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Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids

Research Project

Project/Area Number 17390353
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionSapporo Medical University

Principal Investigator

MITAKA Toshihiro  Sapporo Medical University, Cancer Research Institute, Professor (50231618)

Co-Investigator(Kenkyū-buntansha) KIKKAWA Yamato  Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Assistant Professor (20274227)
KON Junko  Sapporo Medical University, Cancer Research Institute, Instructor (40398318)
ICHINOHE Norihisa  Sapporo Medical University, Cancer Research Institute, Research Associate (80452978)
MIZUGUCHI Toni  Sapporo Medical University, Medical School, Assistant Professor (30347174)
HIRATA Koichi  Sapporo Medical University, Medical School, Professor (50136959)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2005: ¥5,700,000 (Direct Cost: ¥5,700,000)
KeywordsRegenerative medicine / Small hepatocytes / Henatic organoid / Differentiation / Proliferation / Hepatic progenitor cells / human hepatic progenitor cells / Bile duct formation / オーバル細胞 / CD44 / 幹細胞 / 肝臓 / 人工肝臓 / 成熟化 / ヒト
Research Abstract

We have reported that CD44 is specifically expressed in rat small hepatocytes and that CD44^+ hepatocytes transiently appear in injured rat livers. Using a specific antibody, we sorted CD44^+ cells from galactosamine-treated rat livers and cultured them. The phenotypes and gene expression of the cells were similar to those of cultured SHs and the ^+ cells could differentiate into hepatocytes (J Hepatol, 2006). In addition, some Thy1^+ cells that appeared in the galactosamine-treated livers could differentiate into + SHs and mature into hepatocytes. When the Thyl+ and CD44^+ cells were transplanted into livers treated with retrorsine/PH, they could survive and proliferate to form hepatic foci in the recipient livers. Furthermore, when cultured SHs were transplanted into congenic rat livers treated with radiation/PH, the cells migrated into hepatic trabecules and the liver was partially repopulated by the donor cells (Liver Transplant, 2006). Rat SHs cultured in hyaluronic acid (HA ; ligand for CD44)-coated dishes and serum-free medium could selectively proliferate with hepatic functions (Nature Protocols, 2007) and this method could be applied for the isolation of human SHs from normal liver tissues, which were surgically resected from patients with informed consent. The number of human SHs increased about 100-fold within 3 weeks and the cells showed hepatic characteristics such as albumin secretion (Cell Transplant, 2008). Furthermore, we found that the proliferation of rat SHs was enhanced by follistatin produced by SHs to inhibit the action of activin A, which is secreted by mature hepatocytes. On the other hand, we succeeded in reconstructing functional hepatic tissues by stacking up two-dimensional tissues composed of rat SHs (FASEB J, 2006). In addition, we could culture normal rat biliary epithelial cells for a long term and reconstruct functional bile ductules between collagen gels (Am J Pathol, 2008).

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (178 results)

All 2008 2007 2006 2005 Other

All Journal Article (71 results) (of which Peer Reviewed: 21 results) Presentation (100 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Functional Expression of Organic Anion Transporters in Hepatic Organoids Reconstructed by Rat Small Hepatocytes2008

    • Author(s)
      Oshima H, et. al.
    • Journal Title

      Journal of Cellular Biochemistry 104

      Pages: 68-81

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 肝再生過程における小型肝細胞の役割2008

    • Author(s)
      三高 俊広, 他
    • Journal Title

      移植 43

      Pages: 2-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ductular network formation by rat biliary epithelial cells in the dynamical culture with collagen gel and dimethylsurfoxide stimulation2008

    • Author(s)
      Hashimoto W, et. al.
    • Journal Title

      American Journal of Pathology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Proliferation of Hepatocyte Progenitor Cells Isolated from Adult Human livers in Serum-free Medium2008

    • Author(s)
      Sasaki K, et. al.
    • Journal Title

      Cell Transplantation (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Functional Expression of Organic Anion Transporters in Hepatic Organoids Reconstructed by Rat Small Hepatocytes2008

    • Author(s)
      Oshima, H, et. al.
    • Journal Title

      J Cell Biochem 104, (1)

      Pages: 68-81

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Proliferation of Hepatocyte Progenitor Cells Isolated from Adult Human livers in Serum-free Medium2008

    • Author(s)
      Sasaki, K, et. al.
    • Journal Title

      Cell Transplantation (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional Expression of Organic Anion Transporters in Hepatic Organoids Reconstructed by Rat Small Hepatocytes2008

    • Author(s)
      Oshima H, et. al.
    • Journal Title

      J. Cell. Biochem. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肝再生過程における小型肝細胞の役割2008

    • Author(s)
      三高俊広、他.
    • Journal Title

      移植 43(印刷中)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Proliferation of Hepatocyte Progenitor Cells Isolated from Adult Human livers in Serum-free Medium2008

    • Author(s)
      Sasaki K, et. al.
    • Journal Title

      Cell Transplantation (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Proliferation of Rat Hepatocyte Progenitor Cells in Serum-free Culture2007

