Analysis of cell polarity associated molecules in prostate cancer for the application to diagnosis and treatment
| Project/Area Number |
17390442
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
KUBOTA Yoshinobu Yokohama City University, Graduate School of Medicine, Professor (10106312)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UEMURA Hiroji Yokohama City University, Yokohama City University Hospital, Associate Professor (50244439)
YAO Masahiro Yokohama City University, Graduate School of Medicine, Associate Professor (00260787)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥15,700,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2006: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2005: ¥8,800,000 (Direct Cost: ¥8,800,000)
|
|---|
| Keywords | Prnatato ranrar / Cell Polarity / aPKC / aPKC / Neuroserpin |
|---|
| Research Abstract |
The role of cell polarity associated molecules in prostate cancer especially in hormone refractory prostate cancer has been unknown. aPKC which is a key molecule of cell polarity has the various roles for the cell maintenance such as differentiation, growth, and polarity. Thus, we investigated aPKC expression and function in prostate cancer.
aPKC expression showed higher levels in human prostate cancer tissues than in paired normal prostate tissues. Moreover, aPKC expression was related to recurrence free survival time. Then, we performed the experiments using siRNA for aPKC. Prostate cancer cells transfected with siRNA reduced their growth in vitro and in vivo. IL-6, which has been known as the cytokine for prostate cancer progression, was reduced in siRNA transfected cells. These results suggest that aPKC may play a role in prostate cancer progression through IL-6 expression, and also are suggested the close relationships between aPKC cell polarity system and local Rennin Angiotensin System (RAS) in prostate cancer which we have studied and have shown previously.
|
Report
(4 results)
Research Products
(30 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia2006
Author(s)
Sato H., Yazawa T., Suzuki T., Shimoyamada H., Okudela K., Ikeda M., Hamada K., Yamada-Okabe H., Yao M., Kubota Y., Takahashi T., Kamma H., Kitamura H
-
Journal Title
American Journal of Pathology 169(5)
Pages: 1550-1566
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer2005
Author(s)
Uemura H., Hasumi H., Kawahara T., Sugiura S., Miyoshi Y., Nakaigawa N., Teranishi J., Noguchi K., Ishiguro H., Kubota, Y
-
Journal Title
International Journal of Clinical Oncology 10
Pages: 405-410
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
