Mechanisms underlying inhibition of tumor-immunology in malignant glioma and development of immune-activation therapy using suicide-chimeric molecule
| Project/Area Number |
17390405
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Miyazaki (2006-2007)
Kumamoto University (2005) |
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Principal Investigator |
TAKESHIMA Hideo University of Miyazaki, Faculty of Medicine, Professor (70244134)
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| Co-Investigator(Kenkyū-buntansha) |
KURATSU Jun-ichi Kumamoto Univ, Faculty of Medicine, Professor (20145296)
UEHARA Hisao Kumamoto Univ, Faculty of Med, Associate Professor (80203470)
MORIYAMA Takuzo Kumamoto Univ, Faculty of Med, Assistant Professor (50239703)
平野 宏文 鹿児島大学, 医学部・歯学部附属病院, 講師 (00264416)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,400,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2005: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | malignant glioma / tumor immunology / MCP-1 / TGF-[○!R] / ABCA2 / oligodendroglioma / グリオーマ / TGF-b |
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| Research Abstract |
Malignant glioma is the most malignant tumor of the human neoplasms. Despite extensive clinical trials, a good clinical outcome has remained an elusive goal. The success of treatment is hampered by factors such as high degree of infiltration, resistance against irradiation and anti-cancer drugs, and existence of the blood brain barriers that inhibit the drug delivery into the central nervous system. In addition, it has been postulated that immuno-suppressive molecules produced by the tumor cells inhibit the establishment of the anti-tumor immunity such as TGF-β.
In this project, we initially investigated the correlation between the expression of TGF-β and prognosis of the patients with malignant glioma using tissue microarray. However, we failed to show the statistical significance between them. To search for the novel immuno-suppressant produced by the malignant glioma, we investigated the molecules that were specifically expressed by the anaplastic oligodendroglioma, which is malignant but has good prognosis.
Among these molecules, we focused on ABCA2, a membranous protein. Quantitative real-time PCR, immunoblot and immunohistochemical study demonstrated that ABCA2 is highly expressed in oligodendroglial tumors than in astrocytic tumors. Although biological role on the tumor immunology is still under investigation, it is interesting that ABCA2 could serve as a novel tumor marker for oligodendrogliomas.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Clinical significance of ABCA2, a possiblemolecular marker for oligodendrogliomas2007
Author(s)
Obara, S., Nakata, M., Takeshima, H., Arita, Inagaki, N., Kuratsu, J
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Journal Title
Neurosurgery 60
Pages: 707-714
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Single nucleotide polymorphism 309 affects murin-double-minute 2 protein expression but not glioma tumorigenesis2007
Author(s)
Tsuiki, H., Nishi, T., Takeshima, H., Yano, S., Nakamura, H., Makino, K., Kuratsu, J
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Journal Title
Neurol Med Chir(Tokyo) 47
Pages: 203-8
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Role of Kunitz domains in anti-invasive effect of hepatocyte growth factor activator inhibitor type 1 in human glioblastoma cells2007
Author(s)
Miyata, S., Fukushima, T., Kohama, K., Tanaka, H., Takeshima, H., Kataoka, H
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Journal Title
Hum Cell 20
Pages: 100-106
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Recurrent intracranial germinoma outside the initial radiation field a single-institution study2006
Author(s)
Nakamura, H., Takeshima, H., Makino, K., Kochi, M., Ushio, Y., Kurats, J
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Journal Title
Acta Oncol 45
Pages: 476-483
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Rising incidence of primary central nervous system lymphoma in Kumamoto, Japan2006
Author(s)
Makino, K., Nakamura, H., Kino, T., Takeshima, H., Kuratsu, J
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Journal Title
Surg Neurol 66
Pages: 503-506
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] The environment of increased concentration of docosahexaenoic acid in glioblastoma may suppress the anti-tumor effect of macrophages2005
Author(s)
Hirano, H., Takeshima, H., Niiro, M., Nagayama, T., Oyoshi, T., Kuratsu, J
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Journal Title
Oncology Rep 13
Pages: 1185-1191
Description
「研究成果報告書概要(欧文)」より
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