    • Author(s)
      Chen Q, et. al.
    • Journal Title

      Nature Protocols 2

      Pages: 1197-1205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The LG1-3 tandem of laminin α5 harbors the binding sites of Lutheran/B-CAM and α3β1/α6β1 integrlns2007

    • Author(s)
      Kikkawa Y, et. al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 14853-14860

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Selective Proliferation of Rat Hepatocyte Progenitor Cells in Serum-free Culture2007

    • Author(s)
      Chen, Q, et. al.
    • Journal Title

      Nature Protocols 2, (5)

      Pages: 1197-1205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The LG1-3 tandem of laminin a5 harbors the binding sites of Lutheran/B-CAM and a3bl/a6b1 integrins2007

    • Author(s)
      Kikkawa, Y, et. al.
    • Journal Title

      J Biol Chem 282, (20)

      Pages: 14853-60

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The LG1-3 tandem of laminin a5 harbors the binding sites of Lutheran/B-CAM and α3β1/α6β1 integrins2007

    • Author(s)
      Kikkawa Y, et. al.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 14853-14860

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The LGI-3 tandem of laminin α5 harbors the binding sites of Lutheran/B-CAM and α3β1/α6β1 integrins2007

    • Author(s)
      Yamato Kikkawa, et al.
    • Journal Title

      Journal of Biological Chemistry (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Selective Proliferation of Rat Hepatocyte Progenitor Cells in Serum-free Culture2007

    • Author(s)
      Qijie Chen, et al.
    • Journal Title

      Nature Protocolos (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes2007

    • Author(s)
      Mayumi Mochizuki, et al.
    • Journal Title

      Biopolymers 88(2)

      Pages: 122-130

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cyclic peptide analysis of the biologically active loop region in the laminin alpha3 chain LG4 module demonstrates the importance of peptide2007

    • Author(s)
      Kozue Kato-Takagaki, et al.
    • Journal Title

      Biochemistry 46(7)

      Pages: 1952-1960

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation2006

    • Author(s)
      Shibata C, et. al.
    • Journal Title

      Liver Transplantation 12

      Pages: 78-87

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Thermoreversible gelation polymer induces the emergence of hepatic stem cells in a partially injured rat liver2006

    • Author(s)
      Nagaya M, et. al.
    • Journal Title

      Hepatology 43

      Pages: 1053-1062

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Kon J, et. al.
    • Journal Title

      Journal of Hepatology 40

      Pages: 90-98

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 肝再生とラミニンα1鎖2006

    • Author(s)
      吉川 大和、三高 俊広
    • Journal Title

      Surgery Frontier 13

      Pages: 93-95

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Coordinate elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution2006

    • Author(s)
      Manase K, et. al.
    • Journal Title

      Reprod Biol Endocrinol 4

      Pages: 32-38

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cytochrome P450 expressions of cultured rat small hepatocytes after long-term cryopreservation2006

    • Author(s)
      Ooe H, et. al.
    • Journal Title

      Drug Metabolism and Disposition 34

      Pages: 1667-1671

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Portal blood flow regulates volume recovery of the rat liver after partial hepatectomy: Molecular evaluation2006

    • Author(s)
      Nobuoka T, et. al.
    • Journal Title

      European Surgical Research 38

      Pages: 522-532

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation2006

    • Author(s)
      Shibata, C, et. al.
    • Journal Title

      Liver Transpl 12, (1)

      Pages: 78-87

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Thermoreversible gelation polymer induces the emergence of hepatic stem cells in a partially injured rat liver2006

    • Author(s)
      Nagaya, M, et. al.
    • Journal Title

      Hepatology 43, (5)

      Pages: 1053-1062

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Kon, J, et. al.
    • Journal Title

      I Hepatology 40, (1)

      Pages: 90-98

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Coordinate elevation of membrane type 1-matrix metalloproteinase and matrix metalloproteinase-2 expression in rat uterus during postpartum involution2006

    • Author(s)
      Manase, K, et. al.
    • Journal Title

      Reprod Biol Endocrinol 4, (1)

      Pages: 32-38

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cytochrome P450 expressions of cultured rat small hepatocytes after long-term cryopreservation2006

    • Author(s)
      Ooe, H, et. al.
    • Journal Title

      Drug Metab Dispos 34, (10)

      Pages: 1667-1671

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Portal blood flow regulates volume recovery of the rat liver after partial hepatectomy : Molecular evaluation2006

    • Author(s)
      Nobuoka, T, et. al.
    • Journal Title

      Eur Surg Res 38, (6)

      Pages: 522-532

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Analysis of the changes pattern of serum apolipoprotein A-1 after hepatectomy2006

    • Author(s)
      Tadashi Katsuramaki, et al.
    • Journal Title

      Hepatogastroenterology 53(72)

      Pages: 924-927

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Portal blood flow regulates volume recovery of the rat liver after partial hepatectomy : Molecular evaluation2006

    • Author(s)
      Takayuki Nobuoka, et al.
    • Journal Title

      European Surgical Research 38(6)

