| Project/Area Number |
17390500
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Niigata University |
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Principal Investigator |
HOSHINO Etsuro Niigata University, Institute of Medicine and Dentistry, Professor (90124619)
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| Co-Investigator(Kenkyū-buntansha) |
KOTA Kohichi Niigata University, Institute of Medicine and Dentistry, Associate Professor (90018755)
OBSHIMA Hayato Niigata University, Institute of Medicine and Dentistry, Professor (70251824)
鈴木 誠 新潟大学, 医歯学総合病院, 講師 (50107778)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥11,280,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥3,500,000 (Direct Cost: ¥3,500,000)
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| Keywords | pulp treatment / endodontic treatment / Lesion Sterilization and Tissue Repair therapy / 3Mix-MP / Endodontics / LSTR / Save Pulp / LSTR 3Mix-MP療法 / Save-Pulp療法 / 生活歯髄 / 歯髄炎 / 歯髄治療x |
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| Research Abstract |
This project aimed to evaluate the pulp damages pathohistologically after the experience of spontaneous pain, which had been considered to be a clinical symptom of irreversible pulp-damage. The results obtained were as follows:
1. Samples were antagonist-less third molars extracted by expert LSTR dentists under informed consents.
2. Out of a total of 30 teeth, consisted of 22 treated with LSTR 3Mix-MP SavePulp therapy and 8 untreated teeth as controls, 8 pulps were observed to be slight inflammation, and 22 to be moderate inflammation. But, no pulp was necrotic, which would be typical irreversible pulp damage. Immigrated inflammatory cells located in the areas beneath pulp-expose-holes, but the cells were rather rare at the surrounded areas In these areas, nestin-positive intact odontoblast-layers and intact nerve innervations were observed. The severities of Inflammation did not correlate to the severity of spontaneous pains, or other clinical symptoms.
3. The 22 teeth treated with LSTR 3Mix-MP SavePulp therapy showed rather slight pathohistological damages, and, especially the case extracted 3 months after the treatment exhibited almost intact pulp, meaning that LSTR 3Mix-MP SavePulp therapy may not damage pulps furthermore and could result in repair of pulps.
These results agree with the excellent clinical outcomes of LSTR 3Mix-MP SavePulp therapy on teeth with experiences of spontaneous pains to preserve pulps to be sensitive and clinically intact
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