| Project/Area Number |
17390359
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHKOHCHI Nobuhiro University of Tsukuba, Graduate School of Comprehensive Human Sciences, professor (40213673)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Michitaka University of Hokkaido, Graduate School of Medicine, professor (80256510)
TANIGUCHI Hideki Yokohama City University, Department of Regenerative Medicine, professor (70292555)
YASUE Hiroshi National Institute of Agrobiological Sciences, Associate director (80113497)
FUKUNAGA Kiyoshi University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (20361339)
MURATA Soichiro University of Tsukuba, Graduate School of Comprehensive Human Sciences, Assistant professor (40436275)
湯沢 賢治 筑波大学, 大学院・人間総合科学研究科, 講師 (10240160)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,970,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥570,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2006: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2005: ¥9,400,000 (Direct Cost: ¥9,400,000)
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| Keywords | liver / platelet / treatment of liver failure / Kupffer cell / regeneration / Akt / thrombopoietin / anti-platelet antibody / クッパー細胞 / 胚不全治療 / トロンボポチエン / 小板 |
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| Research Abstract |
The aim of this research is to develop new treatment strategy of liver regeneration and liver failure using platelet function of hepato-proliferative effect. In 2005, we revealed that platelets promote liver regeneration after hepatectomy using mice. Platelets had direct effect on hepatocytes proliferation via PI3 kinase/Akt pathway. In 2006, we revealed that platelets promote liver regeneration after excessive hepatectomy. We also revealed that HGF and IGF-1 in platelets are the main effector of hepatocytes proliferation. To preserve platelets for a long time, we created a freeze dried platelet which preserved its shape, growth factors, and the effect of hepatocyte proliferation. In 2007, we revealed that platelets prevent progression of fibrosis and promote liver regeneration in cirrhotic rats and mice. The mechanism of reducing fibrosis by platelets was reducing TGF beta and increasing MMP-9 expression. In this research, we indicated that platelets and platelet products would be effective in liver cirrhosis treatment. We will continue clinical studies for treating severe liver diseases using platelets
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