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Therapy for CNS diseases using intracerebral transplantation of encapsulated neural stem cells

Research Project

Project/Area Number 17390400
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOkayama University

Principal Investigator

DATE Isao  Okayama University, GRADUATE SCHOOL OF MEDICINE DENTISTRY AND PHARMACEUTICAL SCIENCES, PROFESSOR (70236785)

Co-Investigator(Kenkyū-buntansha) SUGIU Kenji  OKAYAMA UNIVERSITY HOSPITALS, 医学部・歯学部附属病院, Senior, Assistan+Professor (40325105)
TOKUNAGA Kouji  OKAYAMA UNIVERSITY HOSPITALS, 医学部・歯学部附属病院, Senior, Assistant+Professor (40294467)
MIYOSHI Yasuyuki  OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE DENTISTRY AND PHARMACEUTICAL SCIENCES, Senior Assistant Professor (00362997)
ONO Shigeki  OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE DENTISTRY AND PHARMACEUTICAL SCIENCES, ASSISTANT PROFESSOR (40335625)
ISHIKAWA Tomotsugu  OKAYAMA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE DENTISTRY AND PHARMACEUTICAL SCIENCES, ASSISTANT PROFESSOR (10362964)
小野田 恵介 (小野田 惠介)  岡山大学, 大学院・医歯薬学総合研究科, 助手 (20379837)
松井 利浩  岡山大学, 大学院・医歯薬学総合研究科, 助手 (80362995)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,910,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2006: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2005: ¥5,500,000 (Direct Cost: ¥5,500,000)
Keywordsneural stem / progenitor cells / encapsulation / Dopamine neuron / Parkinson's disease / cerebral ischemia / neurotrophic factor / カプセル / 細胞外基質 / 腫瘍化 / 分化誘導
Research Abstract

After confirmation of the therapeutic effects of encapsulated ES cell- or NT2 cell-derived dopaminergic neurons on Parkinson's diming= model of rats, adult rat-derived neural stem/progenitor cells were focused on. Encapsulated adult rat-derived neural stem/progenitor calls survived for 2 months with or without prospective neuronal differentiation without tumor formation. Then, neural stem/progenitor cells were isolated from adult macaque subventricular zone or hippocampus. The growth speed of the cells was so slow that it took at least one and a half months to he amplified for encapsulation. Type I collagen remarkably ameliorated the survival of encapsulated neural stem/progenitor rolls and the surviving rate of the encapsulated macaque cells were almost the same as that of rat cells. Neuronal differentiation of encapsulated undifferentiated macaque-derived neural stern/progenitor cells was little with much glial differentiation. Encapsulated undifferentiated cells survived for 1 month in a Parkinson's disease model of macaque, although it did not significantly ameliorate abnormal behavior On the other hand, macaque-derived neural stern/progenitor rolls could be encapsulated after neuronal differentiation. Dopaminergic differentiation with subsequent encapsulation resulted in dopamine-secretion from the capsule. Encapsulated differentiated rolls improved the behavioral scores, indicating that encapsulated dopaminergic neurons derived from adult macaque neural stem/progenitor cells had therapeutic effects on a Parkinson's disease model of macaque with no tumor formation by thstiff capsule wall Clinical application might be achievable in the figure, although several preclinical studies remain to be solved.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (25 results)

All 2007 2006 2005

All Journal Article (18 results) (of which Peer Reviewed: 7 results) Presentation (7 results)

  • [Journal Article] 成体由来神経幹細胞の有用性-臨床応用をめざして-2007

    • Author(s)
      伊達 勲、新郷哲郎、村岡賢一郎, 他2名
    • Journal Title

      Cognition and Dementia 6

      Pages: 18-24

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 神経疾患と神経再生-パーキンソン病と脳虚血を中心に-2007

    • Author(s)
      伊達 勲
    • Journal Title

      日本老年医学会雑誌 44

      Pages: 72-75

    • NAID

      10018513308

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 脳神経再生-パーキンソン病と脳虚血の治療をめざして一2007

    • Author(s)
      伊達 勲
    • Journal Title

      人工臓器 36

      Pages: 130-133

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease2007

    • Author(s)
      Yasuhara T, Shingo T, Date I
    • Journal Title

      Acta Medica Okayama 61

      Pages: 51-56

    • NAID

      120002312040

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intracerebral transplantation of genetically engineered cells for Parkinson's disease2007

    • Author(s)
      Yasuhara T and Date I
    • Journal Title

      Cell Transplantation 16

      Pages: 125-132

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy of adult-derived neural stem/progenitor cells : For clinical application2007

    • Author(s)
      Date, I., Shingo, T., Muraoka, K., Kameda, M., Yasuhara, T
    • Journal Title

      Cognition and Dementia 6(1)

      Pages: 18-24

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuronal regeneration and CNS diseases2007

    • Author(s)
      Date, I
    • Journal Title

      Geriatric Medicine 44(1)

