| Project/Area Number |
17390350
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
EGAWA Hiroto KYOTO UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学研究科, 助教授 (40293865)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Taitra KYOTO UNIVERSITY, FACULTY OF MEDICINE, PROFESSOR, 医学研究科, 教授 (80229286)
TSURUYAMA Tasuaki KYOTO UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 医学研究科, 助教授 (00303842)
HAGA Hironori KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 助手 (10252462)
OIKE Fumitaka KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 助手 (20324650)
OGAWA Kohei KYOTO UNIVERSITY, FACULTY OF MEDICINE, LECTURER, 医学研究科, 助手 (10359789)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2006: ¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | C4d / blood type incompatible / liver transplantation / antibody-mediated rejection / B cell phenotype / CD8 positive cell phenotype / anti-CD20 antibody / 血液型不適合移植 / リツキシマブ / リンパ球 / メモリーB細胞 / 抗体価 / B細胞 / 抗CD 20抗体 / 推奨プロトコール |
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| Research Abstract |
We disclosed the role of compliment and the change of B cell phenotype in antibody mediated rejection in blood type incompatible liver transplantation. Further, we established the strategy to overcome the antibody-mediated rejection using anti-CD-20 antibody and showed the mechanisms of the effects. In order to improve the outcome further, we investigated the role of CD8 positive cells in posttransplant infection, which was the major reason of patient's death after termination of antibody-mediated rejection. We found the significance of dominancy of phenotype of CD8 positive cell in postoperative courses and we are carrying on a prospective study to tailor immunosuppression based on the CD8 positive cell phenotype repertory.
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