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Improving angiogenesis in the ischemic heart : Learning from the development process of coronary artery and wound healing

Research Project

Project/Area Number 17390386
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

TOMIZAWA Yasuko (2006)  Tokyo Women's Medical University, Dept of Cardiovascular Surgery, Instructor, 医学部, 助手 (00159047)

遠藤 真弘 (2005)  東京女子医科大学, 医学部, 教授 (20075302)

Co-Investigator(Kenkyū-buntansha) 冨澤 康子  東京女子医科大学, 医学部, 助手 (00159047)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥15,700,000 (Direct Cost: ¥15,700,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥11,200,000 (Direct Cost: ¥11,200,000)
Keywordsangiogenesis / wound healing / ischemia / coronary artery / reconstruction / development / 虚血性心疾患 / 心不全 / 虚血
Research Abstract

It is known that coronary arteries are formed with vasculogenesis. The proximal part of coronary artery doesn't go out from the aorta (outgrowth), but comes into the aorta (ingrowth) by surrounding small vessels. In 1967, Professor Sakakibara developed a new method to introduce blood from the aorta to the left ventricular wall by making a channel. The idea was excellent, since the channel received blood at the same pressure as the coronary arteries, and it was patent two months after the procedure in a canine study. We often observe natural coronary collateral growth angiographically in patients with ischemic heart disease. It is well known that the heart is an organ rich in endothelial cells. The condition to introduce new blood vessels into the ischemic myocardium was searched. For wound healing, the combination of cells, cytokines and scaffolds are the important factors to accelerate the healing. Recently, it was recognized that none of the clinical studies about angiogenesis was unsuccessful, since the development of coronary arteries has not been clarified, the mechanism of angiogenesis in a heart is not certain, a method is still missing how differentiate the new formed vessels from old ones. We turned back to where the roads branched and started from the observation of angiogenesis with buds of vessels.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (28 results)

All 2007 2006 2005 Other

All Journal Article (28 results)

  • [Journal Article] Local injection of a sustained-release antiandrogen formulation into a target prostatic site : an experimental study2007

    • Author(s)
      Goya N, Tomizawa Y, et al.
    • Journal Title

      BJU Int 99

      Pages: 202-206

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 軽量で開閉可能な家兎耳介観察窓の開発2007

    • Author(s)
      佐藤章, 冨澤康子, 他
    • Journal Title

      呼吸と循環 55

      Pages: 359-362

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Local injection of a sustained-release antiandrogen formulation into a target prostatic site : an experimental study.2007

    • Author(s)
      Goya N, Tomizawa Y, et al.
    • Journal Title

      BJU Int 99

      Pages: 202-206

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Local injection of a sustained-release antiandrogen formulation into a target prostatic site : an experimental study2007

    • Author(s)
      Goya N, Tomizawa Y, et al.
    • Journal Title

      BJU Int, 99

      Pages: 202-206

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 軽量で開閉可能な家免耳介観察窓の開発2007

    • Author(s)
      佐藤 章, 冨澤康子, 他
    • Journal Title

      呼吸と循環 55

      Pages: 359-362

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Corrosion of stainless steel sternal wire after long-term implantation2006

    • Author(s)
      Tomizawa Y
    • Journal Title

      Journal of Artificial Organs 9

      Pages: 61-66

    • NAID

      10017479543

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] A Novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle2006

    • Author(s)
      Murakami Y, Tomizawa Y, et al.
    • Journal Title

      Journal of Biomedical Materials Research-Part A 80

      Pages: 421-427

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 「研究成果報告書概要(和文)」より2006

    • Author(s)
      Sawa Y, Tomizawa Y, et al.
    • Journal Title

      Journal of Artificial Organs 9

      Pages: 1-7

    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Corrosion of stainless steel sternal wire after long-term implantation.2006

    • Author(s)
      Tomizawa Y, et al.
    • Journal Title

      J Artif Organs 9

      Pages: 61-66

    • NAID

      10017479543

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Journal of Artificial Organs 2005 : the year in review.2006

    • Author(s)
      Sawa Y, Tomizawa Y, et al.
    • Journal Title

      J Artif Organs 9

      Pages: 1-7

    • NAID

      10017479260

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Chronic expanding intrapericardial hematoma after pericardial paracentesis.2006

