Establishment of survivin-derived peptide vaccination for patients with urothelial cancer

• Project/Area Number: 17390441
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Sapporo Medical University
• Principal Investigator: TSUKAMOTO Taiji Sapporo Medical University, 医学部, 教授 (50112454)
• Co-Investigator(Kenkyū-buntansha): SATO Noriyuki 札幌医科大学, 医学部, 教授 (50158937) ; MASUMORI Naoya 札幌医科大学, 医学部, 准教授 (20295356) ; TANAKA Toshiaki 札幌医科大学, 医学部, 研究員 (50398327) ; HONMA ICHIYA 札幌医科大学, 医学部, 研究員 (20404676) ; SATO EIJI 札幌医科大学, 医学部, 研究員 (30404677) ; 高橋 敦 札幌医科大学, 医学部, 講師 (20274946)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥16,570,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥1,470,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000); Fiscal Year 2005: ¥7,200,000 (Direct Cost: ¥7,200,000)
• Keywords: 尿路上皮癌 / 免疫療法 / がん抗原 / サバイビン / 癌抗原 / HLA class I抗原 / 腎細胞癌 / HLA cell I抗原

Research Abstract

尿路上皮癌においてサバイビンが高率に発現し、かつ癌抗原として患者の免疫系に認識されていた。進行尿路上皮癌患者に対するサバイビン・ペプチドワクチン療法の臨床第一相試験を行い、安全性を確認し得た。また一部の患者では免疫学的・臨床的反応が認められた。

