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Prognostic factors system for personalized treatment associated with response to radiotherapy in advanced cervical cancer

Research Project

Project/Area Number 17390339
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKansai Medical University

Principal Investigator

HARIMA Yoko  Kansai Med.Univ., Faculty of Medicine, Associate Professor, 医学部, 助教授 (80140276)

Co-Investigator(Kenkyū-buntansha) TERASHIMA Hiromi  Kyushu Univ., Faculty of Medicine, Professor, 医学部, 教授 (40140917)
IMADA Hajime  Occupational and Environmental Health Univ., Faculty of Medicine, Associate Professor, 医学部, 助教授 (50223326)
HIRAKI Yoshiyuki  Kagoshima Univ., Faculty of Medicine, Assistant Professor, 医学部, 講師 (90264423)
寒川 光治  関西医科大学, 医学部, 講師 (10154684)
今井 正浩  関西医科大学, 医学部, 講師 (40268339)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2006: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 2005: ¥6,100,000 (Direct Cost: ¥6,100,000)
Keywordscancer / Radiotherapy / genome / protein / translational research / トランスレーチョナルリサーチ / 子宮頸癌 / 放射線治療 / 治療効果予測因子
Research Abstract

Improvement of management of advanced cervical cancer after radiotherapy requires a better understanding of its biological behavior. In our previous study, some of these genes correlated with response to radiotherapy were already known to be associated with apoptosis (BIK, TEGT, SSI-3), hypoxia-inducible gene (HIF1A, CA12), and tumor cell invasion and metastasis (CTSL, CTSB, PLAU, CD44). In this series, we were analyzed to identify a set of genes related to radiosensitivity of cervical carcinoma and to establish a predictive method using real-time PCR methods. Next, we were evaluated to identify a set of genes related to metastasis of cervical carcinoma and to establish a predictive method using a cDNA microarray. Some of these genes were associated with chromosomal instability (TTK/hMps1), carcinogenesis (PPPIR7), and oncogene (USP6). We developed a "Predictive Score" system that could clearly separate the metastasis-positive group from the metastasis-negative one. These results may eventually lead to the achievement of "personalized therapy" for this disease.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report

Research Products

(23 results)

All 2006 2005

All Journal Article (23 results)

  • [Journal Article] Thermoradiotherapy in advanced cervical cancer : Clinical experiments and molecular research.2006

    • Author(s)
      Yoko Harima, Toshiko Shiga, Minoru Kamata, Hiroyuki Kojima, Shigeki Ikeda, Satoshi Sawada
    • Journal Title

      Jpn. J. Hyperthermic Oncol. 22 (3)

      Pages: 141-150

    • NAID

      10019597031

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Radiotherapy with 8MHz radiofrequency-capacitive regional hyperthermia for pain relief of unresectable and recurrent colorectal cancer.2006

    • Author(s)
      T Ohguri, H Imada, F Kato, K Yahara, T Morioka, K Nakano, Y Korogi
    • Journal Title

      Int. J. Hyperhtermia 22 (1)

      Pages: 1-14

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thermo-radiotherapy plus chemotherapy and hyperbolic oxygen therapy for vertebral metastasis with paralysis from rectal cancer : a case report.2006

    • Author(s)
      Keita Nakano, Hajime Imada, Ichiro Shima, Takayuki Ohguri, Katsuya Yahara, Fumio Kato, Tomoaki Morioka, Yukunori Korogi
    • Journal Title

      Jpn. J. Hyperthermic Oncol. 22 (2)

      Pages: 83-88

    • NAID

      10019597145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thermoradiotherapy in advanced cervical cancer : Clinical experiments and molecular research.2006

    • Author(s)
      Yoko Harima, Toshiko Shiga, Minoru Kamata, Hiroyuki Kojima, Shigeki Ikeda, Satoshi Sawada.
    • Journal Title

      Jpn.J.Hyperthermic Oncol. 22(3)

      Pages: 141-150

    • NAID

      10019597031

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Radiotherapy with 8MHz radiofrequency-capacitive regional hyperthermia for pain relief of unresectable and recurrent colorectal cancer.2006

    • Author(s)
      T Ohguri, H Imada, F Kato, K Yahara, T Morioka, K Nakano, Y Korogi.
    • Journal Title

      Int.J.Hyperhtermia 22(1)

      Pages: 1-14

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thermo-radiotherapy plus chemotherapy and hyperbolic oxygen therapy for vertebral metastasis with paralysis from rectal cancer : a case report.2006

    • Author(s)
      Keita Nakano, Hajime Imada, Ichiro Shima, Takayuki Ohguri, Katsuya Yahara, Fumio Kato, Tomoaki Morioka, Yukunori Korogi.
    • Journal Title

      Jpn.J.Hyperthermic Oncol. 22(2)

      Pages: 83-88

    • NAID

      10019597145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Thermoradiotherapy in advanced cervical cancer : Clinical experiments and molecular research.2006

    • Author(s)
      Yoko Harima, Toshiko Shiga, Minoru Kamata, Hiroyuki Kojima, Shigeki Ikeda, Satoshi Sawada
    • Journal Title

      Jpn. J. Hyperthermic Oncol 22

      Pages: 141-150

    • NAID

      10019597031

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Radiotherapy with 8MHz radiofrequency-capacitive regional hyperthermia for pain relief of unresectable and recurrent colorectal cancer.2006

    • Author(s)
      T Ohguri, H Imada, F Kato, K Yahara, T Morioka, K Nakano, Y Korogi.
    • Journal Title

      Int. J. Hyperhtermia 22

      Pages: 1-14

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Thermo-radiotherapy plus chemotherapy and hyperbolic oxygen therapy for vertebral metastasis with paralysis from rectal cancer : a case report.2006

