| Project/Area Number |
17390469
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKAMOTO Taiji Kagoshima University, Graduate School of Medical and Dental Sciences, Professor (10235179)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Takami Kagoshima University, Graduate School of Medical and Dental Sciences, Professor (30145479)
AOYAGI Takao Kagoshima University, Graduate School of Science and Engineering, Professor (40277132)
TAKAO Sonshin Kagoshima University, Frontier Science Research Center, Professor (80171411)
SUEISHI Katsuo Kyushu University, Graduate School of Medical Sciences, Professor (70108710)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,670,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2006: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2005: ¥7,700,000 (Direct Cost: ¥7,700,000)
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| Keywords | Hyalocvte / Ultrasound / gene transfer / CRP / VEGF / 硝子体手術 |
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| Research Abstract |
The purpose of this project was to investigate the biology of vitreous body, which was not been wellstudied, and to develop new treatments for chorioretinal diseases. The following results were obtained during the study period. Although this may be just the beginning, it will be an important study field from now on.
1.Vitreous body biology: Characteristics of resident cells in the vitreous body (hyalocytes) were studied. The origin of hyalocytes was found to be a bone marrow and hylocytes turned over in 3 months. Most of them were located on vitreo-retinal interface area. We found that there is a specific immune-system called vitreous cavity-associated immune deviation (VCAID). Hyalocytes were major players to identify antigens. There are the new findings.
2. Role of vitreous body in pathogenesis of diseases : Vitreous body was found to affect the progression of retinal diseases. In macular hole, the invasion of glial cells into the vitreous body played a pivotal role. In diabetic retinopathy, the increase of SDF-I and VEGF deteriorated the disease progression.
3. Development of new treatment using vitreous body biology : Visualizing adjuvant for vitreous body was developed and it was used for various disesetreatment. The results showed that the new method is superior to perform the vitreo-retinal surgery safely and securely.
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