Research Products

• [Journal Article] Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer (2009)
  • Author(s): Honma I, Kitamura H, Torigoe T, Takahashi A, Tanaka T, Sato E, Hirohashi Y, Masumori N, Tsukamoto T, Sato N.
  • Journal Title: Cancer Immunol Immunother [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Identification of an Immunogenic CTL Epitope of HIFPH3 for Immunotherapy of Renal Cell Carcinoma (2008)
  • Author(s): Sato E, Torigoe T, Hirohashi Y, Kitamura H, Tanaka T, Honma I, Asanuma H, Harada K, Takasu H, Masumori N, Ito N, Hasegawa T, Tsukamoto T, Sato N.
  • Journal Title: Clin Cancer Res 14 Pages: 6916-23
  • Peer Reviewed
• [Journal Article] Prognostic biomarkers of renal cell carcinoma : recent advances (2008)
  • Author(s): Kitamura H
  • Journal Title: Indian J Urol Jan-Mar Pages: 10-15
  • Peer Reviewed
• [Journal Article] Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma (2008)
  • Author(s): Sato E
  • Journal Title: Clin Cancer Res 14 Pages: 6916-6923
  • Peer Reviewed
• [Journal Article] Phase I clinical study of anti-apoptosis protein survivcn-derived peptide vaccination for patients with advanced or recurrent urothelial cancer (2008)
  • Author(s): Honma I
  • Journal Title: Cancer Imunol Immunother May 18(Published online)
  • Peer Reviewed
• [Journal Article] 臨床的に腫瘍の存在が認められない尿細胞診陽性例の臨床的検討 (2007)
  • Author(s): 栗村雄一郎
  • Journal Title: 泌尿紀要 53 Pages: 455-458
  • Peer Reviewed
• [Journal Article] 高齢者に対する根治的膀胱摘除および尿路変向術後の早期合併症の検討 (2007)
  • Author(s): 市原浩司
  • Journal Title: 泌尿紀要 53 Pages: 527-532
  • Peer Reviewed
• [Journal Article] Adverse events of MVAC chemotherapy in patients with advanced urothelial cancer of the bladder (2007)
  • Author(s): Maeda T
  • Journal Title: Acta Urol. Jpn. 53 Pages: 213-219
  • Peer Reviewed
• [Journal Article] Chemotherapy for bladder cancer: Treatment guidelines for neoadjuvant chemotherapy, bladder preservation, adjuvant chemotherapy, and metastatic cancer (2007)
  • Author(s): Sternberg CN
  • Journal Title: Urology 69(Suppl 1A) Pages: 62-79
  • Peer Reviewed
• [Journal Article] 筋層浸潤膀胱癌におけるneoadjuvant chemotherapyの意義 (2007)
  • Author(s): 塚本泰司
  • Journal Title: 泌尿器外科 20 Pages: 1137-1145
  • Peer Reviewed
• [Journal Article] Expression and antigenicity of surviving, an inhibitor of apotosis family member, in bladder cancer : implication ofs for specific immunotherapy (2006)
  • Author(s): Kitamura H, et al.
  • Journal Title: Urology 67 Pages: 955-959
• [Journal Article] Effect of human leukocyte antigen class I expression of tumor cells on outcome of intraverical instillation of bacillus Calmette-guerin- (2006)
  • Author(s): Kitamura H, et al.
  • Journal Title: Clinaical Cancer Research 12 Pages: 4641-4644
• [Journal Article] Removal of more lymph nodes may provide better outcome, as well as more accurate pathologic findings, in patients with bladder cancer-analysis of role of pelvic lymph node deissecion (2006)
  • Author(s): Honma I, et al.
  • Journal Title: Urology 68 Pages: 543-548
• [Journal Article] Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer : implications for specific immunotherapy (2006)
  • Author(s): Kitamura H, et al.
  • Journal Title: Urology (印刷中)
• [Journal Article] Prognostic biomarkers of RCC : recent advances
  • Author(s): Kitamura H, Tsukamoto T.
  • Journal Title: Ind J Urol 2008 24 Pages: 10-15
  • Peer Reviewed
• [Journal Article] Expression of livin in renal cell carcinoma and detection of anti-livin autoantibody in patients
  • Author(s): Kitamura H, Honma I, Torigoe T, Hariu H, Asanuma H, Hirohashi Y, Sato E, Sato N, Tsukamoto T.
  • Journal Title: Urology 2007 70 Pages: 38-42
  • Peer Reviewed
• [Journal Article] Down-regulation of HLA Class I Antigen Is an Independent Prognostic Factor for Clear Cell Renal Cell Carcinoma
  • Author(s): Kitamura H, Honma I, Torigoe T, Asanuma H, Sato N, Tsukamoto T.
  • Journal Title: J Urol 2007 177 Pages: 1269-72
  • Peer Reviewed