      Pages: 522-532

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cytochrome P450 expressions of cultured small hepatocytes after long-term cryopreservation2006

    • Author(s)
      Hidekazu Ooe, et al.
    • Journal Title

      Drug Metabolism and Disposition 34(10)

      Pages: 1667-1671

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Assessment of nutritional status and prediction of postoperative liver function from serum apolioprotein A-1 levels with hepatectomy2006

    • Author(s)
      Tadashi Katsuramaki, et al.
    • Journal Title

      World Journal of Surgery 30(10)

      Pages: 1886-1891

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers2006

    • Author(s)
      Masaki Kawamoto, et al.
    • Journal Title

      World Journal of Surgery 12(27)

      Pages: 4325-4330

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Junko Kon, et al.
    • Journal Title

      Journal of Hepatology 40(1)

      Pages: 90-98

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular dissection of laminin alpha 5 in vivo reveals separable domain specific roles in embryonic developments and Kidney function2006

    • Author(s)
      Yamato Kikkawa, et al.
    • Journal Title

      Developmental Biology 296(1)

      Pages: 265-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells2006

    • Author(s)
      Noora Vainionpaa, et al.
    • Journal Title

      American Journal of Physiology Cell Physiology 290(3)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 肝再生とメラニンα1鎖2006

    • Author(s)
      吉川大和, 三高俊広
    • Journal Title

      Surgery Frontier 13(2)

      Pages: 93-95

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Thermoreversible gelation polymer induces the emergence of hepatic stem cells in a partially injures rat liver2006

    • Author(s)
      Masaki Nagaya, et al.
    • Journal Title

      Hepatology 43(5)

      Pages: 1053-1062

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In situ graft-trimming method ursing polyester vascular prosthesis for inferior vena cava reconstruction after hepatectomy2006

    • Author(s)
      Toru Mizuguchi, et al.
    • Journal Title

      Digestive Surgery 23(1-2)

      Pages: 115-118

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Serum lipid and lipoprotein alterations represent recovery of liver function after hepatectomy2006

    • Author(s)
      Masaki Kawamoto, et al.
    • Journal Title

      Liver International 26(2)

      Pages: 203-210

    • Related Report
      2006 Annual Research Report 2005 Annual Research Report
  • [Journal Article] The functional integrity of a normothermic perfusion system using artificial blood in pig liver2006

    • Author(s)
      Akihiro Nui, et al.
    • Journal Title

      Journal of Surgical Research 131(2)

      Pages: 189-198

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Liver repopulation and long-term function of rat small hepatocyte transplantation as an alternative cell source for hepatocyte transplantation2006

    • Author(s)
      Chihiro Shibata, et al.
    • Journal Title

      Liver Transplantation 12(1)

      Pages: 78-876

    • Related Report
      2006 Annual Research Report 2005 Annual Research Report
  • [Journal Article] Expression of CD44 in rat hepatic progenitor cells2006

    • Author(s)
      Junko Kon, et al.
    • Journal Title

      Journal of Hepatology In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Thermoreversible gelation polymer induces the emergence of hepatic stem cells in a partially injured rat liver2006

    • Author(s)
      Masaki Nagaya, et al.
    • Journal Title

      Hepatology In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The Functional Integrity of a Normothermic Perfusion System Using Artificial Blood in Pig Liver2006

    • Author(s)
      Akihiro Nui, et al.
    • Journal Title

      Journal of Surgical Research In press

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells2006

    • Author(s)
      N Vainionpaa, et al.
    • Journal Title

      American Journal of Physiology Cellular Physiology 290(3)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transient expression of laminin al chain inr egenerating murine liver: Restricted localization of laminin chanins and nidogen-12005

    • Author(s)
      Kikkawa Y, et. al.
    • Journal Title

      Experimental Cell Research 305

      Pages: 99-109

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatic organoid formation in collagen sponge of cells isolated from human liver2005

    • Author(s)
      Sugimoto S, et. al.
    • Journal Title

      Tissue Engineering 11

      Pages: 626-633

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of cytochrome P450 enzymes in hepatic organoid recon structed by rat small hepatocytes2005

    • Author(s)
      Miyamoto S, et. al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 20

      Pages: 865-872

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Coordination of Bile Canalicular Contraction in Hepatic Organoid Reconstructed by Rat Small Hepatocytes and Nonparenchymal Cells2005

    • Author(s)
      Sudo R, et. al.
    • Journal Title

      Annals of Biomedical Engineering 33

      Pages: 696-708

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranes2005

    • Author(s)
      Sudo R, et. al.
    • Journal Title

      FASEB Journal 19

      Pages: 1695-1697

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hyperbaric oxygen stimulates cell proliferation and normalized MRP2 (anion transporter) protein localization in primary rat hepatocytes2005

    • Author(s)
      Mizuguchi T, et. al.
    • Journal Title

      Wound Repair and Regeneration 13

      Pages: 551-557

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatocyte transplantation for total liver repopulation2005

