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Analysis of functienal domain and expression in bone, cartilage and muscle of minor collagen

Research Project

Project/Area Number 17390418
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionOita University

Principal Investigator

YOSHIOKA Hidekatsu  Oita University, Faculty of Medicine, Dept. of Anatomy, Biology and Medicine, Professor (00222430)

Co-Investigator(Kenkyū-buntansha) MATSUO Noritaka  Oita University, Faculty of Medicine, Dept. of Anatomy, Biology and Medicine, Assistant Professor (10284788)
SUMIYOSHI Hideaki  Oita University, Faculty of Medicine, Dept. of Anatomy, Biology and Medicine, Assistant Professor (60343357)
SHIRABE Komei  Oita University, Faculty of Medicine, Dept. of Anatomy, Biology and Medicine, Associate Professor (50179058)
HAMANAKA Ryoji  Oita University, Faculty of Medicine, Dept. of Anatomy, Biology and Medicine, Assistant Professor (60274750)
NINOMIYA Yoshifumi  Okayama University, Graduate School of Medicine and Dentisuy, Dept. of Molecular Biology and Biochemistry, Professor (70126241)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,500,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥9,600,000 (Direct Cost: ¥9,600,000)
Keywordscollagen / transcriptional regulation / bone / cartilage / muscle / extracellular matrix / 遺伝子発現 / 転写調節機構 / 歯牙 / アデイポネクチン
Research Abstract

1) Initially, to determine the transcription initiation site of mouse α3 (V) gene, Oligo-Cap methods was used. It was located about 100 bp upstream of ATG codon. We used structure-function analysis of the core promoter region to elucidate the transcriptional features of the gene. The core promoter was defined within about 300 bp immediately upstream from the transcription start site by transient transfection experiments. In this region, we identified two nuclear-factor binding sites by electrophoretic mobility shift assay (EMSAs): BS1 (-130 to -110), BS2 (-190 to -170). Oligonucleotide competition and supershift assays revealed that CBF,/NF-Y specifically bind to BS1.
The N-terminal globular domain of the pro-α3 (V) chain has a unique structure that contains a highly basic segment of 23 amino acids. The peptide showed a specific adhesive feature to osteosarcoma cells but not to chondrosarcoma cells. This feature was derived from four heparin binding sites in the segment. When the peptid … More e adhere to the cell, actin fiber was formed, which was inhibited Rho-kinase inhibitor, Y27632.
2) We have characterized the proximal promoter of the human α1 (III) collagen gene (COL3A1). Transient transfection assays indicated that the segment from -96 to -34 was necessary to activate transcription. EMSAs showed that the multiple proteins form the DNA-protein complex in different combinations depending on the cell types. The region of -79 to -63 bp was critical for DNA protein complex formation. This sequence was contained in the B element of mouse al (III) collagen gene (Col3a1) reported by other researcher.
3) Collagen XXIV is a newly discovered and poorly characterized member of the fibril-forming family of collagen molecules, which is expressed predominantly in bone tissue. Cell transfection experiments in combination with DNA binding assay demonstrated that Co124a1 promoter activity was under control of an upstream cis-acting element, which was recognized by specific combination of c jun, CREB1, ATF1, and ATF2 dimers. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (51 results)

All 2007 2006 2005

All Journal Article (36 results) (of which Peer Reviewed: 14 results) Presentation (15 results)

  • [Journal Article] Coexpression of HSP47 gene and type I and type III collagen genes inLPS-induced pulmonary fibrosis on rats2007

    • Author(s)
      Hagiwara, S., et. al.
    • Journal Title

      Lung 183

      Pages: 31-37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Association between heat stress protein 70 induction and decreased pul monary fibrosis in an animal model of acute lung injury2007

    • Author(s)
      Hagiwara, S., et. al.
    • Journal Title

      Lung 185

      Pages: 287-293

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Coexpression of HSP47 gene and type I and type III collagen genes in LPS-induced pulmonary fibrosis in rats2007

    • Author(s)
      Hagiwara, S., Iwasaka, H., Matsumoto, S., Noguchi, T., Yoshioka, H
    • Journal Title

      Lung 183

      Pages: 31-37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Association between heat stress protein 70 induction and decreased pulmonary fibrosis in an animal model of acute lung injury2007

