Hiromi Terashima, Hiroshi Honda.
-
Journal Title
Radiation Medicine 23(6)
Pages: 407-413
Description
「研究成果報告書概要(欧文)」より
Related Report
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