    • Author(s)
      Sughiura T, Tomizawa Y, et al.
    • Journal Title

      J Card Surg 21

      Pages: 491-493

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle.2006

    • Author(s)
      Murakami Y, Tomizawa Y, et al.
    • Journal Title

      J Biomed Mater Res A 29;80A(2)

      Pages: 421-427

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] A Novel synthetic tissue-adhesive hydrogel using a crosslinkable polymeric micelle2006

    • Author(s)
      Murakami Y, Tomizawa Y, et al.
    • Journal Title

      Journal of Mater Res 80

      Pages: 421-427

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chronic expanding intrapericardioal hematoma after pericardial paracetesis2006

    • Author(s)
      Sughiura T, Tomizawa Y, et al.
    • Journal Title

      J Card Surg 21

      Pages: 491-493

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 【体外循環を安全に行うためのシュミレーション教育】体外循環のトラブルシュミレーション ウエットラボの経験2006

    • Author(s)
      冨澤康子
    • Journal Title

      人工臓器 35

      Pages: 219-223

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A single local application of recombinant human basic fibroblast growth factor accelerates initial angiogenesis during wound healing in rabbit ear chamber.2005

    • Author(s)
      Komori M, Tomizawa Y, et al.
    • Journal Title

      Anesth Analg 100

      Pages: 830-834

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Endothelialization and functional neointima on vascular grafts in humans.2005

    • Author(s)
      Tomizawa Y.
    • Journal Title

      Ann Thorac Surg 79

      Pages: 1465-1465

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effects of Colloid Resuscitation on Peripheral Microcirculation, Hemodynamics, and Colloidal Osmotic Pressure During Acute Severe Hemorrhage in Rabbits.2005

    • Author(s)
      Komori M, Tomizawa Y, et al.
    • Journal Title

      Shock 23(4)

      Pages: 377-382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Left ventricular true aneurysm with pseudoaneurysm detected five years and nine months following repair for oozing type free wall rupture.2005

    • Author(s)
      Sato M, Tomizawa Y, et al.
    • Journal Title

      Jpn J Thorac Cardiovasc Surg 53

      Pages: 147-149

    • NAID

      10015522866

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Survival benefit of exclusive use of in situ arterial conduits over combined use of arterial and vein grafts for multiple coronary artery bypass grafting.2005

    • Author(s)
      Nishida H, Tomizawa Y, et al.
    • Journal Title

      Circulation 112(9 Suppl)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Clinical benefits and risk analysis of topical hemostats : a review.2005

    • Author(s)
      Tomizawa Y.
    • Journal Title

      J Artif Organs 8(3)

      Pages: 137-142

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Survival benefit of exclusive use of in situ arterial conduits over combined use of arterial and vein grafts for multiple coronary artery bypass grafting2005

    • Author(s)
      Nishida H, Endo M, et al.
    • Journal Title

      Circulation 112

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Left ventricular true aneurysm with pseudoaneurysm detected five years and nine months following repair for oozing type free wall rupture2005

    • Author(s)
      Sato M, Endo M, et al.
    • Journal Title

      Jpn J Thorac Cardiovasc Surg 53

      Pages: 147-149

    • NAID

      10015522866

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinical benefits and risk analysis of topical hemostats : a review2005

    • Author(s)
      Tomizawa Y
    • Journal Title

      J Artif Organs 8

      Pages: 137-142

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Endothelialization and functional neointima on vascular grafts in humans2005

    • Author(s)
      Tomizawa Y
    • Journal Title

      Ann Thorac Surg 79

      Pages: 1465-1465

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 本邦開発の体内埋込型人工心臓の現状と未来 本邦発体内植込み型遠心ポンプEVAHEARTの臨床治験について2005

    • Author(s)
      山崎健二, 遠藤真弘 他
    • Journal Title

      呼吸と循環 53

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 包括医療(DPC)から見た術式の選択 疾患別IVR vs.手術の比較 冠動脈疾患の治療2005

    • Author(s)
      西田博, 遠藤真弘 他
    • Journal Title

      INNERVISION 20

      Pages: 19-23

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Certified perfusionists in Japan

    • Author(s)
      Tomizawa Y
    • Journal Title

      J Artif Organs 2007(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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