    • Author(s)
      K Nakano, H Imada, I Shima, T Ohguri, K Yahara, F Kato, T Morioka, Y Korogi.
    • Journal Title

      Jpn. J. Hyperthermic Oncol. 22

      Pages: 83-88

    • NAID

      10019597145

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Angiosarcoma of the scalp treated with curative radiotherapy plus recombinant interleukin-2 immunotherapy.2005

    • Author(s)
      Takayuki Ohguri, Hajime Imada, Satoshi Nomoto, Katsuya Yahara, Masanori Hisaoka, Hiroshi Hashimoto, Yoshiki Tokura, Katsumasa Nakamura, Yoshiyuki Shioyama, Hiroshi Honda, Hiromi Terashima, Yoiichi Moroi, Masutaka Furue, Yukunori Korogi
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys. 61 (5)

      Pages: 1446-1453

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx.2005

    • Author(s)
      Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda
    • Journal Title

      Int. J. Radiat. Oncol. Biol. Phys. 62 (3)

      Pages: 680-683

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stage 1 and 11 Non-Hodgkins lymphoma : Results of combined or THP-COP chemotherapy and radiotherapy.2005

    • Author(s)
      Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Schioyama, Tomonari Sasaki, Yusuke Urashima, Hiromi Terashima, Hiroshi Honda
    • Journal Title

      Radiation Medicine 23 (3)

      Pages: 156-161

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stereotactic radiotherapy for lung and liver tumor using a body cast system; Setup accurady and preliminary clinical outcome.2005

    • Author(s)
      Yoshiyuki Shioyama, Katsumasa Nakamura, Shigeo Anai, Tomonari Sasaki, Saiji Ooga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Takashi Toba, Hiromi Terashima, Hiroshi Honda
    • Journal Title

      Radiation Medicine 23 (6)

      Pages: 407-413

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Initial experience of bladder preservation therapy using chemoradiotherapy with regional hyperthermia for muscle-invasive bladder cancer.2005

    • Author(s)
      Takayuki Ohguri, Hajime Imada, Satoshi Nomoto, Fumio Kato, Katsuya Yahara, Tomoaki Morioka, Keita Nakano, Yukunori Korogi
    • Journal Title

      Jpn. J. Hyperthermic Oncol. 21 (3)

      Pages: 151-158

    • NAID

      10029676459

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 子宮頸癌の温熱放射線治療抵抗性における遺伝子発現プロファイル2005

    • Author(s)
      播磨洋子, 今村正浩, 寒川光治, 澤田 敏
    • Journal Title

      臨床放射線 50 (7)

      Pages: 870-874

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 子宮頸癌のゲノム解析による治療効果予測2005

    • Author(s)
      播磨洋子
    • Journal Title

      放射線生物研究 40 (2)

      Pages: 109-116

    • NAID

      40006828260

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Angiosarcoma of the scalp treated with curative radiotherapy plus recombinant interleukin-2 immunotherapy.2005

    • Author(s)
      Takayuki Ohguri, Hajime Imada, Satoshi Nomoto, Katsuya Yahara, Masanori Hisaoka, Hiroshi Hashimoto, Yoshiki Tokura, Katsumasa Nakamura, Yoshiyuki Shioyama, Hiroshi Honda, Hiromi Terashima, Yoiichi Moroi, Masutaka Furue, Yukunori Korogi.
    • Journal Title

      Int.J.Radiat.Oncol.Biol.Phys. 61(5)

      Pages: 1446-1453

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx.2005

    • Author(s)
      Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda.
    • Journal Title

      Int.J.Radiat.Oncol.Biol.Phys. 62(3)

      Pages: 680-683

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stage 1 and 11 Non-Hodgkins lymphoma : Results of combined or THP-COP chemotherapy and radiotherapy2005

    • Author(s)
      Saiji Ohga, Katsumasa Nakamura, Yoshiyuki Schioyama, Tomonari Sasaki, Yusuke Urashima, Hiromi Terashima, Hiroshi Honda.
    • Journal Title

      Radiation Medicine 23(3)

      Pages: 156-161

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stereotactic radiotherapy for lung and liver tumor using a body cast system ; Setup accurady and preliminary clinical outcome.2005

    • Author(s)
      Yoshiyuki Shioyama, Katsumasa Nakamura, Shigeo Anai, Tomonari Sasaki, Saiji Ooga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Takashi Toba, Hiromi Terashima, Hiroshi Honda.
    • Journal Title

      Radiation Medicine 23(6)

      Pages: 407-413

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Initial experience of bladder preservation therapy using chemoradiotherapy with regional hyperthermia for muscle-invasive bladder cancer.2005

    • Author(s)
      Takayuki Ohguri, Hajime Imada, Satoshi Nomoto, Fumio Kato, Katsuya Yahara, Tomoaki Morioka, Keita Nakano, Yukunori Korogi.
    • Journal Title

      Jpn.J.Hyperthermic Oncol. 21(3)

      Pages: 151-158

    • NAID

      10029676459

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 子宮頸癌の温熱放射線治療抵抗性における遺伝子発現プロファイル2005

    • Author(s)
      播磨 洋子
    • Journal Title

      臨床放射線 50・7

      Pages: 870-874

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 子宮頸癌のゲノム解析による治療効果予測2005

    • Author(s)
      播磨 洋子
    • Journal Title

      放射線生物研究 40・2

      Pages: 109-116

    • NAID

      40006828260

    • Related Report
      2005 Annual Research Report

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Published: 2005-03-31   Modified: 2016-04-21  

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