    • Author(s)
      Mizuguchi T, et. al.
    • Journal Title

      Journal of Hepatobiliary Pancreatic Surgery 12

      Pages: 378-385

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transient expression of laminin al chain in regenerating murine liver : Restricted localization of laminin chanins and nidogen-1.2005

    • Author(s)
      Kikkawa, Y, et. al.
    • Journal Title

      Experimental Cell Research 305, (1)

      Pages: 99-109

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hepatic organoid formation in collagen sponge of cells isolated from human liver2005

    • Author(s)
      Sugimoto, S, et. al.
    • Journal Title

      Tissue Engineering 11, (3-4)

      Pages: 626-633

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of cytochrome P450 enzymes, in hepatic organoid reconstructed by rat small hepatocytes2005

    • Author(s)
      Miyamoto, S, et. al.
    • Journal Title

      J. Gastroenterol. Hepatol. 20, (6)

      Pages: 865-872

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Coordination of Bile Canalicular Contraction in Hepatic Organoid Reconstructed by Rat Small Hepatocytes and Nonparenchymal Cells2005

    • Author(s)
      Sudo, R, et. al.
    • Journal Title

      Ann Biomed Engineer 33, (5)

      Pages: 696-708

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranes2005

    • Author(s)
      Sudo, R, et. al.
    • Journal Title

      FASEB J 19, (12)

      Pages: 1695-1697

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperbaric oxygen stimulates cell proliferation and normalized MRP2 (anion transporter) protein localization in primary rat hepatocytes2005

    • Author(s)
      Mizuguchi, T, et. al.
    • Journal Title

      Wound Repair Regen 13, (6)

      Pages: 551-557

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hepatocyte transplantation for total liver repopulation2005

    • Author(s)
      Mizuguchi, T, et. al.
    • Journal Title

      J Hepatobiliary Pancreat Surg 12, (5)

      Pages: 378-385

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hyperbaric oxygen stimulates cell proliferation and normalized MRP2 (anion transporter) protein localization in primary rat hepatocyte2005

    • Author(s)
      Toru Mizuguchi, et al.
    • Journal Title

      Wound Repair and Regeneration 13(6)

      Pages: 551-557

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranes2005

    • Author(s)
      Ryo Sudo, et al.
    • Journal Title

      FASEB Journal 19(12)

      Pages: 1695-1697

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Metastases-related genes in the classification of liver and peritoneal metastasis in human gastric cancer2005

    • Author(s)
      Rika Fukui, et al.
    • Journal Title

      Journal of Surgical Research 129(1)

      Pages: 94-100

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Coordination of Bile Canalicular Contraction in Hepatic Organoid Reconstructed by Rat Small Hepatocytes and Nonparenchymal Cells2005

    • Author(s)
      Ryo Sudo, et al.
    • Journal Title

      Annals of Biomedical Engineering 33(5)

      Pages: 696-708

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of cytochrome P450 enzymes in hepatic organoid reconstructed by rat small hepatocytes2005

    • Author(s)
      Shigeki Miyamaoto, et al.
    • Journal Title

      Journal of Gastroenterology and Hepatology 20(6)

      Pages: 865-872

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hepatocyte transplantation for total liver repopulation2005

    • Author(s)
      Toru Mizuguchi, et al.
    • Journal Title

      Journal of Hepatobiliary Pancreatic Surgery 12(5)

      Pages: 378-385

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hepatic organoid formation in collagen sponge of cells isolated from human liver2005

    • Author(s)
      Shinichi Sugimoto, et al.
    • Journal Title

      Tissue Engineering 11(3-4)

      Pages: 626-633

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Transient expression of laminin α1 chain in regenerating murine liver : Restricted localization of laminin chanins and nidogen-12005

    • Author(s)
      Yamato Kikkawa, et al.
    • Journal Title

      Experimental Cell Research 305(1)

      Pages: 99-109

    • Related Report
      2005 Annual Research Report
  • [Presentation] In vitro hepatic tissue formation by hepatic stem/progenitor cells2008

    • Author(s)
      Mitaka, T
    • Organizer
      Keio University Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2008-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝前駆細胞の分化機構の解析2008

    • Author(s)
      市戸 義久, 他
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 網羅的遺伝子発現解析によるラット小型肝細胞の増殖能および成熟化能の検討2008

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ラット肝前駆細胞small hepatocyte-like progenitor cellにおける分化、再生機序の検討2008

    • Author(s)
      大島 秀紀, 他
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] In vitro hepatic tissue formation by hepatic stem/progenitor cells2008

    • Author(s)
      Mitaka T
    • Organizer
      慶磨義塾大学国際シンポジウム「細胞のマイクロナノバイオエンジニアリング」
    • Place of Presentation
      東京
    • Year and Date
      2008-03-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vitro hepatic tissue formation by hepatic stem/progenitor cells2008

    • Author(s)
      Toshihiro Mitaka
    • Organizer
      慶應義塾大学国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-03-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝再生過程における小型肝細胞の役割2007

    • Author(s)
      三高 俊広、今 純子
    • Organizer
      第34回日本臓器保存生物医学会定期学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-11-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Analysis of differentiation of hepatic progenitor cells derived from severely injured rat livers2007