    • Author(s)
      Hagiwara, S., Iwasaka, H., Matsumoto, S., Noguchi, T., Yoshioka, H
    • Journal Title

      Lung 185

      Pages: 287-293

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Coexpression of HSP47 gene and type I and type III collagen genes in LPS-induced pulmonary fibrosis.2007

    • Author(s)
      Hagiwara, S, et. al.
    • Journal Title

      Lung 183

      Pages: 31-37

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between heat stress protein 70 induction and decreased pulmonary fibrosis in an animal model of acute lung injury2007

    • Author(s)
      Hagiwara, S, et. al.
    • Journal Title

      Lung 185

      Pages: 287-293

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice2006

    • Author(s)
      Goto, M, et. al.
    • Journal Title

      Mol.Cell.Biol. 26

      Pages: 548-558

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] CREB-API protein complexes regulate transcription of the collagen XXIV gene(Col24a1)in osteoblasts2006

    • Author(s)
      Matsuo, N, et. al.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 5445-5452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Characterization and expression of serotonin transporter in zebrafish.2006

    • Author(s)
      Wang, Y.H., et. al.
    • Journal Title

      Tohoku J.Exp.Med. 208

      Pages: 267-274

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Interactions between epiplakin and intermediate filaments2006

    • Author(s)
      Wang W.Q., et. al.
    • Journal Title

      J.Dermatol. 33

      Pages: 518-527

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multifactor complex containing B element binding factor,BBF,and repressors regulate the human α1(III)collagen gene(COL3A1)2006

    • Author(s)
      Sumiyoshi, H, et. al.
    • Journal Title

      Acta Med.Okayama 60

      Pages: 181-189

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice2006

    • Author(s)
      Goto, M., Sumiyoshi, H., Sasaki, T., Fassler, R., Ohashi, S., Adachi, E., Yoshioka, H., Fujiwara, S
    • Journal Title

      Mol. Cell. Biol. 26

      Pages: 548-558

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene(Co124a1) in osteoblast2006

    • Author(s)
      Matsuo, N., Tanaka, S., Gordon, M.K., Koch, M., Yoshioka, H., Ramirez, F
    • Journal Title

      J. Biol. Chem. 281

      Pages: 5445-5452

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Characterization and Expression of serotonin transporter gene in zebrafish2006

    • Author(s)
      Wang, Y.H., Takai, R., Yoshioka, H., Shirabe, K
    • Journal Title

      Tohoku J. Exp. Med 208

      Pages: 267-274

    • NAID

      10017291514

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Interactions between epiplakin and intermediate filaments2006

    • Author(s)
      Wang, W.Q., Sumiyoshi, H., Yoshioka, H., Fujiwara, S
    • Journal Title

      J Dennatol 33

      Pages: 518-527

    • NAID

      10020339625

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multifactor complex containing B element binding factor, BBF, and repressors regulate the human α1(III) collagen gene(COL3A1)2006

    • Author(s)
      Sumiyoshi, H., Matsuo, N., Shin, T., Shirabe, K., Yoshioka, H
    • Journal Title

      Acta Med. Okayama 60

      Pages: 181-189

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice.2006

    • Author(s)
      Goto, M et al.
    • Journal Title

      Mol.Cell.Biol. 26・2

      Pages: 548-558

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24al)in osteoblast.2006

    • Author(s)
      Matsuo N et al.
    • Journal Title

      J.Biol.Chem. 281・9

      Pages: 5445-5452

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Characterization and Expression of serotonin transporter gene in zebrafish.2006

    • Author(s)
      Wang YH et al.
    • Journal Title

      Tohoku J.Exp.Med. 208・3

      Pages: 267-274

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Interactions between epiplakin and intermediate filaments.2006

    • Author(s)
      Wang WQ et al.
    • Journal Title

      J.Dermatol. 33・8

      Pages: 518-527

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Multifactor complex containing B element binding factor, BBF, and repressors regulate the human α1(III) collagen gene (COL3A1).2006

    • Author(s)
      Sumiyoshi H et al.
    • Journal Title

      Acta Med.Okayama 60・3

      Pages: 181-189

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Elimination of epiplakin by gene targeting results in accelation of keratinocyte migration in mice.2006

