| Project/Area Number |
17390464
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
OMORI Koichi Fukushima Medical University, School of Medicine, Professor, 医学部, 教授 (10233272)
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| Co-Investigator(Kenkyū-buntansha) |
HASAMA Akihiro Fukushima Medical University, School of Medicine, Professor, 医学部, 教授 (60218394)
WADA Ikuo Fukushima Medical University, School of Medicine, Professor, 医学部, 教授 (40182969)
NAKAMURA Tatsuo Kyoto University, Institute for Frontier Medical Sciences, Associate Professor, 再生医科学研究所, 助教授 (70227908)
MATSUZUKA Takashi Fukushima Medical University, School of Medicine, Lecturer, 医学部, 講師 (80336461)
YOKOYAMA Shuji Fukushima Medical University, School of Medicine, Assistant Professor, 医学部, 助手 (80381408)
高橋 充 東京医科大学, 医学部, 助手 (80338805)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2006: ¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 2005: ¥9,300,000 (Direct Cost: ¥9,300,000)
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| Keywords | regenerative medicine / neo-vascularization / tissue repair / 頭頸部 / 臓器再生 |
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| Research Abstract |
The purpose of the present study is to clarify the mechanism of neo-vascularization and tissue repair in the regenerative process of the head and neck organs. Fibroblasts, bone marrow stromal cells, adipose tissue derived stem cells (ASCs) were cultured and labeled by m-YFP. These cells were combined with collagen sponge for developing the bio-engineered scaffold. This scaffold was implanted into the tracheal defect of rats. Histological examination demonstrated that tissue repair of the tracheal defect was accelerated by fibroblasts, while neo-vascularization was induced by ASCs. Tissue regeneration of the hard palate was obtained by combination of MSCs and β-TCP. The current study presented the essential role of neo-vascularization and tissue repair for regeneration of head and neck organs.
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