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Clinical application of cervical and lumbar artificial intervertebral disc consisting of composite material for the anterior and posterior replacement

Research Project

Project/Area Number 17390407
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

KOTANI Yoshihisa  Hokkaido University, Grad Schcol of Med., Lecturer (40312368)

Co-Investigator(Kenkyū-buntansha) ABUMI Kuniyoshi  Hokkaido Univ, Health Administration Center, Professor (00159419)
ITO Manabu  Hokkaido University, Grad. School of Med., Asso. Prof. (00271677)
MINAMI Akio  Hokkaido University, Grad. School of Med., Professor (20133738)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥7,440,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2005: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsArtificial intervertebral disc / Spinal Reconstruction / Biomaterial / Hydroxyapatite / Poly-L-lactic acid / Bioresorbable material / 脊住再建
Research Abstract

Our 3^<rd> model of artificial intervertebral disc prosthesis was accomplished based on the detailed in vitro experiment and the long-term animal study. This is the triaxial three-dimensional fabric consisting of ultra-high molecular weight polyethylene fiber and hydroxyapaite/ poly-L-lactic acid. According to the pretrial review with ministry of health in Japan, the randomized clinical trial was recommended for study design, however, the detailed condition of single-arm trial was also advised. This puts the emphasis on the segmental mobility as the originality of the new device based on meta-analysis of published data According to clinical 226 pts data which was retrieved by meta-analysis data, we determined the study population when considering the expected range of motion and the safety range. According to the collaborated study with Kurume biostatistical research center, the final statistical data was calculated and the final protocol for clinical trial was completed. Following the agreement with university medical ethical committee, the multicenter clinical trial is now prepared. We are designing the surgical instrument with US Medtronics Co.. Using the cadaveric spines, the actual modification procedures of surgical instruments were performed in both Memphis, USA and Soeul, Korea.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (65 results)

All 2007 2006 2005

All Journal Article (47 results) (of which Peer Reviewed: 16 results) Presentation (16 results) Book (2 results)

  • [Journal Article] Accuracy analysis of pedicle screw placement in posteior scoliosis surgery: Comparison between conventional fluoroscopic and computer-assisted technique.2007

    • Author(s)
      Kotani Y, et. al.
    • Journal Title

      Spine 32

      Pages: 1543-1550

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evaluation of hydroxyapatite ceramic spacers with different porosities and their binding capability to the vertebral body: An experimental study in sheep.2007

    • Author(s)
      Ito M, Kotani Y, et. al.
    • Journal Title

      J Neurosurg Spine 6

      Pages: 431-437

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Comparison of novel ultra-high molecular weight polyethylene tape versus conventional metal wire for sublaminar segmental fixation in the treatment of adolescent idiopathic scoliosis2007

    • Author(s)
      Takahata M, Kotani Y, et. al.
    • Journal Title

      J Spinal Disord Tech 20

      Pages: 449-455

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical outcome of posterolateral endoscopic surgery for pyogenic spondylodiscitis: Results of 15 patients with serious comorbid conditions.2007

    • Author(s)
      Ito M, Kotani Y, et. al.
    • Journal Title

      Spine 32

      Pages: 313-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 腰椎可動性温存の意義とMotion Preservation technologyの現状(総説)2007

    • Author(s)
      小谷 善久
    • Journal Title

      腰痛シンポジウム講演記録集

      Pages: 3-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Accuracy analysis of pedicle screw placement in postetor scoliosis surgery: Comparison between conventional fluoroscopic and computer-assisted technique.2007

    • Author(s)
      Kotani Y.
    • Journal Title

      Spine 32

      Pages: 1543-50

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Evaluation of hydroxyapatite ceramic spacers with different porosities and their binding capability to the vertebral body: An experimental study in sheep.2007

    • Author(s)
      Ito M, Kotani Y.
    • Journal Title

      J Neurosurg Spine 6

      Pages: 431-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Comparison of novel ultra-high molecular weight polyethylene tape versus conventional metal wire for sublaminar segmental fixation in the treatment of adolescent idiopathic scoliosis2007

    • Author(s)
      Takahata M, Kotani Y.
    • Journal Title

      J Spinal Disord Tech 20

      Pages: 449-55

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Clinical outcome of posterolateral endoscopic surgery for pyogenic spondylodiscitis: Results of 15 patients with serious comorbid conditions.2007

    • Author(s)
      Ito M, Kotani Y.
    • Journal Title

      Spine 32

      Pages: 313-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The significance of lumbar mobility preservation and recent motion preservation technology.2007