    • Author(s)
      Kon J, et. al.
    • Organizer
      The 58th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      Boston,MA,USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Selective proliferation of human hepatocyte progenitor cells in combination with hyaluronic acid and serum-free medium2007

    • Author(s)
      Mitaka T, et. al.
    • Organizer
      The 58th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      Boston,MA,USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of differentiation of hepatic The 58th Annual Meeting of the progenitor cells derived from severely injured rat livers2007

    • Author(s)
      Kon, J, et. al.
    • Organizer
      American Association of the Study of Liver Disea ses
    • Place of Presentation
      Boston, MA, U.S.A.
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Selective proliferation of human hepatocyte progenitor cells in combination with hyaluronic acid and serum-free medium2007

    • Author(s)
      Mitaka, T, et. al.
    • Organizer
      The 58th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      Boston, MA, U.S.A.
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Selective proliferation of human hepatocyte progenitor cells in combination with hyaluronic acid and serum-free medium2007

    • Author(s)
      Toshihiro Mitaka, et. al.
    • Organizer
      The 58th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of differentiation of hepatic progenitor cells derived from severely injured rat livers2007

    • Author(s)
      Junko Kon, et. al.
    • Organizer
      The 58th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of B-CAM/Lutheran binding site on laminin alpa5 chain2007

    • Author(s)
      Kikkawa Y, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of B-CAM/Lutheran binding site on laminin alpha5 chain2007

    • Author(s)
      Yamato Kikkawa, et. al.
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝障害モデルラットにおける肝前駆細胞の分化機構2007

    • Author(s)
      今 純子, 他
    • Organizer
      日本病理学会カンファレンス2007旭川
    • Place of Presentation
      旭川
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞の網羅的遺伝子発現解析2007

    • Author(s)
      大栄 秀和, 他
    • Organizer
      日本病理学会カンファレンス2007旭川
    • Place of Presentation
      旭川
    • Year and Date
      2007-07-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝障害モデルラットにおける肝前駆細胞の分化機構2007

    • Author(s)
      今純子、他
    • Organizer
      日本病理学会カンファレンス2007
    • Place of Presentation
      旭川
    • Year and Date
      2007-07-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット小型肝細胞の網羅的遺伝子発現解析2007

    • Author(s)
      大栄秀和、他
    • Organizer
      日本病理学会カンファレンス2007
    • Place of Presentation
      旭川
    • Year and Date
      2007-07-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Proliferation of Hepatic Progenitor Cells Isolated from Adult Human Livers2007

    • Author(s)
      Sasaki K, et. al.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass,Colorado,USA
    • Year and Date
      2007-07-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CD44 expression in rat small hepatoytes2007

    • Author(s)
      Kon J, et. al.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass,CO,USA
    • Year and Date
      2007-07-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝前駆細胞の分化機構の解析2007

    • Author(s)
      今 純子, 他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝幹細胞研究の現況と展望肝前駆細胞の分化機構の解析2007

    • Author(s)
      今純子、他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] Follistatin産生によるラット小型肝細胞の増殖2007

    • Author(s)
      陳 其潔, 他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝前駆細胞の選択的培養方法の確立とヒト細胞への応用2007

    • Author(s)
      三高 俊広
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞のCAR及びCYP2B1発現における甲状腺ホルモンの必要性2007

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 類洞内皮細胞と小型肝細胞を用いた共培養モデルの評価2007

    • Author(s)
      粕谷 淳一, 他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] コラーゲンゲルサンドイッチ法を用いた初代培養ラット胆管上皮細胞の胆管様構造形成2007

    • Author(s)
      深澤 一知, 他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 小型肝細胞の3次元積層化のためのポリ乳酸-ポリグリコール酸共重合体を用いた生体吸収性微孔薄膜のデザイン2007

    • Author(s)
      田母 神龍, 他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 肝細胞の分化・増殖とシグナル伝達Follistatin産生によるラット小型肝細胞の増殖2007

    • Author(s)
      陳其潔、他
    • Organizer
      第14回肝細胞研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-06-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット肝障害モデルにおける肝前駆細胞の分化・増殖の解析2007

    • Author(s)
      今 純子, 他
    • Organizer
      第43回日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 初代培養ラット胆管上皮細胞の管腔形成に伴う分化の進展2007

    • Author(s)
      深澤 一知, 他
    • Organizer
      第46回日本生体医工学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2007-04-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proliferation of hepatic progenitor cells isolated from resected adult human liver specimens2007

    • Author(s)
      Sasaki K, et. al.
    • Organizer
      2007 Asia Pacific Association for the Study of Liver
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト肝前駆細胞の分離と無血清培養の確立2007

    • Author(s)
      三高 俊広, 他
    • Organizer
      第6回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝障害モデルラットにおける肝前駆細胞の分化機序の解析2007

    • Author(s)
      今 純子, 他
    • Organizer
      第6回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小型肝細胞におけるfollistatinとactivinAの役割2007