      Pages: 72-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Regeneration of neurons : Therapy for Parkinson's disease and cerebral ischemia2007

    • Author(s)
      Date, I
    • Journal Title

      Artificial Organ 36(1)

      Pages: 130-133

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease2007

    • Author(s)
      Yasuhara, T., Shingo, T., Date, I
    • Journal Title

      Acta Medica Okayama 61

      Pages: 51-56

    • NAID

      120002312040

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intracerebral transplantation of genetically engineered cells for Parkinson's disease2007

    • Author(s)
      Yasuhara, T., Date, I
    • Journal Title

      Cell Transplantation 16

      Pages: 125-132

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 脳神経再生-パーキンソン病と脳虚血の治療をめざして-2007

    • Author(s)
      伊達 勲
    • Journal Title

      人工臓器 36

      Pages: 130-133

    • NAID

      10025703845

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glial cell line-derived neurotrophic factor(GDNF)therapy for Parkinson's disease2007

    • Author(s)
      Yasuhara T, Shingo T, Date I
    • Journal Title

      Acta Medica Okayama 61

      Pages: 51-56

    • NAID

      120002312040

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo gene therapy : transplantation of neurotrophic factor-secreting cells for cerebral ischemia2006

    • Author(s)
      Yasuhara T
    • Journal Title

      Frontiers in Bioscience 11

      Pages: 760-775

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Genetically modified cell line grafting for the treatment of Parkinson's disease2006

    • Author(s)
      Date I
    • Journal Title

      Minimally Invasive Neurosurgery and Multidisciplinary

      Pages: 108-113

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neuroprotection and repair by using adult-derived neural stem cell grafting for neurological disorders2006

    • Author(s)
      Date I
    • Journal Title

      Minimally Invasive Neurosurgery and Multidisciplinary

      Pages: 131-137

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing call demonstrating strong neuroprotective effects in a rat model of Parkinson, s disease2005

    • Author(s)
      Yasuhara T
    • Journal Title

      Journal of Neurosurgery 102・1

      Pages: 80-89

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The differences between high and low-dose administration of VEGF to dopaminergic neurons of in vitro and in vivo Parkinson's disease model2005

    • Author(s)
      Yasuhara T
    • Journal Title

      BRAIN RESEARCH 1038

      Pages: 1-10

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Toxicity of semaphorin3A for dopaminergic neurons2005

    • Author(s)
      Yasuhara T
    • Journal Title

      Neuroscience Letters 382

      Pages: 61-65

    • Related Report
      2005 Annual Research Report
  • [Presentation] Adult-derived neural stem cell grafting for the treatment of parkinson's disease and cerebral ischemia2007

    • Author(s)
      Date I
    • Organizer
      8th International Conference Alzheimer's and Parkinson's Diseases: Progress and New Perspectives 2007
    • Place of Presentation
      Salzburg
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 海馬細胞死に対するカプセル化BDNF産生細胞移植による神経細胞保護2007

    • Author(s)
      近藤聡彦、新郷哲郎、森本尊雅, 他6名
    • Organizer
      神経組織の成長・再生・移植研究会第22回学術集会
    • Place of Presentation
      岡山市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Adult-derived neural stem cell (NSC) grafting for the treatment of Parkinson's disease and cerebral ischemia2007

    • Author(s)
      Date I
    • Organizer
      World Federation of Neurosurgical Societies, 13th Interim Meeting, 12th Asian-Australasian Congress of Neurological Surgeons
    • Place of Presentation
      名古屋市
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adult-derived neural stem cell grafting for the treatment of parkinson's disease and cerebral ischemia2007

    • Author(s)
      Date, I
    • Organizer
      8th International Conference Alzheimer's and Parkinson's Diseases : Progress and New Perspectives
    • Place of Presentation
      Salzburg
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Neuroprotection of encapsulated BDNF-secreting cells on hippocampal neuronal cell death2007

    • Author(s)
      Kondo, A., Shingo, T., Morimoto, T., Tajiri, N., Yuen, WJ., Kuramoto, S., Agari, T., Miyoshi, Y., Date, I
    • Organizer
      Growth, Regeneration, and Transplantation of neural tissue
    • Place of Presentation
      Okayama
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adult-derived neural stem cell (NSC) grafting for the treatment of Parkinson's disease and cerebral ischemia2007

    • Author(s)
      Date, I
    • Organizer
      World Federation of Neurosurgical Societies, 13th Interim Meeting, 12th Asian-Australasian Congress of Neurological Surgeons
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adult-derived neural stem cell(NSC)grafting for the treatment of Parkinson's disease and cerebral ischemia2007

    • Author(s)
      Date I
    • Organizer
      World Federation of Neurosurgical Societies, 13th Interim Meeting, 12th Asian-Australasian Congress of Neurological Surgeons
    • Place of Presentation
      名古屋市
    • Related Report
      2007 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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