• [Journal Article] Down-regulation of HLA Class I Antigens in Prostate Cancer Tissues and Up-regulation by Histone Deacetylase Inhibition
  • Author(s): Kitamura H, Torigoe T, Asanuma H, Honma I, Sato N, Tsukamoto T.
  • Journal Title: J Urol 2007 178 Pages: 692-6
  • Peer Reviewed
• [Journal Article] Expression and antigenicity of survivin, an inhibitor of apoptosis family member, in bladder cancer : implications for specific immunotherapy
  • Author(s): Kitamura H, Torigoe T, Honma I, Asanuma H, Nakazawa E, Shimozawa K, Hirohashi Y, Sato E, Sato N, Tsukamoto T.
  • Journal Title: Urology 2006 67 Pages: 955-959
  • Peer Reviewed
• [Journal Article] Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus Calmette- Guerin immunotherapy for bladder cancer
  • Author(s): Kitamura H, Torigoe T, Honma I, Sato E, Asanuma H, Hirohashi Y, Sato N, Tsukamoto T.
  • Journal Title: Clin Cancer Res 2006 12 Pages: 4641-4
  • Peer Reviewed
• [Presentation] <Workshop : Urothelial Cell Cancer> Phase I clinical study of anti-apopotosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent urothelial cancer (2008)
  • Author(s): Honma I., Kitamura H, Torigoe T, Hirohashi Y, Sato E, Takahashi A, Taguchi K, Masumori N, Itoh N, Sato N, Tsukamoto T.
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] HIF prolyl hydroxylase 3(HIFPH3)を標的とした腎細胞癌に対する新規癌免疫療法開発に向けた基礎的研究 (2008)
  • Author(s): 佐藤英次、鳥越俊彦、廣橋良彦、本間一也、北村 寛、中津川宗秀、井野田智子、桐山賢二、舛森直哉、伊藤直樹、塚本泰司、佐藤昇志
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜
• [Presentation] <Workshop : Urothelial Cell Cancer> Phase I clinical study of anti-apoptosis protein, surviving-derived peptide vaccine therapy for patients with advanced or recurrent urothelial cancer (2008)
  • Author(s): Honma I
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜市
• [Presentation] HIF prokyl hydroxylase 3 (HIFPH3)を標的とした腎細胞癌に対する新規癌免疫療法開発に向けた基礎的研究 (2008)
  • Author(s): 佐藤英次
  • Organizer: 第96回日本泌尿器科学会総会
  • Place of Presentation: 横浜市
• [Presentation] Phase I clinical study of anti-apoptosis protein, surviving-derived peptide. Vaccine therapy for patients wit advanced or recurrent urotheial cancer (2007)
  • Author(s): Honma I, et. al.
  • Organizer: 第102回アメリカ泌尿器科学会
  • Place of Presentation: アナハイム(カリフォルニア)
  • Year and Date: 2007-05-21
• [Presentation] 【ワークショップ】新規腫瘍マーカーの臨床応用:新規単クローン抗体による泌尿器癌におけるHLA class I down-regulation解析と臨床所見 (2007)
  • Author(s): 本間一也
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸市
  • Year and Date: 2007-04-15
• [Presentation] Phase I clinical study of anti-apoptosis protein, survivin-derived peptide. Vaccine therapy for patients with advanced or recurrent urothelial cancer (2007)
  • Author(s): Honma I, Kitamura H, Torigoe T, Hirohashi Y, Shimozawa K, Takahashi A, Sato E, Takahashi A, Taguchi K, Masumori N, Itoh N, Sato N, Tsukamoto T.
  • Organizer: 第102回アメリカ泌尿器科学会
  • Place of Presentation: アナハイム(カリフォルニア)
• [Presentation] [ワークショップ]新規腫瘍マーカーの臨床応用 : 新規単クローン抗体による泌尿器癌におけるHLA class I down-regulation解析と臨床所見 (2007)
  • Author(s): 本間一也
  • Organizer: 第95回日本泌尿器科学会総会
  • Place of Presentation: 神戸
• [Presentation] 前立腺癌におけるHLA class I down-regulationと免疫逃避 (2006)
  • Author(s): 北村寛、鳥越俊彦、浅沼広子、本間一也、佐藤英次、舛森直哉、佐藤昇志、塚本泰司
  • Organizer: 第15回泌尿器科分子・細胞研究会
  • Place of Presentation: 京都
• [Presentation] 病理標本で解析し得る新規単クローン抗体EMR8-5を用いた泌尿器科悪性腫瘍HLA class I発現の検討 (2005)
  • Author(s): 北村寛、鳥越俊彦、本間一也、佐藤英次、中澤恵実理、廣橋良彦、浅沼広子、塚本泰司、佐藤昇志
  • Organizer: 第35回日本免疫学会総会
  • Place of Presentation: 横浜
• [Presentation] 新規開発単クローン抗体によるHLAクラスI final output解析と膀胱癌BCG局所注入療法の有効性の相関 (2005)
  • Author(s): 北村寛、鳥越俊彦、浅沼広子、本間一也、佐藤英次、廣橋良彦、中澤恵実理、高橋敦、舛森直哉、塚本泰司、佐藤昇志
  • Organizer: 第64回日本癌学会総会
  • Place of Presentation: 札幌
• [Presentation] 膀胱癌におけるIAP family分子survivinの発現と抗原性の解析 (2005)
  • Author(s): 北村寛、鳥越俊彦、本間一也、浅沼広子、小林淳一、真野佳典、中澤恵実理、佐藤英次、塚本泰司、佐藤昇志
  • Organizer: 第9回基盤的癌免疫研究会
  • Place of Presentation: 東京
• [Book] Bladder Tumor (2006)
  • Author(s): Sternbg CN, 獲C, Paris
  • Total Pages: 404
  • Publisher: Edition 21, Paris