    • Author(s)
      陳 其潔, 他
    • Organizer
      第6回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proliferation of hepatic progenitor cells isolated from resected adult human liver specimens2007

    • Author(s)
      Sasaki, K, et. al.
    • Organizer
      2007 Asia Pacific Association for the Study of Liver (APASL)
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of B-CAM/Lutheran binding site on laminin alpa5 chain2007

    • Author(s)
      Kikkawa, Y, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      Yokohama, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 凍結ラット小型肝細胞におけるCytochrome P450及びその核内受容体の発現解析2006

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第21回日本薬物動態学会年会
    • Place of Presentation
      東京
    • Year and Date
      2006-11-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト小型肝細胞の分離培養とその再生医療への応用2006

    • Author(s)
      三高 俊広
    • Organizer
      DDW-Japan第10回日本肝臓学会
    • Place of Presentation
      札幌
    • Year and Date
      2006-10-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト肝細胞癌におけるラミニンα鎖の発現とその役割2006

    • Author(s)
      吉川 大和, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞の網羅的遺伝子発現解析2006

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第89回北海道癌談話会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 成人ヒト肝組織に存在する肝前駆細胞の分離と無血清培養法の確立2006

    • Author(s)
      佐々木 寿誉, 他
    • Organizer
      第89回北海道癌談話会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞の増殖及び分化機構の解析2006

    • Author(s)
      今 純子, 他
    • Organizer
      第39回北海道病理談話会
    • Place of Presentation
      札幌
    • Year and Date
      2006-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 徐放化bFGFの組み合わせによるチタン不織布の骨再生誘導の増強2006

    • Author(s)
      市戸 義久, 他
    • Organizer
      第9回日本組織工学会
    • Place of Presentation
      京都
    • Year and Date
      2006-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 初代培養ラット胆管上皮細胞によるLarge Bile Duct形成と機能解析2006

    • Author(s)
      深澤 一知, 他
    • Organizer
      第9回日本組織工学会
    • Place of Presentation
      京都
    • Year and Date
      2006-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット初代培養肝細胞の三次元積層培養による形態形成と機能維持2006

    • Author(s)
      須藤 亮, 他
    • Organizer
      第9回日本組織工学会
    • Place of Presentation
      京都
    • Year and Date
      2006-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of cellular configuration by cell-cell adhesion in the 3D stacked-up culture of rat primary hepatocytes2006

    • Author(s)
      Sudo R, et. al.
    • Organizer
      World Congress of Biomechanics
    • Place of Presentation
      Miinchen,Germany
    • Year and Date
      2006-07-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝前駆細胞の増殖及び分化機構の解析2006

    • Author(s)
      今 純子, 他
    • Organizer
      第13回肝細胞研究会
    • Place of Presentation
      旭川
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 成人ヒト肝組織から分離した小型肝細胞の分離と無血清培養2006

    • Author(s)
      佐々木 寿誉, 他
    • Organizer
      第13回肝細胞研究会
    • Place of Presentation
      旭川
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞の無血清培養と遺伝子発現解析2006

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第13回肝細胞研究会
    • Place of Presentation
      旭川
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] EisaiHyperbilirubinemic Rat(EHBR)由来小型肝細胞における有機アニオントランスポーターの発現と機能2006

    • Author(s)
      大島 秀紀, 他
    • Organizer
      第13回肝細胞研究会
    • Place of Presentation
      旭川
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒト肝細胞癌におけるラミニンα鎖の発現2006

    • Author(s)
      吉川 大和, 他
    • Organizer
      第13回肝細胞研究会
    • Place of Presentation
      旭川
    • Year and Date
      2006-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マイクロチタン繊維ScaffoldによるbFGF徐放と骨再生2006

    • Author(s)
      市戸 義久, 他
    • Organizer
      「ナノトキシコロジーアセスと微粒子・ナノチューブのバイオ応用」研究会
    • Place of Presentation
      札幌
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 幹細胞を用いた組織・臓器再生-肝から学ぶ-2006

    • Author(s)
      三高 俊広
    • Organizer
      第3回泌尿器科再建再生研究会
    • Place of Presentation
      札幌
    • Year and Date
      2006-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞を中心とした肝前駆細胞の分化・増殖の解析2006

    • Author(s)
      今 純子, 他
    • Organizer
      第42回日本肝臓学会総会
    • Place of Presentation
      京都
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小型肝細胞・類肝組織による有機アニオン輸送モデルの検討2006

    • Author(s)
      大島 秀紀, 他
    • Organizer
      第42回日本肝臓学会総会
    • Place of Presentation
      京都
    • Year and Date
      2006-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 初代培養ラット胆管上皮細胞の管腔ネットワーク形成2006

    • Author(s)
      深沢 一知, 他
    • Organizer
      第45回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2006-05-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristics of small hepatocytes as hepatic progenitor cells and a reconstruction of hepatic organoids in vitro2006

