• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Mechanism of cerebral aneurysm formation in experimental model rats

Research Project

Project/Area Number 17390401
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionThe University of Tokushima

Principal Investigator

NAGAHIRO Shinji  The University of Tokushima, Institute of Health Biosciences, Professor, 大学院ヘルスバイオサイエンス研究部, 教授 (60145315)

Co-Investigator(Kenkyū-buntansha) SATOH Koichi  The University of Tokushima, Institute of Health Biosciences, Associate Professor, 大学院ヘルスバイオサイエンス研究部, 助教授 (90225938)
MATSUBARA Shunji  Tokushima University, Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (60294675)
NISHI Kyoko  Tokushima University, Hospital, Instructor, 医学部・歯学部附属病院, 助手 (60335817)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2005: ¥7,900,000 (Direct Cost: ¥7,900,000)
Keywordscerebral aneurysm / pathogenesis / experimental model / estrogen / hypertension / female
Research Abstract

Based on epidemiological data indicative of a high incidence of cerebral aneurysm (CA) in postmenopausal women, we established a reproducible CA model in female rats. To identify early ultrastructural morphological changes that lead to the formation of experimental cerebral aneurysm (CA), we induced renal hypertension and right common carotid artery ligation. To further elucidate the role of hormones, we examined the effects of oophorectomy.. The oophorectomy increased the susceptibility of rats to aneurysm formation and the incidence of CA was reduced by hormone replacement therapy, indicating that hormones play a role in the pathogenesis of cerebral aneurysms. (J Neurosurg. 2005 ; 103 : 1046-51) (J Neurosurg. 2005 ; 103 : 1052-7)
To clarify the series of early events that leads to IA formation, the aneurysmal morphological changes on vascular corrosion cast to its parallel pathological changes in cerebral arteries were compared. We proposed that the formation of IAs starts with endothelial injury at the apical intimal pad (stage I), this lead to the formation of inflammatory zone (stage II). Partial tear or defect in the inflammatory zone will follow. Expansion of this defect forms the nidus for IA (stage III). Ours is the first demonstratation of the sequence of ultrastructural morphological and pathological changes that leads to the formation of saccular IAs in vivo. Detailed knowledge regarding these changes is crucial for an understanding of IA pathogenesis, and for introducing new preventive and therapeutic strategies that interrupt this cascade of aneurysmal changes (J Neurosurg. 2007, in press).

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (11 results)

All 2007 2005 Other

All Journal Article (11 results)

  • [Journal Article] Endothelial Injury and Inflammatory Response Induced by Hemodynamic Changes Precede Intracranial Aneurysm Formation : Experimental study in rats2007

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm : an experimental study in rats2005

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery 102

      Pages: 532-535

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part I : experimental study of the effect of oophorectomy in rats2005

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery 103

      Pages: 1046-1051

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II : experimental study of the effects of hormone replacement therapy in rats2005

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery 103

      Pages: 1052-1057

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm : an experimental study in rats.2005

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery 102

      Pages: 532-535

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part I : experimental study of the effect of oophorectomy in rats.2005

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery 103

      Pages: 1046-1051

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II : experimental study of the effects of hormone replacement therapy in rats.2005

    • Author(s)
      Jamous MA
    • Journal Title

      Journal of Neurosurgery 103

      Pages: 1052-1057

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Vascular corrosion casts mirroring early morphological changes that lead to the formation of saccular cerebral aneurysm : an experimental study in rats.2005

    • Author(s)
      Jamous MA, Nagahiro S, Kitazato KT, Satoh K, Satomi J.
    • Journal Title

      Journal of Neurosurgery 102

      Pages: 532-535

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part I : experimental study of the effect of oophorectomy in rats.2005

    • Author(s)
      Jamous MA, Nagahiro S, Kitazato KT, Satomi J, Satoh K.
    • Journal Title

      Journal of Neurosurgery 103

      Pages: 1046-1051

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II : experimental study of the effects of hormone replacement therapy in rats.2005

    • Author(s)
      Jamous MA, Nagahiro S, Kitazato KT, Tamura T, Kuwayama K, Satoh K.
    • Journal Title

      Journal of Neurosurgery 103

      Pages: 1052-1057

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Endothelial injury and inflammatory Response induced by Hemodynamic Changes Precede intracranial Aneurysm Formation : Experimental study in rats

    • Author(s)
      Jamous MA
    • Journal Title

      J Neurosurg (in press)

      Pages: 2007-2007

    • Related Report
      2006 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi