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FSH-R polymorphisms in women with infertility

Research Project

Project/Area Number 17390446
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionGunma University

Principal Investigator

MINEGISHI Takashi  GUNMA UNIVERSITY, Medicine, Professor, 大学院医学系研究科, 教授 (00209842)

Co-Investigator(Kenkyū-buntansha) ITO Masahiro  GUNMA UNIVERSITY, Medicine, Assistant Professor, 医学部, 講師 (20282402)
SINOZAKI Hiromitsu  GUNMA UNIVERSITY, Medicine, Assistant Professor, 医学部, 講師 (30334139)
IGARASHI Shigeo  GUNMA UNIVERSITY, Medicine, Research Associate, 医学部, 助手 (60343084)
KISHI Hiroshi  GUNMA UNIVERSITY, Medicine, Research Associate, 医学部, 助手 (10375545)
HIRAKAWA Takashi  GUNMA UNIVERSITY, Medicine, Research Associate, 大学院医学系研究科, 助手 (80375534)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 2006: ¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2005: ¥8,800,000 (Direct Cost: ¥8,800,000)
Keywordsgene / SNPs / FSH-R / LH-R / ovulation induction / FSH / 不妊症 / シグナル伝達 / ゴナドトロピンレセプター
Research Abstract

Follicle-stimulating hormone plays a crucial role during folliculogenesis by stimulating granulose-cell estrogen production through induction of aromatase activity. The action of FSH is mediated by the FSH receptor, which belongs to the large family of G-protein-coupled receptors. These receptors are characterized by a transmembrane domain consisting of seven membrane transversing α-helices connected by three extracellular and three intracellular loops. The FSH receptor gene is located at chromosome 2p2l to 16.
In normogonadotropic normoestrogenic anovulatory infertility (World Health Organization class II), the response of the ovary to exogenous FSH administration varies considerably among patients. In a recent study, the individual FSH response dose for gonadotropin induction of ovulation in anovulatory infertile women could be predicted on the basis of initial screening characteristics, such as the initial FSH serum level. Recent observations in patients undergoing lVF suggest that the FSH receptor genotype is associated with different requirements for exogenous FSH.
Recently, Sudo et al. reported a significant increase in the Ala/Thr 307 and Asn/Ser 680 genotype in a large cohort of women with PCOS.
In normogonadotropic anovulatory infertile women, the overall frequency distribution for polymorphism at position 307 was 1% for Ala/Ala, 23% for Ala/Thr, and 66% for Thr/Thr ; for polymorphism at position 680, 66% for Asn/Asn, 23% for Asn/Ser, and 1% for Ser/Ser.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (25 results)

All 2007 2006 2005

All Journal Article (23 results) Book (2 results)

  • [Journal Article] The Effect of Splice Variant of the Human Luteinizing Hormone(LH) Receptor on the expression of gonadotropin receptor.2007

    • Author(s)
      Takashi Minegishi
    • Journal Title

      Molecular and Cellular Endocrinology 2・260-262

      Pages: 117-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] The Effect of Splice Variant of the Human Luteinizing Hormone(LH) Receptor on the expression of gonadotropin receptor.2007

    • Author(s)
      Takashi Minegishi et al.
    • Journal Title

      Molecular and Cellular Endocrinology 2(260-262)

      Pages: 117-125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Expression of Gonadotropin Receptors in Ovarian Granulosa Cells2006

    • Author(s)
      Takashi Hirakawa
    • Journal Title

      Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 6・1

      Pages: 57-62

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells.2006

    • Author(s)
      Yumiko Abe
    • Journal Title

      Reproductive Biology and Endocrinology 4・27

      Pages: 1-9

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] ゴナドトロピン受容体とシグナル伝達2006

    • Author(s)
      中村 和人
    • Journal Title

      日本臨床 64・4

      Pages: 161-166

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 卵胞の発育および成熟-卵胞発育過程における中枢(ゴナドトロピン)と局所(卵と顆粒膜細胞間)が持つ相互作用の分子メカニズムについて-2006

    • Author(s)
      中村 和人
    • Journal Title

      産科と婦人科 73・6

      Pages: 706-711

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] 遺伝子異常2006

    • Author(s)
      池田 禎智
    • Journal Title

      臨床婦人科産科 60・9

      Pages: 1210-1213

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Expression of Gonadotropin Receptors in Ovarian Granulosa Cells.2006

    • Author(s)
      Takashi Hirakawa et al.
    • Journal Title

      Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 6(1)

      Pages: 57-62

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-inducible genes in human amniotic epithelial cells.2006

    • Author(s)
      Yumiko Abe et al.
    • Journal Title

      Reproductive Biology and Endocrinology 4(27)

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gonadotropin receptor and its signal transfection.2006

    • Author(s)
      Kazuto Nakamura et al.
    • Journal Title

      Japanese journal of clinical medicine 64(4)

      Pages: 161-166

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Molecular mechanism of regulation between gonadotropin and local factors for follicular development.2006

    • Author(s)
      Kazuto Nakamura et al.
    • Journal Title

      Obstet. Gynecol. 73(6)

      Pages: 706-711

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genetic diseases.2006

    • Author(s)
      Sadatomo Ikeda et al.
    • Journal Title

      Clinical gynecology and Obstetrics 60(9)

      Pages: 1210-1213

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the Expression of Gonadotropin Receptors in Ovarian Granulosa Cells2006

    • Author(s)
      Takashi Hirakawa
    • Journal Title

      Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry 6・1

      Pages: 57-62

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Association of Human Follitropin Receptor with Splicing Variant of Human Lutropin/Choriogonadotropin Receptor Negatively Controls the Expression of Human Follitropin Receptor2005

    • Author(s)
      Soichi Yamashita
    • Journal Title

      Molecular Endocrinology 19・8

      Pages: 2099-2111

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Effect of Follicle-stimulating Hormone and Estrogen on the Expression of Betaglycan Messenger Ribonucleic Acid levels in Cultured Rat Granulosa Cells2005

    • Author(s)
      Yuki Omori
    • Journal Title

      Endocrinology 146・8

      Pages: 3379-3386

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Expression of variant luteinizing hormone/chorionic gonadotropin receptors and degradation of chorionic gonadotropin in human chorionic villous macrophages2005

    • Author(s)
      Naoko Sonoda
    • Journal Title

      Placenta 26・4

      Pages: 298-307

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] ゴナドトロピンレセプターの構造と機能2005

    • Author(s)
      中村 和人
    • Journal Title

      産婦人科の実際 57・7

      Pages: 513-521

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] 妊娠中の内分泌機能-下垂体,甲状腺,副腎,胎盤のホルモン-2005

    • Author(s)
      篠崎 博光
    • Journal Title

      産婦人科の実際 54・2

      Pages: 273-282

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Association of Human Follitropin Receptor with Splicing Variant of Human Lutropin/Choriogonadotoropin Receptor Negatively Controls the Expression of Human Follitropin Receptor.2005

    • Author(s)
      Soichi Yamashita et al.
    • Journal Title

      Molecular Endocrinology 19(8)

      Pages: 2099-2111

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Effect of Follicle-stimulating Hormone and Estrogen on the Expression of Betaglycan Messenger Ribonucleic Acid levels in Cultured Rat Granulosa Cells.2005

    • Author(s)
      Yuki Omori et al.
    • Journal Title

      Endocrinology 146(8)

      Pages: 3379-3386

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of variant luteinizing hormone/chorionic gonadotropin receptors and degradation of chorionic gonadotropin in human chorionic villous macrophages.2005

    • Author(s)
      Naoko Sonoda et al.
    • Journal Title

      Placenta 26(4)

      Pages: 298-307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Structure and function of Gonadotropin receptor.2005

    • Author(s)
      Kazuto Nakamura et al.
    • Journal Title

      Obstetrical and Gynecological Practice 57(7)

      Pages: 513-521

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Endocrine function during pregnancy.2005

    • Author(s)
      Hiromitsu Shinozaki et al.
    • Journal Title

      Obstetrical and Gynecological Practice 54(2)

      Pages: 273-282

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] 生物薬科学実験講座7 情報伝達物質I2005

    • Author(s)
      峯岸 敬
    • Total Pages
      250
    • Publisher
      廣川書店
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Book] Experimental manuals for bio-pharmaceutical sciences vol.72005

    • Author(s)
      Takashi Minegishi
    • Total Pages
      250
    • Publisher
      Hirokawa book-store
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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