Development of novel diagnostic and therapeutic strategies for malignant brain tumors by genome-wide gene expression profile analysis using 100 cases of data set.
| Project/Area Number |
17390394
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kurume University (2006)
Niigata University (2005) |
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Principal Investigator |
YAMANAKA Ryuya Kurume University, Research Center for Innovative Cancer Therapy, Professor, 先端癌治療研究センター, 教授 (20323991)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO Kazuto Kinki University, Medical School, Professor, 医学部, 教授 (10208134)
TAKEDASU Hiroko Kurume University, Medical School, Instructor, 医学部, 助手 (70343697)
TAUMANUMA Itaru Niigata University, Medical and Dental Hospital, Instructor, 医歯学総合病院, 助手 (30313539)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥15,600,000)
Fiscal Year 2006: ¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 2005: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | malignant brain tumor / Gene expression profile / Microarray / Peptide / Molecular Targeted Therapy / SiRNA / 抗体 |
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| Research Abstract |
Glioblastoma, anaplastic glioma(Grade III), low grade glioma, primary central nervous system lymphoma and normal brain samples were-studied ( total of 100 samples ) using cDNA microarray technology. The phylogenetic tree resulting from the hierarchical clustering algorithm have employed. Fifty genes were selected as specific molecular targeted genes in glioblastoma and primary central nervous system lymphoma. In conclusion, accumulation of data with respect to expression profiles of malignant brain tumor specimens, clinico-pathological data, susceptibility to treatment, and outcome will bring us information for identifying optimized therapeutic modalities for individual patients and novel therapeutic targets.
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Report
(3 results)
Research Products
(54 results)
