STUDY OF MECHANISMS FOR GRAFT ACCEPTANCE AND ESTABLISHMENT OF STRATEGY IN HUMAN BLOOD TYPE INCOMPATIBLE LIVER TRANSPLANTATION
| Project/Area Number |
17390350
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
EGAWA Hiroto KYOTO UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学研究科, 助教授 (40293865)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Taitra KYOTO UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学研究科, 教授 (80229286)
TSURUYAMA Tasuaki KYOTO UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学研究科, 助教授 (00303842)
HAGA Hironori KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 助手 (10252462)
OIKE Fumitaka KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 助手 (20324650)
OGAWA Kohei KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 助手 (10359789)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2006: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | C4d / blood type incompatible / liver transplantation / antibody-mediated rejection / B cell phenotype / CD8 positive cell phenotype / anti-CD20 antibody / 血液型不適合移植 / リツキシマブ / リンパ球 / メモリーB細胞 / 抗体価 / B細胞 / 抗CD 20抗体 / 推奨プロトコール |
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| Research Abstract |
We disclosed the role of compliment and the change of B cell phenotype in antibody mediated rejection in blood type incompatible liver transplantation. Further, we established the strategy to overcome the antibody-mediated rejection using anti-CD-20 antibody and showed the mechanisms of the effects. In order to improve the outcome further, we investigated the role of CD8 positive cells in posttransplant infection, which was the major reason of patient's death after termination of antibody-mediated rejection. We found the significance of dominancy of phenotype of CD8 positive cell in postoperative courses and we are carrying on a prospective study to tailor immunosuppression based on the CD8 positive cell phenotype repertory.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients.2007
Author(s)
Tanaka K, Uemoto S, Egawa H, Takada Y, Ozawa K, Teramukai S, Kasahara M, Ogawa K, Ono M, Sato H, Takai K, Fukushima M, Inaba K
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Journal Title
Liver Transpl Feb;13(2)
Pages: 287-293
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] B-cell surface marker analysis for improvement of rituximab prophylaxis in ABO-incompatible adult living donor liver transplantation.2007
Author(s)
Egawa H, Ohmori K, Haga H, Tsuji H, Yurugi K, Miyagawa-Hayashino A, Oike F, Fukuda A, Yoshizawa J, Takada Y, Tanaka K, Maekawa T, Ozawa K, Uemoto S
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Journal Title
Liver Transpl. Mar 29;13(4)
Pages: 579-588
Description
「研究成果報告書概要(和文)」より
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[Journal Article] B cell surface marker analysis for improvement of rituximab prophylaxis in ABO-incompatible adult living donor liver transplantation2007
Author(s)
Egawa H, Ohmori K, Haga H, Tsuji H, Yurugi K, Miyagawa-Hayashino A, Oike F, Fkuda A, Yoshizawa J, Takada Y, Tanaka K, Maekawa T, Ozawa K, Uemoto S
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Journal Title
LiverTransplantation 29
Pages: 579-588
Related Report
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[Journal Article] Cytomtoxic T-cell-mediated defense against infections in human liver transplant recipients.2007
Author(s)
Tanaka K, Uemoto S, Egawa H, Takada Y, Ozawa K, Teramukai S, Kasahara M, Ogawa K, Ono M, Sato H, Takai K, Fukushima M, Inaba K
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Journal Title
LiverTransplantation 13
Pages: 287-293
Related Report
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[Journal Article] Classification of human liver transplant recipients by heir preoperative CD8 cell subpopulation and its relation to outcome.2006
Author(s)
Tanaka K, Ozawa K, Teramukai S, Takada Y, Egawa H, Kaihara S, Fujimoto Y, Ogura Y, Kasahara M, Ono M, Sato H, Takai K, Fukushima M, Minato N
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Journal Title
Liver Transplantation 12
Pages: 792-800
Description
「研究成果報告書概要(和文)」より
Related Report
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[Journal Article] Population pharmacokinetic and pharmacogenomic analysis of Tacrolimus in pediatric living-donor liver transplantation.2006
Author(s)
Fukudo M, Yano I, Masuda S, Goto M, Uesugi M, Katsura T, Ogura Y, Oike F, Takada Y, Egawa H, Uemoto S, Inui K
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Journal Title
Clin Pharmacolo Ther 80
Pages: 332-345
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Antinfectious defense by CD8+ cytotoxic T cells iin human liver transplant recipients2006
Author(s)
Tanaka K, Uemoto S, Egawa H, Takada Y, Ozawa K, Teramukai S, Kasahara M, Ono M, Sato H, Takai K, Fukushima M, Minato N
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Journal Title
LiverTransplantation 12
Pages: 792-800
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[Journal Article] The role of apheresis therapy for ABO incompatible living donor liver transplantation : the Kyoto University experience2006
Author(s)
Kozaki K, Egawa H, Ueda M, Oike F, Yoshizawa A, Fukatsu A, Takada Y, Kozaki K, Egawa H, Ueda M, Oike F, Yoshizawa A, Fukatsu A, Takada Y
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Journal Title
Ther Apher Dial. 10
Pages: 441-448
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[Journal Article] Significance of C4d staining in ABO-identical/compatible liver transplantation.
Author(s)
Sakashita H, Haga H, Ashihara E, Wen MC, Tsuji H, Miyagwa -Hayashino A, Egawa H, Takada Y, Maekawa T, Uemoto S, Manabe T
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Journal Title
Modern Pathology (In press)
Description
「研究成果報告書概要(和文)」より
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