Development of new immunosuppression by intra-portal administration of donor specific miss-match antigen in pancreas transplantation
| Project/Area Number |
17390346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Niigata University |
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Principal Investigator |
SATO Yoshinobu Niigata University, Institute of Medicine and Dentistry, Lecturer (20313538)
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| Co-Investigator(Kenkyū-buntansha) |
ABO Toru Niigata University, Institute of Medicine and Dentistry, Professor (30005079)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥17,120,000 (Direct Cost: ¥16,100,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2006: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 2005: ¥6,900,000 (Direct Cost: ¥6,900,000)
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| Keywords | Living related pancreas transplantation / type I diabetes mellitus / intra-portal donor specific transfusion / Torelance / Rejection / Steroid free regimen / donor pancreas transplantation / 生体膵移植 / I型糖尿病 / キメリズム / ドナー抗原門脈内投与 / 同所性部分膵臓移植 |
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| Research Abstract |
Donor discharged 2 weeks after surgery without any surgical complication. Recipient's postoperative course was also uneventful. Immunosuppresion was performed by steroid free regimen using thymoglobulin and FK506 and MMF with intraportal infusion of donor specific antigens^2. There were neither hemorrhage nor pancreatic leakage. She discharged 15 days after transplantation. Immunological analysis revealed of activation of interleukin 10 of Th2 type cytokine on day 7 after transplantation(Fig1). Mixed lymphocyte reaction demonstrated the donor specific immunosuppression at 8 month after transplantation. She released from hypoglycemia. Her body weight decreased by 56kg and HbA1c decreased to 5.1% for 6 months after the operation. There are no any rejection until now.
The first case of both physiologic enteric drainage and steroid free regiment were successfully performed in LRPT in Japan. Enteric drainage has remarkably increased in cadaver pancreas transplantation. In living partial pancreas transplantation, the enteric drainage is considered to be one option as physiologic reconstruction under careful surgical technique. LRPT might be very useful therapy for type I diabetes mellitus for preventing diabetic complication with cadaver pancreas transplantation. We have already reported about the intraportal administration of donor specific transfusion in living related liver transplantation. In this study, it was demonstrated that the intraportal administration of donor leukocytes might be also effective as induction therapy for steroid free regiment in LRPT such as our experienced of living related liver transplantation.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Present status of pancreas transplantation in Japan-donation predominantly from marginal donors and modified surgical technique: report of Japan pancreas transplantation registry2008
Author(s)
Ishibashi, M, Ishibashi, M, Ito, T, Sugitani, A, Furukawa, H, Sekiguchi, S, Gotoh, M, Teraoka, S, Sato, Y,, et. al.
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Journal Title
Transplant Proc 40(2)
Pages: 486-90
Description
「研究成果報告書概要(欧文)」より
Related Report
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