    • Author(s)
      Mitaka T
    • Organizer
      The 2nd International Symposium on Develop mental Biology and Tissue Engineering
    • Place of Presentation
      Yokohama
    • Year and Date
      2006-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Characteristics of small hepatocytes as hepatic progenitor cells and a reconstruction of hepatic organoids in vitro2006

    • Author(s)
      T., Mitaka
    • Organizer
      The 2nd International Symposium on Developmental Biology and Tissue Engineering.
    • Place of Presentation
      Tokyo Institute of Technology Yokohama, Japan
    • Year and Date
      2006-03-24
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CD44陽性小型肝細胞の増殖及び分化の解析2006

    • Author(s)
      今 純子, 他
    • Organizer
      第5回日本再生医療学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット肝前駆様細胞の分離・培養と肝細胞への分化の検討2006

    • Author(s)
      長屋 昌樹, 他
    • Organizer
      第5回日本再生医療学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 一軸配向性アパタイトセラミックスのin vitro評価2006

    • Author(s)
      市戸 義久, 他
    • Organizer
      第5回日本再生医療学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2006-03-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット初代培養肝細胞の3次元積層培養における細胞間接着の解析2006

    • Author(s)
      須藤 亮, 他
    • Organizer
      第18回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小型肝細胞コロニーの形態形成に対する多孔性膜の影響2006

    • Author(s)
      高橋 憲生, 他
    • Organizer
      第18回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット胆管上皮細胞による管構造ネットワークの再形成2006

    • Author(s)
      橋本 渉, 他
    • Organizer
      第18回バイオエンジニアリング講演会
    • Place of Presentation
      新潟
    • Year and Date
      2006-01-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of cellular configuration by cell-cell adhesion in the 3D stacked-up culture of rat primary hepatocytes2006

    • Author(s)
      Sudo, R, et. al.
    • Organizer
      World Congress of Biomechanics
    • Place of Presentation
      Miinchen, Germany, 2006
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Proliferation of Hepatic Progenitor Cells Isolated from Adult Human Livers2006

    • Author(s)
      Sasaki, K, et. al.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass, Colorado, U.S.A.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CD44 expression in rat small hepatoytes2006

    • Author(s)
      Kon, J, et. al.
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass, Colorado, U.S.A.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞を用いた3次元培養による肝組織形成:各種scaffoldとの共培養2005

    • Author(s)
      西陰 亜紀, 他
    • Organizer
      第43回日本人工臓器学会
    • Place of Presentation
      東京
    • Year and Date
      2005-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Thermoreversible gelation polymer induces the regeneration of partially injured rat liver accompanying the stem/progenitor cells derived from bile ducts2005

    • Author(s)
      Nagaya M, et. al.
    • Organizer
      The 56th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2005-11-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reconstruction of 3D Liver-like Structures by Stacking up Layers of Rat Small Hepatocytes2005

    • Author(s)
      Sudo R, et. al.
    • Organizer
      The Second Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      Kyoto
    • Year and Date
      2005-09-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reconstruction of 3D Liver-like Structures by Stacking up Layers of Rat Small Hepatocytes2005

    • Author(s)
      Sudo, R, et. al.
    • Organizer
      The Second Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2005-09-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 凍結ラット小型肝細胞における薬物代謝酵素及び核内受容体の発現解析2005

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第86回北海道癌談話会
    • Place of Presentation
      札幌
    • Year and Date
      2005-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CD44陽性小型肝細胞の肝障害モデルラットへの移植2005

    • Author(s)
      今 純子, 他
    • Organizer
      第86回北海道癌談話会
    • Place of Presentation
      札幌
    • Year and Date
      2005-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒアルロン酸による小型肝細胞の増殖機構の解析2005

    • Author(s)
      今 純子, 他
    • Organizer
      第12回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット胆管由来肝前駆様細胞の分離と培養2005

    • Author(s)
      長屋 昌樹, 他
    • Organizer
      第12回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小型肝細胞・類肝組織を用いたinvitroにおける胆汁うっ帯病変の解析2005

    • Author(s)
      大島 秀紀, 他
    • Organizer
      第12回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 凍結ラット小型肝細胞における薬物代謝酵素及びその核内受容体の発現解析2005

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第12回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝再生過程におけるラミニンの発現とその役割2005

    • Author(s)
      吉川 大和、三高 俊広
    • Organizer
      第12回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット胆管上皮細胞のゲルサンドイッチ培養による管構造の形成2005

    • Author(s)
      橋本 渉, 他
    • Organizer
      第12回肝細胞研究会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット肝臓における性差2005

    • Author(s)
      三高 俊広
    • Organizer
      第3回北海道性差医学・医療研究会
    • Place of Presentation
      札幌
    • Year and Date
      2005-07-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝前駆細胞による肝再生2005

    • Author(s)
      三高 俊広
    • Organizer
      第23回日本肝移植研究会
    • Place of Presentation
      札幌
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bile canalicular formation in 3D stacked-up culture of rat small hepatocytes and nonparenchymal cells2005

    • Author(s)
      Sudo R, et. al.
    • Organizer
      2005 Summer Bioengineering Conference
    • Place of Presentation
      Vail,Colorado,U.S.A.
    • Year and Date
      2005-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reconstruction of ductular structure by rat biliary epithelial cells2005