    • Author(s)
      Kotani Y.
    • Journal Title

      Low back pain Symposium

      Pages: 3-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evaluation of hydroxyapatite ceramic spacers with different porosities and their binding capability to the vertebral body: An experinental study in sheep2007

    • Author(s)
      Ito M, Kotani Y, et. al.
    • Journal Title

      J Neurosurg Spine 6

      Pages: 431-437

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of novel ultra-high molecular weight polyethylene tape versus conventional metal wire for sublaminar segmental fixation in the treatment of adolescent idiopathic scoliosis2007

    • Author(s)
      Takahata M, Kotani Y, et. Al.
    • Journal Title

      J Spinal Disord Tech 20

      Pages: 449-455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腰椎可動性温存の意義とMotion Preservation technologyの現状2007

    • Author(s)
      小谷善久
    • Journal Title

      第17回腰痛シンポジウム講演記録集

      Pages: 3-12

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 外傷性頚部症候群-最近の進歩、外傷性頚部症候群の生体力学的解析の進歩2007

    • Author(s)
      小谷善久
    • Journal Title

      臨床整形外科 20

      Pages: 449-455

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 外傷性頚部症候群の病態:生体力学と理論物性科学2007

    • Author(s)
      小谷善久
    • Journal Title

      脊椎脊髄ジャーナル 20

      Pages: 303-308

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脊椎脊髄外科における先進医療の現状:画像支援と最小侵襲手術2007

    • Author(s)
      小谷善久
    • Journal Title

      札医通信 476

      Pages: 969-975

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical outcome of posterolateral endoscopic surgery for pyogenic spondylodiscitis : Results of 15 patients with serious comorbid conditions.2007

    • Author(s)
      Ito M, Kotani Y, et al.
    • Journal Title

      Spine 32

      Pages: 200-206

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Accuracy analysis of pedicle screw placement in posteior scoliosis surgery : Comparison between conventional fluoroscopic and computer-assisted technique.2007

    • Author(s)
      Kotani Y, et al.
    • Journal Title

      Spine 31(In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 腰椎可動性温存の意義とMotion Preservation technologyの現状(総説)2007

    • Author(s)
      小谷善久
    • Journal Title

      第17回腰痛シンポジウム講演記録集 17

      Pages: 3-12

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long-term follow-up of surgical treatment outcome for hemodialysis patients with cervical disorders.2006

    • Author(s)
      Sudo H, Kotani Y, et. al.
    • Journal Title

      J Neurosurg Spine 5

      Pages: 313-319

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Biomechanical study on the effect of five different lumbar reconstruction techniques on adjacent-level intradiscal pressure and lamina strain.2006

    • Author(s)
      Sudo H, Kotani Y, et. al.
    • Journal Title

      J Neurosurg Spine 5

      Pages: 150-155

    • NAID

      120000957289

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Palliative spinal reconstruction using cervical pedicle screws for metaststic lesions of the spine. A retrospective analysis of 32 cases.2006

    • Author(s)
      Oda I, Kotani Y, et. al.
    • Journal Title

      Spine 31

      Pages: 1439-1444

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multidirectional flexibility analysis of anterior and posterior lumbar artificialintervertebral disc replacement in human cadaveric spine model.2006

    • Author(s)
      Kotani Y, Cunningham B, et. al.
    • Journal Title

      Eur Spine J 15

      Pages: 1511-1520

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 人工椎間板の臨床応用2006

    • Author(s)
      小谷 善久
    • Journal Title

      整形外科knack & Pitfalls、脊椎外科の要点と盲点:胸腰椎

      Pages: 229-229

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Long-term follow-up of surgical treatment outcome for hemodialysis patients with cervical disorders.2006

    • Author(s)
      Sudo H, Kotani Y.
    • Journal Title

      J Neurosurg Spine 5

      Pages: 313-19

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Biomechanical study on the effect of five different lumbar reconstruction techniques on adjacent-level intradiscal pressure and lamina strain.2006

    • Author(s)
      Sudo H, Kotani Y.
    • Journal Title

      J Neurosurg Spine 5

      Pages: 150-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Palliative spinal reconstruction using cervical pedicle screws for metaststic lesions of the spine. A retrospective analysis of 32 cases.2006

    • Author(s)
      Oda I, Kotani Y.
    • Journal Title

      Spine 31

      Pages: 1439-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cunningham B, et al Multidirectional flexibility analysis of anterior and posterior lumbar artificial intervertebral disc replacement in human cadaveric spine model.2006

