| Project/Area Number |
17390494
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Takashi Osaka University, Graduate School of Human Sciences, Professor, 人間科学研究科, 教授 (60028793)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMURA Tsuyoshi Osaka University, Graduate School of Human Sciences, Associate Professor, 人間科学研究科, 助教授 (80150332)
INUI Tadashi Osaka University, Graduate School of Human Sciences, Res.Associate, 人間科学研究科, 助手 (40324735)
WAKISAKA Satoshi Osaka University, Graduate School of Dentistry, Professor, 歯学研究科, 教授 (40158598)
INOUE Tomio Shouwa University, School of Dentistry, Professor, 歯学部, 教授 (70184760)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2006: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2005: ¥8,600,000 (Direct Cost: ¥8,600,000)
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| Keywords | taste / brain / preference / aversion / reward / imaging |
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| Research Abstract |
The purpose of the present research project was to elucidate brain mechanisms controlling ingestive behavior on the basis of cognitive and affective aspects of taste. The following results were obtained:
1) Conditioned taste aversion
With the c-fos immunohistochemical method, we have suggested that the enhanced taste sensitivity to facilitate detection of the conditioned stimulus originates in the central nucleus of the amygdala and the hedonic shift, from positive to negative, originates in the basolateral nucleus of the amygdala.
2) Brain substance
Injection of cannabinoid agonists into the nucleus accumbens enhanced the ingestion of saccharin, but not quinine, indicating that the cannabinoid receptors in the nucleus accumbens play an important role in eliciting palatability.
3) Reward system
Microinjections of an opioid agonist, DAMGO, or an GABA antagonist, bicuculline, into the ventral pallidum attenuated the expression of conditioned taste aversion, indicating that the reward system is concerned with the taste aversion learning.
4) Brain imaging
Magnetic responses recorded from the human cortex suggest that the sourness component of citric acid is greatly diminished at the level of subcortical relays, and mostly sweetness information reaches the cortical primary taste area.
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