    • Author(s)
      Goto M, Sumiyoshi H, Sakai T, Fassler R, Ohashi S, Adachi E, Yoshioka H, Fujiwara S
    • Journal Title

      Molecular and Cellular Biology 26・2

      Pages: 548-558

    • Related Report
      2005 Annual Research Report
  • [Journal Article] CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblast.2006

    • Author(s)
      Matsuo N, Tanaka S, Gordon MK, Koch M, Yoshioka H, Ramirez F
    • Journal Title

      J Biological Chemistry 281・9

      Pages: 5445-5452

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Spl and Sp3 transcription factors upregulate the proximal promoter of the human prostate-specific antigen(PSA)gene in prostate cancer cells2005

    • Author(s)
      Shin, T, et. al.
    • Journal Title

      Arch Biochem Biophys 435

      Pages: 291-302

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multiple proteins are involved in the protein-DNA complex in the proldmal promoter of the human α1(III)collagen gene(COL3A1)2005

    • Author(s)
      Yoshino, T, et. al.
    • Journal Title

      Biochemica et Biophysica Acta 1729

      Pages: 94-104

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Mn-cadherin and its novel variant are transiently expressed in chickembryo spinal cord2005

    • Author(s)
      Shirabe, K, et. al.
    • Journal Title

      Biochem Biophys Res Commun 334

      Pages: 108-116

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pro-α3(V)collagen chain is expressed in bone and its basic N-termina peptide adheres to osteosarcoma cells2005

    • Author(s)
      Yamaguchi, K, et. al.
    • Journal Title

      Matrix Biol. 24

      Pages: 283-294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Adiponectin is expressed in the brown adipose tissue and surroundingimmature tissues in mouse embryo2005

    • Author(s)
      Fujimoto, N, et. al.
    • Journal Title

      Biochemca Biophysica Acta 1731

      Pages: 1-12

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Sp1 and Sp3 transcription factors upregulate the proximal promoter of the human prostate-specific antigen(PSA) gene in prostate cancer cells2005

    • Author(s)
      Shin, T., Sumiyoshi, H., Matsuo, N., Satoh, F., Nomura, Y., Mimata, H., Yoshioka, H
    • Journal Title

      Arch Biochem Biophys 435

      Pages: 291-302

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human α1(III) collagen gene(COL3A1)2005

    • Author(s)
      Yoshino, T., Sumiyoshi, H., Shin, T., Matsuo, N., Inagaki, Y., Ninomiya, Y., Yoshioka, H
    • Journal Title

      Biochimca Biophysica Acta 1729

      Pages: 94-104

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Mn-cadherin and its novel variant are transiently expressed in chick embryo spinal cord2005

    • Author(s)
      Shirabe, K., Kimura, Y., Matsuo, N., Fukushima, M., Yoshioka, H., Tanaka, H.
    • Journal Title

      Biochem Biophys Res Commun 334

      Pages: 108-116

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The pro-α3(V) collagen chain is expressed in bone and its N-terminal basic peptide is adhesive to osteosarcoma cells2005

    • Author(s)
      Yamaguchi, K., Matsuo, N., Sumiyoshi, H., Fujimoto, F., Iyama, K., Yanagisawa, S., Yoshioka, H
    • Journal Title

      Matrix Biol 24

      Pages: 283-294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos2005

    • Author(s)
      Fujimoto, N., Matsuo, N., Sumiyoshi, H., Yamaguchi, K., Saikawa, T., Yoshimatsu, H., Yoshioka, H
    • Journal Title

      Biochimca Biophysica Acta 1731

      Pages: 1-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Adiponectin is expressed inthebrown adipose tissue and surrounding immature tissues in mouse embryo.2005

    • Author(s)
      Fujimoto T, Matsuo T, Sumiyoshi H, Yamaguchi K, Saikawa T, Yoshimnatsu H, Yoshioka H
    • Journal Title

      Biochemica et Biophysica Acta 1731・1

      Pages: 1-12

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pro-α3(V) collagen chain is expressed in bone and its basic N-terminal peptide adheres to osteosarcoma cells.2005

    • Author(s)
      Yamaguchi K, Matsuo T, Sumiyoshi H, Fujimoto T, Yoshioka H
    • Journal Title