    • Author(s)
      Hashimoto W, et. al.
    • Organizer
      2005 Summer Bioengineering Conference
    • Place of Presentation
      Vail,Colorado,U.S.A.
    • Year and Date
      2005-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小型肝細胞・類肝組織における有機アニオントランスポーター発現の検討2005

    • Author(s)
      大島 秀紀, 他
    • Organizer
      第41回日本肝臓学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞特異的遺伝子CD44の機能解析2005

    • Author(s)
      今 純子, 他
    • Organizer
      第41回日本肝臓学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アデノウイルスベクターを用いたPDX-1遺伝子の肝細胞への導入とβ細胞化2005

    • Author(s)
      川崎 浩之, 他
    • Organizer
      第41回日本肝臓学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In Vitroでの肝前駆様細胞誘導(HPC)とその分離及び解析2005

    • Author(s)
      長屋 昌樹, 他
    • Organizer
      第41回日本肝臓学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット小型肝細胞における薬物代謝酵素の発現解析2005

    • Author(s)
      大栄 秀和, 他
    • Organizer
      第41回日本肝臓学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Filled thermoreversible gelation polymer resulted in the complete recovery of focal defect in a rat2005

    • Author(s)
      Nagaya M, et. al.
    • Organizer
      40th Congress of the European Society for Surgical Research
    • Place of Presentation
      Konya,Turkey
    • Year and Date
      2005-05-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 温度感受性ハイドロゲル(TGP)を充填した肝小欠損蒼曜における新しい再生のメカニズムと肝前駆細胞2005

    • Author(s)
      長屋 昌樹, 他
    • Organizer
      第105回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-05-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット胆管上皮細胞による管構造の再形成2005

    • Author(s)
      橋本 渉, 他
    • Organizer
      第44回日本生体医工学会大会
    • Place of Presentation
      つくば
    • Year and Date
      2005-04-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reconstruction of 3D liver-like structures by stacking cell-layers cultured on microporous membranes2005

    • Author(s)
      Sudo R, et. al.
    • Organizer
      6th Asian-Pacific Conference on Medical and Biological Engineering
    • Place of Presentation
      Tsukuba
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラット胆管上皮細胞による管構造の形成2005

    • Author(s)
      橋本 渉, 他
    • Organizer
      第26回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reconstruction of 3D liver-like structures by stacking cell-layers cultured on microporous membranes2005

    • Author(s)
      Sudo, R, et. al.
    • Organizer
      6th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE2005)
    • Place of Presentation
      Tsukuba, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Filled thermoreversible gelation polymer resulted in the complete recovery of focal defect in a rat2005

    • Author(s)
      Nagaya, M, et. al.
    • Organizer
      40th Congress of the European Society for Surgical Research (ESSR)
    • Place of Presentation
      Konya, Turkey
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Bile canalicular formation in 3D stacked-up culture of rat small hepatocytes and nonparenchymal cells2005

    • Author(s)
      Sudo, R, et. al.
    • Organizer
      2005 Summer Bioengineering Conference
    • Place of Presentation
      Vail, Colorado, U.S.A.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reconstruction of ductular structure by rat biliary epithelial cells2005

    • Author(s)
      Hashimoto, W, et. al.
    • Organizer
      2005 Summer Bioengineering Conference
    • Place of Presentation
      Vail, Colorado, U.S.A
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Thermoreversible gelation polymer induces the regeneration of partially injured rat liver accompanying the stem/progenitor cells derived from bile ducts2005

    • Author(s)
      Nagaya, M, et. al.
    • Organizer
      The 56th Annual Meeting of the American Association of the Study of Liver Diseases
    • Place of Presentation
      San Francisco, U.S.A.
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝子医学MOOK別冊「進みつづける細胞移植治療の実際」2008

    • Author(s)
      今 純子、三高 俊広
    • Publisher
      株式会社メディカルドゥ(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 遺伝子医学MOOK別冊「進みつづける細胞移植治療の実際」2008

    • Author(s)
      今 純子、他
    • Publisher
      株式会社メディカル ドゥ(印刷中)
    • Related Report
      2007 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://web.sapmed.ac.jp/canpath/

    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 特異的抗体を用いる小型肝細胞の分離法2005

    • Inventor(s)
      今純子 三高俊広
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Filing Date
      2005-06-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] ヒアルロン酸を用いた小型肝細胞の選択的培養法及び分離法2005

    • Inventor(s)
      今純子 三高俊広
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Filing Date
      2005-06-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Overseas
  • [Patent(Industrial Property Rights)] 特異的抗体を用いる小型肝細胞の分離法2005

    • Inventor(s)
      今 純子, 三高 俊広
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Filing Date
      2005-06-29
    • Related Report
      2005 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒアルロン酸を用いた小型肝細胞の選択的培養法及び分離法2005

    • Inventor(s)
      今 純子, 三高 俊広
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Filing Date
      2005-06-29
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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