    • Author(s)
      Kotani Y.
    • Journal Title

      Eur Spine J 15

      Pages: 1511-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multidirectional flexibility analysis of anterior and posterior lumbar artificial intervertebral disc replacement in human cadaveric spine model.2006

    • Author(s)
      Kotani Y, et al.
    • Journal Title

      Eur Spine Journal 15

      Pages: 1511-1520

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Palliative spinal reconstruction using cervical pedicle screws for metaststic lesions of the spine. A retrospective analysis of 32 cases.2006

    • Author(s)
      Oda I, Kotani Y, et al.
    • Journal Title

      Spine 31

      Pages: 1439-1444

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Biomechanical study on the effect of five different lumbar reconstruction techniques on adjacent-level intradiscal pressure and lamina strain.2006

    • Author(s)
      Sudo H, Kotani Y, et al.
    • Journal Title

      J Neurosurg Spine 5

      Pages: 150-155

    • NAID

      120000957289

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long-term follow-up of surgical treatment outcome for hemodialysis patients with cervical disorders.2006

    • Author(s)
      Sudo H, Kotani Y, et al.
    • Journal Title

      J Neurosurg Spine 5

      Pages: 313-319

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 頚椎・胸椎手術におけるコンピュータ支援2006

    • Author(s)
      小谷善久, 他
    • Journal Title

      整形災害外科 49

      Pages: 1469-1480

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multidirectional flexibility analysis of anterior and posterior lumbar artificial intervertebral disc replacement in human cadaveric spine model.2006

    • Author(s)
      Kotani Y, et al.
    • Journal Title

      Eur Spine Journal 2(In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Iliac crest reconstruction with a bioactive ceramic spacer.2005

    • Author(s)
      Ito M, Kotani Y, et. al.
    • Journal Title

      Eur Spine J 14

      Pages: 99-102

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] An investigational study on the healing process of anterior spinal arthrodesis using a bioactive ceramic spacer and the change in load-sharing of spinal instrumentation.2005

    • Author(s)
      Takahata M, Kotani Y, et. al.
    • Journal Title

      Spine 30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cervical spine injuries associated with lateral mass and facet joint fractures: New classification and surgical treatment with pedicle screw fixation.2005

    • Author(s)
      Kotani Y, Abumi K, et. al.
    • Journal Title

      Eur Spine J 14

      Pages: 69-77

    • NAID

      120000963007

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 人工椎間板の臨床応用2005

    • Author(s)
      小谷 善久
    • Journal Title

      整形災害外科 48

      Pages: 1547-1553

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al Iliac crest reconstruction with a bioactive ceramic spacer.2005

    • Author(s)
      Ito M, Kotani Y.
    • Journal Title

      Eur Spine J 14

      Pages: 99-102

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] et al An investigational study on the healing process of anterior spinal arthrodesis using a bioactive ceramic spacer and the change in load-sharing of spinal instrumentation.2005

    • Author(s)
      Takahata M, Kotani Y.
    • Journal Title

      Spine 30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Abumi K, et at Cervical spine injuries associated with lateral mass and facet joint fractures: New classification and surgical treatment with pedicle screw fixation.2005

    • Author(s)
      Kotani Y.
    • Journal Title

      Eur Spine J 14

      Pages: 69-77

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical application of artificial intervertebral disc.2005

    • Author(s)
      Kotani Y.
    • Journal Title

      Orthopaedics and Traumatology 48

      Pages: 1547-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A biomechanical and histological evaluation of bioresorbable lumbar interbody fusion cage.2005

    • Author(s)
      Hojo Y, Kotani Y, et al.
    • Journal Title

      Biomaterials 26

      Pages: 2643-2651

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multidirectional flexibility analysis of cervical artificial intervertebral disc replacement in human cadaveric spine model.2005

    • Author(s)
      Kotani Y, et al.
    • Journal Title

      J Neurosurg (Spine) 2

      Pages: 188-194

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Cervical spine injuries associated-with lateral mass and facet joint fractures : new classification and surgical treatment with pedicle screw fixation.2005

    • Author(s)
      Kotani Y, et al.
    • Journal Title

      Eur Spine Journal 14

      Pages: 69-77

    • NAID

      120000963007

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 新しい医療技術:人工椎間板の臨床応用2005

    • Author(s)
      小谷 善久他
    • Journal Title

      整形災害外科 48

      Pages: 1547-1553

    • NAID

      40007052538

    • Related Report
      2005 Annual Research Report
  • [Journal Article] An investigational study on the healing process of anterior spinal arthrodesis using a bioactive ceramic spacer and the change in load-sharing of spinal instrumentation.2005