      Matrix Biology 24・4

      Pages: 283-294

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human α1(III) collagen gene(COL3A1).2005

    • Author(s)
      Yoshino T, Sumiyoshi H, Shin T, Matsuo N, Inagaki Y, Ninomiya Y, Yoshioka H
    • Journal Title

      Biochemica et Biophysica Acta 1729・2

      Pages: 94-104

    • Related Report
      2005 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程をモデルとした組織線維化のメカニズムの解析2007

    • Author(s)
      住吉秀明, 他
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウス24型コラーゲンα1鎖遺伝子の発現調節機構の解析2007

    • Author(s)
      松尾哲孝, 他
    • Organizer
      第30回日本分子生物学会・第80回日本生化学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 線維性コラーゲン遺伝子の発現調節機構の解析2007

    • Author(s)
      松尾哲孝
    • Organizer
      第31回蛋白質と酵素に関する九州シンポジウム
    • Place of Presentation
      ゆふいん七色の風(由布市)
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程をモデルとした組織線維化のメカニズムの解析2007

    • Author(s)
      住吉秀明
    • Organizer
      第31回蛋白質と酵素に関する九州シンポジウム
    • Place of Presentation
      ゆふいん七色の風(由布市)
    • Year and Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] III型コラーゲン遺伝子の転写調節機構 Vol 32007

    • Author(s)
      住吉秀明, 他
    • Organizer
      第39回日本結合組織学会・第54回マトリックス研究会
    • Place of Presentation
      北とぴあ(東京都)
    • Year and Date
      2007-05-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] Adiponectin is expressed in the brown adipose tissue and surroundingimmature tissue in mouse embryo2006

    • Author(s)
      Hidekatsu Yoshioka, et. al.
    • Organizer
      第20回国際生化学会・分子生物学会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2006-06-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Adiponectin is expressed in the brown adipose tissue and surrounding immature tissue in mouse embryos2006

    • Author(s)
      Hidekatsu, Yoshioka, Noritaka, Fujimoto, Noritaka, Matsuo, Hideaki, Sumiyoshi
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human type III collagen gene2006

    • Author(s)
      Hideaki Sumiyoshi, et. al.
    • Organizer
      第20回国際生化学会・分子生物学会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcriptional of mous6 type XXIV collagen(Col24a1)gene2006

    • Author(s)
      Noritaka Matsuo, et. al.
    • Organizer
      第20回国際生化学会・分子生物学会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression and regulation of the zebrafish serotonin transporter gene2006

    • Author(s)
      Yuhong Wang, et. al.
    • Organizer
      第20回国際生化学会・分子生物学会
    • Place of Presentation
      国立京都国際会議場
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Multiple proteins are involved in the protein-DNA complex in the proximal promoter of the human type III collagen gene2006

    • Author(s)
      Hideaki, Sumiyoshi, Noritaka, Matsuo, Toshitaka, Shin, Hidekatsu, Yoshioka
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Transcriptional regulation of mouse type XXIV collagen(Co124a1) gene2006

    • Author(s)
      Noritaka, Matsuo, Shzuko, Tanaka, Hideaki, Sumiyoshi, Hidekatsu, Yoshioka, Francesco, Ramirez
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression and regulation of the Zebrafish serotonin transporter gene2006

    • Author(s)
      Yuhong, Wang, Masatoshi, Sakainoto, Rie, Takai, Hidekatsu, Yoshioka, Komei, Shirabe
    • Organizer
      20th IUBMB International Congress of Biochemistry. and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression and regulation of pro-α3(V)conagen gene2005

    • Author(s)
      Hidekatsu Yoshioka, et. al.
    • Organizer
      2005年ゴードン会議「コラーゲン」
    • Place of Presentation
      アメリカ合衆国、コルビー.ソーヤー大学
    • Year and Date
      2005-07-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression and regulation of pro-α3(V) collagen gene2005

    • Author(s)
      Hidekatsu, Yoshioka, Hitoshi, Nagato, Kenji, Yamaguchi, Ken-ich, Iyama, Keiko, Sakata-Takatani, Hideaki, Sumiyoshi, Noritaka, Matsuo
    • Organizer
      Gordon "Collagen"
    • Place of Presentation
      Colby-Sawyer College, NH, USA
    • Year and Date
      2005-07-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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