| Project/Area Number |
17390390
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MATSUMURA Akira University of Tsukuba, Graduate School of Comprehensive Human Science, Professor (90241819)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (30375505)
SHIBATA Yasushi University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (50400685)
KAGEJI Teruyoshi University of Tsukuba, Department of Neurosurgery, Assistant Professor (70294684)
KUMADA Hiroaki Japan Atomic Energy Agency, Departmentof Research Reactor and TandemAccelerator, Researcher (30354913)
ISOBE Tomonori University of Tsukuba, Graduate School of Comprehensive Human Science, Assistant Professor (70383643)
森田 明夫 東京大学, 医学部附属病院, 助教授 (60302725)
藤堂 具紀 東京大学, 医学部附属病院, 講師 (80272566)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥15,810,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2005: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | Glioma / BNCT / Boron / Neutron / Brain Tumor / 脳腫瘍 / BMCT / グリオブラストーマ |
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| Research Abstract |
Clinical trial of BNCT for Glioblastoma
Eight patients with histological proven glioblastoma with an average age of 65 years (range 32-76, M:F=2:6) were underwent BNCF with new protocol which add 30Gy X ray irradiation after BNCT. 7 patients were treated with intra-operative BNCT before the protocol. In these 15 cases, 5 cases are alive; the average post BNCT follow up period was 20.3 months. Time to progression was 11.9 months, overall survival was 25.3 months. Adverse event (Grade 3>) were seen in 2 cases; convulsion and brain swelling (1 case) and transient oculomotor palsy (1 case). These result superior to standard treatments and suggest the effectiveness of the BNCT for malignant glioma
MR spectroscopy
For estimating absolute concentration of boron compounds in tissue, proton MR spectroscopy (MRS) was applied to quantify phenylalanine and L-p-boronophenylalanine (BPA). We could identify several characteristic resonances, peak of 7.32ppm (phenylalanine), four peak ranged 7.1 ppm to 7.6 ppm (BPA). A water phantom were used, and absolute concentration were obtained by proton MRS using a tissue water signal as an internal standards. These methods have high correlation between the calculated concentrations based on MRS and the known concentration. (R=0.99: phenylalanine and BPA).
These clinical results appear to encouraging, but the effectiveness of the invading tumor cells are still unclear. Improved tumor targeting boron delivery and neutron distribution will enhance the therapeutic effectiveness of BNCT.
MR spectroscopy results indicate that proton MRS can be non-invasive and potentially useful technique for BPA quantification in BNCT.
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