    • Author(s)
      Takahata M, Kotani Y, et al.
    • Journal Title

      Spine 30

    • Related Report
      2005 Annual Research Report
  • [Presentation] 本邦における人工椎間板研究の現状と臨床応用2007

    • Author(s)
      小谷 善久
    • Organizer
      第80回日本整形外科学会学術集会
    • Place of Presentation
      兵庫県神戸市神戸ポートピアホテル
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Present status and clinical application of artificial disc.2007

    • Author(s)
      Kotani Y.
    • Organizer
      80th japan Orthopaedic Association
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 脊椎外科におけるMotion Preservation Technologyの現状と展望2006

    • Author(s)
      小谷 善久
    • Organizer
      第7回千葉脊椎カンファレンス
    • Place of Presentation
      千葉県千葉市幕張プリンスホテル
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Present status and future prospectives of motion preservation Technology.2006

    • Author(s)
      Kotani Y.
    • Organizer
      7th Chiba Spine conference
    • Place of Presentation
      Makuhari
    • Year and Date
      2006-07-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 腰椎可動性温存の意義とMotion Preservation Technologyの現状2006

    • Author(s)
      小谷 善久
    • Organizer
      第17回 腰痛シンポジウム
    • Place of Presentation
      東京都千代田区東京国際フォーラム
    • Year and Date
      2006-03-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The significance of lumbar mobility preservation and recent motion preservation technology.2006

    • Author(s)
      Kotani Y.
    • Organizer
      Low back pain Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2006-03-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 本邦における人工椎間板研究の現状と臨床展望2006

    • Author(s)
      小谷 善久
    • Organizer
      第15回日本脊椎インストルメンテーション学会
    • Place of Presentation
      大阪府豊中市千里ライフサイエンスセンター
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Perspectives for artificial intervertebral disc in Japan.2006

    • Author(s)
      Kotani Y
    • Organizer
      Asia Pacific Spine Symposium in Thailand
    • Place of Presentation
      Pattaya, Thailand Sheraton Hotel
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Present status and clinical application of artificial disc.2006

    • Author(s)
      Kotani Y.
    • Organizer
      15th Japan spinal instrumentation
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Perspectives for artificial intervertebral disc in Japan.2006

    • Author(s)
      Kotani Y.
    • Organizer
      Asia Pacific Spine Symposium
    • Place of Presentation
      Thailand
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo evaluation of biomimetic three-dimensional fabric disc for total cervical disc arthroplasty in a non-human primate model2005

    • Author(s)
      Kotani Y
    • Organizer
      North American Spine Society
    • Place of Presentation
      Philadelphia, PA, USA Pennsylvania Convention Center
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo evaluation of biomimetic three-dimensional fabric disc for total cervical disc arthroplasty in a non-human primate model2005

    • Author(s)
      Kotani Y.
    • Organizer
      North American SPine Society
    • Place of Presentation
      Philadelphia, PA
    • Year and Date
      2005-09-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo evaluation of biomimetic three-dimensional fabric disc for total cervical disc arthroplasty in a non-human primate model.2005

    • Author(s)
      Kotani Y
    • Organizer
      International meeting on advanced spine techniques (IMAST)
    • Place of Presentation
      Banff, Alberta, Canada Banff Convention Center
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo evaluation of biomimetic three-dimensional fabric disc for total cervical disc arthroplasty in a non-human primate model2005

    • Author(s)
      Kotani Y
    • Organizer
      Scoliosis Research Society, 40th Annual Meeting
    • Place of Presentation
      Miami, Florida, USA Loews Miami Beach Hotel
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo evaluation of biomimetic three-dimensional fabric disc for total cervical disc arthroplasty in a non-human primate model.2005

    • Author(s)
      Kotani Y.
    • Organizer
      International meeting on advanced spine techniques (IMAST)
    • Place of Presentation
      Banff, Canada
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] In vivo evaluation of biomimetic three-dimensional fabric disc for total cervical disc arthroplasty in a non-human primate model2005

    • Author(s)
      Kotani Y.
    • Organizer
      Scoliosis Research Society, 40th Annual Meetin
    • Place of Presentation
      Miami FL
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Clinical application of artificial intervertebral disc.2006

    • Author(s)
      Kotani Y.
    • Total Pages
      229
    • Publisher
      Orthopaedic knock & Pitfalls
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 整形外科knack & Pitfalls、脊椎外科の要点と盲点 : 胸腰椎2006

    • Author(s)
      小谷 善久
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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