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Repair of dental pulps-Pathohistological evaluation of LSTR 3Mix-MP SavePulp therapy-

Research Project

Project/Area Number 17390500
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionNiigata University

Principal Investigator

HOSHINO Etsuro  Niigata University, Institute of Medicine and Dentistry, Professor (90124619)

Co-Investigator(Kenkyū-buntansha) KOTA Kohichi  Niigata University, Institute of Medicine and Dentistry, Associate Professor (90018755)
OBSHIMA Hayato  Niigata University, Institute of Medicine and Dentistry, Professor (70251824)
鈴木 誠  新潟大学, 医歯学総合病院, 講師 (50107778)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥11,280,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2006: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2005: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordspulp treatment / endodontic treatment / Lesion Sterilization and Tissue Repair therapy / 3Mix-MP / Endodontics / LSTR / Save Pulp / LSTR 3Mix-MP療法 / Save-Pulp療法 / 生活歯髄 / 歯髄炎 / 歯髄治療x
Research Abstract

This project aimed to evaluate the pulp damages pathohistologically after the experience of spontaneous pain, which had been considered to be a clinical symptom of irreversible pulp-damage. The results obtained were as follows:
1. Samples were antagonist-less third molars extracted by expert LSTR dentists under informed consents.
2. Out of a total of 30 teeth, consisted of 22 treated with LSTR 3Mix-MP SavePulp therapy and 8 untreated teeth as controls, 8 pulps were observed to be slight inflammation, and 22 to be moderate inflammation. But, no pulp was necrotic, which would be typical irreversible pulp damage. Immigrated inflammatory cells located in the areas beneath pulp-expose-holes, but the cells were rather rare at the surrounded areas In these areas, nestin-positive intact odontoblast-layers and intact nerve innervations were observed. The severities of Inflammation did not correlate to the severity of spontaneous pains, or other clinical symptoms.
3. The 22 teeth treated with LSTR 3Mix-MP SavePulp therapy showed rather slight pathohistological damages, and, especially the case extracted 3 months after the treatment exhibited almost intact pulp, meaning that LSTR 3Mix-MP SavePulp therapy may not damage pulps furthermore and could result in repair of pulps.
These results agree with the excellent clinical outcomes of LSTR 3Mix-MP SavePulp therapy on teeth with experiences of spontaneous pains to preserve pulps to be sensitive and clinically intact

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (2 results)

All 2007

All Presentation (2 results)

  • [Presentation] Histo-pathology of Pulpitis with Spontaneous Pain2007

    • Author(s)
      T. Haniastuti
    • Organizer
      国際歯学研究学会・東南アジア部会
    • Place of Presentation
      インドネシア・バリ
    • Year and Date
      2007-09-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Histopathology of Pulpitis with Spontaneous Pain2007

    • Author(s)
      T, Haniastuti, E., Hoshino
    • Organizer
      International Association For Dental Research, Southeast Asian Division Annual Meeting
    • Place of Presentation
      Bali
    • Year and Date
      2007-09-08
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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